A complete quantum solution provides all possible knowledge of a system, whereas semiclassical theory provides at best approximate solutions in a limited region. Nevertheless, semiclassical methods based on the work of Martin Gutzwiller can provide stunning physical insights in regimes where quantum solutions are opaque. Furthermore, they can provide a unique bridge between the quantum and classical worlds. We illustrate these ideas with an account of a theoretical and experimental attack on the paradigm problem of the hydrogen atom in strong (...) magnetic and electric fields. (shrink)

Several researchers have suggested that a talented, quality workforce will become a more important source of competitive advantage for firms in the future. Drawing on social identity theory and signaling theory, the authors hypothesize that firms can use their corporate social performance (CSP) activities to attract job applicants. Specifically, signaling theory suggests that a firm’s CSP sends signals to prospective job applicants about what it would be like to work for a firm. Social identity theory suggests that job applicants have (...) higher self-images whenworking for socially responsive firms over their less responsive counterparts. The authors conducted an experiment in which they manipulated CSP and found that prospective job applicants are more likely to pursue jobs from socially responsible firms than from firms with poor social performance reputations. The implications of these findings for academicians and practitioners alike are discussed. (shrink)

Nelson Goodman's acceptance and critique of certain methods and tenets of positivism, his defence of nominalism and phenomenalism, his formulation of a new riddle of induction, his work on notational systems, and his analysis of the arts place him at the forefront of the history and development of American philosophy in the twentieth-century. However, outside of America, Goodman has been a rather neglected figure. In this first book-length introduction to his work Cohnitz and Rossberg assess Goodman's lasting contribution to philosophy (...) and show that although some of his views may be now considered unfashionable or unorthodox, there is much in Goodman's work that is of significance today. The book begins with the "grue"-paradox, which exemplifies Goodman's way of dealing with philosophical problems. After this, the unifying features of Goodman's philosophy are presented - his constructivism, conventionalism and relativism - followed by an discussion of his central work, The Structure of Appearance and its significance in the analytic tradition. The following chapters present the technical apparatus that underlies his philosophy, his mereology and semiotics, which provides the background for discussion of Goodman's aesthetics. (shrink)

Predictive Processing accounts of Cognition, PPC, promise to forge productive alliances that will unite approaches that are otherwise at odds. Can it? This paper argues that it can’t—or at least not so long as it sticks with the cognitivist rendering that Clark and others favor. In making this case the argument of this paper unfolds as follows: Sect. 1 describes the basics of PPC—its attachment to the idea that we perceive the world by guessing the world. It then details the (...) reasons why so many find cognitivist interpretations to be inevitable. Section 2 examines how prominent proponents of cognitivist PPC have proposed dealing with a fundamental problem that troubles their accounts—the question of how the brain is able to get into the great guessing game in the first place. It is argued that on close inspection Clark’s solution, which he calls bootstrap heaven is—once we take a realistic look at the situation of the brain—in fact bootstrap hell. Section 3 argues that it is possible to avoid dwelling in bootstrap hell if one adopts a radically enactive take on PPC. A brief sketch of what this might look like is provided. (shrink)

Possible worlds have found many applications in contemporary philosophy: from theories of possibility and necessity, to accounts of conditionals, to theories of mental and linguistic content, to understanding supervenience relationships, to theories of properties and propositions, among many other applications. Almost as soon as possible worlds started to be used in formal theories in logic, philosophy of language, philosophy of mind, metaphysics, and elsewhere, theorists started to wonder whether impossible worlds should be postulated as well. In many applications, possible worlds (...) face limitations that can be dealt with through postulating impossible worlds as well. This chapter examines some of the uses of impossible worlds, and philosophical challenges theories of impossible worlds face. (shrink)

At the end of a chapter in his book Race, Racism and Reparations, Angelo Corlett notes that “[t]here remain other queries about racism [than those he addressed in his chapter], which need philosophical exploration. … Perhaps most important, how might racism be unlearned?” (2003, 93). We agree with Corlett’s assessment of its importance, but find that philosophers have not been very keen to directly engage with the issue of how to best deal with, and ultimately do away with, racism. Rather, (...) they have tended to make cursory remarks about the issue at the end of papers devoted to defining “racism” or attempting to capture the essence of racism itself. In this article, we put the issue of how to best deal with racism front and center. We need not start from scratch, however. Despite not being central to many philosophical discussions about race, a number of different strategies for dealing with racism have been suggested. To that end, we have identified three of the most concrete proposals made by philosophers and social theorists, each of which seeks to mitigate racism by inducing psychological changes in individuals.2 For each, we formulate the.. (shrink)

