In this book, Norbert Wiley offers a new interpretation of the nature of the self in society.

The myf5 and myoD genes are implicated in the specification of vertebrate skeletal muscle. These genes have been thought to be functionally redundant because neonatal mice bearing homozygous null mutations in either gene show grossly normal muscle development. By analyzing the early embryonic development of the mutants, Michael Rudnicki and coworkers show that trunk muscle development is retarded in embryos bearing myf5 null mutations, while early limb and branchial arch muscle development is retarded by myoD null mutations.1 These results indicate (...) that the myoD and myf5 genes are not redundant but that each controls the early specification of distinct muscle cell lineages. BioEssays 20:357–362, 1998.© 1998 John Wiley & Sons Inc. (shrink)

The H‐NS protein is a major component of the nucleoid in Gram‐negative bacterial cells. It is a global regulator of transcription that affects the expression of many genes, including virulence genes in pathogenic species. At a local level, it facilitates the formation of nucleoprotein structures that repress transcriptional promoter function. H‐NS can form bridges between different DNA molecules or between different sections of the same molecule, allowing it to compact and impose structure on the nucleoid. A recent paper by Dame (...) et al.1 reports new insights into H‐NS‐mediated DNA bridging that were obtained using an optical tweezers device. BioEssays 29: 212–216, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Evolutionary investigations of human crania typically take a limited view of cranial diversity as they discount the possibility that human cranial variation could simply be due to the effects of random genetic drift, gene flow and mutation in favor of natural selection and developmental changes. Natural selection alone cannot explain similarities between patterns of cranial and molecular diversity observed in humans. It appears that the amount of phenotypic variance in the human cranium decreases at the population level as a function (...) of distance from Sub‐Saharan Africa much in the same way as observed for human molecular data.1 BioEssays 29:1185–1188, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Dawkins in his The Selfish Gene(1) quite aptly applies the term “selfish” to parasitic repetitive DNA sequences endemic to eukaryotic genomes, especially vertebrates. Doolittle and Sapienza(2) as well as Orgel and Crick(3) enlivened this notion of selfish DNA with the identification of such repetitive sequences as remnants of mobile elements such as transposons. In addition, Orgel and Crick(3) associated parasitic DNA with a potential to outgrow their host genomes by propagating both vertically via conventional genome replication as well as infectiously (...) by horizontal gene transfer (HGT) to other genomes. Still later, Doolittle(4) speculated that unchecked HGT between unrelated genomes so complicates phylogeny that the conventional representation of a tree of life would have to be replaced by a thicket or a web of life.(4) In contrast, considerable data now show that reconstructions based on whole genome sequences are consistent with the conventional “tree of life”.(5–10) Here, we identify natural barriers that protect modern genome populations from the inroads of rampant HGT. BioEssays 27:741–747, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Humanism, in the context of the classical world, contrasted the vitality of human life with the shadowy existence of the underworld endured after death. The buzz of ideas that permeated Athens in the fifth century is usually known as ‘Sophism’. The Sophists were attracted to Athens from throughout the Greek world, and they loved argument for its own sake. Much more important in the humanist tradition is Aristotle, who came to Athens from the northern Aegean to study with Plato in (...) Athens. It is a measure of a humanist society that it never allows dogma to impede progress, and after the fourth century the Greek tradition continued to be dynamic, especially in the Hellenistic city of Alexandria, where mathematics and science flourished into the second century CE. The way that Christianity developed can be seen in the contrasting interpretations of Christianity by the Greek theologian Origen and the Latin Augustine. (shrink)

The gelsolin gene family encodes a number of higher eukaryotic actin-binding proteins that are thought to function in the cytoplasm by severing, capping, nucleating or bundling actin filaments. Recent evidence, however, suggests that several members of the gelsolin family may have adopted unexpected nuclear functions including a role in regulating transcription. In particular, flightless I, supervillin and gelsolin itself have roles as coactivators for nuclear receptors, despite the fact that their divergence appears to predate the evolutionary appearance of nuclear receptors. (...) Flightless I has been shown to bind both actin and the actin-related BAF53a protein, which are subunits of SWI/SNF-like chromatin remodelling complexes. The primary sequences of some actin-related proteins such as BAF53a exhibit conservation of residues that, in actin itself, are known to interact with gelsolin-related proteins. In summary, there is a growing body of evidence supporting a biological role in the nucleus for actin, Arps and actin-binding proteins and, in particular, the gelsolin family of actin-binding proteins. (c) 2005 Wiley Periodicals, Inc. (shrink)

