The mechanical properties of vertebrate cells are largely defined by the system of intermediate filaments (IF). As part of a dense network, IF polymers are constantly rearranged and relocalized in the cell to fulfill their duty as cells change shape, migrate, or divide. With the development of new imaging technologies, such as photoconvertible proteins and super‐resolution microscopy, a new appreciation for the complexity of IF dynamics has emerged. This review highlights new findings about the transport of IF, the remodeling of (...) filaments by a process of severing and re‐annealing, and the subunit exchange that occurs between filament precursors and a soluble pool of IF. We will also discuss the unique dynamic features of the keratin IF network. Finally, we will speculate about how the dynamic properties of IF are related to their functions. (shrink)

2. The equal status mentioned in Thesis 2 need not mean, "equally concrete" or "inclusive," but only, "equally real," where "real" means having a character of its own with reference to which opinions can be true or false. But becoming or process is alone fully concrete or inclusive, since if A is without becoming, and B becomes, then the togetherness of AB also becomes. A new constituent means a new totality. In this sense, becoming is the ultimate principle.

The idea that nous comes from without, deriving from Aristotle’s Generation of Animals II.3, became a key element in late ancient and Medieval accounts of human rationality drawing on Aristotle’s De Anima. But two very different understandings of the concept were around (often occurring next to each other): either it was taken to refer to the human capacity for thought and its origin outside the natural ontogenetic process; or it was taken to stand for the most perfect act of thought, (...) existing separately as the supreme divinity, and becoming, hopefully, ours at the very climax of human development. This paper shows how these two influential conceptions derive from the work of the two greatest scholars of Aristotle’s school, Theophrastus and Alexander of Aphrodisias, respectively. More to the point: it shows that (i) there is an intriguing philosophical story to be told of how the notion developed from one understanding to the other, this being the core of a larger story of nous from without in Western thought; and that (ii) this story sheds new light on what was at stake in the early – genuinely Peripatetic – reception of Aristotle’s account of nous (as contrasted with later, heavily Platonized, interpretations). (shrink)

The ‘musca depicta’ trope is well known to art historians, with a history going back to Pliny. It flourished in the Renaissance, but in eighteenth-century England the meaning of the trope was altered greatly when employed in popular culture, both in live theatrical presentations (by George Alexander Stevens) and in published poetry (by James Robertson, comedian of York). Originally, the trope signalled the virtuosity of the painter, who was able to fool the eye by depicting flies so real that the (...) viewer attempted to shoo them off the picture. However, in the hands of Stevens and Robertson, that bit of theatre was turned on its head, as the supposed connoisseur engaged in a harsh criticism of a painting is startled when a fly that he thinks poorly depicted suddenly flies off the canvas, thereby rendering the connoisseur a satiric target. (shrink)

RESUMO Um problema de longa data na erudição aristotélica diz respeito à questão de como reconciliar a dupla descrição de Aristóteles da metafísica como ontologia (a ciência universal do ser enquanto ser) e teologia (a ciência da substância imutável e separada). Uma tentativa importante de responder a esta questão (iniciada primeiro por G. Patzig) consiste em dizer que a substância imutável e separada é focalmente anterior (ou o significado focal da) substância e, portanto, de ser em geral (uma vez que (...) a substância é focalmente anterior a ser no geral). Este artigo visa refutar esse tipo de abordagem para o problema da unidade da metafísica de Aristóteles, argumentando que (i) as relações de significado focal implicam a prioridade lógica (definição) dos itens anteriores sobre os itens dependentes situados em tais relações; (ii) a substância imutável e separada não é logicamente anterior aos outros tipos de substâncias distinguidas por Aristóteles; e, portanto, (iii) a substância imutável e separada não é focalmente anterior à (o significado focal de) substância. (shrink)

Jan Patočka was one of the first philosophers in Czechoslovakia who, in addition to other areas of philosophy, also dealt with the philosophy of education. These ideas of his, concerned with the philosophical view of education, are still relevant today. The starting point of this study is, above all, Patočka's basic thesis, which states that a teacher who forms his/her pupils in a fundamental way must him/herself have a certain attitude towards the world and his/her life clarified, which means creating (...) his/her own life schedule that gives his/her life meaning. For Patočka, this meaning is the result of a daily struggle to continually acquire it. It is the formation of this world view, which the teacher then transmits to his/her pupils, that is, according to Patočka, the purpose of education as such. It thus prepares the teacher for the responsible exercise of his/her profession so that he/she can perform it adequately as a humanly valuable personality. This is a crucial moment in which philosophy can go beyond a purely theoretical approach to the world towards a practical application in the educational process. (shrink)

The author's thesis is that there is a conceptually necessary connection between law and morality which means legal positivism must fail as a comprehensive theory. The substantiation of this thesis takes place within a conceptual framework which shows that there are at least 64 theses to be distinguished, concerning the relationship of law and morality. The basis for the author's argument in favour of a necessary connection, is formed by the thesis that individual legal norms and decisions as well as (...) whole legal systems necessarily make a claim to correctness. The explication of this claim within the frame of discourse theory shows that the law has a conceptually necessary, ideal dimension, which connects law with a procedural, universalistic morality. (shrink)

Studie over de filosofie van de in Oostenrijk geboren Engelse wijsgeer.

