This paper argues that higher-order doubt generates an epistemic dilemma. One has a higher-order doubt with regards to P insofar as one justifiably withholds belief as to what attitude towards P is justified. That is, one justifiably withholds belief as to whether one is justified in believing, disbelieving, or withholding belief in P. Using the resources provided by Richard Feldman’s recent discussion of how to respect one’s evidence, I argue that if one has a higher-order doubt with regards to P, (...) then one is not justified in having any attitude towards P. Otherwise put: No attitude towards the doubted proposition respects one’s higher-order doubt. I argue that the most promising response to this problem is to hold that when one has a higher-order doubt about P, the best one can do to respect such a doubt is to simply have no attitude towards P. Higher-order doubt is thus much more rationally corrosive than non-higher-order doubt, as it undermines the possibility of justifiably having any attitude towards the doubted proposition. (shrink)

A number of philosophers have recently claimed that unjustified beliefs can be defeaters. However these claims have been made in passing, occurring in the context of defenses of other theses. As a result, the claim that unjustified beliefs can be defeaters has been neither vigorously defended nor thoroughly explained. This paper fills that gap. It begins by identifying problems with the two most in-depth accounts of the possibility of unjustified defeaters due to Bergmann and Pryor. It then offers a revised (...) version of Pryor’s account. On this proposal, an unjustified belief can be a defeater if it is rational, all things considered. If a belief is rational, all things considered, it can require one to abandon other beliefs with which it conflicts—even if it is unjustified. Finally, this paper shows that the proposed account of unjustified defeaters is one that can and should be embraced by leading accounts of justified belief as diverse as reliabilism and evidentialism. (shrink)

In this paper I defend epistemic circularity by arguing that the “No Self-Support” principle (NSS) is false. This principle, ultimately due to Fumerton ( 1995 ), states that one cannot acquire a justified belief in the reliability of a source of belief by trusting that very source. I argue that NSS has the skeptical consequence that the trustworthiness of all of our sources ultimately depends upon the trustworthiness of certain fundamental sources – sources that we cannot justifiably believe to be (...) reliable. This is a problem, I claim, because if the trustworthiness of all of our sources depends upon sources that we should not believe to be reliable, then a reflective individual should not trust any of his sources at all. The hidden cost of rejecting epistemic circularity is thus the unacceptable skeptical thesis that reflective individuals like you and I have no justified beliefs whatsoever. (shrink)

Background There is considerable variation in the functionality of bioethical services in different institutions and countries for children in hospital, despite new challenges due to increasing technology supports for children with serious illness and medical complexity. We aimed to understand how bioethics services address bioethical concerns that are increasingly encountered in paediatric intensive care. Methods A qualitative descriptive design was used to describe clinician’s perspectives on the functionality of clinical bioethics services for paediatric intensive care units. Clinicians who were members (...) of formal or informal clinical bioethics groups, or who were closely involved with the process of working through ethically challenging decisions, were interviewed. Interviews took place online. Resulting transcripts were analysed using thematic analysis. Results From 33 interviews, we identified four themes that described the functionality of bioethics services when a child requires technology to sustain life: striving for consensus; the importance of guidelines; a structure that facilitates a time-sensitive and relevant response; and strong leadership and teamwork. Conclusions Clinical bioethics services have the potential to expand their role due to the challenges brought by advancing medical technology and the increasing options it brings for treatment. Further work is needed to identify where and how bioethics services can evolve and adapt to fully address the needs of the decision-makers in PICU. (shrink)

BackgroundDecision-making in initiating life-sustaining health technology is complex and often conducted at time-critical junctures in clinical care. Many of these decisions have profound, often irreversible, consequences for the child and family, as well as potential benefits for functioning, health and quality of life. Yet little is known about what influences these decisions. A systematic review of reasoning identified the range of reasons clinicians give in the literature when initiating technology dependence in a child, and as a result helps determine the (...) range of influences on these decisions.MethodsMedline, EMBASE, CINAHL, PsychINFO, Web of Science, ASSIA and Global Health Library databases were searched to identify all reasons given for the initiation of technology dependence in a child. Each reason was coded as a broad and narrow reason type, and whether it supported or rejected technology dependence.Results53 relevant papers were retained from 1604 publications, containing 116 broad reason types and 383 narrow reason types. These were grouped into broad thematic categories: clinical factors, quality of life factors, moral imperatives and duty and personal values; and whether they supported, rejected or described the initiation of technology dependence. The majority were conceptual or discussion papers, less than a third were empirical studies. Most discussed neonates and focused on end-of-life care.ConclusionsThere is a lack of empirical studies on this topic, scant knowledge about the experience of older children and their families in particular; and little written on choices made outside ‘end-of-life’ care. This review provides a sound basis for empirical research into the important influences on a child’s potential technology dependence. (shrink)

