Drosophila responds to a septic injury by the rapid synthesis of antimicrobial peptides. These molecules are predominantly produced by the fat body, a functional equivalent of mammalian liver, and are secreted into the hemolymph where their concentrations can reach up to 100 μM. Six distinct antibacterial peptides (plus isoforms) and one antifungal peptide have been characterized in Drosophila and their genes cloned. The induction of the gene encoding the antifungal peptide relies on the spätzle/Toll/cactus gene cassette, which is involved in (...) the control of dorsoventral patterning in the embryo, and shows interesting structural and functional similarities with cytokine‐induced activation of NF‐ϰB in mammalian cells. An additional pathway, dependent on the as yet unidentified imd (for immune‐deficiency) gene, is required for the full induction of the antibacterial peptide genes. Mutants deficient for the Toll and imd pathways exhibit a severely reduced survival to fungal and bacterial infections, respectively. Recent data on the molecular mechanisms underlying recognition of non‐self are also discussed in this review. (shrink)

The combination of increased availability of large amounts of fine-grained human behavioral data and advances in machine learning is presiding over a growing reliance on algorithms to address complex societal problems. Algorithmic decision-making processes might lead to more objective and thus potentially fairer decisions than those made by humans who may be influenced by greed, prejudice, fatigue, or hunger. However, algorithmic decision-making has been criticized for its potential to enhance discrimination, information and power asymmetry, and opacity. In this paper, we (...) provide an overview of available technical solutions to enhance fairness, accountability, and transparency in algorithmic decision-making. We also highlight the criticality and urgency to engage multi-disciplinary teams of researchers, practitioners, policy-makers, and citizens to co-develop, deploy, and evaluate in the real-world algorithmic decision-making processes designed to maximize fairness and transparency. In doing so, we describe the Open Algortihms project as a step towards realizing the vision of a world where data and algorithms are used as lenses and levers in support of democracy and development. (shrink)

Segundo uma célebre tese defendida por Philip Pettit, um agente é livre conquanto cada uma de suas ações seja não somente acessível, mas também não-dominada, no sentido de que ninguém tenha o poder de bloquear o acesso a tais ações. Através de contraexemplos, esse artigo procura demonstrar que a vontade de eliminar a dominação pode diminuir antes que reforçar a liberdade individual.

Através da análise da trajetória do aquitano Bernardo de Agen, bispo e senhor de Sigüenza entre os anos de 1124 a 1151, discutiremos neste artigo como o processo de reconquista territorial empreendida durante a Idade Média Central foi um dos fundamentos para o exercício da dominação eclesiástica na região de Castela, na Península Ibérica. Munido de um poder específico o qual chamamos de poder senhorial-episcopal, o bispo seguntino despontou como um dos principais nomes inseridos na política castelhano-leonesa, encabeçada por uma (...) gama de interdependências entre a monarquia e os episcopados. (shrink)

Abstract: The standard picture of rationality requires that the agent acts so as to realize her most preferred alternative in the light of her own desires and beliefs. However, there are circumstances where such an agent can predict that she will act against her preferences. The story of Ulysses and the Sirens is the paradigmatic example of such cases. In those circumstances the orthodoxy requires the agent to be ‘sophisticated’. That is to say, she should take into account her expected (...) future choices and prevent her future self to act in certain ways. She should ‘bind’ herself to a certain course of action. This is a form of causal commitment. It is generally recognized that this form of self-commitment is the only one that is available to a rational agent. Rational commitment, where the agent gives herself a reason to act in a certain way rather than making herself act in that way, is considered not feasible. In this paper, I question this verdict. I sketch the broad outlines of a model of rational commitment, which takes as its starting point Michael Bratman’s ‘planning theory’ of intention. There are two important objections against this theory (one by John Broome and one by the Dutch philosopher Govert den Hartogh.) Both criticisms claim that such a theory is a form of ‘bootstrapping’ reasons for action into existence. In the remainder of the paper, I will defend the theory against these objections. This way, I hope to establish that defending the feasibility of rational commitment is not an obvious mistake. (shrink)

