Plant cells are caged within a distended polymeric network (the cell wall), which enlarges by a process of stress relaxation and slippage (creep) of the polysaccharides that make up the load‐bearing network of the wall. Protein mediators of wall creep have recently been isolated and characterized. These proteins, called expansins, appear to disrupt the noncovalent adhesion of matrix polysaccharides to cellulose microfibrils, thereby permitting turgor‐driven wall enlargement. Expansin activity is specifically expressed in the growing tissues of dicotyledons and monocotyledons. Sequence (...) analysis of cDNAs indicates that expansins are novel proteins, without previously known functional motifs. Comparison of expansin cDNAs from cucumber, pea, Arabidopsis and rice shows that the proteins are highly conserved in size and amino acid sequence. Phylogenetic analysis of expansin sequences suggests that this multigene family diverged before the evolution of angiosperms. Speculation is presented about the role of this gene family in plant development and evolution. (shrink)

ObjectiveTo further delineate risk and resilience factors contributing to trajectories of mental health symptoms experienced by college students through the pandemic.Participantsn = 183 college students.MethodsLinear mixed models examined time effects on depression and anxiety. Propensity-matched subgroups exhibiting “increased” versus “low and stable” depression symptoms from before to after the pandemic-onset were compared on pre-pandemic demographic and psychological factors and COVID-related experiences and coping strategies.ResultsStudents experienced worsening of mental health symptoms throughout the pandemic, particularly during Fall 2020 compared with Fall 2019. (...) The propensity-matched subgroup exhibiting relative resilience reported less alcohol use prior to the pandemic, greater use of active coping strategies, and less of an impact on their college progress.ConclusionsResults point to several potential targets of screening and intervention to decrease residual impacts of the pandemic. (shrink)

The question of whether chimpanzees, like humans, reason about unobservable mental states remains highly controversial. On one account, chimpanzees are seen as possessing a psychological system for social cognition that represents and reasons about behaviors alone. A competing account allows that the chimpanzee's social cognition system additionally construes the behaviors it represents in terms of mental states. Because the range of behaviors that each of the two systems can generate is not currently known, and because the latter system depends upon (...) the former, determining the presence of this latter system in chimpanzees is a far more difficult task than has been assumed. We call for recognition of this problem, and a shift from experimental paradigms that cannot resolve this question, to ones that might allow researchers to intelligently determine when it is necessary to postulate the presence of a system which reasons about both behavior and mental states. (shrink)

The ultimate goal of the pioneering project outlined in this book is to map our genome--the key to what makes us human--in detail. The Code of Codes is a collective exploration of the substance and possible consequences of th is project in relation to ethics, law, and society.

We read with interest the recent article on criteria for patient selection of cardiac xenotransplantation by Kögel et al.1 The authors recognise the benefits and concerns of first developing xenotransplantation trials in children (or at least concurrent development). They conclude that, based on (1) the vulnerable nature of children and (2) the observation that ‘the benefits of cardiac xenotransplantation have never been systematically proven in humans,’ that the ‘very first clinical trials should be conducted with adult patients.’ This is a (...) long-standing contention in xenotransplantation that, to our knowledge, finds its origins in the Nuffield Council on Bioethics’ 1996 report on xenotransplantation, which states: ‘It would be difficult to justify the involvement of children in major and risky xenotransplantation trials before some of the uncertainties have been eliminated in trials involving adults.’2 However, given the cardiac allotransplant waitlist mortality borne by some paediatric patients, as well as other factors that raise unique candidacy considerations in children compared with adults—and arguably make some children better candidates than adults—we do not believe …. (shrink)

