Bacteria have evolved advanced strategies for surviving during nutritional stress, including expression of specialized enzyme systems that allow them to grow on unusual nutrient sources. Inorganic phosphate (Pi) is limiting in most ecosystems, hence organisms have developed a sophisticated, enzymatic machinery known as carbon‐phosphorus (C‐P) lyase, allowing them to extract phosphate from a wide range of phosphonate compounds. These are characterized by a stable covalent bond between carbon and phosphorus making them very hard to break down. Despite the challenges involved (...) in both synthesizing and catabolizing phosphonates, they are widespread in nature. The enzymes required for the bacterial C‐P lyase pathway have been identified and for the most part structurally characterized. Nevertheless, the mechanistic principles governing breakdown of phosphonate compounds remain enigmatic. In this review, an overview of the C‐P lyase pathway is provided and structural aspects of the involved enzyme complexes are discussed with a special emphasis on the role of ATP‐binding cassette (ABC) proteins. (shrink)

Bjarne Melkevik, docteur s droit de Paris II, est professeur titulaire la Facult de droit de l'Universit Laval (Qubec) et professeur associ au Dpartement de droit et Justice, Universit Laurentienne (Ontario).

The shared circuits model (SCM) is a useful explanatory framework that can be applied to interpersonal synchrony by incorporating temporal dynamics. Temporally precise predictive simulations and mirroring enable interpersonal synchrony. When partners' movements are highly synchronous, the self/other distinction can be blurred.

Listening to the Concerto for Violin and Orchestra in D-major by Brahms takes twenty-two minutes. It varies a few minutes depending of the soloist and conductor, but the duration is fairly constant. Reading Anna Karenina by Leo Tolstoy takes many hours. The duration varies a lot depending on the reader's pace, but reading literature, just as listening to music, takes a considerable amount of time. Looking at a work of visual art, on the other hand, typically takes less than a (...) minute. This may be an exaggeration, but museum studies show that visitors to an art museum usually spend only a few moments in front of the individual work of art. Jeffrey K. Smith and Lisa F. Smith found that visitors to the Metropolitan... (shrink)

The desire to guide research and innovation in more ‘responsible’ directions is increasingly emphasised in national and international policies, the funding of inter- and trans-disciplinary collaborations and academic scholarship on science policy and technology governance. Much of this growth has occurred simultaneously with the development of nanoscale sciences and technologies, where emphasis on the need for responsible research and innovation has been particularly widespread. This paper describes an empirical study exploring the potential for RRI within nanosafety research in Norway and (...) Denmark. It identifies three different ways nanosafety scientists relate to core RRI criteria, demonstrating areas of both convergence and divergence between their views and those of academics and policymakers currently defining and working to promote RRI. The paper identifies a range of practical barriers and cultural differences that are creating such divergences and inhibiting the enactment of RRI within the particular site of research laboratories. It concludes that the identified differences and challenges demand critical reflection on both the appropriateness and applicability of RRI characteristics for enactment at the level of individual research scientists. Significant changes are therefore advocated as required if RRI, as currently imagined and promoted, is to become an integral mode of scientific culture. (shrink)