Collecting, comparing, and computing molecular sequences are among the most prevalent practices in contemporary biological research. They represent a specific way of producing knowledge. This paper explores the historical development of these practices, focusing on the work of Margaret O. Dayhoff, Richard V. Eck, and Robert S. Ledley, who produced the first computer-based collection of protein sequences, published in book format in 1965 as the Atlas of Protein Sequence and Structure. While these practices are generally associated with the rise of (...) molecular evolution in the 1960s, this paper shows that they grew out of research agendas from the previous decade, including the biochemical investigation of the relations between the structures and function of proteins and the theoretical attempt to decipher the genetic code. It also shows how computers became essential for the handling and analysis of sequence data. Finally, this paper reflects on the relationships between experimenting and collecting as two distinct “ways of knowing” that were essential for the transformation of the life sciences in the twentieth century. (shrink)

Vient ensuite une approche du style des philosophes dans son rapport à la construction même d'un système argumentatif autant qu'à divers modes d'expression : langage et littérarité donc, afin de sonder les voies de la création chez ...

To become aware of the depth of the ecological mutation, one has to criticize the notion of abstract space. It turns out that, in many of his works, Carl Schmitt has found ways to politicize the production of neutral depoliticized space. This is especially true in “Dialogue on New Space.” The dialogue summarizes Schmitt’s earlier works, but it also tries to relate, audaciously, the character of being human with the different conceptions of space entertained by each protagonist of the dialogue. (...) Especially important in the plot is the interpretation of the expression of “unencumbered technology” that Schmitt associates with the destiny of liberalism and the sort of spatial domination ad infinitum that it implies. The final point of the dialogue is that you cannot be really human in the wrong space. The article does not pretend to make Schmitt a thinker of ecology but to extract from his highly peculiar critique of space something that could be useful to help criticize a depoliticized notion of green space. (shrink)

How are ideas about education and democracy configured and reconfigured as they travel? Democracy and the Intersection of Religion looks at the work of John Dewey, the renowned philosopher, psychologist, and educational reformer, and the ways in which his educational ideas and democratic ideals have been configured and reconfigured, adopted, and interpreted in different historical and cultural spaces.

In response to the Covid‐19 pandemic, health care systems worldwide canceled or delayed elective surgeries, outpatient procedures, and clinic appointments. Although such measures may have been necessary to preserve medical resources and to prevent potential exposures early in the pandemic, moving forward, the indirect effects of such an extensive medical shutdown must not outweigh the direct harms of Covid‐19. In this essay, we argue for the reopening of evidence‐based health care with assurance provided to patients about the safety and necessity (...) of high‐value vaccinations, screenings, therapeutics, and procedures. To ensure that virtually all non‐Covid‐related services do not come to a halt again, health care systems and physician practices must preemptively increase their capacity, secure adequate personal protective equipment to safeguard health care personnel, and develop a measured approach to reclosing such routine health care, should it become necessary in the future. (shrink)

Game theory is the systematic study of interdependent rational choice. It should be distinguished from decision theory, the systematic study of individual (practical and epistemic) choice in parametric contexts (i.e., where the agent is choosing or deliberating independently of other agents). Decision theory has several applications to ethics (see Dreier 2004; Mele and Rawlings 2004). Game theory may be used to explain, to predict, and to evaluate human behavior in contexts where the outcome of action depends on what several agents (...) choose to do and where their choices depend on what others choose to do. (See the entry on game theory) Game theory consequently is relevant to ethics, and it is used in moral and political philosophy in a variety of ways. We shall concentrate on the influence and use of game theory in ethics and those parts of political theory involving norms or principles of justice, ignoring questions about political and legal institutions on the one hand and questions about issues dealing with moral virtues on the other. (shrink)

