Despite their seemingly endless diversity, proteins adopt a limited number of structural forms. It has been estimated that 80% of proteins will be found to adopt one of only about 400 folds, most of which are already known. These folds are largely formed by a limited ‘vocabulary’ of recurring supersecondary structure elements, often by repetition of the same element and, increasingly, elements similar in both structure and sequence are discovered. This suggests that modern proteins evolved by fusion and recombination from (...) a more ancient peptide world and that many of the core folds observed today may contain homologous building blocks. The peptides forming these building blocks would not in themselves have had the ability to fold, but would have emerged as cofactors supporting RNA‐based replication and catalysis (the ‘RNA world’). Their association into larger structures and eventual fusion into polypeptide chains would have allowed them to become independent of their RNA scaffold, leading to the evolution of a novel type of macromolecule: the folded protein. BioEssays 25:837–846, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Reduced self-awareness is a well-known phenomenon investigated in patients with vascular disease; however, its impact on neuropsychological functions remains to be clarified. Importantly, selective vascular lesions provide an opportunity to investigate the key neuropsychological features of reduced self-awareness in neurocognitive disorders. Because of its rarity, we present an unusual case of a woman affected by a combined polar and paramedian bilateral thalamic infarction. The patient underwent an extensive neuropsychological evaluation to assess cognitive, behavioral, and functional domains, with a focus on (...) executive functions. She was assessed clinically in the acute phase and after 6 months from the stroke, both clinically and by magnetic resonance imaging. The patient developed a cognitive impairment, characterised by prevalent executive dysfunction associated with reduced self-awareness and mood changes, in terms of apathy and depression. Such condition persisted after 6 months. In May 2020, the patient underwent the serology test in chemiluminescence to detect IgG antibodies against SARS-CoV-2. The result of the quantitative test highlighted a high probability of previous contact with the virus. We suggest that reduced self-awareness related to executive dysfunction and behavioral changes may be due to combined polar and paramedian bilateral thalamic lesion. Metacognitive–executive dysfunction affecting the instrumental abilities of everyday life might make people less able to take appropriate precautions, facilitating the risk of SARS-CoV-2 contagion. (shrink)

El presente artículo aborda la estrategia escritural de Daniela Catrileo. Se propone revisar la elaboración del concepto de piñen examinando la relación entre lenguaje y colonialidad, para, de ese modo, subrayar el potencial político y reivindicativo que comporta en la novela del mismo nombre, Piñen (2019). Dicha hipótesis articulará el ejercicio de lectura aquí propuesto, atendiendo principalmente las estrategias narrativas empleadas –servirse de un polilingüismo que rompe estructuras gramaticales– para descentrar el lenguaje de su determinismo colonial. Así, interpretamos dicha (...) estrategia escritural en consonancia con las potencias micropolíticas y descolonizadoras del arte descritas por Suely Rolnik y, en consecuencia, apostando por la posibilidad de diagramar un devenir minoritario que dispute los imaginarios del inconsciente colonial-capital. (shrink)

Vaccination is considered a key factor in the sanitary resolution of the COVID-19 pandemic. However, vaccine hesitancy can undermine its diffusion with severe consequences on global health. While beliefs in conspiracy theories, mistrust in science and in policymakers, and mistrust in official information channels may also increment vaccine hesitancy, understanding their psychological causes could improve our capacity to respond to the pandemic. Thus, we designed a cross-sectional study with the aim of probing vaccine propensity in the Italian population and explored (...) its relationship with sociodemographic and psychological variables, and with misbeliefs in COVID-19. A battery of questionnaires was administered to a sample of 374 Italian adults during the first national lockdown. The materials included an original instrument—Beliefs in COVID-19 Inventory—and questionnaires measuring perceived stress, anxiety, death anxiety, psychological distress, psychoticism, paranoia, anger, and somatization. The exploratory factor analysis on Beliefs in COVID-19 suggested the existence of three factors: belief in conspiracy theories, mistrust in medical information, and mistrust in medicine and science. These factors were positively correlated with female sex, age, religious beliefs, psychiatric conditions, and psychological variables, while negatively correlated with education levels. We conducted a mediation analysis by means of a structural equation model, including psychological factors as predictors, beliefs in COVID-19 scales as mediators, and vaccine propensity as an outcome. The model showed that death anxiety had a direct positive effect on the propensity to get vaccinated. It also showed that death anxiety reduced the propensity to get vaccinated through a mediated path in believing in conspiracy theories, whereas paranoia was linked to a reduction in vaccination adherence with the mediation effect of mistrust in medical science. Psychological distress reduced vaccination propensity by increasing both conspiracy beliefs and mistrust. On the other hand, anxiety increased the propensity to get vaccinated through a decrease in both belief in conspiracy theories and mistrust in science. Our results suggest that psychological dimensions are differentially related to belief in conspiracy theories, to mistrust in science, and to the propensity to get vaccinated. Based on this result, we propose an original interpretation of how conspiracy beliefs build on a paranoid and suspicious attitude. We also discuss the possible clinical implications of treatment for such pathological beliefs. (shrink)

