Over the past year, technology companies have made headlines claiming that their artificially intelligent (AI) products can outperform clinicians at diagnosing breast cancer, brain tumours, and diabetic retinopathy. Claims such as these have influenced policy makers, and AI now forms a key component of the national health strategies in England, the United States, and China. While it is positive to see healthcare systems embracing data analytics and machine learning, concerns remain about the efficacy, ethics, and safety of some commercial, AI (...) health solutions. This paper argues that improved regulation and guidance is urgently required to mitigate risks, ensure transparency and best practice, Without this, patients, clinicians, and other stakeholders cannot be assured of an app’s efficacy, and safety. (shrink)

A much‐debated series of articles in the New England Journal of Medicine in May 2015 labeled the pharmaceutical industry's critics “pharmascolds.” Having followed the debate for two decades, I count myself among the scolds. The weight of the evidence overwhelmingly supports the claim that pharmaceutical policy no longer serves the public interest; the central questions now are how this happened and what to do about it. I approached three of the most recent books on the industry with these questions in (...) mind. Deadly Medicine and Organized Crime (CRC Press, 2013), by Peter Gøtzsche, Bad Pharma (Faber & Faber, 2013), by Ben Goldacre, and Good Pharma (Palgrave MacMillan, 2015), by Donald Light and Antonio Maturo, all situate their critical assessments in high‐income countries globally, depicting the problem of pharmaceuticals as too many drugs approved with too little evidence, causing too many needless deaths, and prices spiraling to heights unimaginable just a decade ago. Light and Maturo, while no less critical of the status quo than Gøtzsche and Goldacre, take a different tack: they detail the success of an alternative model for pharmaceutical research, the Mario Negri Institute in Italy, citing it as proof positive that we can indeed defy capitalism's profit imperative. (shrink)

Bender, Robert Review of: Bad science, by Ben Goldacre, 2008, Harper/Collins 370 pages.

The philosophical study of well-being concerns what makes lives good for their subjects. It is now standard among philosophers to distinguish between two kinds of well-being: - lifetime well-being, i.e., how good a person's life was for him or her considered as a whole, and - temporal well-being, i.e., how well off someone was, or how they fared, at a particular moment in time or over a period of time longer than a moment but shorter than a whole life, say, (...) a day, month, year, or chapter of a life. Many theories have been offered of each of these kinds of well-being. A common view is that lifetime well-being is in some way constructed out of temporal well-being. This book argues that much of this literature is premised on a mistake. Lifetime well-being cannot be constructed out of temporal well-being, because there is no such thing as temporal well-being. The only genuine kind of well-being is lifetime well-being. The Passing of Temporal Well-Being will prove essential reading for professional philosophers, especially in moral and political philosophy. It will also be of interest to welfare economists and policy-makers who appeal to well-being. (shrink)

Proceeding of the Third International Conference of the French-Speaking Society for Theoretical Biology Content Type Journal Article Category Editorial Pages 1-2 DOI 10.1007/s10441-012-9156-2 Authors Slimane Ben Miled, ENIT-LAMSIN, Tunis el Manar University, 13, place Pasteur, Belvédère, B.P. 74, 1002 Tunis, Tunisia Journal Acta Biotheoretica Online ISSN 1572-8358 Print ISSN 0001-5342.

An overview (about 8,000 words) of act utilitarianism, covering the basic idea of the theory, historical examples, how it differs from rule utilitarianism and motive utilitarianism, supporting arguments, and standard objections. A closing section provides a brief introduction to indirect utilitarianism (i.e., a Hare- or Railton-style view distinguishing between a decision procedure and a criterion of rightness).

