The generation of panels of mutant mice by homologous recombination has greatly increased the ability to assess the function of particular gene products in vivo. The ability to control the developmental stage, the tissue and the nature of the mutation would be an important innovation. A recent report(1) demonstrates that the conservative site‐specific recombination of bacteriophage P1, namely Cre‐lox, can be used successfuly in combination with homologous recombination to generate temporal‐and cell‐restricted mutations in vivo. The technical advance allows a greater (...) flexibility in gene targeting and will have a significant impact on how complex gene functions are studied in vivo. (shrink)

The pathologies of the democratic public sphere, first articulated by Plato in his attack on rhetoric, have pushed much of deliberative theory out of the mass public and into the study and design of small scale deliberative venues. The move away from the mass public can be seen in a growing split in deliberative theory between theories of democratic deliberation (on the ascendancy) which focus on discrete deliberative initiatives within democracies and theories of deliberative democracy (on the decline) that attempt (...) to tackle the large questions of how the public, or civil society in general, relates to the state. Using rhetoric as the lens through which to view mass democracy, this essay argues that the key to understanding the deliberative potential of the mass public is in the distinction between deliberative and plebiscitary rhetoric. (shrink)

In this paper, I argue that the asymmetrical mediated communication of the broad democratic public sphere can profitably be understood through the lens of deliberative democracy only if we adopt a system approach to deliberation. A system approach, however, often introduces a division of labor between ordinary citizens and experts. Although this division of labor is unavoidable and I believe compatible with a deliberative principle of legitimacy, it flirts with elitist theories of democracy: epistemic elites come up with the agendas, (...) ideas, and policy positions and democratic publics ratify or repudiate the agendas but do not generate or really engage with them. This I argue would violate an essential defining feature of deliberative democracy, namely that epistemic quality and equal participation are tightly linked. I turn to Habermas and his idea of a feedback loop as a possible solution to this dilemma. (shrink)

This paper sets out the case for abolishing state-recognized marriage and replacing it with piecemeal regulation of personal relationships. It starts by analysing feminist objections to traditional marriage, and argues that the various feminist critiques can best be reconciled and answered by the abolition of state-recognized marriage. The paper then considers the ideal form of state regulation of personal relationships. Contra other recent proposals, equality and liberty are not best served by the creation of a new holistic status, such as (...) civil union, nor by leaving regulation to private contracts. Instead, the state should develop piecemeal regulations that apply universally. (shrink)

The prospects of enhancing cognitive or motor functions using neuroscience in otherwise healthy individuals has attracted considerable attention and interest in neuroethics (Farah et al., Nature Reviews Neuroscience 5:421–425, 2004; Glannon Journal of Medical Ethics 32:74–78, 2006). The use of stimulants is one of the areas which has propelled the discussion on the potential for neuroscience to yield cognition-enhancing products. However, we have found in our review of the literature that the paradigms used to discuss the non-medical use of stimulant (...) drugs prescribed for attention deficit/hyperactivity disorder (ADHD) vary considerably. In this brief communication, we identify three common paradigms—prescription drug abuse, cognitive enhancement, and lifestyle use of pharmaceuticals—and briefly highlight how divergences between paradigms create important “ethics blind spots”. (shrink)

Over the past decade, Jacques Rancière’s writings have increasingly provoked and inspired political theorists who wish to avoid both the abstraction of so-called normative theories and the philosophical platitudes of so-called postmodernism. Rancière offers a new and unique definition of politics, la politique, as that which opposes, thwarts and interrupts what Rancière calls the police order, la police — a term that encapsulates most of what we normally think of as politics (the actions of bureaucracies, parliaments, and courts). Interpreters have (...) been tempted to read Rancière as proffering a formally pure conception of politics, wherein politics is ultimately separate from and in utter opposition to all police orders. Here I provide a different account of Rancière’s thinking of politics: for Rancière politics goes on within police orders and for this reason he strongly rejects the very idea of a pure politics. Politics is precisely that which could never be pure; politics is an act of impurity, a process that resists purification. In carefully delineating the politique—police relation I show that the terms of Rancière’s political writings are multiple and multiplied. Rancière consistently undermines any effort to render politics pure, and therein lies his potential contribution to contemporary political theory. (shrink)