This study examines the impact of government divestiture on corporate environmental investment (EI) and investigates how regional development moderates this relationship. Using a sample of Chinese listed firms from 2012 to 2022, we employ a fixed-effect model to analyze the data. Our findings reveal a negative effect of government divestiture on EI. Furthermore, we observe that regional development mitigates this negative impact, indicating that firms operating in developed environments are more inclined to prioritize environmental concerns, likely due to increased stakeholder (...) monitoring. To address concerns regarding endogeneity, we utilize propensity score matching (PSM), Heckman tests, and the generalized method of moments (GMM). Overall, our results carry significant policy implications, particularly regarding the environmental consequences of privatization in emerging markets like China. (shrink)

The lung allocation score system in the United States and several European countries gives more weight to risk of death without transplantation than to survival following transplantation. As a result, centers transplant sicker patients, leading to increased length of initial hospitalization. The care of patients who have accumulated functional deficits or additional organ dysfunction during their prolonged stay can be ethically complex. Disagreement occurs between the transplant team, patients and families, and non-transplant health care professionals over the burdens of ongoing (...) intensive intervention. These cases highlight important ethical issues in organ transplantation, including the nature and requirements of transplant informed consent, the limits of physician prognostication, patient autonomy and decision-making capacity following transplant, obligations to organ donors and to other potential recipients, and the impact of program metrics on individualized recipient care. We outline general ethical principles for the care of lung transplant recipients with prolonged hospitalization and give regulatory, research, and patient-centered recommendations for these cases. (shrink)

Research on language evolution is an established subject area yet permeated by terminological controversies about which topics should be considered pertinent to the field and which not. By consequence, scholars focusing on language evolution struggle in providing precise demarcations of the discipline, where even the very central notions of evolution and language are elusive. We aimed at providing a data-driven characterisation of language evolution as a field of research by relying on quantitative analysis of data drawn from 697 reviews on (...) 255 submissions from the Joint Conference on Language Evolution 2022 (Kanazawa, Japan). Our results delineate a field characterized by a core of main research topics such as iconicity, sign language, multimodality. Despite being explored within the framework of language evolution research, only very recently these topics became popular in linguistics. As a result, language evolution has the potential to emerge as a forefront of linguistic research, bringing innovation to the study of language. We also see the emergence of more recent topics like rhythm, music, and vocal learning. Furthermore, the community identifies cognitive science, primatology, archaeology, palaeoanthropology, and genetics as key areas, encouraging empirical rather than theoretical work. With new themes, models, and methodologies emerging, our results depict an intrinsically multidisciplinary and evolving research field, likely adapting as language itself. (shrink)