Regulation of gene expression by premature termination of transcription, or transcription attenuation, is a common regulatory strategy in bacteria. Various mechanisms of regulating transcription termination have been uncovered, each can be placed in either of two broad categories of termination events. Many mechanisms involve choosing between two alternative hairpin structures in an RNA transcript, with the decision dependent on interactions between ribosome and transcript, tRNA and transcript, or protein and transcript. In other examples, modification of the transcription elongation complex is (...) the crucial event. This article will describe and compare several of these regulatory strategies, and will cite specific examples to illustrate the different mechanisms employed. BioEssays 24:700–707, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Receptor tyrosine kinases and integrins are activated by growth factors and extracellular matrix, respectively. Their activation leads to signal transduction cascades that control many aspects of cell phenotype, including progression through the G1 phase of the cell cycle. However, the signalling cassettes driven by growth factors and matrix do not work independently of each other. Integrin triggering is essential to facilitate kinase‐ and GTPase‐mediated signals and thereby drive efficient transfer of information through the growth factor–cyclin axis. A recent study indicates (...) that an additional type of player has a key role in adhesion‐regulated control of cell cycle, namely ubiquitin ligase.(1) BioEssays 24:17–21, 2002. © 2002 John Wiley & Sons, Inc. (shrink)

N- and O-linked glycan structures of cell surface and secreted glycoproteins serve a variety of functions related to cell–cell communication in systems affecting development and disease. The more sophisticated N-glycan biosynthesis pathway of metazoans diverges from that of yeast with the appearance of the medial-Golgi β-N-acetylglucosaminyltransferases (GlcNAc-Ts). Tissue-specific regulation of medial- and trans-Golgi glycosyltransferases contribute structural diversity to glycoproteins in metazoans, and this can affect their molecular properties including localization, half-life, and biological activity. Null mutations in glycosyltransferase genes positioned later (...) in the biosynthetic pathway disrupt expression of smaller subsets of glycan structures and are progressively milder in phenotype. In this review, we examine data on targeted mutations affecting glycosylation in mice and congenital mutations in man, with a view to understanding the molecular functions of glycan structures as modulators of glycoprotein activity. Finally, pathology associated with the expression of GlcNAc-Ts in cancer and diabetes-induced cardiac hypertrophy suggest that inhibitors of these enzymes may have therapeutic value. BioEssays 21:412–421, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

_The Wiley Blackwell Handbook of Humanism_ presents an edited collection of essays that explore the nature of Humanism as an approach to life, and a philosophical analysis of the key humanist propositions from naturalism and science to morality and meaning. Represents the first book of its kind to look at Humanism not just in terms of its theoretical underpinnings, but also its consequences and its diverse manifestations Features contributions from international and emerging scholars, plus renowned figures such as Stephen (...) Law, Charles Freeman and Jeaneanne Fowler Presents Humanism as a positive alternative to theism Brings together the world’s leading Humanist academics in one reference work. (shrink)

Charles Darwin remarked that “males, with their superior strength, pugnacity, armaments, unwieldly passion and love songs, are almost always the more active and most often, the initiators of sexual interactions”.1 Here, we propose that such male sex drive directly impacts the genome by leading to its progressive masculinization—genes that possess sex-specific effects on male fitness accumulate to a much greater extent and are generally more diverged.2,3 The larger proportion of male versus female fitness modifiers in combination with stronger sexual (...) selection may generate evolutionary signatures such as a greater sensitivity to male sterility4 and a paucity of X-linked male-specific genes.5-8 Male sex-drive theory complements the female-choice theory of sexual selection and allows for the genetic variation of costly sexual traits to be continuously replenished. BioEssays 27: 518–525, 2005. © 2005 Wiley periodicals, Inc. (shrink)

