We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

The book moves from descriptive through to more interpretative phenomenological methods to enable the reader to learn to use the main approaches to ...

Self-locating beliefs cause a problem for conditionalization. Miriam Schoenfield offers a solution: that on learning E, agents should update on the fact that they learned E. However, Schoenfield is not explicit about whether the fact that they learned E is self-locating. I will argue that if the fact that they learned E is self-locating then the original problem has not been addressed, and if the fact that they learned E is not self-locating then the theory generates implausible verdicts which Schoenfield (...) explicitly rejects. (shrink)

We give an analysis of the Monty Hall problem purely in terms of confirmation, without making any lottery assumptions about priors. Along the way, we show the Monty Hall problem is structurally identical to the Doomsday Argument.

Narrative construction is a discursive practice: storytellers draw on the language, signs and symbols of their culture to provide meaning through stories. Stories that reflect the values, ideals an...

ABSTRACT Hegel gave the bureaucracy a distinctively corporatist and collegiate structure and insulated it from legislative control. The close match between these features of the Philosophy or Right and the structure of the Prussian bureaucracy, which had been used by reformers to insulate progressive decisions from Junker resistance, suggests that Hegel, too, wanted the bureaucracy to spearhead reform within a hostile environment.

If an agent believes that the probability of E being true is 1/2, should she accept a bet on E at even odds or better? Yes, but only given certain conditions. This paper is about what those conditions are. In particular, we think that there is a condition that has been overlooked so far in the literature. We discovered it in response to a paper by Hitchcock (2004) in which he argues for the 1/3 answer to the Sleeping Beauty problem. (...) Hitchcock argues that this credence follows from calculating her fair betting odds, plus the assumption that Sleeping Beauty’s credences should track her fair betting odds. We will show that this last assumption is false. Sleeping Beauty’s credences should not follow her fair betting odds due to a peculiar feature of her epistemic situation. (shrink)

I argue that Diogenes and early Cynicism can be understood in an explicitly social and political context, where Cynic praxis, performative public action, can be seen to make visible oppositions inherent to the polity. In doing so, Diogenes’ praxis should be understood as a form of immanent critique, one that demonstrates, for example, that nature and custom are interrelated oppositions in the polis. Cynicism here is understood as a form of immanent critique because Diogenes challenges the social norms of the (...) polis without endorsing external universal standards or predetermined models, but from illuminating dynamics from within the polis and polity. (shrink)

This chapter explores the nature of dehumanizing speech. It begins by considering the nature of dehumanization simpliciter, building on the work of David Livingstone Smith. It argues that dehumanization can take multiple forms; it can be demonizing, enfeebling, mechanizing, or objectifying. It then argues, contra Smith, that dehumanization is not always a way of conceiving of someone. Instead, dehumanization can also be a linguistic phenomenon, whereby one asserts, implicates, or presupposes dehumanizing propositions or attitudes. The chapter then explores how one (...) might assert dehumanizing propositions, and suggests that one can do this with both literal and figurative language. It also explains why some uses of animalistic figurative language are dehumanizing and some are not. The chapter concludes by identifying a uniquely linguistic version of the paradox of dehumanization: dehumanizing speakers who directly address their targets often assert that these targets are subhuman, while, through the mechanism of second-personal address, presupposing that they are human after all. (shrink)

This paper investigates ethical perceptions among Hong Kong Chinese managers of themselves and peers according to age, location of education and employment (local vs. multinational), based upon responses to thirteen potentially unethical situations.The major conclusions of the study are: (1) there is little consistency among perceptions of ethical situations; (2) Hong Kong managers perceive their peers as more unethical than themselves; (3) ethical perceptions in some situations are affected by age and to a lesser extent, place of education; and (4) (...) significant interactions were found between age and the nature of employer, as well as between the place of education and the nature of employer. (shrink)