The dominant framework for addressing procreative ethics has revolved around the notion of harm, largely due to Derek Parfit’s famous non-identity problem. Focusing exclusively on the question of harm treats what procreators owe their offspring as akin to what they would owe strangers (if they owe them anything at all). Procreators, however, usually expect (and are expected) to parent the persons they create, so we cannot understand what procreators owe their offspring without also appealing to their role as prospective parents. (...) I argue that prospective parents can wrong their future children just by failing to act well in their role as parents, whether or not their offspring are ultimately harmed or benefitted by their creation. Their obligations as prospective parents bear on the motivations behind their reproductive choices, including the choice to select for some genetic trait in their offspring. Even when procreators’ motivations aren’t malicious, or purely selfish, they can still fail to recognize and act for the end of the parental role. Procreators can wrong their offspring by selecting for some genetic trait, then, when doing so would violate their obligations as prospective parents, or when their motivation for doing so is antithetical to the end of the parental role. (shrink)

Many accounts of the morality of abortion assume that early fetuses must all have or lack moral status in virtue of developmental features that they share. Our actual attitudes toward early fetuses don’t reflect this all-or-nothing assumption: early fetuses can elicit feelings of joy, love, indifference, or distress. If we start with the assumption that our attitudes toward fetuses reflect a real difference in their moral status, then we need an account of fetal moral status that can explain that difference. (...) I argue that we can have or lack relational obligations to early fetuses in light of our own activities or choices, independent of the fetus’s own features or properties. Those relational obligations make the early fetus morally considerable to the persons who stand in a moral relation to it. Pregnant persons (and other participants in the procreative process) can come to have relational obligations to an early fetus just in virtue of their own decision to create a person, either by intentionally getting pregnant or by deciding to continue a pregnancy. That decision not only makes it appropriate for them to care about the fetus, but it also generates obligations to the fetus that they didn’t have before that decision. (shrink)

ABSTRACT Diana Mutz's individual-level data show that participation and deliberation are often inversely related. This, according to Mutz, undermines many claims made by deliberative-democratic theory. However, a systemic approach to deliberative democracy challenges the significance of this finding. Although it is true that some citizens are political activists not open to hearing the other side and other citizens are less active but more open minded, both types of citizens make equally important and positive contributions to deliberative politics when it is (...) viewed as a system that deploys a division of labor. (shrink)

W.K.C. Guthrie has written a survey of the great age of Greek philosophy - from Thales to Aristotle - which combines comprehensiveness with brevity. Without pre-supposing a knowledge of Greek or the Classics, he sets out to explain the ideas of Plato and Aristotle in the light of their predecessors rather than their successors, and to describe the characteristic features of the Greek way of thinking and outlook on the world. Thus The Greek Philosophers provides excellent background material for the (...) general reader - as well as providing a firm basis for specialist studies. (shrink)

Cognitive Science, Volume 46, Issue 4, April 2022.

The field of deliberative democracy now generally recognizes the co-dependence of deliberation and voting. The field tends to emphasize what deliberation accomplishes for vote-based decisions. In this paper, we reverse this now common view to ask: In what ways does voting benefit deliberation? We discuss seven ways voting can complement and sometimes enhance deliberation. First, voting furnishes deliberation with a feasible and fair closure mechanism. Second, the power to vote implies equal recognition and status, both morally and strategically, which is (...) a condition of democratic deliberation. Third, voting politicizes deliberation by injecting the strategic features of politics into deliberation—effectively internalizing conflict into deliberative processes, without which they can become detached from their political environments. Fourth, anticipation of voting may induce authenticity by revealing preferences, as what one says will count. Fifth, voting preserves expressions of dissent, helping to push back against socially induced pressures for consensus. Sixth, voting defines the issues, such that deliberation is focused, and thus more likely to be effective. And, seventh, within contexts where votes are public—as in representative contexts, voting can induce accountability, particularly for one’s claims. We then use these points to discuss four general types of institutions—general elections, legislatures, minipublics, and minipublics embedded in referendum processes—that combine talking and voting, with the aim of identifying designs that do a better or worse job of capitalizing upon the strengths of each. (shrink)

