In the late 19th century, physiologists such as David Ferrier, Eduard Hitzig, and Hermann Munk argued that cerebral brain functions are localized in discrete structures. By the early 20th century, this became the dominant position. However, another prominent physiologist, Friedrich Goltz, rejected theories of cerebral localization and argued against these physiologists until his death in 1902. I argue in this paper that previous historical accounts have failed to comprehend why Goltz rejected cerebral localization. I show (...) that Goltz adhered to a falsificationist methodology, and I reconstruct how he designed his experiments and weighted different kinds of evidence. I then draw on the exploratory experimentation literature from recent philosophy of science to trace one root of the debate to differences in how the German localizers designed their experiments and reasoned about evidence. While Goltz designed his experiments to test hypotheses about the functions of predetermined cerebral structures, the localizers explored new functions and structures in the process of constructing new theories. I argue that the localizers relied on untested background conjectures to justify their inferences about functional organization. These background conjectures collapsed a distinction between phenomena they produced direct evidence for (localized symptoms) and what they reached conclusions about (localized functions). (shrink)

Alzheimer's disease is characterized by amyloid-beta peptide -loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1 , which has been shown to be required for the regulation of APP and Abeta. To understand the role of SP1 in APP biogenesis, herein we have characterized the relative distribution and (...) class='Hi'>localization of SP1, APP, and Abeta in various brain regions of rodent and primate models using immunohistochemistry. We observed that overall distribution and cellular localization of SP1, APP, and Abeta are similar and neuronal in origin. Their distribution is abundant in various layers of neocortex, but restricted to the Purkinje cell layer of the cerebellum, and the pyramidal cell layer of hippocampus. These findings suggest that overproduction of Abeta in vivo may be associated with transcriptional pathways involving SP1 and the APP gene. (shrink)

A new view of the functional role of the left anterior cortex in language use is proposed. The experimental record indicates that most human linguistic abilities are not localized in this region. In particular, most of syntax (long thought to be there) is not located in Broca's area and its vicinity (operculum, insula, and subjacent white matter). This cerebral region, implicated in Broca's aphasia, does have a role in syntactic processing, but a highly specific one: It is the neural (...) home to receptive mechanisms involved in the computation of the relation between transformationally moved phrasal constituents and their extraction sites (in line with the Trace-Deletion Hypothesis). It is also involved in the construction of higher parts of the syntactic tree in speech production. By contrast, basic combinatorial capacities necessary for language processing – for example, structure-building operations, lexical insertion – are not supported by the neural tissue of this cerebral region, nor is lexical or combinatorial semantics. The dense body of empirical evidence supporting this restrictive view comes mainly from several angles on lesion studies of syntax in agrammatic Broca's aphasia. Five empirical arguments are presented: experiments in sentence comprehension, cross-linguistic considerations (where aphasia findings from several language types are pooled and scrutinized comparatively), grammaticality and plausibility judgments, real-time processing of complex sentences, and rehabilitation. Also discussed are recent results from functional neuroimaging and from structured observations on speech production of Broca's aphasics. Syntactic abilities are nonetheless distinct from other cognitive skills and are represented entirely and exclusively in the left cerebral hemisphere. Although more widespread in the left hemisphere than previously thought, they are clearly distinct from other human combinatorial and intellectual abilities. The neurological record (based on functional imaging, split-brain and right-hemisphere-damaged patients, as well as patients suffering from a breakdown of mathematical skills) indicates that language is a distinct, modularly organized neurological entity. Combinatorial aspects of the language faculty reside in the human left cerebral hemisphere, but only the transformational component (or algorithms that implement it in use) is located in and around Broca's area. Key Words: agrammatism; aphasia; Broca's area; cerebral localization; dyscalculia; functional neuroanatomy; grammatical transformation; modularity; neuroimaging; syntax; trace deletion. (shrink)