According to illusionism, phenomenal consciousness is an introspective illusion. The illusion problem is to explain the cause of the illusion, or why we are powerfully disposed to judge—erroneously—that we are phenomenally conscious. I propose a theory to solve the illusion problem. I argue that on the basis of three hypotheses about the mind—which I call introspective opacity, the infallibility intuition, and the justification constraint—we can explain our disposition, on introspection, to draw erroneous unconscious inferences about our sensory states. Being subject (...) to the illusion of phenomenal consciousness consists in having this disposition. I explain our ‘problem intuitions’ about consciousness —that our sensory states bear phenomenal properties that are qualitatively like something with which we are directly acquainted that is ineffable, atomic, intrinsic, private, and non-physical. I also address the illusion meta-problem, which is to explain why illusionism seems especially counterintuitive. (shrink)

Situation semantics as conceived in Kratzer (1989) has been shown to be a valuable companion to the e-type pronoun analysis of donkey sentences (Heim 1990, and recently refined in Elbourne 2001b), and more generally binding out of DP (BOOD; Tomioka 1999; Büring 2001). The present paper proposes a fully compositional version of such a theory, which is designed to capture instances of crossover in BOOD.

In theCritique of Pure Reason,Kant argues for two principles that concern magnitudes. The first is the principle that ‘All intuitions are extensive magnitudes,’ which appears in the Axioms of Intuition (B202); the second is the principle that ‘In all appearances the real, which is an object of sensation, has an intensive magnitude, that is, a degree,’ which appears in the Anticipations of Perception (B207). A circle drawn in geometry and the space occupied by an object such as a book are (...) paradigm examples of extensive magnitudes, while the intensity of a light is a paradigm example of an intensive magnitude. These principles justify and explain the possibility of applying mathematics to objects of experience. The Axioms principle also explains the possibility of any mathematical cognition at all. (shrink)

Although scholarship in the social construction of technology has contributed much to illuminating technological development, most work using this theoretical approach is committed to an agency-centered approach. SCOT scholars have made only limited contributions to illustrating the influence of social structures. In this article, the authors argue for the importance of structural concepts to understanding technological development. They summarize the SCOT conceptual framework defined by Trevor Pinch and Wiebe Bijker and survey some of the methodological and explanatory difficulties that arise (...) with their approach. Then the authors present concepts from organizational sociology and political economy that illuminate structural influences in shaping phenomena of interest to SCOT scholars. These structural concepts can be applied to the study of the design, development, and transformation of technology. The authors conclude that the limited amount of scholarship on structural factors in the social shaping of technological development presents numerous opportunities for research. (shrink)

As a strategy for exploring the relationship between understanding and knowledge, we consider whether epistemic luck – which is typically thought to undermine knowledge – undermines understanding. Questions about the etiology of understanding have also been at the heart of recent theoretical debates within epistemology. Kvanvig (2003) put forward the argument that there could be lucky understanding and produced an example that he deemed persuasive. Grimm (2006) responded with a case that, he argued, demonstrated that there could not be lucky (...) understanding. In this paper, we empirically examine how participants' patterns of understanding attributions line up with the predictions of Kvanvig and Grimm. We argue that the data challenge Kvanvig's position. People do not differentiate between knowing-why and understanding-why on the basis of proper etiology: attributions of knowledge and understanding involve comparable (and minimal) roles for epistemic luck. We thus posit that folk knowledge and understanding are etiologically symmetrical. (shrink)

Based on various stimuli, the findings for the inattentional blindness paradigm suggest that many observers do not perceive an unexpected object in a dynamic setting. In a first experiment, inattentional blindness was combined with eye tracking data from children. Observers who did not notice the unexpected object in the basketball game test by Simons and Chabris spent on average as much time looking at the unexpected object as those subjects who did perceive it. As such, individual differences that are responsible (...) for the recognition of unexpected objects have to be found as further indicators. In a second experiment, the expert-novice paradigm was used to show that the probability of seeing an unexpected object can be increased with specific previous experience. The results in the same task indicate significant differences between basketball experts and basketball novices. The ages of the subjects in both experiments are discussed in connection with the inattentional blindness paradigm. (shrink)