Verbs are more difficult to produce than nouns. Thus, if executive resources are reduced as in Parkinson's disease (PD), verbs are penalized compared to nouns. However, in an experimental condition in which it is the noun that must be selected from a larger number of alternatives compared to the verb, it is the noun production that becomes slower and more prone to errors. Indeed, patients are slower and less accurate than normal subjects when required to produce nouns from verbs (VN) (...) in a morphology derivation tasks (e.g., “osservazione” from “osservare”) [“observation” from “observe”] than verbs from nouns in a morphology generation task, in which only a verb can be generated from the noun (NV) (e.g., “fallire” from “fallimento”) [“to fail” from “failure”]. In the Italian language morphology, in fact, generation and derivation tasks differ in the number of lexical entries among which the response must be selected. The left Inferior Frontal Gyrus (IFG) has been demonstrated to be involved in selection processes. In the present study, we explored if the ability to select words is related to the cortical thickness of the left IFG. Twelve right-sided PD with nigrostriatal hypofunctionality in the left hemisphere (RPD-LH), 9 left-sided PD with nigrostriatal hypofunctionality in the right hemisphere (LPD-RH) and 19 healthy controls (HC) took part in the study. NV and VN production tasks were administered; accuracy and reaction times (RTs) were collected. All 40 subjects received a structural MRI examination. Cortical thickness of the IFG and volumetric measurements for subcortical regions, thought to support selection processes, were computed using FreeSurfer. In VN derivation tasks RPD-LH patients were less accurate than LPD-RH patients (accuracy: 66% vs. 77%). No difference emerged among the three groups in RTs. Task accuracy/RTs and IFG thickness showed a significant correlation only in RPD-LH. Not only nouns (as expected) but also verbs were correlated with cortical thickness. This suggests that the linguistic nature of the stimuli along with executive resources are both relevant during word selection processes. Our data confirm that executive resources and language interact in the left IFG in word production tasks. (shrink)

El artículo explora las posiciones discursivas valorativas multimodales, es decir, que integran el modo verbal y el de la imagen por medio de ensambles, en un corpus conformado por ocho pósteres académicos del curso Biología Celular de una universidad estatal chilena, realizados por estudiantes de primer año entre 2016 y 2019. De cada cohorte, se seleccionaron los dos afiches que obtuvieron la calificación más alta. El objetivo es identificar, a través del marco conceptual de la Lingüística Sistémico Funcional (LSF) (Halliday, (...) 2004, 2014; Martin y White, 2005) y de la Semiótica Social (Kress y van Leeuwen, 2006; Martin, 2010, 2017; Unsworth, 2021), cómo se codifican los significados interpersonales multimodales en el corpus. A partir del análisis, se aporta evidencia para la caracterización de este género académico desde la perspectiva de las posiciones valorativas verbales del texto que se ensamblan con los recursos visuales para configurar el espacio semántico. Los resultados muestran juicios evocados a agentes elididos que dan cuenta de valoración, como una estrategia discursiva de los estudiantes frente a temas controversiales de la ciencia, tales como utilización de células madre y experimentación con animales. Los hallazgos también evidencian la necesidad de incluir un abordaje multimodal en procesos pedagógicos que consideren la literacidad de las ciencias en el género póster académico, ya que los significados verbales se ensamblan con los visuales para marcar posiciones valorativas. Finalmente, se proponen sugerencias para que los estudiantes adquieran las estrategias valorativas adecuadas al discurso académico científico. (shrink)

The demand for integrating and sharing heterogeneous data online has attracted the interest of cultural institutions in making information access and retrieval more effective via Semantic Web technologies. The present study proposes a digital repository for 3D scans of modernist sculptures in public spaces in the city of Rio de Janeiro, Brazil, with a view to ensuring access, use, reuse and preservation of this information. This is a qualitative exploratory experimental study based on the scientific literature and specific empirical material. (...) It presents the analysis results of vocabularies for physical artifact documents and their digital counterparts on the Semantic Web and a discussion on how these align with the nature of the metadata determined here, as well as a metadata modeling prototype implemented on the Tainacan platform and aimed at cataloging digital 3D replicas. We claim that the proposed model for documenting cultural heritage assets on Tainacan is easy to implement, in that it uses accessible technology with a wide internet user base, highly expressive in its descriptions of 3D and multimedia content and based on well-established metadata and ontology standards recommended by regulatory bodies and communities such as the World Wide Web Consortium and International Organization for Standardization. Keywords: networked heritage documents, digital repositories, 3D digitization, semantic annotation. (shrink)

Se caracteriza las estrategias de afrontamiento que presentan 278 estudiantes, de 10 a 15 años, víctimas de acoso escolar y cyberbullying. La investigación es cuantitativa, con alcance descriptivo-relacional, haciendo uso de la escala Brief COPE. La data reportó que los estudiantes víctimas usaron pocas veces estrategias de primera dimensión, centradas en la resolución del problema y búsqueda de apoyo social.

