Phosphatidylinositol 5‐phosphate (PtdIns5P), the least characterized among the three phosphatidylinositol monophosphates, is emerging as a bioactive lipid involved in the control of several cellular functions. Similar to PtdIns3P, it is present in low amounts in mammalian cells, and can be detected at the plasma membrane and endomembranes as well as in the nucleus. Changes in PtdIns5P levels are observed in mammalian cells following specific stimuli or stresses, and in human diseases. Recently, the contribution of several enzymes such as PIKfyve, myotubularins, (...) and type II PtdInsP‐kinases to PtdIns5P metabolism has gained a strong experimental support. Here, we provide a picture emerging from recent studies showing how this lipid can be generated and act as a regulator of membrane and cytoskeleton dynamics, and as a modulator of gene expression. We briefly summarize the current methods and tools for studying PtdIns5P, and discuss how PtdIns5P can integrate and coordinate different functions in a spatiotemporal manner. (shrink)

How I became a philosopher -- To love, to love me, to love us.

For some decades, the concept of human dignity has been widely discussed in bioethical literature. Some authors think that this concept is central to questions of respect for human beings, whereas others are very critical of it. It should be noted that, in these debates, dignity is one component of a long-lasting and widespread conceptual construct used to support a stance on the ethical question of the moral status of an action or being. This construct has been used from Modernity (...) onward to condemn slavery and torture as violations of human dignity. In spelling it out, we can come to a better understanding of what “dignity” means and become aware that there exists a quite useful place for this notion in our ethical thought, albeit a modest one. (shrink)

Current thinking and research on consciousness and the brain.

Sustainability is typically viewed as consisting of three forces, economic, social, and ecological, in tension with one another. In this paper, we address the dangers posed to societal sustainability. The concern being addressed is the very survival of societies where the rights of individuals, personal and collective freedoms, an independent judiciary and media, and democracy, despite its messiness, are highly valued. We argue that, as a result of various technological innovations, a range of dysfunctional impacts are threatening social and political (...) stability. For instance, robotics and automation are replacing human labor and decision-making in a range of industries; search engines, monetized through advertising, have access to, and track, our interests and preferences; social media, in connecting us to one another often know more about us than we ourselves do, enabling them to profit in ways which may not coincide with our well-being; online retailers have not only acquired the ability to track and predict our buying choices, but also they can squeeze vendors based on their outsize bargaining power; and, in general, virtual technologies have changed both the way we think and our sense of self. With the rising deployment of the Internet of Things, and developments in machine learning and artificial intelligence, the threats to individual freedoms and rights, societal cohesion and harmony, employment and economic well-being, and trust in democracy are being ratcheted up. This paper lauds the benefits and addresses the harm wrought by the high tech giants in Information and Communication Technologies. The search for rapidly growing revenues drives firms to accelerate product innovation without fully investigating the entire gamut of their impacts. As greater wealth accrues to the leaders of tech firms, inequalities within firms and societies are widening, creating social tensions and political ferment. We explore the ethical nature of the challenge employing a simple utilitarian calculus, complemented by approaches rooted in rights, justice, and the common good. Various options to address the challenges posed by ICTs are considered and evaluated. We argue that regulation may do little more than slow down the damage to society, particularly since societal values and political preferences vary internationally. Firms need to establish ethical standards, imbuing the upholders of these standards with sufficient authority, while creating a culture of morality. User involvement and activism, and shareholders’ concerns for the sustainability of societies on whose continued prosperity they depend, are imperative to humanity’s ability to decide the future direction of technology. (shrink)

L ’ ambition de cet article est double. D ’ une part, il tente de dépasser le fossé qui existe entre les travaux en philosophie morale et politique, qui traitent rarement de réels raisonnements moraux en contexte, et les recherches en sociologie, en sciences politiques ou en analyse de discours, qui éludent les contenus de ces raisonnements. D ’ autre part, le cas étudié, extrait d ’ une conférence de consensus, un publiforum suisse sur le génie génétique et l ’ (...) alimentation, a l ’ avantage de mettre en contact divers types d ’ experts en éthique et des citoyens ordinaires, convoqués au sein de nouvelles formes d ’ institutionnalisation, connues principalement en Europe sous le nom d ’ Évaluation technologique participative (ETP). Cet article propose une nouvelle méthode de sociologie éthique de l ’ évaluation qui vise la restitution de jugements de tiers en contexte, en tâchant de tirer le meilleur des ressources de la philosophie morale à des fins de clarification, tout en respectant les exigences de la sociologie, notamment son souci de mise à distance et d ’ objectivation. Il discute certaines des difficultés propres à ce type de recherche à l ’ interface de la sociologie et de la philosophie. Il analyse dans le détail diverses positions exhibées par des personnes de référence et la façon dont des citoyens s ’ en saisissent pour élaborer leurs préconisations dans un rapport, fruit de leurs travaux, transmis au Parlement du pays concerné et diffusé largement dans la société. La discussion qui clôt cet article remet en cause les solutions procédurales rawlsienne et habermassienne qui s ’ en remettent à une coopération équitable entre individus libres et égaux ou au droit, aboutissant à une abstinence épistémique ou à une sous-estimation de la capacité qu ’ aurait un individu de produire une justification rationnelle de son jugement moral. (shrink)

This book focuses on the various racial and cultural challenges facing African-Americans in the context of present day educational, political, and historical realities. It discusses the psychology of race and power, the plight of the modern black intellectual, and the need to enhance the educational standing of American citizens.