A popular response to the Exclusion Argument for physicalism maintains that mental events depend on their physical bases in such a way that the causation of a physical effect by a mental event and its physical base needn’t generate any problematic form of causal overdetermination, even if mental events are numerically distinct from and irreducible to their physical bases. This paper presents and defends a form of dualism that implements this response by using a dispositional essentialist view of properties to (...) argue that the psychophysical laws linking mental events to their physical bases are metaphysically necessary. I show the advantages of such a position over an alternative form of dualism that merely places more “modal weight” on psychophysical laws than on physical laws. The position is then defended against the objection that it is inconsistent with dualism. Lastly, some suggestions are made as to how dualists might clarify the contribution that mental causes make to their physical effects. (shrink)

This paper considers whether an analogy between distance and dissimilarlity supports the thesis that degree of dissimilarity is distance in a metric space. A straightforward way to justify the thesis would be to define degree of dissimilarity as a function of number of properties in common and not in common. But, infamously, this approach has problems with infinity. An alternative approach would be to prove representation and uniqueness theorems, according to which if comparative dissimilarity meets certain qualitative conditions, then it (...) is representable by distance in a metric space. I will argue that this approach faces equally severe problems with infinity. (shrink)

Mill’s harm principle is commonly supposed to rest on a distinction between self-regarding conduct, which is not liable to interference, and other-regarding conduct, which is. As critics have noted, this distinction is difficult to draw. Furthermore, some of Mill’s own applications of the principle, such as his forbidding of slavery contracts, do not appear to fit with it. This article proposes that the self-regarding/other-regarding distinction is not in fact fundamental to Mill’s harm principle. The sphere of protected liberty includes not (...) only self-regarding conduct, but also actions that affect only consenting others. On the other hand, the occasional permissibility of interfering with self-regarding conduct can plausibly be explained by reference to the agent’s consent. Thus, the more important distinction appears to be that between consensual and non-consensual harm, rather than that between the self-regarding and non-self-regarding action. That is, interference can be justified in order to prevent non-consensual harms, but not to prevent consensual harms. It is argued that the harm principle, thus reformulated, both captures Mill’s intentions and is a substantively plausible position. (shrink)

Sometimes people desire that their lives go badly, take pleasure in their lives going badly, or believe that their lives are going badly. As a result, some popular theories of welfare are paradoxical. I show that no attempt to defend those theories from the paradox fully succeeds.

The introduction (about 6,000 words) to _The Cambridge Companion to Utilitarianism_, in three sections: utilitarianism’s place in recent and contemporary moral philosophy (including the opinions of critics such as Rawls and Scanlon), a brief history of the view (again, including the opinions of critics, such as Marx and Nietzsche), and an overview of the chapters of the book.

In this paper I argue that the analysis of natural properties as convex subsets of a metric space in which the distances are degrees of dissimilarity is incompatible with both the definition of degree of dissimilarity as number of natural properties not in common and the definition of degree of dissimilarity as proportion of natural properties not in common, since in combination with either of these definitions it entails that every property is a natural property, which is absurd. I suggest (...) it follows that we should think of the convex class analysis of natural properties as a variety of resemblance nominalism. (shrink)

Greg Bognar has recently offered a prioritarian justification for ‘fair innings’ distributive principles that would ration access to healthcare on the basis of patients' age. In this article, I agree that Bognar's principle is among the strongest arguments for age-based rationing. However, I argue that this position is incomplete because of the possibility of ‘time-relative' egalitarian principles that could complement the kind of lifetime egalitarianism that Bognar adopts. After outlining Bognar's position, and explaining the attraction of time-relative egalitarianism, I suggest (...) various ways in which these two kinds of principle could interact. Since various options have very different implications for age-based rationing, proponents of such a rationing scheme must take a position on time-relative egalitarianism to complement a lifetime prioritarian view like Bognar's. (shrink)

ABSENCE is the claim that, if a symbol appears on a map, then absence of the symbol from some map coordinate signifies absence of the corresponding property from the corresponding location. This claim is highly intuitive and widely endorsed. And if it is true, then cartographic representation is strikingly different from linguistic representation. I argue, however, that ABSENCE is false of various maps and that we have no reason to believe it is true of any maps. The intuition to the (...) contrary results from mistaking what a map simply conveys for what it literally represents. (shrink)