Contrary to what many philosophers believe, Calvinism neither makes the problem of evil worse nor is it obviously refuted by the presence of evil and suffering in our world. Or so most of the authors in this book claim. While Calvinism has enjoyed a resurgence in recent years amongst theologians and laypersons, many philosophers have yet to follow suit. The reason seems fairly clear: Calvinism, many think, cannot handle the problem of evil with the same kind of plausibility as other (...) more popular views of the nature of God and the nature of God's relationship with His creation. This book seeks to challenge that untested assumption. With clarity and rigor, this collection of essays seeks to fill a significant hole in the literature on the problem of evil. (shrink)

This paper reviews the actual and potential use of social media in emergency, disaster and crisis situations. This is a field that has generated intense interest. It is characterised by a burgeoning but small and very recent literature. In the emergencies field, social media (blogs, messaging, sites such as Facebook, wikis and so on) are used in seven different ways: listening to public debate, monitoring situations, extending emergency response and management, crowd-sourcing and collaborative development, creating social cohesion, furthering causes (including (...) charitable donation) and enhancing research. Appreciation of the positive side of social media is balanced by their potential for negative developments, such as disseminating rumours, undermining authority and promoting terrorist acts. This leads to an examination of the ethics of social media usage in crisis situations. Despite some clearly identifiable risks, for example regarding the violation of privacy, it appears that public consensus on ethics will tend to override unscrupulous attempts to subvert the media. Moreover, social media are a robust means of exposing corruption and malpractice. In synthesis, the widespread adoption and use of social media by members of the public throughout the world heralds a new age in which it is imperative that emergency managers adapt their working practices to the challenge and potential of this development. At the same time, they must heed the ethical warnings and ensure that social media are not abused or misused when crises and emergencies occur. (shrink)

Over the course of human history, the sciences, and biology in particular, have often been manipulated to cause immense human suffering. For example, biology has been used to justify eugenic programs, forced sterilization, human experimentation, and death camps—all in an attempt to support notions of racial superiority. By investigating the past, the contributors to _Biology and Ideology from Descartes to Dawkins_ hope to better prepare us to discern ideological abuse of science when it occurs in the future. Denis R. Alexander (...) and Ronald L. Numbers bring together fourteen experts to examine the varied ways science has been used and abused for nonscientific purposes from the fifteenth century to the present day. Featuring an essay on eugenics from Edward J. Larson and an examination of the progress of evolution by Michael J. Ruse, _Biology and Ideology_ examines uses both benign and sinister, ultimately reminding us that ideological extrapolation continues today. An accessible survey, this collection will enlighten historians of science, their students, practicing scientists, and anyone interested in the relationship between science and culture. (shrink)

The current interest in bioregionalism, stimulated in part by Kirkpatrick Sale’s Dwellers in the Land, shows that people are looking for a form of political praxis which addresses the importance of region. In this paper, I argue that much of the bioregional literature written to date mystifies the concept of region, discounting the role of subjectivity and culture in shaping regional boundaries and veers toward asimplistic view of “nature knows best.” Bioregionalism can be rehabilitated, provided we treat it not as (...) a “revealed wisdom” for the reconstruction of human society, but as a sensibility and environmental ethic that can infuse our work even as we make use of the functional regionalisms that increasingly shape people’s consciousness. I conclude by citing Lewis Mumford’s concept of a region as capturing the dialectical interplay of natural and cultural elements. (shrink)

It is commonly thought that evolution is a chance process, an idea found in popular writings on evolution, but also in academic writing in a broad range of scientific disciplines: scientific, philosophical and theological. One problem is that words such as ‘chance’ and ‘random’ are used with a range of different meanings according to context, and in evolutionary biology the word ‘chance’ is sometimes used in a way that is different from its use in mathematics and philosophy. The present article (...) aims to clarify the range of meanings and to argue the case that the evolutionary process is far from being a ‘theory of chance’ from biological, mathematical, or indeed philosophical and theological perspectives. (shrink)

Cosmological arguments have received more attention in the past ten years. One reason for this is that versions with restricted or even no reliance on the principle of sufficient reason (PSR) have been formulated. By not relying on PSR – what many consider to be a necessary falsehood – philosophers have been able to escape many of the old criticisms of cosmological arguments. In this essay I survey two recent attempts at presenting a sound version of a cosmological argument. I (...) spend more time on Robert Koons’ since his has not yet received the kind of quality attention that the other has. (shrink)