We propose to present the clinical case of a woman diagnosed with Borderline Personality Disorder. The descriptive and comprehensive analysis of his biography and the psychotherapeutic relationship is carried out against the background of existential psychoanalysis and the progressive-regressive method formulated by Jean-Paul Sartre. The need for the psychotherapist to have a reflective and critical awareness of how the relationship with the client is established is the fundamental point, considering that it is a dialectical relationship and being under the same (...) aegis of the ambivalence reported by the philosopher to explain how human reality is, in phenomenological-hermeneutic terms, constructed. The detailing of the case promotes reflections, understanding, in practice, the existential and phenomenological project of being. Finally, the study leads us to reflect that the procedures with these psychopathological cases require much more than the professional role of a psychotherapist ordinarily fulfills, because it is only when one manages to be aware of their experience in the relationship, that one can hermeneutically situate how the client apprehends herself originally and existentially. (shrink)

Resumen: Dada la multiplicidad de planos que acompañan a las observaciones de la actual pandemia, importa identificar aquellas que alcanzan una mayor resonancia. Así, observamos cómo los ciudadanos y los agentes de decisión han incrementado sus demandas de informaciones validadas por medio de la aplicación de la racionalidad, los métodos y los procedimientos de la ciencia de manera exponencial. En este trabajo desarrollamos en forma sintética un conjunto seleccionado de lineamientos sobre cómo se aborda la actual pandemia desde las ciencias (...) sociales sistémicas, para luego exponer algunas de sus propuestas respecto a las condiciones, a nivel organizacional, las cuales podrían permitir alcanzar los niveles de diálogo y cooperación requeridos para enfrentar la pandemia actual.: Given the multiplicity of perspectives that accompany the observation of the current pandemic, becomes relevant to identify those that achieve the greatest resonance. Thus, it is observed how citizens and decision makers have increased their demands for valid information by applying rationality, methods, and procedures of science in an exponential manner. In this paper we develop a synthetic set of selected guidelines on how the current pandemic is approached from systemic social sciences, and then present some of their proposals regarding the conditions, at the organizational level, which could enable the achievement of the levels of dialogue and cooperation required to address the current pandemic. (shrink)

ORCA.IT, a new online test of online research and comprehension was developed for the Italian population. A group of 183 students attending various types of upper secondary schools in Northern Italy were tested with the new tool and underwent further cognitive and neuropsychological assessment. The different school types involved in the study are representative of the school population in the Italian system, but can also be easily compared with the educational systems of other countries. The new test turned out to (...) have good psychometric properties after accurate item construction and final selection. In particular, Version 1 showed better characteristics than Version 2. Subsequently, comparison with one-way ANOVAs were performed to test whether differences exist between different school types, between groups with and without reading difficulties, and between males and females. Such differences are sometimes reported in the literature, but many remain controversial. Further, Pearson’s bivariate correlations were calculated to analyze associations between scores on the ORCA.IT and cognitive/neuropsychological variables. Finally, a stepwise regression analysis was performed on aggregated scores to identify the predictors of performance on each of the two versions, The test, especially in the most complete version (Version 1), appears to accurately and reliably capture students’ web searching abilities and online reading comprehension. The tool could highlight differences in online search and comprehension ability between students with and without reading difficulties, not penalizing overall performance but allowing very specific weaknesses to be pointed out. Further, it seems to be able to capture differences due to both educational pathways (different school types) and social attitudes (differences between males and females). Most interesting, it shows to be clearly resting on specific cognitive and neuropsychological abilities, including language, memory and attentional skills, which explain a large portion of the total variance. Offline text reading comprehension is a crucial predictor of online reading performance, while decoding ability is not. Prior knowledge also influences the results, as expected. The new tool turns out to be rather independent from previous internet experience and to measure more cognitively grounded processes related to information gathering, processing and communicating. (shrink)