Virtue-approaches to medical ethics are becoming ever more influential. Virtue theorists advocate redefining right or good action in medicine in terms of the character of the doctor performing the action. In medical education, too, calls are growing to reconceive medical education as a form of character formation. Empirical studies of doctors’ ethics from a virtue-perspective, however, are few and far between. In this respect, theoretical and empirical study of medical ethics are out of alignment. In this paper, we survey the (...) empirical study of medical ethics and find that most studies of doctors’ ethics are rules- or principles-based and not virtue-based. We outline the challenges that exist for studying medical ethics empirically from a virtue-based perspective and canvas the runners and riders in the effort to find virtue-based assessments of medical ethics. (shrink)

Some people claim that evolution is "just a theory". Do you know what a scientific theory really is? Just a theory is an overview of the modern concepts of science. A clear understanding of the nature of science will enable you to distinguish science from pseudoscience (which illegitimately wraps itself in the mantle of science), and real social issues in science from the caricatures portrayed in postmodernist critiques. Prof. Ben-Ari's style is light (even humorous) and easy to read, bringing the (...) latest concepts of science to the general reader. Of particular interest is his analysis of the terminology of science (fact, law, proof, theory) in relation to the colloquial meaning of these terms. Between chapters are biographical vignettes of scientists — both familiar and unfamiliar — showing their common commitment to the enterprise of science, together with a diversity of backgrounds and personalities. This accessible, informative, and comprehensive work will give lay readers a good grasp of real science. (shrink)

The Exclusion Argument for physicalism maintains that since (1) every physical effect has a sufficient physical cause, and (2) cases of causal overdetermination are rare, it follows that if (3) mental events cause physical events as frequently as they seem to, then (4) mental events must be physical in nature. In defence of (1), it is sometimes said that (1) is supported if not entailed by conservation laws. Against this, I argue that conservation laws do not lend sufficient support to (...) (1) to render its denial ‘unscientific’, and that those who accept (3) and deny (4) may consequently respond to the Exclusion Argument by denying (1) without thereby setting themselves at odds with current science. I also argue that conservation laws are compatible with (3) and the negation of (4), and that one can therefore accept conservation laws and (3) while denying both (1) and (4). (shrink)

In a world of industralized farming and feed lots, is eating meat ever a morally responsible choice? Is eating organic or free range sufficient to change the moral equation? Is there a moral cost in not eating meat? As billions of animals continue to be raised and killed by human beings for human consumption, affecting the significance and urgency in answering these questions grow. This volume collects twelve new essays by leading moral philosophers who address the difficult questions surrounding meat (...) eating by examining various implications and consequences of our food choices. Some argue for the moral permissibility of eating meat by suggesting views such as farm animals would not exist and flourish otherwise, and the painless death that awaits is no loss to them. Others consider more specific examples like whether buying french fries at McDonalds is just as problematic as ordering a Big Mac due to the action's indirect support of a major purveyor of meat. The Moral Complexities of Eating Meat is a stimulating contribution to the ongoing debate on meat consumption and actively challenges readers to reevlaute their stand on food and animal ethics. (shrink)

In “Tropes and Ordinary Physical Objects”, Kris McDaniel argues that ordinary physical objects are fusions of monadic and polyadic tropes. McDaniel calls his view “TOPO”—for “Theory of Ordinary Physical Objects”. He argues that we should accept TOPO because of the philosophical work that it allows us to do. Among other things, TOPO is supposed to allow endurantists to reply to Mark Heller’s argument for perdurantism. But, we argue in this paper, TOPO does not help endurantists do that; indeed, we argue (...) that anyone who accepts TOPO should reject endurantism. (shrink)