Large prospective biobanks are being established containing DNA, lifestyle and health information in order to study the relationship between diseases, genes and environment. Informed consent is a central component of research ethics protection. Disclosure of information about the research is an essential element of seeking informed consent. Within biobanks, it is not possible at recruitment to describe in detail the information that will subsequently be collected because people will not know which disease they will develop. It will also be difficult (...) to describe the specific research that will be performed using the biobank, other than to stipulate categories of research or diseases that are not included. Potential subjects can only be given information about the sorts of research that will be performed and by whom. Organisations responsible for biobanks usually argue that this disclosure of information is adequate when seeking informed consent, especially if coupled with a right to withdraw, as it would not be feasible or it would be too expensive to seek consent renewal on a regular basis. However, there are concerns about this ‘blanket consent’ approach’. Consent waivers have also been proposed in which research subjects entrust their consent with an independent third party to decide whether subsequent research using the biobank is consistent with the original consent provided by the subject. (shrink)

In this paper I argue that Turing’s responses to the mathematical objection are straightforward, despite recent claims to the contrary. I then go on to show that by understanding the importance of learning machines for Turing as related not to the mathematical objection, but to Lady Lovelace’s objection, we can better understand Turing’s response to Lady Lovelace’s objection. Finally, I argue that by understanding Turing’s responses to these objections more clearly, we discover a hitherto unrecognized, substantive thesis in his philosophical (...) thinking about the nature of mind. (shrink)

In this paper, I argue that the notion of ‘reasonableness’ that is, for many, at the heart of the Philosophy for Children approach particularly and education for democratic citizenship more broadly, is constituted within the epistemology of ‘white ignorance’ and operates in such a way that it is unlikely to transgress the boundaries of white ignorance so as to view it from without. Drawing on scholarship in critical legal studies and social epistemology, I highlight how notions of reasonableness often include (...) consensus, ‘racialised common sense’ and the ‘typical’ view. In addition the promotion of particular dispositions on the grounds of ‘reasonableness’ both promotes stability and limits how one may think otherwise. Thus, P4C practices that fail to historicise, examine and challenge prevailing notions of reasonableness establish an epistemically ‘gated’ community of inquiry. (shrink)

In an effort to build on the current knowledge of ethical behaviour in Asia this paper proposes to replicate existing ethical research and to investigate specific questions relating to intra-cultural differences in Hong Kong. Four major conclusions were derived from this descriptive empirical study. A statistically significant correlation exists between age and ethical beliefs, with older employees less likely to express agreement to an unethical action than younger employees. In contrast to many previous studies no statistically significant differences in ethical (...) beliefs were found in relation to gender, level in the organisation, company size, and whether the respondent worked in a multinational or local company. Significant differences in responses to ethical dilemmas were identified between local and expatriate personnel with expatriate respondents indicating a lower level of agreement to unethical actions. For local respondents, of Hong Kong origin, there was no significant correlation between level of education, religiosity, years of business experience, functional origin and their ethical responses. (shrink)

The independence problems for functionalism stem from the worry that if functional properties are defined in terms of their causes and effects then such functional properties seem to be too intimately connected to these purported causes and effects. I distinguish three different ways the independence problems can be filled out – in terms of necessary connections, analytic connections and vacuous explanations. I argue that none of these present serious problems. Instead, they bring out some important and over-looked features of functionalism.

Formal methods are changing how epistemology is being studied and understood. A Critical Introduction to Formal Epistemology introduces the types of formal theories being used and explains how they are shaping the subject. Beginning with the basics of probability and Bayesianism, it shows how representing degrees of belief using probabilities informs central debates in epistemology. As well as discussing induction, the paradox of confirmation and the main challenges to Bayesianism, this comprehensive overview covers objective chance, peer disagreement, the concept of (...) full belief, and the traditional problems of justification and knowledge. Subjecting each position to a critical analysis, it explains the main issues in formal epistemology, and the motivations and drawbacks of each position. Written in an accessible language and supported study questions, guides to further reading and a glossary, positions are placed in an historic context to give a sense of the development of the field. As the first introductory textbook on formal epistemology, A Critical Introduction to Formal Epistemology is an invaluable resource for students and scholars of contemporary epistemology. (shrink)