In this volume, Charles Taliaferro and Jil Evans promote aesthetic personalism by examining three domains of aesthetics - the philosophy of beauty, aesthetic experience, and philosophy of art - through the lens of Judaism, Christianity, Islam, theistic Hinduism, and the all-seeing Compassionate Buddha. These religious traditions assume an inclusive, overarching God's eye, or ideal point of view, that can create an emancipatory appreciation of beauty and goodness. This appreciation also recognizes the reality and value of the aesthetic experience of (...) persons and deepens the experience of art works. The authors also explore and contrast the invisibility of persons and God. The belief that God or the sacred is invisible does not mean God or the sacred cannot be experienced through visual and other sensory or unique modes. Conversely, the assumption that human persons are thoroughly visible, or observable in all respects, ignores how racism and other forms of bias render persons invisible to others. (shrink)

In English law there is a strong (though rebuttable) presumption that life should be maintained. This article contends that this presumption means that it is always unlawful to withdraw life-sustaining treatment from patients in permanent vegetative state (PVS) and minimally conscious state (MCS), and that the reasons for this being the correct legal analysis mean also that such withdrawal will always be ethically unacceptable. There are two reasons for this conclusion. First, the medical uncertainties inherent in the definition and diagnosis (...) of PVS/MCS are such that, as a matter of medical fact, it can never be established, with the degree of certainty necessary to rebut the presumption, that it is not in the patient’s best interest to remain alive. And second (and more controversially and repercussively), that even if permanent unconsciousness can be unequivocally demonstrated, the presumption is not rebutted. This is because there is plainly more to human existence than consciousness (or consciousness the markers of which can ever be demonstrated by medical investigations). It can never be said that the identity of the patient whose best interests are at stake evaporates (so eliminating the legal or ethical subject) when that person ceases to be conscious. Nor can it be said that the best interests of an unconscious person do not mandate continued biological existence. We simply cannot know. That uncertainty is legally conclusive, and (subject to resource allocation questions and views about the relevance of family wishes and the previously expressed wishes of the patient) should be ethically conclusive. (shrink)

Though some doubts about the principle that every proposition is either true or false were entertained even by Aristotle, both the number and the vigor of criticisms of this principle have been increasing in recent years. This paper attempts a restatement and a re-examination of the issues involved in this dispute, and in particular an evaluation of the effects on the argument of such recent discoveries as that of the “many-valued logics.”.

Although Gaius Julius Victor has attracted scholarly attention due to his inclusion of letter-writing in his fourth-century rhetorical manual, his peculiar notion of sermocinatio or “impersonation” has gone largely unnoticed. Set against the backdrop of earlier accounts of sermocinatio as a technique of the grand style—including accounts in Quintilian and Cicero—Julius Victor presents impersonation as a method of subtle eloquence most germane to plain-style rubrics. Given Julius Victor’s coupling of sermocinatio and letter-writing, too, his manual suggests that the ascending importance (...) of writing tracks this stylistic reorientation, anticipating our own era’s evolving media and techniques for impersonating others. (shrink)

The question a judge has to ask in deciding whether or not life-sustaining treatment should be withdrawn is whether the continued treatment is lawful. It will be lawful if it is in the patient’s best interests. Identifying this question gives no guidance about how to approach the assessment of best interests. It merely identifies the judge’s job. The presumption in favour of the maintenance of life is part of the job that follows the identification of the question.The presumption is best (...) regarded as a presumption of law. It has long been recognised as part of the way in which the English law discharges its obligations under Article 2 of the European Convention on Human Rights (the right to life). But even if it is a ‘mere’ evidential presumption it cannot, on the facts of most cases involving applications for the withdrawal of life-sustaining treatment from patients in prolonged disorders of consciousness, be rebutted. (shrink)