The 70th anniversary of Aldo Leopold’s A Sand County Almanac (1949) approaches. For philosophers—environmental ethicists in particular—this text has been highly influential, especially the ‘Land Ethic’ essay contained therein. Given philosophers’ acumen for identifying and critiquing arguments, one might reasonably think a firm grasp of Leopold’s ideas to have emerged from such attention. I argue that this is not the case. Specifically, Leopold’s main interpreter and systematiser, philosopher J. Baird Callicott, has shoehorned Aldo Leopold’s ideas into differing monistic moral theories (...) that ill-serve a proper understanding. Against Callicott, my paper argues that Aldo Leopold embraces a robust moral pluralism, one that goes beyond mere pragmatics, and he does so while seeking a consistency maximisation of values. A new, improved understanding of Leopold’s ideas thus emerges. (shrink)

Joseph Ben-David (1920-1986) fut un des sociologues des sciences les plus innovateurs et les plus en vue des années soixante et soixante-dix. Travaillant dans le cadre des théories sociologiques de Max Weber, Talcott Parsons et Robert Kmerton, il élabora dans ses ouvrages et nombreux articles une théorie sociologique originale du développement scientifique. Par sa démarche diachronique, il se démarque des sociologues des sciences de l'école fonctionnaliste ; par sa perspective sociologique, il définit des nouvelles problématiques qui viennent s'ajouter à celles (...) des historiens des sciences travaillant dans une optique " internaliste ". Dans le présent ouvrage ont été réunis et traduits les articles les plus importants de Ben-David, qui, ensemble, dessinent les contours d'une sociologie historique des sciences. Par son pouvoir explicatif, cette théorie est à même d'enrichir la pratique de l'historien des sciences, tandis que, par sa réaffirmation des vertus éthiques des rôles sociaux du savant et de l'Université, elle est d'une grande actualité pour les débats sur l'enseignement supérieur en France. (shrink)

It is widely believed to be permissible for a physician to discontinue any treatment upon the request of a competent patient. Many also believe it is never permissible for a physician to intentionally kill a patient. I argue that the prospect of deactivating a patient’s artificial heart presents us with a dilemma: either the first belief just mentioned is false or the second one is. Whichever horn of the dilemma we choose has significant implications for contemporary medical ethics.

Millianism and Fregeanism agree that a sentence that contains a name expresses a structured proposition but disagree about whether that proposition contains the object that the name refers to (Millianism) or rather a mode of presentation of that object (Fregeanism). Various problems – about simple sentences, propositional‐attitude ascriptions, and sentences that contain empty names – beset each view. To solve these problems, Millianism can appeal to modes of presentation, and Fregeanism can appeal to objects. But this raises a further problem: (...) namely, to explain why the proposition expressed by a sentence that contains a name matters in some cases but not in others. (shrink)

Opponents of legalised assisted dying often assert that palliative care is worse in countries where assisted dying has been legalised, and imply that legalised assisted dying makes palliative care worse. This study considers five versions of this claim: that it is difficulty to access expert palliative care in countries where assisted dying has been legalised, that those countries rank low in their quality of end‐of‐life care; that legalising assisted dying doesn't expand patient choice in respect of palliative care; that growth (...) in palliative care services has stalled in countries where assisted dying has been legalised; and that legalised assisted dying impedes the growth of palliative care or causes it to decline. In each case, it concludes that neither argumentation nor evidence supports these claims. (shrink)

I argue that a reasonable understanding of Leopold’s ‘Land Ethic’ is one that identifies possession of health as being a sufficient condition for moral consideration. With this, Leopold extends morality not only to biotic wholes, but to individual organisms, as both can have their health undermined. My argument centers on explaining why Leopold thinks it reasonable to analogize ecosystems both to an organism and to a community: both have a health. My conclusions undermine J. Baird Callicott’s rhetorical dismissal of the (...) organism analogy’s importance, a dismissal crucially serving his thesis that Leopoldians should hold community membership necessary for moral standing. (shrink)

A book chapter (about 7,000 words, plus references) on the interpretation of Mill’s criterion of right and wrong, with particular attention to act utilitarianism, rule utilitarianism, and sanction utilitarianism. Along the way, major topics include Mill’s thoughts on liberalism, supererogation, the connection between wrongness and punishment, and breaking rules when doing so will produce more happiness than complying with them will.