Background: In the present study, we aimed to better investigate attention system profile of Parkinson's disease-Mild Cognitive Impairment patients and to determine if specific attentional deficits are associated with 123I-FP-CIT SPECT.Methods: A total of 44 de novo drug-naïve PD patients [ with normal cognition and 17 with MCI ], 23 MCI patients and 23 individuals with subjective cognitive impairment were recruited at the Clinical Neurology Unit of Santa Chiara hospital. They were assessed by a wide neuropsychological battery, including Visual Search (...) Test measuring selective attention. Performances among groups were compared by non-parametric tests. Further, Spearman's rank correlations were performed to explore the association between neuropsychological variables and 123I-FP-CIT SPECT data in PD subgroup.Results: PD-MCI patients performed worse on VST than patients with PD-NC, patients with MCI and individuals with SCI. The performance of PD-MCI patients on VST significantly correlated with caudate nucleus 123I-FP-CIT SPECT uptake, whereas a negative correlation between such test and 123I-FP-CIT SPECT uptake in the left putamen was found in PD-NC patients.Conclusions: We suggest that selective attention deficit might be a trigger of cognitive decay in de novo PD-MCI patients. The VST should be routinely used to detect attentional deficits in hospital clinical practice, in the light of its closely association with dopamine depletion of basal ganglia in mildly impaired PD patients. (shrink)

Comparative study of the knowledge of IVF in medical students of universities with different ethical and humanistic valuesEstudo comparativo do conhecimento das técnicas de reprodução assistida em estudantes de Medicina de universidades com diferentes ideários éticos e humanísticosIn vitro fertilization continues to be presented as a relatively simple solution to produce a pregnancy without exposing the medical and ethical problems that this represents. This project consisted of conducting a survey to medical students from three medical schools in Mexico City with (...) different ethical and humanistic ideas with the aim of evaluating knowledge about IVF techniques and their ethical implications. The survey was applied to 404 medical students. Students in schools with personalistic ethics had a greater recognition of the bioethical principles involved in the use of these techniques. Knowledge of the technique and ethical issues involved in assisted reproduction could improve the sensitivity of medical students to ethical dilemmas that arise in their professional practice.Para citar este artículo / To reference this article / Para citar este artigoCantú-Quintanilla G, Vidal-Sentíes C, Marcó-Bach FJ, Camargo-Prieto F, Aguiñaga-Chiñas N, Contreras-Estrada D. Estudio comparativo del conocimiento de las técnicas de reproducción asistida en estudiantes de medicina de universidades con diferentes idearios éticos y humanísticos. Pers Bioet. 2020;24:166-176. DOI: https://doi.org/10.5294/pebi.2020.24.2.4Recibido: 04/09/2019Aceptado: 05/08/2020Publicado: 27/11/2020. (shrink)

Three types of problems are raised in this commentary: On the linguistic side, we emphasize the importance of an appropriate definition of the different domains of linguistics. This is needed to define the domains (lexicon-syntax-semantics) to which transformational relations apply. We then question the concept of Broca's aphasia as a “functional” syndrome, associated with a specific lesion. Finally, we discuss evidence from functional brain imaging. The breadth and potential impact of such evidence has grown considerably in the last few years, (...) expanding our knowledge of the multiple contributions of the “Broca's region” to phonological, lexical-semantic, and syntactic processing. “Lumping” under diagnostic labels, such as Broca's aphasia, should be replaced by more detailed linguistic and neurological descriptions of the clinical cases. (shrink)

When analyzing food systems challenges, considering multiple different narratives might lead to solutions that are more innovative and grounded in the local context relative to considering just a single narrative. However, the relationship between narrative diversity and innovation in food systems is not fully understood. Understanding the structure of and interactions between different food systems narratives can help researchers to identify opportunities (e.g., policies, interventions, and institutions) that could facilitate food systems transformations. This paper explores how narratives about food systems (...) converge and vary between different groups of actors in rural Colombia as well as the implications for the co-development of innovative solutions amongst these actors to address food system challenges. As a case study, we focus on an important national policy initiative in Colombia, A Ciencia Cierta, which connects public science and civil society to implement community-based innovations. We conducted 47 interviews with key stakeholders, including policymakers, facilitators, academics, community leaders, and community participants who had been part of the initiative in Colombia, and experts about narratives in food systems globally. We found that actors (both individuals and groups) possess multiple narratives about food systems which evolve over time and adjust according to varying circumstances. Our findings indicate that hybrid innovations enabled by diverse knowledge(s) provide alternative solutions to overcome challenges faced by actors in food systems. This paper generates theoretical and empirical contributions to the growing study of how epistemic plurality can enhance innovation pathways in food systems. (shrink)