Health communication researchers and practitioners continue to debate about the types of influence that are appropriate in health promotion. A widely held assumption is that health campaigns and communicators should respect the autonomy of their audiences, and that the most appropriate way to do so is to persuade them by means of truthful substantive information. This approach to ethical persuasion, though, suffers from certain blind spots. To account for circumstances when respecting autonomy might take a back seat to other ethical (...) considerations, a comprehensive framework for the ethics of health communication needs to acknowledge types of communication that aim to do something other than provide substantive information (disclosive and directive communication), and subjective circumstances when people are not motivated to process information or make active choices (low processing motivation and decision aversion). (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Communicative Implications of Kant’s Aesthetic TheoryThomas HoveIn recent discussions of aesthetic theory, critics who raise social, cultural, and political concerns have issued important challenges to the Kantian legacy. Kant’s Critique of the Power of Judgment (1790) continues to be widely regarded as one of the founding documents of modern aesthetic theory. But the arguments he laid out in that notoriously enigmatic work remain controversial on a variety of fronts. (...) One of those arguments concerns his distinction between pleasures that are beautiful and those that are agreeable. According to Kant’s definition, what makes experiences of the beautiful special is that they have a potentially communicable universal validity. By contrast, pleasures that are merely agreeable are incommunicable and remain confined to private sensation. Philosophers have found this distinction problematic for a variety of reasons. Their detailed commentaries have examined the intricate logical and conceptual difficulties that Kant’s theory raises (see Allison 2001; Guyer 1982, 1997, 2002; Kalar 2000; Wenzel 2005). On another front, sociologists and cultural critics—whom I will broadly refer to as “social critics”—typically raise concerns about the theory’s hidden social implications (Bourdieu 1984; Eagleton 1990; Smith 1988; Shumway 2005). Specifically, they question Kant’s proposal that judgments about the beautiful ought to have universal validity. Taking an external standpoint, they tend to regard aesthetic judgments either as the peculiar habits of [End Page 103] specific social classes, or as badges of hierarchical distinction, or as weapons in symbolic struggles for cultural dominance.To suggest why Kant’s theory is worth revisiting in the wake of such critiques, the following analysis defends his theoretical effort to distinguish the experience of the beautiful from that of the agreeable. This feature of his aesthetic theory highlights an alternative to the cognitive and practical concerns that social critics emphasize. In particular, I indicate how Kant’s aesthetic theory offers directions for the effort to explain how aesthetic experience promotes communicative sociability. By emphasizing this theme, I hope to supplement the rival emphasis that social critics place on the Kantian legacy’s elitist undercurrents. Social critiques characteristically overlook the affective type of sociability to which aesthetic experience gives rise. This oversight occurs because those critiques tend to privilege the theoretical and practical dimensions of communication. In the process, they disregard the special types of validity claims that are unique to aesthetic discourse. Following the lead of his academic precursors Meier and Baumgarten, Kant tried to define a possible third mental “faculty” that differs from cognitive and practical reason (see Henrich 1992, 31–36). But the difficulty of defining this third faculty, much less determining its existence, continues to vex both philosophers and communication theorists.Kant’s Account of Aesthetic Experience and Its CriticsIn the opening sections of the Critique of Judgment, Kant attempts to establish the independence of aesthetic judgment from theoretical and practical cognition. Those faculties are concerned with cognitive and moral concepts. By contrast, the aesthetic properties that concern taste judgments have a unique ontological and epistemological status. Kant’s argument about that status is itself enormously complex, involving as it does an intricate network of idiosyncratically defined concepts (for example, the understanding, the imagination, intuition, representations, objects, etc.). But to avoid getting lost in those intricacies, we can bracket them by simply referring to aesthetic “experience.” Also, we can concentrate on the two properties that distinguish aesthetic experience from other kinds of experience. First, aesthetic properties relate to the feelings of pleasure that are aroused by certain encounters with objects. Second, aesthetic properties are “merely subjective” (Kant 2000, 75). They do not have an objective status because we cannot associate the feelings they arouse with determinate concepts and objects. [End Page 104] As Miles Rind puts it, “in making a cognitive judgment one requires everyone to conceptualize an object in a certain way, while in making a judgment of taste one requires others to share one’s liking for an object” (Rind 2000, 83). In sum, Kant differentiates aesthetic judgment from both theoretical and practical cognition because it is radically subjective and because its unique grounding lies in feelings of pleasure and displeasure.Social critics tend to downplay the idea that there... (shrink)

Although Denmark managed to stay neutral throughout World War I, it nevertheless generated a heated debate in the country; most people took a clear stand for one side or the other. After the traumatic Danish defeat in the 1864 war with Prussia and Austria, Germany was regarded as the arch enemy and not unexpectedly mostDanes sided against the Central Powers in the public debate. This was not least the case amongst the national-conservative politicians, intellectuals and artists. They form the focus (...) of my article, and the questions I address are: how did the national-conservatives experience the mental watershed of the war? Was it as a blessing or a curse? (shrink)

The psychological effects of aesthetic education have often been discussed, and major studies such as Michael Parsons’s inquiry into art understanding show that the development of understanding works of visual art is influenced by education.1 His findings show that the way people talk about art can be structured in five stages of development according to the model of Jean Piaget’s theory of cognitive development. He believes that the understanding of art, just like general cognition, is based on mental maturation but (...) that some kind of education is necessary to acquire the different skills of the understanding of art at each stage of development. Parsons’s study does not include educational strategies, but his .. (shrink)

logique. Dans la société moderne et pluraliste, l'identité des sujets est en fait une combinaison de ces identités. Ainsi, la pluralité n'est pas extérieure ...