This paper reviews the literature concerning the neural correlates of the self, the relationship between self and memory and the profile of memory impairments in Alzheimer’s disease and explores the relationship between the preservation of the self and anosognosia in this condition. It concludes that a potential explanation for anosognosia in AD is a lack of updating of personal information due to the memory impairments characteristic of this disease. We put forward the hypothesis that anosognosia is due in part to (...) the “petrified self.”. (shrink)

We examine a condition in which units of time, such as months of the year, are associated with specific locations in space. For individuals with this time-space synaesthesia, contiguous time units such as months are spatially linked forming idiosyncratically shaped patterns such as ovals, oblongs or circles. For some individuals, each time unit appears in a highly specific colour. For instance, one of the synaesthetes we studied experienced December as a red area located at arms length to the left of (...) their body. For the same individual May was a blue area located roughly at arms length to the right of their body. We studied four synaesthetes who report spatial associations for the months of the year. We found that the time-space associations experienced by these individuals were consistent across test–retest. In addition, month names directed visual attention to particular locations in space. For some synaesthetes, this directing of spatial attention was quite rapid-in accord with their reports that month names involuntarily bring to mind spatial locations. (shrink)

Kevin Elliott and Dan McKaughan argue that, in some cases, nonepistemic values provide legitimate reasons for scientists to accept an epistemically inferior option, a claim that they support with two case studies. This essay argues that Elliott and McKaughan have not shown that their case studies are indeed ones in which an epistemically inferior option was accepted. Specifically, their interpretation of these cases depends on problematic premises that it is epistemically better to wait for a slower-but-more-reliable method than to accept (...) the result of a quicker-but-less-reliable one and that a more detailed model is epistemically preferable to a simpler one. (shrink)

It is traditional to ascribe to Locke the view that every person who acquires natural property rights by labouring on resources is obligated to leave sufficient resources for everyone else. But during the last several decades, a number of authors have contributed to a compelling textual case against this reading. Nevertheless, Locke clearly indicates that there is something wrong with distributions in which some suffer while others thrive. But if he does not endorse the traditional proviso, what exactly is the (...) problem? In this paper, I offer a solution to this puzzle. I argue that according to Locke, once people use their natural rights to acquire large properties, many individuals are unable to enjoy the material and moral wellbeing, or “preservation,” that is the end of natural law. For even if such large properties pose no problem for material preservation, they foster arbitrary power that offends against moral preservation. (shrink)

We pass all the time. I’m keen to maintain my standing as an oppression theorist, so I pretend I’ve read Nineteen Eighty-Four when it comes up in conversations. I’ve failed to mention my penchant for puns and my extensive board game collection on first dates, because it turns out neither of those are particularly appealing for some mysterious reason. And I trained myself out of my Minnesotan accent in graduate school, after noticing that some folks were having a little difficulty (...) taking me seriously during presentations. Some people try to pass as younger, or older, looking for the opportunities and recognition that come with being thought a certain age. Some pass as members of different political parties, hoping to avoid attention or debate when they realize they’re in the minority at a gathering. Some pass as fans of popular figures or pastimes, seeing the value in fitting in with friends and coworkers, and some pass as aficionados of more selective pleasures, wanting to be seen as refined. Some pass as more confident than they are, more experienced than they are, more charitable than they are, more well-adjusted than they are, more appropriate than they are, more typical than they are. Sometimes the most advantageous identities or personal histories are not our own. (shrink)

Psychological research has been discovering a number of puzzling features of morality and moral cognition recently.2 Zhong & Liljenquist (2006) found that when people are asked to think about an unethical deed or recall one they themselves have committed in the past, issues of physical cleanliness become salient. Zhong & Liljenquist cleverly designate this phenomenon the “Macbeth Effect,” and it takes some interesting forms. For instance, reading a story describing an immoral deed increased people’s desire for products related to cleansing, (...) like a shower soap, disinfectants, or antiseptic wipes. Moreover, Zhong & Liljenquist found that cleaning one’s hands after describing a past unethical deed actually reduced moral emotions such as guilt and shame. So much so that those who did “wash away their sins” were less likely than other participants to help out a.. (shrink)