El presente artículo ahonda en la vulnerabilidad de las y los migrantes en México, ya sean en tránsito o de destino, haciendo énfasis en la falta de políticas públicas al respecto, las cuales si las hay, no contemplan la perspectiva de género, categoría de análisis imprescindible. La llamada “feminización de las migraciones” está aumentando, adquiriendo especial importancia en la Frontera Sur. La violación sistemática de los derechos humanos hacia las mujeres migrantes y su situación de indefensión, hace que sean objeto (...) de vejaciones que ni si quiera pueden denunciar por su condición irregular, así como por sus factores sociales y culturales (género, clase, etnia…), lo que les hace estar desprovistas de los recursos necesarios de empoderamiento y acción. Se analiza la desprotección de las migrantes centroamericanas en Chiapas así como los Convenios nacionales e internacionales en defensa de sus derechos, acabando el artículo con propuestas específicas, relativas a las políticas públicas para el caso estudiado. (shrink)

BackgroundDefinition and concept of the ‘beginning of human life’ are weakened by co-existing contrasting hypotheses based on humanistic or religious beliefs rather than scientific foundations. This plethora of conceptually distant views have important common concerns in different fields of science and shape, in turn, several societal aspects including laws related, for instance, to inheritance eligibility or abortion, end-of-life care and euthanasia, and reproductive technology. Also, they are fundamental to evaluate opportunity for resuscitation vs. palliative care in extremely preterm infants. In (...) this article, we address one of the most common tenets in medicine: the acceptance that human life starts with first breath, even though several events are well-documented to take place before its occurrence.Main textSeveral studies show how pivotal physiological events take place before first breath. Evidence of a number of neurological events occurring before first breath opens the way to the primacy of the Central Nervous System, given its immediate extra-uterine activation at birth. This activation eventually sets specific physiological conditions that allow the complex sequence of events determining the muscle activity associated with the influx of air in the lung and the settling of a continuous and successful extra-uterine respiration. We would like to invite the scientific community to endorse a clear-cut position against the paradigm of ‘first breath’ as the beginning of life. Herein, we also assume how, a still undefined, yet possibly specific quid in the external environment triggers further physiological response in newborns. Better understanding of the critical events that occur at the beginning of human life is likely to cause great concern and expectations in scientists, researchers and physicians working in the domain of brain, and its physiology, and mental health.ConclusionsThe comparison between beliefs and evidence-based observations generates confusion, misperceptions and false expectations in society, hence, in the scientific and medical community. Different and more solid alternatives about the carachterization of the ‘beginning of human life’ are indeed available and require to be explored and defined. (shrink)

Nature connectedness is determined by the representation individuals have about themselves within nature. This concept is often studied in relation to the direct contact individuals have with natural environment, which according to some studies have demonstrated to generate positive effects by fostering a feeling of connecting and bonding with nature, as well as improving their wellbeing. The main focus of this study was to calculate and assess the relation between Nature Connectedness and wellbeing of participants. The methodological approach of this (...) research reaches quantitative data comparing results obtained from both samples, as well as correlations between the variables. The sample for this study was composed by two groups of university students. Both contrast group and experience group filled the questionnaire in two separate moments and in different environments. First data collection moment for both groups was held inside a university classroom. A second moment of data collection was carried out after a month from the first application, having the contrast group answer the questionnaire on a classroom again whilst the experience group responded it during an excursion to Isla Del Tiburon in Northwestern Mexico after performing some recreational activities being totally immersed in a local desertic environment. Questionnaire was composed by a 6 point Likert type scale measuring Nature Connectedness through concepts such as Nature relatedness and Love and care for the natural, as well as Subjective and Psychological Wellbeing of participants. Results show that both wellbeing and Nature Connectedness are positively influenced by performing activities out in the natural environment. This work was also conducted in response to the need to understand the full extent of Contact and Connectedness to nature, carrying out an exploratory study in desertic settings when much of the early work centers around the study of these variables in green nature environments. (shrink)