Research on metaphor has over the past decades increasingly been extended to its visual and multimodal varieties. While analysts of verbal metaphors are helped by the fact that languages have grammars and vocabularies, researchers of visual and multimodal metaphors need to rely on other methods for identification and interpretation. One approach that claims to have developed a robust method for analyzing metaphor in moving images is FILMIP, which has hitherto focused on the specific genre of commercials. In this paper it (...) is argued that there are serious problems with FILMIP. First, the theoretical basis of FILMIP and two empirical studies drawing on it are discussed. Subsequently, its limited use for analyzing metaphors in the genre of feature films is demonstrated on the basis of four case studies. The paper ends with sketching some general advice pertaining to researching metaphor in film, and provides a cautious alternative to FILMIP. (shrink)

Preview: “America does not think much of its philosophers,” Douglas Anderson writes in his introduction to Philosophy Americana. “We do not teach philosophy in our high schools. A majority in America have no idea what philosophy is about or why it might be interesting, if not important.” Perhaps that lack of appreciation for philosophy is coeval with its beginnings when the ancient Athenians put Socrates to death. Anderson’s lament is clearly present from the supposed birth of Western philosophy, and vividly (...) so in 1486 in Italian humanist Giovanni Pico della Mirandola’s discourse known as The Dignity of Man, where he states, “The whole of philosophy is occasion for contempt and contumely, rather than honor and glory. The deadly and monstrous persuasion has invaded practically all minds, that philosophy ought not to be studied at all or by very few people; as though it were a thing of little worth to have before our eyes and at our fingertips....Thus,” Pico said six centuries ago, “we have reached a point, it is painful to recognize, where the only persons accounted wise are those who can reduce the pursuit of wisdom to a profitable traffic.” So it seems today in America and so it has apparently been and will ever be. Nevertheless, Anderson hopes to open a discussion about how philosophy does and does not manifest itself in American culture, how its practitioners remain “invisible,” and largely misunderstood “in rural, laboring, underclassed, and unschooled settings.” It is not his intention, at least in this book, to take up the issue of race in a discipline as overwhelmingly white as Western philosophy. Yet this has been for me, a black American philosopher, a lifelong meditation, which I will attempt to address in this essay. (shrink)

There are general aspects of mental life it is reasonable to believe do not vary even when subjects vary in their first‐person judgments about them. Such lack of introspective agreement gives rise to “phenomenological disputes.” These include disputes over how to describe the perspectival character of perception, the phenomenal character of perceptual recognition and conceptual thought, and the relation between consciousness and self‐consciousness. Some suppose that when we encounter such disputes we have no choice but to abandon first‐person reflection in (...) philosophy of mind in favor of a third‐person methodology. Such reaction is unwarranted. A reasoned assessment of phenomenological disputes that relies on first‐person reflection is explained, illustrated, and advocated. (shrink)

In this paper I will suggest an interpretation of Spinoza's ontological argument on which the argument, properly construed, is valid, and Spinoza, if granted the claim that it is possible that God exists, is successful in obtaining the conclusion of the argument. The interpretations given by H.A. Wolfson, G.H.R. Parkinson, and William A. Earle will then be argued to be deficient on textual and logical grounds. Leibniz’ assessment of the argument, namely that it “permits us only to conclude that God's (...) existence follows if his possibility is already proven,” is thus held to be correct. (shrink)

Healthcare ethics committees (HEC) have emerged as institutional forums for addressing bioethical dilemmas. Psychiatrists have important roles to play on these committees. Their skills in group process assessment, mental status examination, and character assessment have diverse applications. Psychiatrists can facilitate communication within the committee and as HEC-based clinical ethics consultants. HECs must be concerned with how they arrive at ethical decisions, guarding against political influence or individual monopolization. Psychiatrists can assist these efforts as organizational consultants to HECs. The perception of (...) psychiatrists as reflective, tolerant of ambiguity, humanizing, and approachable about ethical aspects of health care suggests they would make excellent committee leaders. Psychiatrists also have important committee roles to play as ethics educators and policy makers. More demographic data is needed to investigate psychiatrist participation on HECs. Studies of how they are perceived by their ethics committee colleagues may reveal new roles and potential pitfalls for HEC psychiatrists. (shrink)