During the nineteenth century, neuroanatomical knowledge and the clinical practice of treating mental illnesses develop at the same time. Some practitioners of mental medicine try to combine the clinical practice of treating mental diseases with neuroanatomical knowledge using the idea of cerebral localisations. This point of view is advocated by Gall and the field of phrenology. But there is no obvious success of such a localisationist project before Broca and Wernicke’s works on aphasia. This discovery will provoke a revival (...) of the desire to localise the cerebral zones involved in mental diseases. However, the cerebral localisation project progressively decreases during the end of the nineteenth century while neurological clinical practice emerges. Moreover, neurological clinical practice aims to localise anatomical lesions through clinical examination. From a philosophy of science point of view, this segment of history brings into question the relation between a scientific object (the cerebral localisation of zones involved in diseases) and a scientific subject (psychiatry and neurology). It stresses how a scientific project can migrate from one subject to another. (shrink)

Ranging from behavioral to molecular levels of analysis, this informative study presents the results of recent research into the biochemistry and neural mechanisms of imprinting. Horn discusses some of the difficulties that researchers have encountered in analyzing the neural basis of memory and describes ways in which these difficulties have been overcome through the analysis of memories underlying habituation and imprinting. He also considers the biochemical consequences of imprinting and its cerebral localization, and examines the relationships between human (...) and animal memory. (shrink)

Riassunto: Al centro di questo lavoro è l’analisi di due disturbi acquisiti del linguaggio: l’afasia di Broca e l’afasia di Wernicke. Tradizionalmente, tali disturbi sono stati interpretati come deficit che colpiscono le funzioni legate, rispettivamente, alla produzione articolatoria e alla comprensione del parlato in seguito a lesioni in due specifiche regioni cerebrali: nel caso dell’afasia di Broca, la terza circonvoluzione frontale sinistra; nel caso dell’afasia di Wernicke, la porzione posteriore del giro temporale superiore sinistro. Per tale ragione, queste due regioni (...) cerebrali, a cui ci si riferisce anche nei termini di area di Broca e area di Wernicke, sono state considerate le sedi neuroanatomiche della produzione e comprensione del linguaggio. Questo articolo mostra che, alla luce delle ricerche condotte negli ultimi decenni: non è più possibile sul piano dei deficit linguistici continuare a considerare l’afasia di Broca e l’afasia di Wernicke come disturbi unitari; non è più possibile continuare a sostenere l’esclusiva localizzazione delle funzioni di produzione e comprensione del linguaggio nelle due regioni cerebrali ad esse classicamente associate. Parole chiave: Afasia di Broca; Afasia di Wernicke; Area di Broca; Area di Wernicke; Disturbi del linguaggio; Localizzazione cerebrale; Neuroscienze Broca’s and Wernicke’s Aphasias in the Light of Contemporary Neuroscience: This paper analyzes two acquired language disorders: Broca’s aphasia and Wernicke’s aphasia. It has been commonly suggested that these disorders respectively affect functions related to speech production and language comprehension and they have been understood to result from two specific types of brain lesions: Broca’s aphasia from lesions in the third left frontal convolution; Wernicke’s aphasia from lesions in the posterior section of the left superior temporal gyrus. For this reason, these cerebral regions, also known as Broca’s area and Wernicke’s area, have long been viewed as the neuroanatomical correlates of language production and comprehension. This paper shows that in light of current research: with regard to language disorders, it is no longer possible to conceive of Broca’s and Wernicke's aphasias as unitary disorders; with regard to the cerebral localization of linguistic functions, it no longer possible to suggest that Broca’s and Wernicke’s areas are the only regions involved in speech production and comprehension. Keywords: Broca’s Aphasia; Wernicke’s Aphasia; Broca’s Area; Wernicke’s Area; Language Impairments; Cerebral Localization; Neuroscience. (shrink)

The German pioneer of electrophysiology, Emil du Bois-Reymond (1818–1896), is generally assumed to have remained silent on the subject of the brain. However, the archive of his papers in Berlin contains manuscript notes to a lecture on “The Seat of the Soul” that he delivered to popular audiences in 1884 and 1885. These notes demonstrate that cerebral localization and brain function in general had been concerns of his for quite some time, and that he did not shy away (...) from these subjects. (shrink)