This long-awaited book by one of the world's leading philosophers offers a systematic account of kinds of being, ways in which things can be or can fail to be.

The principle of natural selection is stated. It connects fitness values (actual reproductive success) with expected fitness values. The term 'adaptedness' is used for expected fitness values. The principle of natural selection explains differential fitness in terms of relative adaptedness. It is argued that this principle is absolutely central to Darwinian evolutionary theory. The empirical content of the principle of natural selection is examined. It is argued that the principle itself has no empirical biological content, but that the presuppositions of (...) its applicability are empirical. They form the empirical biological core of evolutionary theory. (shrink)

Understanding cooperation and punishment in small-scale societies is crucial for explaining the origins of human cooperation. We studied warfare among the Turkana, a politically uncentralized, egalitarian, nomadic pastoral society in East Africa. Based on a representative sample of 88 recent raids, we show that the Turkana sustain costly cooperation in combat at a remarkably large scale, at least in part, through punishment of free-riders. Raiding parties comprised several hundred warriors and participants are not kin or day-to-day interactants. Warriors incur substantial (...) risk of death and produce collective benefits. Cowardice and desertions occur. (shrink)

Simone Weil is one of the most challenging and yet beguiling thinkers of the twentieth century. There is a highly charged mystical current that runs through her life and works that seems almost timeless. And yet Weil was a keen observer of the modern condition, coming of age as she did during the 1930s. Amid the recurrent indignities and inhumanities of modern life, she wondered what is to become of the precious space we have for grace, for friendship, and for (...) truth? One of our most astute historians of existentialism, Robert Zaretsky shifts his attention to the utterly original Simone Weil with this new book. Taking up the central elements of her philosophy-affliction, attention, resistance, roots, and spirituality-he explores how they animated her life, and how they might animate ours. (shrink)

Pollution is currently responsible for 16% of premature deaths worldwide and poses the greatest long-term threat to public health due to the effects of climate change. The current framework of publ...

The place of self-concern in Christian love is studied, beginning with Fénelon's extreme claim that in perfect love for God one would desire nothing for its own sake except that God's will be done. This view is criticized. A distinction is made between self-interest (desire for one's own good for its own sake) and other sorts of self-concern; and it is argued that self-concern has an important role in the Christian virtues, but that self-interest has a less important role than (...) other sorts of self-concern. Finally, it is argued that Eros and Agape are not opposites, but Agape includes a certain sort of Eros. (shrink)

Argument teachers and scholars have frequently invoked external justification-impressing one's viewpoint upon another-as the primary social function of argument. Pluralism and fundamental disagreement in contemporary democratic societies raise questions regarding the status of argument, including the functions argument should serve. In this essay, I suggest alternatives of agenda expansion, responsibility attribution, and identity formation as important functions of argument in diverse societies. Thesealternative functions are especially important under conditions of social inequality, since they allow less powerful individuals and groups to (...) confront more powerful actors in situations where decision making is not open to all. (shrink)

In this essay, I argue that a proper understanding of the historicity of love requires an appreciation of the irreplaceability of the beloved. I do this through a consideration of ideas that were first put forward by Robert Kraut in “Love De Re” (1986). I also evaluate Amelie Rorty's criticisms of Kraut's thesis in “The Historicity of Psychological Attitudes: Love is Not Love Which Alters Not When It Alteration Finds” (1986). I argue that Rorty fundamentally misunderstands Kraut's Kripkean analogy, (...) and I go on to criticize her claim that concern over the proper object of love should be best understood as a concern over constancy. This leads me to an elaboration of the distinct senses in which love can be seen as historical. I end with a further defense of the irreplaceability of the beloved and a discussion of the relevance of recent debates over the importance of personal identity for an adequate account of the historical dimension of love. (shrink)

This paper is about two kinds of mental content and how they are related. We are going to call them representation and indication. We will begin with a rough characterization of each. The differences, and why they matter, will, hopefully, become clearer as the paper proceeds.