Is democracy worth saving? Responding to the erosion of democracy, philosophical debates have pivoted from analyzing the best forms of democracy to questioning what is so valuable about democracy to begin with, how we can save it, and whether it is indeed worth saving. Contemporary Democratic Theory charts this pivot and surveys the most important new developments in the philosophical, theoretical, and normative examination of the concept of democracy. Comparisons that dominated 20th century democratic theory - between direct democracy, participatory (...) democracy, deliberative democracy, and agonistic democracy - are in the 21st century giving way to comparisons between democracy and its challengers: epistocracy, technocracy, meritocracy, oligarchy, and autocracy. Philosophical interest in the canonical figures of democratic theory like Aristotle, Rousseau and Mill is being eclipsed by damage control in the face populism, sinking trust in democratic institutions, failing political parties, and the spread of misinformation. (shrink)

At my university, many non-philosophy majors take our introductory ethics course to fulfill a core or general education requirement. I designed a course with these non-majors in mind called, "The Ethics of a Human Life." The course traces the arc of a human life by way of investigating a series of pessimistic ethical issues that arise: why it might be bad to be born, the challenges of being a child or an adolescent, the moral dangers of friendship, sex, love, marriage, (...) and parenting, and whether we should worry about aging, dying, or the afterlife. The arguments we examine challenge students’ ordinary assumptions about what is good or right, not to dissuade them of their optimism, but to show them that philosophy has tools that can help them navigate the ordinary (and extraordinary!) moral problems they will face over the course of their lives. (shrink)

This article examines relationships between civil society and state. It explains that civil society refers to uncoerced associational life distinct from the family and institutions of the state Civil society is also often thought to be distinct from the economy, but their separation is a matter of some dispute. Despite differences in definitional boundaries, contemporary interest in civil society focuses predominantly on associational life rather than market or exchange relations. This article describes the six relationships between civil society and state, (...) and suggests that these relations are not mutually exclusive and they do not necessarily compete with each other. (shrink)

In 2007, a private corporation specializing in deep-sea salvage retrieved a treasure-laden shipwreck in international waters southwest of the Iberian Peninsula. The wreck was that of a Spanish warship that sunk during the Napoleonic wars. Following the discovery, a legal dispute arose in U.S. federal courts, between the corporate salvors, the Kingdom of Spain, and other litigants. At issue in the legal proceedings was the status of the shipwreck and whether it was protected by sovereign immunity. At the heart of (...) this case are differing political imaginations concerning the authority of states and the role of corporations in the contemporary global order. Through a close reading of court documents and the narratives in which the courts’ rulings are embedded, we demonstrate that the case is symptomatic of the tension in neoliberal sovereignty between two overlapping and at times competing political rationalities: the neoliberal logic of capital and commerce and the logic of sovereign prerogative. (shrink)