Psychoanalysis is often divided into two parts: the clinical theory and the metapsychology. Recent historical and philosophical work has led some psychoanalysts to argue that the metapsychology is a cryptic biology and not a psychological theory at all. Evidence for this view is largely that metapsychological concepts can be traced to Freud's "Project for a Scientific Psychology", in which he seems to argue that systems of neurons perform both psychological and neuro-physiological functions. The conclusion these writers have drawn is that (...) Freud's metapsychology represents an attempt to unify two putatively incommensurable conceptual frameworks: the psychological and the physiological. ;In the first chapter I review the dispute between Wernicke and Freud on the issue of aphasia and place it in the context of 19th century psychological explanatory traditions. One of these traditions, developed by Franz Joseph Gall, predominates in Wernicke's work. The other tradition, associationism as developed by John Stuart Mill and Alexander Bain, predominates in Freud's critique of Wernicke. I suggest that Wernicke's cerebral localization strategy amounts to a type-type identity theory, and that Freud presented both empirical and conceptual reasons for rejecting this commitment. ;In the second chapter I explicate Freud's "Project" and chapter VII of The Interpretation of Dreams. In the latter, I argue, Freud develops a version of functionalism. His break with his neurological background is exemplified by his insistence that psychology is autonomous. ;In the third chapter I evaluate critically the arguments presented by Merton Gill, George Klein, and Roy Schaffer that purport to show Freud's metapsychology is not a psychology at all, but a neuro-biology. Against this view I suggest that Freud describes mental structures that serve various design functions. These structures, attributed to persons by the metapsychology of infantile wishes and regression, are cognitively impenetiable. The notion that the design or functional architecture of a system is cognitively impenetiable is used to account for the protracted nature, perhaps interminability, of psychoanalytic therapy. Freud's therapeutic pessimism has its roots in theory rather than therapeutic failure. (shrink)

The traditional verbal/nonverbal dichotomy is inadequate for completely describing cerebral lateralization. Musical functions are not necessarily mediated by the right hemisphere; evidence for a specialist left-hemisphere mechanism dedicated to the encoded speech signal is weakening, and the right hemisphere possesses considerable comprehensional powers. Right-hemisphere processing is often said to be characterized by holistic or gestalt apprehension, and face recognition may be mediated by this hemisphere partly because of these powers, partly because of the right hemisphere's involvement in emotional affect, (...) and possibly through the hypothesized existence of a specialist face processor or processors in the right. The latter hypothesis may, however, suffer the same fate as the one relating to a specialist encodedness processor for speech in the left. Verbal processing is largely the province of the left because of this hemisphere's possession of sequential, analytic, time-dependent mechanisms. Other distinctions are special cases of an analytic/holistic dichotomy. More fundamentally, however, the left hemisphere is characterized by its mediation of discriminations involving duration, temporal order, sequencing, and rhythm, at thesensory level, and especially at themotorlevel. Spatial aspects characterize the right, the mapping of exteroceptive body space, and the positions of fingers, limbs, and perhaps articulators, with respect to actual and target positions. Thus there is a continuum of function between the hemispheres, rather than a rigid dichotomy, the differences being quantitative rather than qualitative, of degree rather than of kind. (shrink)

Treatment of diseases of the brain by drugs or surgery necessitates an understanding of its structure and functions. The philosophical neurosurgeon soon encounters difficulties when localising the abstract concepts of mind and soul within the tangible 1300-gram organ containing 100 billion neurones. Hippocrates had focused attention on the brain as the seat of the mind. The tabula rasa postulated by Aristotle cannot be localised to a particular part of the brain with the confidence that we can localise spoken speech to (...) Broca's area or the movement of limbs to the contralateral motor cortex. Galen's localisation of imagination, reasoning, judgement and memory in the cerebral ventricles collapsed once it was evident that the functional units-neurones-lay in the parenchyma of the brain. Experiences gained from accidental injuries (Phineas Gage) or temporal lobe resection (William Beecher Scoville); studies on how we see and hear and more recent data from functional magnetic resonance studies have made us aware of the extensive network of neurones in the cerebral hemispheres that subserve the functions of the mind. The soul or atman, credited with the ability to enliven the body, was located by ancient anatomists and philosophers in the lungs or heart, in the pineal gland (Descartes), and generally in the brain. When the deeper parts of the brain came within the reach of neurosurgeons, the brainstem proved exceptionally delicate and vulnerable. The concept of brain death after irreversible damage to it has made all of us aware of 'the cocktail of brain soup and spark' in the brainstem so necessary for life. If there be a soul in each of us, surely, it is enshrined here. (shrink)