People often fail to detect large changes to scenes, provided that the changes occur during a visual disruption. This phenomenon, known as ''change blindness,'' occurs both in the laboratory and in real-world situations in which changes occur unexpectedly. The pervasiveness of the inability to detect changes is consistent with the theoretical notion that we internally represent relatively little information from our visual world from one glance at a scene to the next. However, evidence for change blindness does not necessarily imply (...) the absence of such a representation-people could also miss changes if they fail to compare an existing representation of the pre-change scene to the post-change scene. In three experiments, we show that people often do have a representation of some aspects of the pre-change scene even when they fail to report the change. And, in fact, they appear to ''discover'' this memory and can explicitly report details of a changed object in response to probing questions. The results of these real-world change detection studies are discussed in the context of broader claims about change blindness. (shrink)

ABSTRACTRecent rejections of epistemic consequentialism, like those from Firth, Jenkins, Berker, and Greaves, have argued that consequentialism is committed to objectionable trade-offs and suggest...

Law and the legal system through which law is effected are very powerful, yet the power of the law has always been limited by the laws of nature, upon which the law has now direct grip. Human law now faces an unprecedented challenge, the emergence of a second limit on its grip, a new “species” of intelligent agents (AI machines) that can perform cognitive tasks that until recently only humans could. What happens, as a matter of law, when another species (...) interacts with us, can be integrated into human minds and bodies, makes “real-world” decisions—not through human proxies, but directly—and does all this “intelligently”, with what one could call autonomous agency or even a “mind” of its own? The article starts from the clear premise that control cannot be exercised directly on AI machines through human law. That control can only be effected through laws that apply to humans. This has several regulatory implications. The article’s first discusses what, in any attempt to regulate AI machines, the law can achieve. Having identified what the law can do, the article then canvases what the law should aim to achieve overall. The article encapsulate its analysis in a list of both doctrinal and normative principles that should underpin any regulation aimed at AI machines. Finally, the article compares three transnational options to implement the proposed regulatory approach. (shrink)

Fleming, Daniel J; Ryan, Thomas Three recent phrases of Pope Francis warrant attention and guide this article. First, there is his call for 'witnesses of God's love' in his tribute to modern martyrs. The second is 'the pedagogy of grace' and the work of the Spirit explained in 'Amoris Laetitia'. Third, from the same document, we find his discussion of accompaniment in the process of moral discernment within the church. With these as guideposts and drawing on recent studies in (...) moral philosophy and psychology, this article unfolds in five steps: setting the scene; witness in relation to moral understanding and intersubjectivity; intersubjectivity and conscience; a pedagogy of grace: Holy Spirit and nonbelievers; and a pedagogy of grace in relation to moral development. (shrink)

Hasdai Crescas fue un importante pensador, autor y líder comunitario judío de finales del siglo XIV y principios del XV, cuyas obras son estudiadas con detalle en el mundo académico. No obstante, su impacto sobre la comunidad judía tradicional ha sido casi inexistente. Nunca terminó su obra legal, la que podría haber tenido impacto en los judíos tradicionales. Sus escritos filosóficos conservados son difíciles de seguir; solo sobrevive una de las dos polémicas anticristianas vernáculas, en una traducción/paráfrasis hebrea. Aunque Crescas (...) fue bien recordado en el siglo posterior a su muerte, ya en este período se pueden detectar las razones de su posterior olvido. Un examen de la historia de la recepción de la obra de Crescas en el siglo XV demuestra hasta qué punto sus posiciones polémicas, dogmáticas y filosóficas fueron mayoritariamente rechazadas, más allá de que tuvo partidarios, fundamentalmente entre sus alumnos más cercanos. No es de extrañar, entonces, que en los siglos posteriores, la memoria de Crescas fuera casi borrada de la conciencia comunitaria judía. (shrink)

I present an account of an aspect of people’s intellectual characters that has yet to receive such direct treatment in the literature on the intellectual virtues. That aspect is our capacity to influence others in ways that make inquiry go more successfully, which I call “intellectual charisma”. In presenting this account, I first draw on work in empirical psychology to build a partial picture of intellectual charisma as a social-psychological phenomenon. I then draw on this partial picture in defining intellectual (...) charisma, explaining some important features of it, and making the case that it meets some important conditions for qualifying as an intellectual virtue. I conclude by first discussing some of the ways that including intellectual charisma within our overall picture of the intellectual virtues changes that picture, and then outlining some of the benefits that result from those changes. (shrink)