El conocimiento, más que un medio para saber es un instrumento para convivir. Su función más importante no consiste en reflejar una supuesta verdad objetiva, adecuando nuestras percepciones a la realidad exterior, sino en convertirse en el dispositivo más poderoso a la hora de configurar un espacio democrático de vida común entre los seres humanos. Y es que nuestros principales problemas colectivos no son, contra lo que suele afirmarse, problemas de voluntad, de falta de decisión o de inmoralidad; deberíamos considerarlos (...) también fracasos cognoscitivos o que tienen su origen en un organización deficiente del conocimiento desde el punto de vista de su legitimidad democrática. Este libro desarrolla la tesis de que el conocimiento y sus aledaños (las políticas de la ciencia y la innovación, el asesoramiento político a los gobiernos, la evaluación de las políticas públicas, la comprensión de las actuales transformaciones sociales o la competencia cognoscitiva de los reguladores) son ámbitos donde se decide no sólo la prosperidad económica sino, fundamentalmente, la calidad democrática. Las políticas del conocimiento y a través del conocimiento se nos han convertido en un asunto de ciudadanía democrática, donde nos jugamos muchos problemas teóricos pero, principalmente, la calidad de nuestro espacio público. (shrink)

Several political philosophers have recently developed novel legitimacy-based theories of migration. These accounts argue that individual states’ legitimacy depends upon their role in a legitimate state system characterized by global cooperation on migration. This review critically assesses these arguments, as articulated by Christopher Bertram, Gillian Brock, and David Owen.

On the Lockean thesis one ought to believe a proposition if and only if one assigns it a credence at or above a threshold (Foley in Am Philos Q 29(2):111–124, 1992). The Lockean thesis, thus, provides a way of characterizing sets of all-or-nothing beliefs. Here we give two independent characterizations of the sets of beliefs satisfying the Lockean thesis. One is in terms of betting dispositions associated with full beliefs and one is in terms of an accuracy scoring system for (...) full beliefs. These characterizations are parallel to, but not merely derivative from, the more familiar Dutch Book (de Finetti in Theory of probability, vol 1, Wiley, London, 1974) and accuracy (Joyce in Philos Sci 65(4):575–603, 1998) arguments for probabilism. (shrink)

Although thought experiments were first discovered as a sui generis methodological tool by philosophers of science (most prominently by Ernst Mach), the tool can also be found – even more frequently – in contemporary philosophy. Thought experiments in philosophy and science have a lot in common. However, in this chapter we will concentrate on thought experiments in philosophy only. Their use has been the centre of attention of metaphilosophical discussion in the past decade, and this chapter will provide an overview (...) of the results this discussion has achieved and point out which issues are still open. (shrink)

De Jaegher’s (2009) paper argues that Gallagher, who aims to replace traditional theory-of-mind accounts of social understanding with accounts based on direct perception (hereafter DP), has missed an important opportunity. Despite a desire to break faith with tradition, there is a danger that proponents of DP accounts will remain (at least tacitly) committed to an unchallenged, and perhaps unnoticed, sort of individualism inherent in traditional theories (i.e. those that regard our engagement with others as a ‘problem’ to be solved: a (...) problem of other minds). Taking a more root and branch approach, De Jaegher recommends a complete shift of focus. She proposes that a more thoroughgoing and fruitful response to traditional approaches must attend to, and seek to understand, interactional phenomena proper—for it is the nature of interactions themselves that importantly influence individuals. Hence, it is the processes of interacting which ‘span individuals’ and their specific, dynamic evolution over time that should take pride of place in research into social cognition. De Jaegher wants to put interactional processes – those that can ‘take on life of their own’ and ‘influence interactors’ – at the heart of enquiries into intersubjectivity. Citing other recent work she has done with Di Paolo, she bills this as ‘‘the central task of any account of intersubjectivity” (De Jaegher, 2009, p. 2; De Jaegher & Di Paolo, 2007). The trouble is that this way of putting matters can make it look as if there is just one task facing researchers in this area; that we are faced with an either/or choice. But it is clear that any fully illuminated understanding of interactional phenomena will require accounts of what individuals and their sub-personal processes/mechanisms are doing in this larger process and, presumably, how their mechanisms/tendencies of response constrain and shape local bouts of interacting, even if we assume it is the dynamics of such encounters that importantly influence and shape what comes next.. (shrink)

A number of attempts have been made to construct a plausible ontology of rock music. Each of these ontologies identifies a single type of ontological entity as the “work” in rock music. Yet, all the suggestions advanced to date fail to capture some important considerations about how we engage with music of this tradition. This prompted Lee Brown to advocate a healthy skepticism of higher-order musical ontologies. I argue here that we should instead embrace a pluralist ontology of rock, an (...) ontology that recognizes more than one kind of entity as “the work” in rock music. I contend that this approach has a number of advantages over other ontologies of rock, including that of allowing us to make some comparisons across ontological kinds. (shrink)