Despite technological and interpretative advances, the non-invasive modalities used for pre-surgical evaluation of patients with drug-resistant epilepsy, fail to generate a concordant anatomo-electroclinical hypothesis for the location of the seizure onset zone in many patients. This requires chronic monitoring with intracranial electroencephalography, which facilitates better localization of the seizure onset zone, and allows evaluation of the functional significance of cortical regions-of-interest by electrical stimulation mapping. There are two principal modalities for intracranial EEG, namely subdural electrodes and stereotactic depth electrodes. (...) Although ESM is considered the gold standard for functional mapping with subdural electrodes, there have been concerns about its utility with stereo-EEG. This is mainly because subdural electrodes allow contiguous sampling of the dorsolateral convexity of cerebral hemispheres, and permit delineation of the extent of eloquent functional areas on the cortical surface. Stereo-EEG, while having relatively sparse sampling on the cortical surface, offers the ability to access the depth of sulci, mesial and basal surfaces of cerebral hemispheres, and deep structures such as the insula, which are largely inaccessible to subdural electrodes. As stereo-EEG is increasingly the preferred modality for intracranial monitoring, we find it opportune to summarize the literature for ESM with stereo-EEG in this narrative review. Emerging evidence shows that ESM for defining functional neuroanatomy is feasible with stereo-EEG, but probably requires a different approach for interpretation and clinical decision making compared to ESM with subdural electrodes. We have also compared ESM with stereo-EEG and subdural electrodes, for current thresholds required to evoke desired functional responses vs. unwanted after-discharges. In this regard, there is preliminary evidence that ESM with stereo-EEG may be safer than ESM with subdural grids. Finally, we have highlighted important unanswered clinical and scientific questions for ESM with stereo-EEG in the hope to encourage future research and collaborative efforts. (shrink)

Stroke is a severe health issue, and motor recovery after stroke remains an important challenge in the rehabilitation field. Neurofeedback, as part of a brain–computer interface, is a technique for modulating brain activity using on-line feedback that has proved to be useful in motor rehabilitation for the chronic stroke population in addition to traditional therapies. Nevertheless, its use and applications in the field still leave unresolved questions. The brain pathophysiological mechanisms after stroke remain partly unknown, and the possibilities for intervention (...) on these mechanisms to promote cerebral plasticity are limited in clinical practice. In NFB motor rehabilitation, the aim is to adapt the therapy to the patient’s clinical context using brain imaging, considering the time after stroke, the localization of brain lesions, and their clinical impact, while taking into account currently used biomarkers and technical limitations. These modern techniques also allow a better understanding of the physiopathology and neuroplasticity of the brain after stroke. We conducted a narrative literature review of studies using NFB for post-stroke motor rehabilitation. The main goal was to decompose all the elements that can be modified in NFB therapies, which can lead to their adaptation according to the patient’s context and according to the current technological limits. Adaptation and individualization of care could derive from this analysis to better meet the patients’ needs. We focused on and highlighted the various clinical and technological components considering the most recent experiments. The second goal was to propose general recommendations and enhance the limits and perspectives to improve our general knowledge in the field and allow clinical applications. We highlighted the multidisciplinary approach of this work by combining engineering abilities and medical experience. Engineering development is essential for the available technological tools and aims to increase neuroscience knowledge in the NFB topic. This technological development was born out of the real clinical need to provide complementary therapeutic solutions to a public health problem, considering the actual clinical context of the post-stroke patient and the practical limits resulting from it. (shrink)