Since the 1980s the concept of ANT has remained unsettled. ANT has continuously been critiqued and hailed, ridiculed and praised. It is still an open question whether ANT should be considered a theory or a method or whether ANT is better understood as entailing the dissolution of such modern ‘‘genres’’. In this paper the authors engage with some important reflections by John Law and Bruno Latour in order to analyze what it means to ‘‘do ANT,’’ and, doing so after ‘‘doing (...) ANT on ANT.’’ In particular the authors examine two post-ANT case studies by Annemarie Mol and Marilyn Strathern and outline the notions of complexity, multiplicity, and fractality. The purpose is to illustrate the analytical consequences of thinking with post-ANT. The analysis offers insights into how it is possible to ‘‘go beyond ANT,’’ without leaving it entirely behind. (shrink)

Anthony K. Jensen - Nietzsche's Life Sentence: Coming to Terms with Eternal Recurrence - Journal of the History of Philosophy 44:4 Journal of the History of Philosophy 44.4 671-672 Muse Search Journals This Journal Contents Reviewed by Anthony K. Jensen Emory University Lawrence J. Hatab. Nietzsche's Life Sentence: Coming to Terms with Eternal Recurrence. New York-London: Routledge, 2005. Pp. xix + 191. Paper, $24.95. In his latest book, Lawrence Hatab brings together several threads from his previous writing into (...) an elegant expression that examines a wide range of Nietzsche's thought through the single prism of his notoriously obscure conception of "Eternal Recurrence." The opening chapters establish the affirmation of becoming and the "tragic" view of the world (which Nietzsche had already articulated in his earliest.. (shrink)

In this paper, we sketch the development of two important themes of modern set theory, both of which can be regarded as growing out of work of Kurt Gödel. We begin with a review of some basic concepts and conventions of set theory.§0. The ordinal numbers were Georg Cantor's deepest contribution to mathematics. After the natural numbers 0, 1, …, n, … comes the first infinite ordinal number ω, followed by ω + 1, ω + 2, …, ω + ω, (...) … and so forth. ω is the first limit ordinal as it is neither 0 nor a successor ordinal. We follow the von Neumann convention, according to which each ordinal number α is identified with the set {ν ∣ ν α} of its predecessors. The ∈ relation on ordinals thus coincides with <. We have 0 = ∅ and α + 1 = α ∪ {α}. According to the usual set-theoretic conventions, ω is identified with the first infinite cardinal ℵ0, similarly for the first uncountable ordinal number ω1 and the first uncountable cardinal number ℵ1, etc. We thus arrive at the following picture:The von Neumann hierarchy divides the class V of all sets into a hierarchy of sets Vα indexed by the ordinal numbers. The recursive definition reads: ;Vλ = ∪v<λVv for limit ordinals λ. We can represent this hierarchy by the following picture. (shrink)

This article argues for the value of working with conflicts in social practice as resources for collaboration, learning and development. The interest in conflicts in social practice is rooted in a preoccupation with social power relations and how to understand and analyse power relations from a subject-science perspective. Following this interest, a methodological framework, best described as a kind of ‘mobile ethnography’, is discussed and exemplified through an empirical example. A preliminary conceptual framework for understanding power as a capacity for (...) action is presented. The overarching ambition of the article is to consider what democratic collaboration and coexistence entails and how it might be supported conceptually and analytically by the notion of conflicts as heuristics for social inquiry and by the notion of power as a capacity for action and social participation. (shrink)

Ethical decision making is of concern to researchers across all fields. However, researchers typically focus on the biases that may act to undermine ethical decision making. Taking a new approach, this study focused on identifying the most common compensatory strategies that counteract those biases. These strategies were identified using a series of interviews with university researchers in a variety of areas, including biological, physical, social, and health as well as scholarship and the performing arts. Interview transcripts were assessed with two (...) scoring procedures, an expert rating system and computer-assisted qualitative analysis. Although the expert rating system identified Understanding Guidelines, Recognition of Insufficient Information, and Recognizing Boundaries as the most frequently used compensatory strategies across fields, other strategies, Striving for Transparency, Value/norm Assessment, and Following Appropriate Role Models, were identified as most common by the computer-assisted qualitative analyses. Potential reasons for these findings and implications for training and practice are identified and discussed. (shrink)