Wants, preferences, and cares are physical things or events, not ideas or propositions, and therefore no chain of pure logic can conclude with a want, preference, or care. It follows that no pure-logic machine will ever want, prefer, or care. And its behavior will never be driven in the way that deliberate human behavior is driven, in other words, it will not be motivated or goal directed. Therefore, if we want to simulate human-style interactions with the world, we will need (...) to first understand the physical structure of goal-directed systems. I argue that all such systems share a common nested structure, consisting of a smaller entity that moves within and is driven by a larger field that contains it. In such systems, the smaller contained entity is directed by the field, but also moves to some degree independently of it, allowing the entity to deviate and return, to show the plasticity and persistence that is characteristic of goal direction. If all this is right, then human want-driven behavior probably involves a behavior-generating mechanism that is contained within a neural field of some kind. In principle, for goal directedness generally, the containment can be virtual, raising the possibility that want-driven behavior could be simulated in standard computational systems. But there are also reasons to believe that goal-direction works better when containment is also physical, suggesting that a new kind of hardware may be necessary. (shrink)

In this essay, I argue in favor of a novel interpretation of the semantic theory that can be found in the Later Mohist writings. Recent interpretations by Chad Hansen and Chris Fraser cast the Later Mohist theory as a realist theory; this includes attributing to the Later Mohists what we can call “kind-realism,” the idea that there is some correct scheme of kind-terms that carves the world at its joints. While I agree with Hansen and Fraser that the Later Mohist (...) theory is realist in various ways, I offer challenges to their kind-realist interpretations, and argue instead for a kind-conventionalist interpretation on which there is no fixed, correct set of kinds, leaving schemes of kind terms to be determined by conventional decisions that occur during disputation. (shrink)

The chapter describes a detailed chronology of Michel Foucault's life and work. This substantial and detailed intellectual biography avoids the worst excesses of some of Foucault's earlier biographers, providing an austere yet personal insight into the intertwining of Foucault's personal, political, and scholarly trajectory.

Integrating concepts of maintenance and of origins is essential to explaining biological diversity. The unified theory of evolution attempts to find a common theme linking production rules inherent in biological systems, explaining the origin of biological order as a manifestation of the flow of energy and the flow of information on various spatial and temporal scales, with the recognition that natural selection is an evolutionarily relevant process. Biological systems persist in space and time by transfor ming energy from one state (...) to another in a manner that generates structures which allows the system to continue to persist. Two classes of energetic transformations allow this; heat-generating transformations, resulting in a net loss of energy from the system, and conservative transformations, changing unusable energy into states that can be stored and used subsequently. All conservative transformations in biological systems are coupled with heat-generating transformations; hence, inherent biological production, or genealogical proesses, is positively entropic. There is a self-organizing phenomenology common to genealogical phenomena, which imparts an arrow of time to biological systems. Natural selection, which by itself is time-reversible, contributes to the organization of the self-organized genealogical trajectories. The interplay of genealogical (diversity-promoting) and selective (diversity-limiting) processes produces biological order to which the primary contribution is genealogical history. Dynamic changes occuring on times scales shorter than speciation rates are microevolutionary; those occuring on time scales longer than speciation rates are macroevolutionary. Macroevolutionary processes are neither redicible to, nor autonomous from, microevolutionary processes. (shrink)

This article clarifies the Buddhist position on freedom and responsibility, while arguing for three central claims. The first is that it is an open question whether Buddhists endorse causal determinism or causal indeterminism. The second claim is that the most promising contemporary interpretations of the Buddhist view fail in important respects. The final claim is that the best interpretation of the Buddhist position on freedom and responsibility is Buddhist Perspectivalism, the view that we should view ourselves as genuinely free and (...) responsible, while viewing others as neither free nor responsible. (shrink)

An infonnal fallacy is a reasoning error with three features: the reasoning employs an implicit cogent pattern; the fallacy results from one or more false premises; there is culpable ignorance or deception associated with the falsity of the premises. A reconstruction and analysis of the cogent reasoning patterns in fourteen standard infonnal fallacy types plus several variations are given. Defense of the CMR account covers: a general failure to apply the principle of charity in informal fallacy contexts; empirical evidence for (...) it; how it explains Walton's point that there are both fallacious and non-fallacious instances of fallacy types; how it avoids most "relevance" problems, pennits clearer taxonomizing, and promises pedagogical advantages; how it solves a "demarcation problem.". (shrink)

