Western philosophers have traditionally concentrated on theory as the means for expressing knowledge about a variety of phenomena. This absorbing book challenges this fundamental notion by showing how objects themselves, specifically scientific instruments, can express knowledge. As he considers numerous intriguing examples, Davis Baird gives us the tools to "read" the material products of science and technology and to understand their place in culture. Making a provocative and original challenge to our conception of knowledge itself, _Thing Knowledge _demands that we (...) take a new look at theories of science and technology, knowledge, progress, and change. Baird considers a wide range of instruments, including Faraday's first electric motor, eighteenth-century mechanical models of the solar system, the cyclotron, various instruments developed by analytical chemists between 1930 and 1960, spectrometers, and more. (shrink)

By a close examination of changes in analytical chemistry between the years 1920 and 1950, I document the case that natural science has undergone and continues to undergo a major revolution. The central feature of this transformation is the rise in importance of scientific instrumentation. Prior to 1920, analytical chemists determined the chemical constitution of some unknown by treating it with a series of known compounds and observing the kind of reactions it underwent. After 1950, analytical chemists determined the chemical (...) constitution of an unknown by using a variety of instruments which allow one to discriminate chemicals in terms of their physical properties. This transformation involved changes in the practice of analytical chemistry. It involved the development of a new family of scientific instrument-making companies, and a new level of capital expenditure necessary to do analytical chemistry. It involved the development of new means to disseminate information about scientific instruments. While I do not document the broader case, these changes have been widespread throughout the natural sciences. It is the rise in the importance of instrumentation which is the key conceptual change in what has been identified as the fourth big scientific revolution. (shrink)

In a recent article Ian Hacking argues that there can be cases where no probabilities may correctly be ascribed to individual members of a population, while probabilities are correctly ascribable to the population as a whole. In this paper a simple artificial coin-flipping model for such probabilities, not 'grounded from below' is constructed. The inferences licensed by this model and a consequence of the model for the theory of statistical tests is explored.

According to Peter Galison , science has a highly fractionated structure with multiple sub-sub-disciplines, each with its own agenda. Cooperative trading between groups is necessary for most scientific work to move forward, and it is this trading that preserves the stability of science. We argue that it is not trading per se, but trading in a gift economy that guarantees stability. We support our claims with an examination of contemporary work on magnetic resonance imaging instrumentation. Specifically, we consider: How a (...) feature improvement, intended to reduce scan time, led to substantial medical mis-diagnosis; How a technical error, when corrected, created a consumer crisis in which radiologists preferred technically flawed instruments; How new magnetic resonance theory radically altered the physical interpretation of MRI images; How the MRI instrument at first was financially supported by, and--ironically--ultimately invalidated, the accepted understanding of the nature, source and management of chronic back pain. Ultimately there are three reasons stability requires gifting. First, without a general sense of shared purpose traders will not be committed to mutual engagement; profit does not provide an adequate shared purpose for the MRI community. Second, stability requires trust, and profits are not an adequate foundation for trust. Finally, knowledge is a gift that will not keep on giving if treated simply as a source of profit. (shrink)

This comprehensive volume marks a new standard in scholarship in the still emerging field of the philosophy of chemistry. With selections drawn from a wide range of scholarly disciplines, philosophers, chemists, and historians of science here converge to ask some of the most fundamental questions about the relationship between philosophy and chemistry. What can chemistry teach us about longstanding disputes in the philosophy of science over such issues as reductionism, autonomy, and supervenience? And what new issues may chemistry bring to (...) the forefront now that it has joined physics and biology as a serious topic for philosophical reflection? This newest addition to the prestigious Boston Studies in the Philosophy of Science series marks the true arrival of philosophy of chemistry within the corpus of the philosophy of science. (shrink)

In this paper we elucidate a particular type of instrument. Striking-phenomenon instruments assume their striking profile against the shifting backdrop of theoretical uncertainties. While technologically stable, the phenomena produced by these instruments are linguistically fuzzy, subject to a variety of conceptual representations. But in virtue of their technological stability alone, they can provide a foundation for further technological as well as conceptual development. Sometimes, as in the case of the pulse glass, the phenomenon is taken to confirm conflicting theoretical views; (...) sometimes, as in the case of the Lichtenberg-figures, it holds out the false promise of crucial theoretical importance; sometimes, as in the case of the airpump in the 18th century, it emphatically short-circuits theory and human ingenuity, giving a voice to nature herself; and sometimes, finally, as in the case of the quincunx, the phenomenon stands in for theoretical accounts. We propose and develop the salient features of these instruments demonstrating their importance to our understanding of science. (shrink)

I present five theses to characterize and argue for "Instrumental Realism," a realism wedded to what we do with instruments, and not what our theories say: The Independence Thesis: Questions about realism are independent of questions about meaning. The Intervening Thesis: Our ability to produce consistent effects with our instruments provides one guarantee that we are engaged with the real world. The Historical Thesis: If the descriptions of what we know and do are of something real, then it will be (...) possible to trace a history from earlier antiquated names and actions to current usages. The Instruments-Do-Not-Always-Work-Right Thesis: Since instruments do not always work right, a successful instrumental intervention cannot be a social construct. The Tinkering Thesis: Since instruments are created by tinkering, we should not take any claim that generalizes away from our instrumental practice realistically. (shrink)