Is love best when it is fresh? For many, the answer is a resounding “yes.” The intense experiences that characterize new love are impossible to replicate, leading to wistful reflection and even a repeated pursuit of such ecstatic beginnings. Aaron Ben-Ze’ev takes these experiences seriously, but he’s also here to remind us of the benefits of profound love—an emotion that can only develop with time. In The Arc of Love, he provides an in-depth, philosophical account of the experiences that arise (...) in early, intense love—sexual passion, novelty, change—as well as the benefits of cultivating long-term, profound love—stability, development, calmness. Ben-Ze’ev analyzes the core of emotions many experience in early love and the challenges they encounter, and he offers pointers for weathering these challenges. Deploying the rigorous analysis of a philosopher, but writing clearly and in an often humorous style with an eye to lived experience, he takes on topics like compromise, commitment, polyamory, choosing a partner, online dating, and when to say “I love you.” Ultimately, Ben-Ze’ev assures us, while love is indeed best when fresh, if we tend to it carefully, it can become more delicious and nourishing even as time marches on. (shrink)

This article is about the potential justification for deploying some form of affirmative action (AA) in the context of healthcare, and in particular in relation to the pandemic. We call this Affirmative Action in healthcare Resource Allocation (AARA). Specifically, we aim to investigate whether the rationale and justifications for using prioritization policies based on race in education and employment apply in a healthcare setting, and in particular to the COVID-19 pandemic. We concentrate in this article on vaccines and ventilators because (...) these are both highly scarce resources in the pandemic, and there has been a need to develop policies for allocating them. However, as will become clear, the ethical considerations relating to them may diverge. We first set out two rationales for AAs and what they might entail in a healthcare setting. We then consider some disanalogies between AA and AARA, as well as the different implications of AARA for allocating ventilators as opposed to vaccines. Finally, we consider some of the practical ways in which AARA could be implemented, and conclude by responding to some key objections. (shrink)

ʻEdut be-Hosef -- Derekh ʻets ha-ḥayim -- Refuʼat ha-nefesh -- ha-Tapuaḥ.

While cancer survivors commonly experience fear and anxiety, a substantial minority experience an enduring and debilitating fear that their cancer will return; a condition commonly referred to as fear of cancer recurrence. Despite recent advances in this area, little is known about FCR among people from Indigenous or other ethnic and racial minority populations. Given the high prevalence and poor outcomes of cancer among people from these populations, a robust understanding of FCR among people from these groups is critical. The (...) current review identified and aggregated existing literature on FCR amongst adult cancer survivors from Indigenous and minority populations. The protocol of this review was registered with PROSPERO in July 2020. A systematic search of bibliographic databases was conducted for relevant articles published from 1997 to November 2019. Data from eligible articles were extracted and appraised for quality by two independent reviewers. Nineteen articles from four countries met the inclusion criteria, including 14 quantitative, 4 qualitative and 1 mixed-methods study. Only one article reported on an Indigenous population. Few studies reported on FCR prevalence or severity. While the variation in tools used to measure FCR hindered a robust estimate of severity, results suggested some differences in FCR severity between minority and dominant populations, although these may have been due to study metholodological differences. Few factors were reported as being associated with FCR in minorities across multiple studies. The qualitative synthesis found five themes associated with the lived experience of FCR: variations in the lived experience of FCR; spirituality and worldview impacting on FCR; the importance of staying positive; complexities around support; and increasing cancer knowledge. The findings of this review highlight differences in FCR across cultures and contexts, which reinforces the need for culturally-specific approaches to this condition. The dearth of research in this area is of concern given the significant burden of cancer in these populations. A deeper understanding of this condition among Indigenous and minority populations is critical to developing and delivering appropriate and effective psychosocial care for cancer survivors from these groups. Systematic Review Registration: identifier [CRD42020161655]. (shrink)

Eric Davidson was a legend both in his science and his personality. He inspired and challenged a new generation of developmental biologists and I was lucky to be one of them. He changed the way we think about biological interactions by synthesizing a large scale, almost incomprehensible set of data into a causal model of a gene regulatory network. While his death leaves a big hole in our lives, his contribution to the conceptualization of regulatory biology will inspire developmental and (...) evolutionary biologists for decades to come. (shrink)

ḥeleḳ 1. Pirḳe ʻiyun be-gidre mitsṿat ha-biṭaḥon be-mishnato shel Baʻal Ḥovot ha-levavot.