Inferential Internalists accept the Principle of Inferential Justification (PIJ), according to which one has justification for believing P on the basis of E only if one has justification for believing that E makes probable P. Richard Fumerton has defended PIJ by appeal to examples, and recently Adam Leite has argued that this principle is supported by considerations regarding the nature of responsible belief. In this paper, I defend a form of externalism against both arguments. This form of externalism recognizes what (...) I call the phenomenon of reflective defeat: if one is justified in not believing that E makes probable P, then this defeats whatever justification one has for believing P upon the basis of E. I argue that this modified version of externalism has the virtue of accommodating the intuitions that motivate internalism, without the cost of the vicious regress that makes internalism so unattractive. (shrink)

'Everyone agrees that the moral features of things supervene on their natural features' (Smith (1994), 22). Everyone is wrong, or so I will argue. In the first section, I explain the version of moral supervenience that Smith and others argue everyone should accept. In the second section, I argue that the mere conceptual possibility of a divine command theory of morality (DCT) is sufficient to refute the version of moral supervenience under consideration. Lastly, I consider and respond to two objections, (...) showing, among other things, that while DCT is sufficient to refute this version of moral supervenience it is not necessary. (shrink)

In this paper I argue that Cartesian skepticism about the external world is self-defeating. The Cartesian skeptic holds that we are not justified in believing claims about the external world on the grounds that we cannot rule out the possibility of our being in a radical skeptical scenario. My argument against this position builds upon a critique of Wilson in Analysis, 72, 668–673. Wilson argues that the Cartesian’s skeptical reasoning commits him to mental state skepticism and that this undermines his (...) ability to claim that he is truly skeptical about the external world. I show that Wilson’s argument does not succeed. She is correct that the Cartesian is committed to mental state skepticism. However, she is mistaken in thinking that there is anything incoherent about combining the Cartesian position that one ought to doubt external world claims with doubt about whether one is in fact such a skeptic. I propose an alternative explanation as to why mental state skepticism proves to be the Cartesian’s undoing. I suggest that mental state skepticism leads to epistemic skepticism and that this undermines the Cartesian’s position that belief about the external world is unjustified. (shrink)

: The Convention on Human Rights and Biomedicine developed by the Council of Europe, now undergoing ratification, is the first international treaty focused on bioethics. This article describes the background of the Convention's development and its general provisions and provides a comparison of its requirements with those of federal regulations governing research with human subjects. Although most provisions are comparable, there are significant differences in scope and applicability, for example, in the areas of compensation for injury, research participation by persons (...) with limited capacity to consent, assisted reproduction, organ transplantation, and research in emergency situations. The Convention represents a milestone in international bioethics and protection of human rights that will probably be referred to with increasing frequency. (shrink)

This article represents comments arising from The Compatibility of Evolution and Design by Rope Kojonen (Palgrave Macmillan, 2021) concerning the role of chance and randomness in evolution (citations from this book are shown as page numbers in brackets). The various meanings of chance and randomness as used in descriptions of biological evolution are discussed and contrasted with their meanings in mathematics and metaphysics. The discussion relates to the role of contingency in evolution and to ideological and rhetorical extrapolations from biology (...) into philosophical world views. Overall it is concluded that evolution is not a chance process, except in the epistemic sense of “chance.” Theologically, this has implications for the idea that God creates through “a free evolutionary process” and may also influence our perspectives on divine action and intentionality in evolutionary history. (shrink)

In “Weak Inferential Internalism” I defended the frequently voiced criticism that any internalist account of inferential justification generates a vicious regress. My defense involved criticizing a recent form of internalism, “Weak Inferential Internalism” , defended by Hookway and Rhoda. I argued that while WII does not generate a vicious regress, the position is only distinguishable from externalism insofar as it makes an arbitrary distinction between individuals who believe for the very same reason. Either way, WII is not a defensible internalist (...) account of inferential justification. In his “In Defense of Weak Inferential Internalism,” Rhoda has responded to my dilemma argument. He argues that it is mistaken to assume that WII must be incompatible with externalism, and that contrary to my claims, WII is distinguishable from externalism in several ways. In this reply, I explain why none of Rhoda’s replies suggest that there is a defensible internalist account of inferential justification. (shrink)

There is a common misconception that our genomes - all unique, except for those in identical twins - have the upper hand in controlling our destiny. The latest genetic discoveries, however, do not support that view. Although genetic variation does influence differences in various human behaviours to a greater or lesser degree, most of the time this does not undermine our genuine free will. Genetic determinism comes into play only in various medical conditions, notably some psychiatric syndromes. Denis Alexander here (...) demonstrates that we are not slaves to our genes. He shows how a predisposition to behave in certain ways is influenced at a molecular level by particular genes. Yet a far greater influence on our behaviours is our world-views that lie beyond science - and that have an impact on how we think the latest genetic discoveries should, or should not, be applied. Written in an engaging style, Alexander's book offers tools for understanding and assessing the latest genetic discoveries critically. (shrink)