This article focuses on the experience of unsettling art and its psychological impact. Although it is widely recognized that works of art can be highly unsettling and disturbing, there seem to be no studies revealing the psychological importance of such experiences. Through a selection of interviews conducted according to phenomenological principles, a few essential features of the unsettling art experience are identified. These features include a strong negative emotional response, feelings of attraction, and pictorial vividness. Furthermore, these experiences form memory (...) traces that are powerful, persistent, and long-lasting. The present study shows that when experiencing an unpleasant emotional response to a work of art, the emotion is linked to the sensate form of the picture and thereby objectified, allowing contemplation of the existential importance of the experience. Furthermore, this study uncovers a possible relation between prior traumatic episodes and an intense emotional response to unsettling art, and it is suggested that experiences with unsettling works of art allow the individual to reconcile with their prior trauma. (shrink)

How does man find himself in a society that cannot offer clear answers to the fundamental question: What is the meaning of existence? This introduction to Søren Kierkegaard's psychological thinking may provide part of the answer. For those interested in psychology and philosophy and anyone else interested in existential dilemmas.

Quels sont les horizons de la philosophie du droit? Quelle place occupe-t-elle dans notre modernité juridique? Quels sont ses enjeux? L'euthanasie, les droits des minorités et l'écologie sont des thèmes qui s'inscrivent naturellement dans le contexte contemporain de la philosophie du droit. Par une réflexion qui invite au dialogue et à la production d'arguments réfléchis, l'auteur cherche à démontrer que la philosophie du droit peut combler certaines lacunes du positivisme juridique qui marque notre modernité.

La philosophie du droit a pour fonction d’assister la réflexion sur le monde du juridique, sur « le droit qui se fait », sur la doctrine juridique et notre façon de l’écrire, et sur l’appréciation (ou l’indifférence, l’hostilité, etc.) qu’un individu distancié peut éprouver à l’égard du droit et des juristes. Elle assiste et elle participe en examinant notre façon d’opérationnaliser les sources du droit, de forger des arguments pouvant être juridiques, d’évaluer les narrations qui se présentent au droit, d’examiner (...) la pertinence de la doctrine, notre façon de pratiquer le droit et de faire des jugements judiciaires. Elle ne réside de toute évidence pas « en haut » et elle ne « surplombe » pas l’écriture de la doctrine. Elle ne se glorifie pas en distribuant (en toute incompétence) l’étiquette de « scientificité » au bon candidat, que celui-ci soit auteur d’un article, d’un livre ou d’une théorie. Admettons plutôt lucidement que la philosophie du droit ne donne pas de certificat de « scientificité » et que toute revendication en ce « sens » n’a pas de « sens ». (shrink)

The significance of epigraphy to the study of Greek religion is so apparent that any volume presenting new insights into the religion of the ancient Greek world would inevitably make substantial use of inscriptions. Conversely, that a conference on ancient epigraphy had so many contributions dealing with Greek religion that they necessitated a second, separate volume of conference proceedings is equally not surprising. The chapters of Greek Epigraphy and Religion were originally presented at...

The purpose of this paper is to reflect on how the Corona pandemic might influence human understanding of our position of being in the world. In the first part of the paper, we present how a pandemic can be under- stood in relation to our society and our educational system. Then, we will present problems and questions highlighted by the pandemic and the kind of transformations needed to address these problems. The core ele- ments that require transformation are the understanding (...) of the essence of man or the human condition, the understanding of what caring for nature and even a pandemic means, and how to measure human action and values. (shrink)

The influence of conscience on nurses in terms of guilt has frequently been described but its impact on care has received less attention. The aim of this study was to describe nurses' conceptions of the influence of conscience on the provision of inpatient care. The study employed a phenomenographic approach and analysis method. Fifteen nurses from three hospitals in western Sweden were interviewed. The results showed that these nurses considered conscience to be an important factor in the exercise of their (...) profession, as revealed by the descriptive categories: conscience as a driving force; conscience as a restricting factor; and conscience as a source of sensitivity. They perceived that conscience played a role in nursing actions involving patients and next of kin, and was an asset that guided them in their efforts to provide high quality care. (shrink)