This review article critically surveys the following literature by placing it under the historiographical banner of ‘the history of the brain and mind sciences’: Fernando Vidal and Francisco Ortega, Being Brains: Making the Cerebral Subject (New York: Fordham University Press, 2017); Katja Guenther, Localization and its Discontents: A Genealogy of Psychoanalysis & the Neuro Disciplines (Chicago: University of Chicago Press, 2015); Stephen Casper and Delia Gavrus (eds), The History of the Brain and Mind Sciences: Technique, Technology, Therapy (Rochester: (...) University of Rochester Press, 2017); Jonna Brenninkmeijer, Neurotechnologies of the Self: Mind, Brain and Subjectivity (London: Palgrave Macmillan, 2016). This framework highlights contemporary attempts to historicize the integrative project of neuroscience and set the correct limits to interdisciplinary collaboration. While attempts to critically engage with the ‘neuro’ rhetoric of contemporary neuroscientists can seem at odds with historians seeking to write the history of neuroscience from the margins, it is argued that together these two projects represent a positive historiographical direction for the history of the neurosciences after the decade of the brain. (shrink)

Analytic functions, typified by reflexes, use stable inherited structures which are organized for adjustments in behavioral space and time. Individually acquired integrative functions, typified by conditioning, symbolism, and reasoning, are wholly internal and may use any nervous tissue not differentiated for other specific activities. They must be defined relati‐vistically. The highest members of both classes are in the cerebral cortex, the first in the relatively stable projection centers, the second in the more labile areas of elaboration where there is (...) no inflexible localization of function. When consciousness emerges within the second class, the mechanism employed probably must be described in accordance with still unknown relativistic principles. (shrink)

Many studies have argued for distinct but complementary contributions from each hemisphere in the control of movements to visual targets. Investigators have attempted to extend observations from patients with unilateral left- and right-hemisphere damage, to those using neurologically-intact participants, by assuming that each hand has privileged access to the contralateral hemisphere. Previous attempts to illustrate right hemispheric contributions to the control of aiming have focussed on increasing the spatial demands of an aiming task, to attenuate the typical right hand advantages, (...) to try to enhance a left hand reaction time advantage in right-handed participants. These early attempts have not been successful. The present study circumnavigates some of the theoretical and methodological difficulties of some of the earlier experiments, by using three different tasks linked directly to specialized functions of the right hemisphere: bisecting, the gap effect, and visuospatial localization. None of these tasks were effective in reducing the magnitude of left hand reaction time advantages in right handers. Results are discussed in terms of alternatives to right hemispheric functional explanations of the effect, the one-dimensional nature of our target arrays, power and precision given the size of the left hand RT effect, and the utility of examining the proportions of participants who show these effects, rather than exclusive reliance on measures of central tendency and their associated null hypothesis significance tests. (shrink)

The article proposes systematisation and development of the discourse of the East European methodological traditions regarding application of the systematic approach as a way of subject localisation in psychological research. In particular, the author’s version of systematic localisation of psychological research subjects by means of structural and ontological visualisations has been developed. The procedure proposed for systematic localisation of the researched subject includes four subsequent stages: 1) fixation of the borders and structure of the ontological field which is being studied; (...) 2) segment analysis of the obtained structure; 3) study of specifics and contents of structural and functional ties; 4) visual mapping of genesis of the core processes. The article describes specifics of application of systematic localisation of the subject of research at the example of such researched object as personal socialisation. (shrink)

In the vision of ubiquitous computing it should be possible to create situational and context-aware applications of the internet. But there is a conflict between the global claim of the system and the context-aware local application. First of all it must be clear, what context means. Is the context determined by the material local environment or by the special intention of a person’s action. What role do cultural factors with their historical implications and scales of value play? The meaning of (...) locality depends on the definition of the term context. Thus the term locality specifies an analogy to the term ‘context’. It is necessary especially to also clarify categories like “Leib” and “Lebenswelt”. Finally it is pointed out that special claims of ubiquitous computing like the idea of a global world-model are untenable. Though ubiquitous computing technologies are calm and invisible, it is important to make visible their components. The antagonism between localisation and globalisation shows the real potential of, as well as the claims of, ubiquitous computing. (shrink)

Nous abordons, dans cet article, le fonctionnement discursif des adverbiaux de localisation spatiale dehors et au dehors. Notre objectif est de mettre en valeur leur rôle dans la structuration du discours. Nous proposons aussi un examen des propriétés combinatoires et des conditions d’emploi de ces deux expressions dans les séquences narratives.. Nous montrerons enfin que, dans certains contextes, la valeur spatiale liée à l’emploi de ces adverbiaux peut être dédoublée d’une valeur temporelle.