In the first book-length study of American philosophy at the turn of the century, Daniel J. Wilson traces the formation of philosophy as an academic discipline. Wilson shows how the rise of the natural and physical sciences at the end of the nineteenth century precipitated a "crisis of confidence" among philosophers as to the role of their discipline. Deftly tracing the ways in which philosophers sought to incorporate scientific values and methods into their outlook and to redefine philosophy itself, (...) Wilson moves between close analysis of philosophical texts and consideration of professional careers of illustrative philosophers, such as Charles Sanders Peirce, John Dewey, and Josiah Royce. The author situates the emergence of professional philosophy in the context of the professionalization of American higher education and articulates, in the case of philosophy, the structures and values of a professional discipline. One of the most important consequences of this transformation was a new emphasis on communal theories of truth. Peirce, Dewey, and Royce all developed sophisticated and important theories of community as they were engaged in reshaping and redefining the limits of philosophy. This book will be of great importance for those interested in the history of philosophy, the rise of professions, and American intellectual and educational history, and to all those seeking to understand the contemporary revival of pragmatic thought and theories of community. (shrink)

Sex differences in mortality rates stem from genetic, physiological, behavioral, and social causes that are best understood when integrated in an evolutionary life history framework. This paper investigates the Male-to-Female Mortality Ratio (M:F MR) from external and internal causes and across contexts to illustrate how sex differences shaped by sexual selection interact with the environment to yield a pattern with some consistency, but also with expected variations due to socioeconomic and other factors.

Joshua Daniel offers a reconstruction of the influence of Josiah Royce and George Herbert Mead on H. Richard Niebuhr to counter predominate strains in Christian ethics that overemphasize the role of socialization in moral formation at the expense of acknowledging the agency of individuals and their importance in preventing communities from turning in on themselves or becoming static. Daniel characterizes the driving worry of postliberal Christian ethics as “the accommodation of Christian communities to prevailing social forces and norms, (...) which is understood to radically undermine the churches’ existence and mission”. The primary accusation against these prevailing social norms is individualism. The modern... (shrink)

Jaakko Hintikka (1998) has argued that clarifying the notion of abduction is the fundamental problem of contemporary epistemology. One traditional interpretation of Peirce on abduction sees it as a recipe for generating new theoretical discoveries . A second standard view sees abduction as a mode of reasoning that justifies beliefs about the probable truth of theories. While each reading has some grounding in Peirce's writings, each leaves out features that are crucial to Peirce's distinctive understanding of abduction. I develop and (...) defend a third interpretation, according to which Peirce takes abductive reasoning to lead to judgments about the relative pursuitworthiness of theories; conclusions that can be thoroughly disconnected from assessments of truth-value. Even if Peirce's use of "abduction" slides around among each of these three importantly different though potentially compatible senses, this neglected third understanding makes sense of a large number of Peirce's remarks and directs our attention to the cognitive structure of judgments that scientists face after the initial proposal of explanatory hypotheses but prior to their experimental testing; a topic which should be of interest to contemporary philosophers of science. (shrink)

I remember the first time that I heard James Cone's voice. A well-established, white scholar had just given what I thought to be a solid presentation on Martin Luther King Jr.'s notion of the "beloved community." When he had finished, Cone was one of the first to speak in the question and answer period. His strong tenor was piercing: "You can't talk about the dream, if you're not going to talk about the nightmare." He went on to clarify his worry (...) that the heart of King's message was too often lost when white scholars failed to put his thought in the context of the history and reality of the oppression of and violence against blacks in America. I have become afraid that my own thinking and writing about King's... (shrink)

European Journal of Philosophy, Volume 29, Issue 4, Page 731-745, December 2021.