Recently at the J. Craig Venter Institute, a microorganism has been created through synthetic biology. In the future, more complex living beings will very probably be produced. In our natural environment, we live amongst a whole variety of beings. Some of them have moral status — they have a moral importance and we cannot treat them in just any way we please —; some do not. When it becomes possible to create artificially living beings who naturally possess moral status, will (...) this artificiality modify their status? Many people contend that it will, but I am not of the same mind and will develop three arguments against it. (shrink)

This new volume of philosophical papers by Bernard Williams is divided into three sections: the first Action, Freedom, Responsibility, the second Philosophy, Evolution and the Human Sciences; in which appears the essay which gives the collection its title; and the third Ethics, which contains essays closely related to his 1983 book Ethics and the Limits of Philosophy. Like the two earlier volumes of Williams's papers published by Cambridge University Press, Problems of the Self and Moral Luck, this volume will (...) be welcomed by all readers with a serious interest in philosophy. It is published alongside a volume of essays on Williams's work, World, Mind, and Ethics: Essays on the Ethical Philosophy of Bernard Williams, edited by J. E. J. Altham and Ross Harrison, which provides a reappraisal of his work by other distinguished thinkers in the field. (shrink)

Selon les stoïciens, il y a en tout être vivant une impulsion vitale, un élan de la nature qui le porte à persévérer dans son être. En la plupart des êtres, cette inclination naturelle est fatale, aveugle et inconsciente. Chez l'homme, au contraire, cette tendance initiale s'élève peu à peu à la conscience et se transforme ainsi en désir. Il semble bien que l'ρμ stoïcienne présente quelque analogie avec le conatus spinoziste. Spinoza, en effet, affirme que chaque chose s'efforce de (...) persévérer dans son être : « Unaquaeque res, quantum in se est, in suo esse perseverare conatur». Cet effort, quand il se rapporte à 1'homme considéré comme formé d'une âme et d'un corps, est appelé appétit. Quant au désir, il n'est autre chose que l'appétit avec conscience de lui-même : «Il n'y a nulle différence entre l'Appétit et le Désir, sinon que le Désir se rapporte généralement aux hommes, en tant qu'ils ont conscience de leurs appétits ». A ce niveau, il existe done une étrange ressemblance entre le désir selon les Stoïciens et le désir selon Spinoza, puisque tous deux ont une racine commune, à savoir la tendance de l'être à persévérer dans son être : le désir est cette tendance elle-même, telle qu'elle se manifeste chez l'être raisonnable, conscient de ses appétits. (shrink)

In the Grundlagen Frege says that "line a is parallel to line b" differs from "the direction of a = the direction of b" in that "we carve up the content in a way different from the original way". It seems that such recarving is crucial to Frege's logicist program of defining numbers, but it also seems incompatible with his later theory of sense and reference. I formulate a restriction on recarving, in particular, that no names may be introduced that (...) introduce new possibilities of reference failure, which is observed by Frege's examples. This restriction discriminates between various relatives of the "slingshot" argument which rely on a step of recarving. I offer an argument for the restriction based on Fregean principles, which I formalize in Church's "Logic of Sense and Denotation", and briefly discuss various axioms of his "Alternative (0)" which are incompatible with recarving. (shrink)

Notre recherche consiste à retrouver, sous la partie visible des sciences cognitives, la partie invisible toujours active qui les fonde c'est-à-dire les nœuds liant à propos du cerveau-corps-esprit la médecine, la psychologie, la philosophie et la psychiatrie. Une certaine histoire philosophique de la psychologie voudrait imposer la thèse d'une indépendance de l'esprit par rapport au corps comme de la psychologie par rapport à la physiologie, la biologie, la neurologie ou encore la génétique. Pourtant l’étude des troubles neurologiques, des neuropathies du (...) développement des cerveaux de l’enfant prématuré, des psychopathologies des affects et des lésions, dont le XIXe siècle avait constitué ces modèles, se poursuivent aujourd’hui pour maintenir l’interrogation sur la relation esprit-cerveau-corps. (shrink)

Introduction -- L'action et la création comme manifestations intensives de la vie -- Le primat de l'action et la place de la création dans les philosophies de l'action -- Le primat contemporain de la création -- Danse et musique, corps et rythme -- La création musicale aujourd'hui : du démembrement à la recomposition? -- Conclusion.