L'Auteur confirme, par une révision de l'inventaire athénien ID, 1417, A, I, 1. 69-70, la localisation du Thesmophorion délien qu'il avait proposée BEG 99 (1986), p. 309-317, près du rivage Nord-Est de la calanque de Skardhana. Le sanctuaire est aujourd'hui, au moins en majeure partie, englouti. Une prospection sous-marine pourrait en retrouver des vestiges.

La mondialisation économique qui définit nos sociétés contemporaines comme globales a entraîné une rencontre de la traduction avec les technologies, de façon à les adapter aux diverses situations locales. Dénommée tout d'abord « localisation » dans certains milieux professionnels, cette rencontre s'est vite complexifiée en incluant d'abord l'industrie de l'informatique puis divers marchés , affectant manifestement des secteurs entiers de la communication et de notre organisation sociale. Cet article traite plusieurs des faits marquants de cette rencontre de l'Internet et des (...) nouvelles technologies de l'information et de la communication avec la traduction, qui est devenue une composante majeure de l'internationalisation des produits et des services.Economic globalization that defines our contemporary societies as global resulted in a meeting with the translation technologies, so as to adapt them to different local situations. First called "localization" in some professional circles, this meeting was quickly complicated by including first the computer industry and various markets , Clearly affecting sectors whole communication and social organization. This article discusses several of the highlights of this meeting of the Internet and new information technologies and communications with the translation, which became a major component of the internationalization of products and services. (shrink)

In this journal, Bucci (2022) has argued that two famous experiments in the neuroscientific literature can be used to support property dualism about the mind. In what follows, I attempt to illustrate that those experiments are completely compatible with a naive identity mind-brain/body identity theory.

Given a cofinal cardinal function $h\in {}^{\kappa }\kappa $ for $\kappa $ inaccessible, we consider the dominating h-localisation number, that is, the least cardinality of a dominating set of h-slaloms such that every $\kappa $ -real is localised by a slalom in the dominating set. It was proved in [3] that the dominating localisation numbers can be consistently different for two functions h (the identity function and the power function). We will construct a $\kappa ^+$ -sized family of functions h (...) and their corresponding localisation numbers, and use a ${\leq }\kappa $ -supported product of a cofinality-preserving forcing to prove that any simultaneous assignment of these localisation numbers to cardinals above $\kappa $ is consistent. This answers an open question from [3]. (shrink)

We reimplement the creature forcing construction used by Fischer et al. :1045–1103, 2017. https://doi.org/10.1007/S00153-017-0553-8. arXiv:1402.0367 [math.LO]) to separate Cichoń’s diagram into five cardinals as a countable support product. Using the fact that it is of countable support, we augment our construction by adding uncountably many additional cardinal characteristics, sometimes referred to as localisation cardinals.

The analysis of demonstration locations classified by degree of urbanization shows that demonstrating is an urban phenomenon. Seldom are demonstrations held in thinly populated residential areas. A demonstration can thus be considered among the farms of political action for which the participation stimulating factors are clearly more present in urban areas than in rural areas.The distribution of the demonstrations over the regions indicates that more demonstrating is done in Flanders than in Wallonia. Flemings and 'walloons, moreover, appeared in the streets (...) for different points of confiict during the period from 1953 to 1974.Demonstrations with ideological themes overwhelmingly, and communitarian themes mostly, occurred in Flanders ; demonstrations for socioeconomic purposes occurred mostly in Wallonia. Demonstrations in the capital, Brussels, had the most participants on the average in general andalso for the three conflict areas. (shrink)

The central aim of this book is to understand modules and the categories they form through associated structures and dimensions, which reflect the complexity of these, and similar, categories.