Since at least the mid-2000s, political commentators, environmental advocates, and scientists have raised concerns about an “anti-science” approach to environmental policymaking in conservative governments in the US and Canada. This paper explores and resolves a paradox surrounding at least some uses of the “anti-science” epithet. I examine two cases of such “anti-science” environmental policy, both of which involve appeals to epistemic values that are widely endorsed by both scientists and philosophers of science. It seems paradoxical to call an appeal to (...) epistemic values “anti-science.” I develop an analysis that, I argue, can resolve this paradox. This analysis is a version of the “aims approach” to science and values, drawing on ideas from axiology and virtue ethics. I characterize the paradox in terms of conflicts or tensions between epistemic and pragmatic aims, and argue that there is a key asymmetry between them: epistemic aims are valuable, in part, because they are useful for pursuing pragmatic aims. Thus, when epistemic and pragmatic aims conflict, epistemic aims need to be reconceptualized in order to reconcile them to pragmatic aims. When this is done, in the “anti-science” cases, the epistemic values are scientific vices rather than virtues. Thus the “anti-science” epithet is apt. (shrink)

Stollenwerk, Daniel J In this essay on the social encyclical Caritas in Veritate, the author looks at Pope Benedict XVI's defense of reason in an age that has lost its faith in reason. Benedict insists we are faced with a choice between being closed within immanence - which leads to an irrational rejection of meaning and value - or open to reason that leads to the transcendent. Pope Benedict, the author concludes, is a contemporary apologist, claiming that Christianity is (...) not only the most reasonable of worldviews, but also necessary for the very survival of humanity. (shrink)

Stollenwerk, Daniel J Like so much of Catholic social teaching before it, Pope Francis' Laudato Si' points to synthesis-a synthesis of reason and faith, science and religion, technology and ethics, practicality and beauty-as the key to not only care for our common home, but also the alleviation of poverty, and a sustainable and integral, ecological and human development. What the social teachings of the church have slowly established as a principle for development, education and ecumenism, Pope Francis specifically applies (...) to today's ecological and humanitarian crisis. This article will look at the principle of synthesis as crucial to understanding Laudato Si' and its place in recent Catholic social teaching. (shrink)

This paper argues that a plant together with the symbiotic fungus attached to its roots, a mycorrhizal collective, is an evolutionary individual, and further, that mycorrhizal individuality has important implications for evolutionary theory. Theoretical individuation is defended and then employed to show that mycorrhizal collectives function as interactors according to David Hull’s replicator-interactor model of evolution by natural selection, and because they have the potential to engage in pseudo-vertical transmission, mycorrhizal collectives also function as Darwinian individuals, according to Peter Godfrey-Smith’s (...) Darwinian Populations model of evolution by natural selection. Mycorrhizae in nature usually connect the roots of multiple plants, so mycorrhizal individuality entails the existence of overlapping evolutionary individuals, and because the potential to engage in pseudo-vertical transmission comes in degrees, it follows that these overlapping evolutionary individuals also come in degrees. I suggest here that the degree of evolutionary individuality in a symbiotic collective corresponds to its probability of reproducing with vertical or pseudo-vertical transmission. This probability constitutes a fourth parameter of graded Darwinian individuality in collective reproducers and warrants an update to Godfrey-Smith’s 3D model. (shrink)

Philosophers are approaching a consensus that biological individuality, including evolutionary individuality, comes in degrees. Graded evolutionary individuality presents a puzzle when juxtaposed with another widely embraced view: that evolutionary individuality follows from being a selectable member of a Darwinian population. Population membership is, on the orthodox view, a bivalent condition, so how can members of Darwinian populations vary in their degree of individuality? This article offers a solution to the puzzle, by locating difference in degree of evolutionary individuality at the (...) level of population lineages, some of which are more Darwinian than others. In doing so, it sheds light on graded individuality in overlapping and nested population lineages, such as those that arise in multilevel selection and symbiotic collectives. (shrink)

Standard approaches to defining and evaluating environmental risk tend to reflect technocratic rather than democratic values. One consequence is that institutional mechanisms for achieving citizen participation in risk decisions rarely are studied or evaluated. This article presents a survey of five institutional mechanisms for allowing the lay public to influence environmental risk decisions: public hearings, initiatives, public surveys, negotiated rule making, and citizens review panels. It also defines democratic process criteria for assessing these and other participatory mechanisms.