The article addresses the question of how should scientific peers revise their beliefs (if at all) upon recognized disagreement. After presenting the basics of peer disagreement in sections 1 and 2, we focus, in section 3, on a concrete case of scientific disagreement, to wit, the dispute over the evidential status of randomized control trials in medical practice. The examination of this case motivates the idea that some scientific disagreements permit a steadfast reaction. In section 4, we support this conclusion (...) by providing a normative argument in the same direction; if we are correct, typical reasons for conciliation are absent in this kind of scientific disagreements. (shrink)

The constructive mathematics developed by Bishop in Foundations of Constructive Analysis succeeded in gaining the attention of mathematicians, but discussions of its underlying philosophy are still rare in the literature. Commentators seem to conclude, from Bishop’s rejection of choice sequences and his severe criticism of Brouwerian intuitionism, that he is not an intuitionist–broadly understood as someone who maintains that mathematics is a mental creation, mathematics is meaningful and eludes formalization, mathematical objects are mind-dependent constructions given in intuition, and mathematical truths (...) are experienceable. This paper develops and defends an intuitionistic interpretation of Bishop’s philosophical views. (shrink)

Strong forces lead to a withering of academia as it exists today. The major causal forces are the rankings mania, increased division of labor in research, intense publication pressure, academic fraud, dilution of the concept of ‘university’, and inadequate organizational forms for modern research. Academia, in a broader sense understood as ‘the locus of seeking truth and learning through methodological inquiry’, will subsist in different forms. The conclusion is therefore pessimistic with respect to the academic system as it presently exists (...) but not to scholarly endeavour as such. However, the transformation predicted is expected to be fundamental. (shrink)

Athanasios Tziafalias, Bruno Helly Two Unpublished Decrees from Larisa p. 377-420 Among the epigraphical documents found at Larisa in recent years, two of the city's decrees have a particular interest. The first, a proxenia decree for a Mytilinian, that can be dated to the earliest years of the 2nd c. BC, is in a dialect and reflects the relations that were established before the engagement of the Second Macedonian War and were renewed, for the admission of the Asclepieia of (...) Mytilini, between the Thessalian Confederation and the cities that composed it on the one hand and the Mytilinians on the other. This casts new light on a well-known document, the Mytilini decree for the Thessalian Confederation IG XII Suppl., 3, and supplements the history of the relations between the two parties, which were prolonged up to the period of Augustus, as we know from the fragments of decrees in honour of the Mytilenian Potamon, son of Lesbonax. The second Larisa decree, which was voted for two citizens of Chalkis in Euboea and which is in koine, should be placed more than a century later, towards 70 BC; it shows the procedure by which a foreigner who had received the proxenia of the Thessalian Confederation could acquire, at his request, citizenship in a member city of this Confederation. (shrink)

What has happened to the project of ‘symmetrical anthropology’ in the last twenty years? What difference does it make to consider a multiplicity of cultures over the background of a unified nature, or a multiplicity of natures in addition to a multiplicity of cultures? In which way does it open up another type of scientific anthropology, no longer based on comparison but on ‘diplomacy’? Can modernity, as an interpretation of the former West, be recalled? Translated by Stephen Muecke.

In this anthology, most of the important cosmological hypotheses within the Western tradition, from the Enuma Elish creation-myth of Babylon to the continuous “creation” hypothesis of Bondi and Gold, are gathered together. Most of them are presented in their originator’s own words. The work falls into three parts. The first deals rather summarily with the Greek period. Despite the research of the past few decades into mediaeval science, the mediaeval period is represented only by a rather dated and onesided article (...) by Dreyer. The second part covers the Copernicus-Kant period in some detail; it includes authors as diverse as Cusa and Bruno, Huygens and Herschel. The third begins with Einstein, works through the “expanding universe” theories of Lemaître and Gamow and ends with Hoyle’s “infinite” universe. The editor has added brief introductory notes and a bibliography. (shrink)