Abstract: In this article, I offer a proposal to clarify what I believe is the proper relation between value maximization and stakeholder theory, which I call enlightened value maximization. Enlightened value maximization utilizes much of the structure of stakeholder theory but accepts maximization of the long-run value of the firm as the criterion for making the requisite tradeoffs among its stakeholders, and specifies long-term value maximization or value seeking as the firm’s objective. This proposal therefore solves the problems that arise (...) from the multiple objectives that accompany traditional stakeholder theory. I also discuss the Balanced Scorecard, which is the managerial equivalent of stakeholder theory, explaining how this theory is flawed because it presents managers with a scorecard that gives no score—that is, no single-valued measure of how they have performed. Thus managers evaluated with such a system (which can easily have two dozen measures and provides no information on the tradeoffs between them) have no way to make principled or purposeful decisions. The solution is to define a true (single dimensional) score for measuring performance for the organization or division (and it must be consistent with the organization’s strategy), and as long as their score is defined properly, (and for lower levels in the organization it will generally not be value) this will enhance their contribution to the firm. (shrink)

Purpose. The purpose of this study is to investigate how professionals learn from varying experiences with errors in health-care digitalization and develop and use negative knowledge and digital ignorance in efforts to improve digitalized health care. Design/methodology/approach. A two-year qualitative field study was conducted in the context of a public health-care organization working with digital patient communication. The data consisted of participant observation, semistructured interviews and document data. Inductive coding and a theoretically informed generation of themes were applied. Findings. The (...) findings show that both health-care and digital communication professionals learn through experiences with digital “rule-” and “knowledge-based” errors in patient communication and develop negative knowledge and awareness of digital ignorance. In their joint efforts, they use negative knowledge to “bend the rules” and to explore digital ignorance in efforts to improve patient communication. Originality/value. This study provides insight into the importance of collaboration between professionals with varying experience of errors in digitalizing patient communication. Such collaboration is required to acknowledge own shortcomings and create complementary negative knowledge to improve digital patient communication. This is particularly important when working with innovative digitalization in health care. (shrink)

This article argues for a view on languaging as inherently affective. Informed by recent ecological tendencies within cognitive science and distributed language studies a distinction between first order languaging (language as whole-body sense making) and second order language (language as system like constraints) is put forward. Contrary to common assumptions within linguistics and communication studies separating language-as-a-system from language use (resulting in separations between language vs. body-language and verbal vs. non-verbal communication etc.) the first/second order distinction sees language as emanating (...) from behavior making it possible to view emotion and affect as integral parts languaging behavior. Likewise, emotion and affect are studied, not as inner mental states, but as processes of organism-environment interactions. Based on video recordings of interaction between (1) children with special needs, and (2) couple in therapy and the therapist patterns of reciprocal influences between interactants are examined. Through analyzes of affective stance and patterns of inter-affectivity it is exemplified how language and emotion should not be seen as separate phenomena combined in language use, but rather as completely intertwined phenomena in languaging behavior constrained by second order patterns. (shrink)

New-born screening programs for congenital disorders and chronic disease are expanding worldwide and children “at risk” are identified by nationwide tracking systems at the earliest possible stage. These practices are never neutral and raise important social and ethical questions. An emergent concern is that a reflexive professionalism should interrogate the ever earlier interference in children’s lives. The Flemish community of Belgium was among the first to generalize the screening for hearing loss in young children and is an interesting case to (...) study the public justification of early interventions for families with deaf children. This article uses a critical lens to study the archive of the government child healthcare organization in Flanders in order to uncover underlying constructions of childhood, deafness, and preventive health. We focus on two interrelated themes. The first is the notion of exclusion of the human factor through the mediation of technology. The second is the idea of deafness as endangering a healthy development, an impairment that can nevertheless be treated if detected early enough. It is argued that, since deafness cannot be viewed as a life-threatening condition, the public interest which is implicitly defended is not the rescue of deaf children rather the exclusion of otherness. (shrink)