RésuméDans cet article, j'analyse des passages cruciaux de la composition finale du théologien Faḫr al-Dīn al-Rāzī, Al-Maṭālib al-῾āliya, afin de théoriser sur la nature de deux de ses études : la cosmologie et l'angélologie. En cherchant à prouver l'existence de ces êtres, Rāzī divise la réalité en deux domaines : matériel et intelligible. Les anges, qui symbolisent les intellects et les sphères, existent dans une réalité intelligible comme des êtres qui n'occupent pas d'espace. Parmi eux, certains sont associés aux corps (...) célestes, et d'autres ne s'associent à aucune chose matérielle. Dans un deuxième temps, je présente des arguments suggérant que Rāzī pensait peut-être que ces êtres célestes sont prééternels avec Dieu. Ces conceptions montrent une continuité avec la tradition philosophique islamique, et elles la structure philosophique de la réalité intégrée par al-Ġazālī dans quelques textes théologiques. De plus, on a examiné d'autres courants philosophiques développés dans le monde islamique qui ont pu agir sur la cosmologie de Rāzī, en lien avec la tradition hermétique et avec les Épîtres des frères de la Pureté. (shrink)

Johannes Kniess argues that a generational smoking ban, which prevents all those born after a certain date from buying tobacco, need not violate relational egalitarian commitments.1 Those denied the freedom to smoke need not be regarded as inferior, discriminated against, stigmatised or have their interests neglected. However, his argument focuses on a comparison between the younger cohort, who are permanently denied the freedom to smoke, and existing smokers, who retain the freedom to smoke because withdrawing this would impose greater burdens (...) on them. As illustrated in table 1, there are three relevant groups in society: (1) older smokers, (2) older non-smokers and (3) younger non-smokers. (The ban, if effective, means that there will not be any smokers in the younger cohort, so the potential fourth category is empty.) The comparisons Kniess makes focus on groups 1 and 3, but neglect group 2: those who are old enough to smoke, but who are not already smokers. View this table: Table 1 Groups in society A generational ban involves differential treatment of older cohorts (groups 1 and 2) and younger cohorts (group 3). Kniess argues that such differential treatment can be …. (shrink)

This essay formulates a moral principle I call sustainability’s golden rule. This principle, I will argue, goes a long way in providing correct moral guidance for sustainable development. In laying out these ideas, the essay proceeds as follows: first, a very basic, oft-privileged definition of sustainable development is put forward; second, I make clear how sustainability’s golden rule is formulable from basic moral considerations that explain why sustainable development should be pursued at all; and lastly, I deduce some of the (...) general implications sustainability’s golden rule has for sustainable development. (shrink)

Nicholas Agar argues that we should avoid certain ‘radical’ enhancement technologies. One reason for this is that they will alienate us from current sources of value by altering our evaluative outlooks. We should avoid this, even if enhancing will provide us with novel, objectively better sources of value. After noting the parallel between Agar’s views and G. A. Cohen’s work on the ‘conservative bias’, I explore Agar’s suggestion in relation to two kinds of radical enhancement: cognitive and anti-ageing. With regard (...) to both, there are reasons to doubt Agar’s empirical predictions about the severity of the evaluative changes we will undergo. Nonetheless, there is some force to the argument as applied to cognitive enhancement; in particular, radical cognitive enhancement may endanger our current valuable relationships with our loved ones. However, even if we find this a plausible worry for radical cognitive enhancement, it is not plausible for even radical anti-ageing enhancement, because the change Agar predicts will not affect our core motivations in the way that cognitive enhancement threatens to. (shrink)