In this paper I introduce a problem regarding whether there are good reasons to accept fallibilism about justified belief. According to this species of fallibilism, one can be justified in believing a proposition on the basis of reasons that do not justify certainty. Call such reasons “fallible reasons.” The problem is this: can one justifiably believe fallibilism on the basis of fallible reasons? To do so would seem to beg the question. If you are undecided as to whether you should (...) accept anything on the basis of fallible reasons, then you should also be undecided as to whether you should accept fallibilism on the basis of such reasons. In this paper I consider several possible responses to this problem. I argue that the most appealing is to grant that good but fallible reasons on behalf of fallibilism are possible, and that this shows that one’s basic rational commitments cannot be defended in a non-circular fashion. (shrink)

Over the past centuries the pendulum has constantly swung between an emphasis on the role of either nature or nurture in shaping human destiny, a pendulum often energised by ideological considerations. In recent decades the flourishing of developmental biology, genomics, epigenetics and our increased understanding of neuronal plasticity have all helped to subvert such dichotomous notions. Nevertheless, the media still report the discovery of a gene 'for' this or that behaviour, and the field of behavioural genetics continues to extend its (...) reach into the social sciences, reporting the heritability of such human traits as religiosity and political affiliation. There are many continuing challenges to notions of human freedom and moral responsibility, with consequent implications for social flourishing, the legal system and religious beliefs. In this book, Denis Alexander critically examines these challenges, concluding that genuine free will, often influenced by genetic variation, emerges from an integrated view of human personhood derived from contemporary biology. (shrink)

Inferential internalism holds that for one to be inferentially justified in believing P on the basis of E one must be justified in believing that E makes probable P. Inferential internalism has long been accused of generating a vicious regress on inferential justification that has drastic skeptical consequences. However, recently Hookway and Rhoda have defended a more modest form of internalism that avoids this problem. They propose a form of weak inferential internalism according to which internalist conditions are restricted to (...) only certain kinds of inferential justification. In this paper, I clarify and argue against weak internalism. I contend that while weak internalism avoids the vicious regress, it does so at the cost of compromising its internalist credentials. For I show that unless weak internalism makes an arbitrary distinction between individuals who believe for the very same reasons, the view collapses into externalism. (shrink)

David Alexander has argued that “weak inferential internalism” (WII), a position which amounts to a qualified endorsement of Richard Fumerton’s controversial “principle of inferential justification,” is subject to a fatal dilemma: Either it collapses into externalism or it must make an arbitrary epistemic distinction between persons who believe the same proposition for the same reasons. In this paper, I argue that the dilemma is a false one, for weak inferential internalism does not entail internalism simpliciter. Indeed, WII is compatible with (...) modest externalism, and so is consistent with what Armstrong calls “Type II justification,” the rejection of which leads to the arbitrary epistemic distinctions to which he rightly objects. (shrink)

In the last two decades, the greatest threat to armchair philosophy has been the natural kinds approach. On this view, philosophic theorizing should not be obsessed with the ideas of justice, goodness, and truth but should look outward to the world of objects to find these things. And if these things happen to be natural kinds, like kinds of rock or fish for instance, then clearly we should reject the armchair for the lab. The philosopher should leave the office and (...) join the scientist out in the field. Philosophy should become a species of science. We attempt to defend traditional/armchair philosophy by examining Hilary Kornblith’s naturalistic methodological approach to epistemology. Among other things, we argue that Kornblith’s approach leads to some surprising, undesirable results (at least undesirable to the naturalist), one of which is that Kornblith cannot discount epistemic internalism as a viable contender in the search for the nature of knowledge. His methodology actually requires that we take epistemic internalism seriously. (shrink)

Phosphotyrosine phosphatases (PTPases) are the enzymes which remove phosphate groups from protein tyrosine residues. An enormous number of phosphatases have been cloned and sequenced during the past decade, many of which are expressed in haematopoietic cells. This review focuses on the biochemistry and cell biology of three phosphatases, the transmembrane CD45 and the cytosolic SH2‐domain‐containing PTPases SHP‐1 and SHP‐2, to illustrate the diverse ways in which PTPases regulate receptor signal transduction. The involvement of these and other PTPases has been demonstrated (...) in haematopoietic cell development, apoptosis, activation and non‐responsiveness. A common theme in the actions of many haematopoietic cell PTPases is the way in which they modulate the thresholds for receptor signalling, thereby regulating critical events in the positive and negative selection of lymphocytes. There is growing interest in haematopoietic PTPases and their associated regulatory proteins as targets for pharmaceutical intervention and in the involvement of these enzymes in human disease. (shrink)