Embora Adorno tenha abordado predominantemente o problema do “fim da arte” como um processo repressivode liquidação da arte levado adiante pela dominação da indústria cultural, ele viu uma possibilidade promissora parao conceito de desartificação em sua Teoria Estética. Ali, ele reconheceu uma tendência evolutiva desseconceito pela intensificação do tremor de uma subjetividade fixa através da experiência da não‑identidade e deuma possível reconciliação com uma natureza não inteiramente submetida à exploração. O objetivo deste trabalhoé examinar a articulação de duas teses em (...) Adorno: uma que antecipa o fim da arte em uma sociedade sem classes,relacionado à superação da tensão entre o real e o possível, e uma segunda que reconhece na expressão artísticaconhecida alguma promessa de felicidade, ao apontar para uma realidade latente que insiste em retornar, na medidaem que as obras de arte são a “historiografia inconsciente de si mesma de sua época.”. (shrink)

Ανέκδοτα ψηφίσματα από τη Λάρισσα (3) Συνεχίζοντας τις δΰο προηγούμενες δημοσιεύσεις που αφορούσαν σε ψηφίσματα της Λάρισσας (BCH 128-129 (2005), p. 377-417 ; BCH 130 (2006) [20081, Ρ· 435-483), παρουσιάζουμε εδώ μια τρίτη στήλη, η οποία φέρει τρία κείμενα: δύο ψηφίσματα της Λάρισσας, που ψηφίστηκαν κατά τη διάρκεια της στρατηγείας του Παυσανία, υιού του Θρασυμήδη από τις Φέρες (περίπου 130/129 π. Χ.), το ένα για έναν Αθηναίο φιλόσοφο και το άλλο για τρεις πολίτες της Κω· ένα τρίτο ψήφισμα προέρχεται από (...) τη Συνομοσπονδία των Μολοσσών και ανταμοίβει δικαστές από τη Λάρισσα, οι οποίοι εστάλησαν στην Ήπειρο για να διαιτητεύσουν σε μια διαμάχη μεταξύ Μολοσσών και Ακαρνάνων. Τα κείμενα αυτά, γραμμένα σε θεσσαλική διάλεκτο, η οποία την εποχή εκείνη χρησίμευε στη μεταγραφή εγγράφων της καγκελλαρίας των ελληνιστικών πόλεων σε μια γλώσσα που χάνει προοδευτικά τη συνοχή και την ιδιομορφία της και καταλήγει να διατηρεί μόνο μια «θεσσαλίζουσα» απόχρωση, έχουν αξία για την ιστορία της Λάρισσας, αφού αναφέρονται στην πνευματική ζωή και σε ορισμένες εκφάνσεις των πολιτικών ή οικονομικών δραστηριοτήτων των Λαρισσαίων στο δεύτερο μισό του 2ου αι. π. Χ. (shrink)

We develop a Sylow theory for stable groups satisfying certain additional conditions (2-finiteness, solvability or smallness) and show that their maximal p-subgroups are locally finite and conjugate. Furthermore, we generalize a theorem of Baer-Suzuki on subgroups generated by a conjugacy class of p-elements.

There is a growing consensus, long maintained by Derek Parfit, that there is an important distinction between what we have reason to do on the one hand, and what it is rational for us to do on the other. Philosophers are now realising that there is a conceptual distinction between rationality and normativity. Given this distinction, it thus becomes a substantive question whether rationality is genuinely normative; that is, whether there is any reason to do what rationality requires. While some (...) philosophers have argued that we sometimes have reason to do what rationality requires, it is notoriously difficult to show that there are always universal and categorical reasons to do what rationality requires. But if it is not the case that there are always universal and categorical reasons to do what rationality requires, then rationality is not genuinely normative.This dissertation offers a vindication of the normativity of rationality. I maintain that there is a robust relation between rational requirements and normative reasons. In arguing for this claim, I develop what I call the reasons-sensitive view of rationality, according to which rational requirements are normative verdicts: they are second-order claims about what there is conclusive reason of rationality to do. This view explains why there are always universal and categorical reasons to be rational. So while we may not always have most reason to do what it is rational for us to do, there is always some reason—reasons of rationality—to do what it is rational for us to do. I then show how this reasons-sensitive view addresses and responds to what I diagnose to be the major sources of skepticism about the normativity of rationality. (shrink)