Biology and the social sciences share an interest in phylogeny. Biologists know that living species are descended from past species, and use the pattern of similarities among living species to reconstruct the history of phylogenetic branching. Social scientists know that the beliefs, values, practices, and artifacts that characterize contemporary societies are descended from past societies, and some social science disciplines, linguistics and cross cultural anthropology for example, have made use of observed similarities to reconstruct cultural histories. Darwin appreciated that his (...) theory of descent with modification had many similarities of pattern and process to the already well developed field of historical linguistics. In many other areas of social science, however, phylogenetic reconstruction has not played a central role. (shrink)

Because of their vastness and rather fragmentary character, the writings of Leibniz leave the student unusually dependent on secondary literature for guidance. That the literature on Leibniz is exceptionally good is all the more reason to welcome the kind of orientation to the riches of both primary and secondary sources that this Companion aims to provide. Announcing itself as “the most accessible and comprehensive guide to Leibniz currently available” for nonspecialists and “a conspectus of recent developments in the interpretation of (...) Leibniz” for specialists, it lives up to both aspirations remarkably well. (shrink)

Numerous labor-management issues possess ethical dimensions and pose ethical questions. In this article, the authors discuss four labor-management issues that present important contemporary problems: union organizing, labor-management negotiations, employee involvement programs, and union obligations of fair representation. In the authors view, labor and management too often view their ethical obligations as beginning and ending at the law''s boundaries. Contemporary business realities suggest that cooperative and enlightened modes of interaction between labor and management seem appropriate.

The central idea of T. M. Scanlon’s “contractualism” has been well known to ethical theorists since Scanlon 1982. In What We Owe to Each Other it has grown into a comprehensive and impressively developed theory of the nature of right and wrong—or at least of what Scanlon regards as the most important of the “normative kinds” that go under the names of ‘right’ and ‘wrong’. Rejecting aggregative consequentialism, Scanlon aims to articulate principles of right and wrong for individual action in (...) such a way that the interests of each affected person are taken fairly into account. (shrink)

Robert Wolfe writes about the nature of the ajata teachings, or the nature of emptiness and absolute reality.

Robert Myers presents an original moral theory which charts a course between the extremes of consequentialism and contractualism, portraying morality not simply as a matter of promoting the overall good but rather as a matter of cooperating in its promotion. This gives him answers to two of the most vexing questions in moral philosophy: how can increasing general welfare and respecting individual rights be equally fundamental features of moral activity, and what gives morality's demands their special character of inescapability?

In responding here to four respected colleagues I am grateful for their perceptive, and sympathetic but not uncritical, attention to my book. I discuss their comments in an order that permits me to focus first on the good and then on the right. I begin with some remarks addressed to two of my critics at once; there follow sections addressed to each of the four individually.

The post-Darwinian double-aspect theory that Professor Robert Kunzendorf's introduces in On the Evolution of Conscious Sensation, Conscious Imagination, and Consciousness of Self points to evolutionary functions of certain sensations, youngling vivid images, and self-consciousness.

The rational choice assumption that any chosen behavior can be understood as optimizing material self?interest is not borne out by psychological research. Expressive motives, for example, are prominent in the symbols of politics, in social relationships, and in the arts of persuasion. Moreover, instrumentality is a mindset that is learned (perhaps overlearned), and can be situationally manipulated; because it is valued in our society, it provides a privileged vocabulary for justifying behaviors that may have been performed for other reasons, and (...) encourages the illusory belief in the universality of rational choice. (shrink)

This paper criticises John Harris's attempts to defend an account of a ‘harmed condition’ that can stand independently of intuitions about what is ‘normal’. I argue that because Homo sapiens is a sexually dimorphic species, determining whether a particular individual is in a harmed condition or not will sometimes require making reference to the normal capacities of their sex. Consequently, Harris's account is unable to play the role he intends for it in debates about the ethics of human enhancement.

This article aims to argue in favour of two different kinds of responsibility: moral and organizational. I present the notion of moral responsibility and, specifically, moral accountability, which stands at the centre of the later discussion. I address Coleen Macnamara’s view of accountability, a model of enforcement involved in setting demands and sanctions. Then I account for some cases of morally impaired persons’ failure to respond adequately to moral demands, in contrast to their capacity to respond effectively to organizational demands. (...) I take the latter findings to show that there are two distinct kinds of accountability, moral and organizational. While moral accountability is connected to the arousal of emotions, I claim that organizational accountability is related to inner-organizational reactive procedures associated with employment benefits (such as promotion and other employment rewards) or sanctions. However, this can be distant from emotions. (shrink)