ObjectiveTo assess the impact of the closure of group-based cardiac rehabilitation training during the first COVID-19 lockdown in spring 2020 on patients’ physical activity, cardiorespiratory fitness, and cardiovascular risk, and to describe the patient experience of lockdown and home-based exercise training during lockdown.DesignMixed methods study. Prospectively collected post-lockdown measurements were compared to pre-lockdown medical record data. Quantitative measurements were supplemented with qualitative interviews about the patient experience during lockdown.SettingOutpatient CR centre in Salzburg, Austria.ParticipantsTwenty-seven patients [six female, mean age 69 years] (...) who attended weekly CR training sessions until the first COVID-19 lockdown in March 2020.Outcome MeasureQuantitative: exercise capacity, cardiovascular risk. Qualitative: individual semi-structured interviews.ResultsExercise capacity had significantly reduced from pre- to post-lockdown: mean power in maximal ergometry 165 vs. 151, p < 0.001; submaximal ergometer training 99 vs. 97, p = 0.038. There was no significant difference in Framingham risk score and other cardiovascular risk factors. Qualitative data showed that almost all patients had kept physically active during lockdown, but 17 said they had been unable to maintain their exercise levels, and 15 felt their cardiorespiratory fitness had deteriorated. Many patients missed the weekly CR training and the motivation and sense of community from training together with others. Several patients stated that without professional supervision they had felt less confident to carry out home-based exercise training at high intensity.ConclusionThis study highlights the importance of group-based supervised exercise training for patients who engage well in such a setting, and the detrimental impact of disruption to this type of CR service on physical activity levels and exercise capacity. Additionally, learning from the COVID-19 pandemic may inform the development and implementation of remote CR modalities going forward. (shrink)

The aim of the present study was to investigate the association between attachment dimensions and neural correlates in response to the Rorschach inkblots. Twenty-seven healthy volunteers were recruited for the electroencephalographic registration during a visual presentation of the Rorschach inkblots and polygonal shapes. The Attachment Style Questionnaire was administered to participants. Correlations between the ASQ scores and standardized low-resolution brain electromagnetic tomography intensities were performed. The Rorschach inkblots elicited several projective responses greater than the polygonal shapes. Only during the Rorschach (...) inkblots presentation, discomfort with closeness and relationships as secondary subscales were negatively correlated with the activation of right hippocampus, parahippocampus, amygdala, and insula; need for approval subscale was negatively correlated with the activation of orbital and prefrontal cortex and left hippocampus. Moreover, the correlations between attachment dimensions and neural activation during the Rorschach inkblots were significantly higher compared to the same correlations in response to polygonal shapes. These findings suggest that attachment style can modulate brain activation during the projective activity of the Rorschach inkblots. (shrink)

El presente trabajo tiene como objetivo describir la funcionalidad discursivo-pragmática de sujetos adultos mayores sanos y con demencia leve, en sus aspectos de coherencia y coherencia pragmática, a través del análisis de producción lingüística oral, de ambos grupos, mediante la tarea denominada “monólogo audible” del protocolo MetAphAs. La muestra fue seleccionada de la base de datos NEUROLEN, en la cual se eligieron 9 sujetos sanos y 9 sujetos con demencia leve. Los datos fueron analizados desde una perspectiva de investigación cualitativa (...) descriptiva, con base en la funcionalidad discursiva-pragmática y la comparación con el marco teórico disponible. Los resultados arrojaron diferencias significativas en el desempeño de ambos grupos de senescentes. A pesar de presentar fallas en la producción del lenguaje a causa del envejecimiento fisiológico, los adultos mayores sanos son capaces de desarrollar comunicación funcional con su entorno, no ocurre lo mismo en el caso de los sujetos con demencia, debido a su deterioro cognitivo, el cual generaría dificultades en la producción discursiva. (shrink)

O estudo investigou a experiência de transição para a aposentadoria na perspectiva subjetiva dos sujeitos que a vivenciaram. Foram entrevistados 20 trabalhadores aposentados no período de até 18 meses após o desligamento de suas atividades laborais. As entrevistas seguiram roteiro semi-estruturado e..