Negative Concord (NC) constructions such as the news anchor didn’t warn nobody about the floods (meaning “the news anchor warned nobody”), in which two syntactic negations contribute a single semantic one, are stigmatized in English, while their Negative Polarity Item (NPI) variants, such as the news anchor didn’t warn anybody about the floods, are prescriptively correct. Because acceptability is often equated with grammaticality, this pattern has led linguists to treat NC as ungrammatical in “Standard” or standardized English (SE). However, it (...) is possible that SE grammars do generate NC sentences, and their low incidence and acceptability is instead due to social factors. To explore this question, and the relationship between NC and NPI constructions, we compared the acceptability of overtly negative noun phrases (e.g., nobody ), NPIs (e.g., anybody), and bare plurals (e.g., people ), in negative contexts and in conditionals. Negative items were followed by a consequence which supported their single negative meaning, while conditional items were followed by a consequence compatible with the NPI and the bare plural but not the negative noun phrase. Acceptability ratings of the critical NC sentences were reliably lower than constructions with NPIs and bare plurals, but the consequences for all three of these sentence types were rated highly. This reflects an asymmetry in participants’ acceptance of NC and their readiness to interpret it in context. A follow-up study with only conditionals revealed that speakers can also find NPIs infelicitous in conditional contexts with consequences that are compatible with a negative interpretation of the NPI, and that negative arguments are felicitous in these same contexts. Taken together, the results support the hypothesis that speakers who do not accept NC have grammars that generate both NC and NPI constructions, and further, that these speakers have two underlying structures for any -NPIs in English. (shrink)

This article draws on hermeneutics and interactivism to challenge the prevailing dichotomization of culture/self and fact/value by proposing a theoretical perspective that culture provides a moral framework in which people are embedded and that cultural values and assumptions are distributed across different levels of knowing. I then address the problems of relativism raised by the claim that cultures are different moral topographies, and consider how hermeneutic dialogue is a way of working towards "truth without certainty." I conclude by suggesting that (...) mindfulness and contemplative practices offer tangible ways of fostering the openness required for hermeneutic dialogue and cultural learning. 2012 APA, all rights reserved). (shrink)

Mechanisms of selective attention are vital for coherent perception and action. Recent advances in cognitive neuroscience have yielded key insights into the relationship between neural mechanisms of attention and eye movements, and the role of frontal and parietal brain regions as sources of attentional control. Here we explore the growing contribution of reversible neurodisruption techniques, including transcranial magnetic stimulation and microelectrode stimulation, to the cognitive neuroscience of spatial attention. These approaches permit unique causal inferences concerning the relationship between neural processes (...) and behaviour, and have revealed fundamental mechanisms of attention in the human and animal brain. We conclude by suggesting that further advances in the neuroscience of attention will be facilitated by the combination of neurodisruption techniques with established neuroimaging methods. (shrink)

This article addresses ethical issues in conducting randomized clinical trials with youth. Ethical considerations that occur prior to treatment, during treatment, and following treatment are reviewed. Recommendations, based on empirical evidence and clinical experience, are offered for conducting ethical treatment research with youth and future directions for carrying out research on the ethics of conducting RCTs with youth are offered.

Although children’s negative affectivity is a temperamental characteristic that is biologically based, it is framed within and shaped by their emotional environments which are partly created by maternal emotion expressivity in the family. Children, in turn, play a role in shaping their family emotional context, which could lead to changes in mothers’ emotion expressivity in the family. However, these theorized longitudinal bidirectional relations between child negative affectivity and maternal positive and negative expressivity have not been studied from toddlerhood to early (...) school-age. The current study utilized a cross-lagged panel model to examine the reciprocal relations between children’s negative affectivity and maternal expressivity within the family over the course of early childhood. Participants were 140 mother–child dyads. Mothers reported the positive and negative expressivity in the family and children’s negative affectivity in toddlerhood, preschool, and school-age. Maternal negative expressivity and child negative affectivity at T1 were significantly correlated. Maternal negative expressivity at T1 significantly predicted child negative affectivity at T3. Children’s negative affectivity at T2 significantly predicted mothers’ negative expressivity at T3. Mothers’ positive expressivity was not related to children’s negative affectivity at any of the three time points. The findings demonstrate the reciprocal relations between children’s negative affectivity and maternal negative expressivity in the family, suggesting the importance of the interplay between child temperament and maternal expressivity within the family emotional context. (shrink)