It is common to think that certain acts are supererogatory, especially certain heroic or saintly self-sacrifices for the good. The idea seems to have an ordinary and clear application. Nothing shows this better than the well-known cases which J. O. Urmson adduced. Urmson argued that no major moral theory could give a proper account of the supererogatory character of such acts, and that therefore none could account for “all the facts of morality,” as he put it. But his arguments were (...) sketchy. This paper shall show, in some detail, that he was essentially right about Kant’s moral theory, and that the criticism goes deep and holds up against recent sympathetic interpretation of Kant’s views of duty and worth. (shrink)

This article traces the history of the concept of dignity in Western thought, arguing that it became a formal Catholic theological concept only in the late nineteenth century. Three uses of the word are distinguished: intrinsic, attributed, and inflorescent dignity, of which, it is argued, the intrinsic conception is foundational. The moral norms associated with respect for intrinsic dignity are discussed briefly. The scriptural and theological bases for adopting the concept of dignity as a Christian idea are elucidated. The article (...) concludes by discussing the relevance of this concept of dignity to the spiritual and ethical care of the dying. (shrink)

Although Thomas Hobbes’s critics have often accused him of espousing a form of extreme subjection that differs only in name from outright slavery, Hobbes’s own striking views about slavery have attracted little notice. For Hobbes repeatedly insists that slaves, uniquely among the populace, maintain an unlimited right of resistance by force. But how seriously should we take this doctrine, particularly in the context of the rapidly expanding Atlantic slave trade of Hobbes’s time? While there are several reasons to doubt whether (...) Hobbes’s arguments here should be taken at face value, the most serious stems from the highly restricted definition that he gives to the term “slave,” one that would seem to make his acceptance of slave resistance entirely hollow in practice. Yet a closer examination of Hobbes’s theory indicates that his understanding of slavery is less narrow than it might initially appear—and thus that his argument carries a genuine political bite. (shrink)

This article re-assesses classical social theory's relationship with cosmopolitanism. It begins by briefly reconstructing the universalistic thrust that is core to cosmopolitanism and then argues that the rise of classical social theory is marked by the tension of how to retain, but in a renovated form, cosmopolitanism's original universalism. On the one hand, as the heir of the tradition of the Enlightenment, classical social theory remains fully committed to cosmopolitanism's universalism. On the other, however, it needed to rejuvenate that commitment (...) to universalism so that it could work without the normative burden that its traditional natural law elements now represented in the modern context. The article then argues that, in the cases of Karl Marx, Georg Simmel, Emile Durkheim and Max Weber, they all started to differentiate the claim to universalism into three different realms: (1) the normative idea of a single modern society that encompasses the whole of humanity; (2) the conceptual definition of what the social element in modern social relations is; and (3) the methodological justification of how to generate adequate empirical knowledge. The conclusion is that, despite differences and shortcomings, it is precisely this claim to universalism that makes classical social theory classical. (shrink)

in two letters concerning the Spanish-American War of 1898, Charles Sanders Peirce openly expresses some egregious prejudices against several groups of people, including Hispanics—people of at least partly Spanish origin in the Iberian Peninsula or the Americas (L 254 and L 339; reprint, translation to Spanish, and commentary in Nubiola and Zalamea 76–811). In an undated letter to his cousin Henry Cabot Lodge, a Massachusetts politician, Peirce writes regarding the war: “I don’t believe the Spaniards will make a good fight; (...) for as I have studied them in Spain, the whole people has been corrupted with the centuries of cruelty, injustice and rapine they have indulged in, and have little real manhood left” (L 254; .. (shrink)

Chronic myeloid leukemia (CML) is a cancer of the hematopoietic system initiated by a single genetic mutation which results in the oncogenic fusion protein Bcr-Abl. Untreated, patients pass through different phases of the disease beginning with the rather asymptomatic chronic phase and ultimately culminating into blast crisis, an acute leukemia resembling phase with a very high mortality. Although many processes underlying the chronic phase are well understood, the exact mechanisms of disease progression to blast crisis are not yet revealed. In (...) this paper we develop a mathematical model of CML based on causal Bayesian networks in order to study possible disease progression mechanisms. Our results indicate that an increase of Bcr-Abl levels alone is not sufficient to explain the phenotype of blast crisis and that secondary changes such as additional mutations are necessary to explain disease progression and the poor therapy response of patients in blast crisis. (shrink)