The use of human fetal tissue for scientific research has enormous potential but is subject to government legislation. In the United Kingdom the Polkinghorne Committee's guidelines were accepted by the Department of Health in 1990. These guidelines set out to protect women undergoing termination of pregnancy from exploitation but in so doing may significantly restrict potential research. Although the committee took evidence from a wide variety of experts they did not seek the views of the general public. We asked 108 (...) women about to have a therapeutic abortion; 167 women who had had a pregnancy terminated in the past, and 419 women who had never had an abortion, their views on research using human fetal tissue. Regardless of their past experiences the women were overwhelmingly in favour of research using fetal tissue (94 per cent). They made little distinction between basic research and research with obvious clinical relevance and supported the concept of using transplanted fetal tissue for the treatment of adult disease such as Parkinsonism. Women about to undergo an abortion were significantly more likely (p < 0.001) to approve of all types of research including that aimed at improving methods of abortion and research using live fetuses in utero. (shrink)

Recently we have learned how experiment can have a life of its own. However, experiment remains epistemologically disadvantaged. Scientific knowledge must have a theoretical/propositional form. To begin to redress this situation, I discuss three ways in which instruments carry meaning: 1. Scientific instruments can carry tremendous loads of meaning through association, analogy and metaphor. 2. Instrumental models of complicated phenomena work representationally in much the same way as theories. 3. Instruments which create new phenomena establish a new field of material (...) possibilities. I suggest that scientists employ a "visual/physical/material logic," analogous to propositional logic, which establishes relations between different material forms. (shrink)

We live in a world that increasingly is designed by engineers. So it is worth asking what are engineers doing when they design. There is no simple universal answer to this question, and my strategy for answering it both acknowledges the impossibility of a simple answer, while also identifying and elaborating some important elements to engineering realities. I start with the simple posit that engineering a reality is about controlling aspects of that reality through designed artifice. I then “complexify” this (...) simple idea by examining one company’s multiple contributions to engineering realities. Ometric Corporation was birthed out of the USC NanoCenter in the fall of 2004. The company makes spectrometric equipment that allows for “real time in line” analysis—and control—of materials. Markets that Ometric is focusing on include pharmaceuticals, food and energy. But Ometric lives in an engineer’s reality, while simultaneously working to engineer realities. It must survive financially, initially by selling the ideas behind its innovations to venture capitalists, and then by selling products to markets that may or may not currently exist. Ometric is the product of the University of South Carolina’s efforts to turn its intellectual property into gold for the University. Ometric, thus, is part of a larger effort to re-engineer the University and its relationship to industry. My examination of Ometric, then, identifies some key ways that “control through designed artifice” is a complex, and yet prevalent and powerful force in the construction of our realities. (shrink)

Sir Dugald Baird sketches the history of abortion legislation in Great Britain from the beginning of the century. In his views the 1967 Abortion Act has been one of the most important and beneficial pieces of social legislation enacted in Britain in the last 100 years. It has, however, brought problems both of administration in the hospitals and to individual doctors and nurses, particularly when the patients are young single women and even schoolgirls. One of the consequences of the Abortion (...) Act has been a fall in maternal mortality and perinatal mortality rates. Abortion does not seem to be followed by serious emotional sequelae. Nevertheless recent changes in sexual mores have introduced new and serious social problems which are discussed in relation to the role of the doctor in his relationship with patients seeking abortion. (shrink)

The rule of implication, (+) If hypothesis H implies hypothesis I, then evidence sufficient to warrant the rejection of I, in turn warrants the rejection of H, is a very plausible principle of inductive inference. It is shown that significance tests violate this principle. Two ways to account for this violation are considered; neither account is fully satisfactory. First, a distinction might be made between the absolute degree of confirmation and the change in the degree of confirmation due to a (...) specific result. Measures of the change in the degree of confirmation need not obey the rule of implication. Unfortunately, it is difficult to interpret significance tests as a measure of the change in degree of confirmation of an hypothesis. Second, it might be observed that hypotheses are sought that are informative as well as faithful to observations. Amalgamating a measure of informativeness with a measure of faithfulness can result in violations of the rule of implication. Unfortunately, it is unclear why significance tests amalgamating measures of informativeness and faithfulness are desirable. (shrink)

Musgrave opens the book defending the general claim that knowledge consists of justified true beliefs. He concedes that there may well be other kinds of knowledge--knowledge of things, knowing how --but still, he contends, there is much of interest in "knowledge that", and this kind of knowledge is best analyzed in terms of a justified true belief account. If, then, knowing that is a matter of belief, truth, and justification, the most obvious difficulty concerns what counts as an appropriate justification. (...) Generally, knowledge may be justified by appeal to experience or by appeal to certain propositions known a priori. The bulk of Musgrave's book details the three-cornered fight between the empiricists, the rationalists, and the sceptics. (shrink)