We discuss how the law and scholars have approached three questions. First, what acts count as acts of entrapment? Secondly, is entrapment a permissible method of law-enforcement and, if so, in what circumstances? Thirdly, what must criminal courts do, in response to the finding that an offence was brought about by an act of entrapment, in order to deliver justice? While noting the contrary tendency, we suggest that the first question should be addressed in a manner that is neutral about (...) the answers to the other two. On the second question, we summarize various arguments about the permissibility of entrapment, while remaining largely neutral about their merits. With regard to the third question, we summarize the approaches to entrapment in various jurisdictions, and we note some patterns, across the jurisdictions here surveyed, concerning shifts from one sort of entrapment remedy to another. (shrink)

One recent trend in Western philosophical ethics has been a push toward ethical naturalism, and with it, psychological realism.1 One part of such psychological realism involves the attempt to recast the ethical project in light of our recent acceptance that the sources of human behavior are complex and multifarious, that we are not, as it were, autonomous rational agents who can comply with our moral norms simply by choosing to do so. This keener empirical understanding of the sources of human (...) behavior leads ethicists of a psychologically realist bent to see the project of developing empirically sound methods of ethical cultivation as an important part of the ethical project.2This trend in Western ethics has... (shrink)

The author, a health insurance industry leader and a prominent voice in the national reform debate, shares his perspective on attempts to transform health care over nearly a decade. He advocates for a bipartisan solution to stabilize the health insurance market in the near term, and for private sector innovation in partnership with government to create sustainable long-term change. He encourages ASLME members to continue to lend their expertise to the process of transformation.

The neurophysiological evidence from the Miyashita group's experiments on monkeys as well as cognitive experience common to us all suggests that local neuronal spike rate distributions might persist in the absence of their eliciting stimulus. In Hebb's cell-assembly theory, learning dynamics stabilize such self-maintaining reverberations. Quasi-quantitive modeling of the experimental data on internal representations in association-cortex modules identifies the reverberations (delay spike activity) as the internal code (representation). This leads to cognitive and neurophysiological predictions, many following directly from the language (...) used to describe the activity in the experimental delay period, others from the details of how the model captures the properties of the internal representations. (shrink)

En los últimos años de su vida, el poeta nicaragüense Rubén Darío volvió a trabajar el cuento fantástico porque el género ofrecía la mejor expresión narrativa a la confusión y la incredulidad que estaba viviendo. En septiembre de 1910 Darío hizo su única visita a México, que estaba entonces en vísperas de la gran Revolución que derrocaría a la dictadura de Porfirio Díaz, la cual había controlado al país por treinta y cuatro años. La experiencia de estar en medio de (...) una gran agitación social, como un invitado de honor y, sin embargo, no habérsele permitido ascender a la capital, fue probablemente una inspiración para su penúltimo cuento, “Huitzilopoxtli: leyenda mexicana” (1977a). (shrink)

Empirical tests described in this article support hypotheses derived from evolutionary theory on the perceptions of literary characters. The proper and dark heroes in British Romantic literature of the late eighteenth and early nineteenth centuries respectively represent long-term and short-term mating strategies. Recent studies indicate that for long-term relationships, women seek partners with the ability and willingness to sustain paternal investment in extended relationships. For short-term relationships, women choose partners whose features indicate high genetic quality. In hypothetical scenarios, females preferred (...) proper heroes for long-term relationships. The shorter the relationship under consideration, the more likely women were to choose dark heroes as partners. (shrink)