To date the teaching of business ethics has been examined from the descriptive, prescriptive, and analytical perspectives. The descriptive perspective has reviewed the existence of ethics courses (e.g., Schoenfeldtet al., 1991; Bassiry, 1990; Mahoney, 1990; Singh, 1989), their historical development (e.g., Sims and Sims, 1991), and the format and syllabi of ethics courses (e.g., Hoffman and Moore, 1982). Alternatively, the prescriptive literature has centred on the pedagogical issues of teaching ethics (e.g., Hunt and Bullis, 1991; Strong and Hoffman, 1990; Reeves, (...) 1990; Castro, 1989; George, 1987; Golenet al., 1985) and in providing recommendations for teachers of business ethics (e.g., Nappi, 1990; Hosmer and Steneck, 1989). From the analytical perspective judgments have been made as to whether courses in ethics are in fact effective in achieving value and attitudinal modifications in students (e.g., Loeb, 1991; Weber, 1990; Wynd and Mager, 1989; Pamental, 1989; Martin, 1982; Purcell, 1977). The evidence to date suggests that courses can be a means of achieving ethical awareness and sensitivity in students although it should be recognized that significant objections to the teaching of business ethics do exist and greatly inhibit their successful introduction. This paper addresses a number of the common objections to the teaching of business ethics that must be overcome if ethical programs are to continue in the future, and concludes with recommendations to facilitate the establishment of ethical training in an academic context. (shrink)

Arguably, the modern missionary movement’s foundational text, the ‘Great Commission’ of Matthew 28:18–20 has been criticized for its use in legitimizing colonial oppression. Focusing on reception history in South Asian polycolonial contexts, this article uses ‘Saidian’ contrapuntal reading to explore whether and for whom the commission is ‘great’? William Carey used it as a proof-text in his ‘Enquiry’ for Christians to engage in foreign mission. RS Sugirtharajah brings a postcolonial critique to Carey, but Saugata Bhaduri appreciates the unintended de-colonizing consequences (...) of Carey’s vernacular literature. Jayachitra Lalitha questions why women were absent in Matthew 28:18–20 and why Dalit women still struggle. George Soares-Prabhu’s reading alongside a Buddhist text suggests more integral mission and liberation. Despite colonialism’s distorting affect, there is historical irony in Matthew 28’s influence in South India. Contrapuntal conversations helpfully focus on the well-being of overlooked groups and recover some of the resistance implicit in Matthew’s composition. (shrink)

The orientation of public space is either logocentric or eclectic. The surface of a Philippine jeepney is an example of a successful inversion of American militaristic individualism into a place for the celebration of idiosyncrasies. Using Walter Benjamin’s differentiation between allegory and symbolism – and photographs of Philippine jeepney art – this essay problematizes the collapse of contemporary spirituality into a political demographic.

This paper examines John Scottus Eriugena's account of material bodies. Some scholars have argued that Eriugena's account prefigures Berkeleyan idealism. The interpretation offered in the paper rejects the Berkeleyan interpretation on the grounds that Eriugena, unlike Berkeley, did not propose a thoroughly immaterialist view of reality.

In the following article, I situate Daniel Bensaïd’s ‘Strategy and Politics’ within the different phases of his thinking about strategy as well as his own general theoretical background that informs parts of the text.

This is the first book to consider the increasing importance of Jean-Luc Nancy's work, which has influenced key thinkers such as Jacques Derrida. All his major works have been translated into English, yet until now little has been made available on his place in contemporary philosophy. By showing how he situates his work in a contemporary context - the collapse of communism, the Gulf War, and the former Yugoslavia - this outstanding collection reveals how Nancy's engagement with Hegel, Marx, Nietzsche, (...) Heidegger and Derrida makes him one of the key contemporary continental philosophers. Providing new perspectives on the issues of sense, art and community, these essays make it impossible to approach philosophy without reference to the work Jean-Luc Nancy. (shrink)

Background: Alexithymia is a personality trait which is characterized by an inability to identify and describe conscious emotions of oneself and others.Aim: The present study aimed to determine whether various measures of mental health, interoception, psychological flexibility, and self-as-context, predicted through linear associations alexithymia as an outcome. This also included relevant mediators and non-linear predictors identified for particular sub-groups of participants through cluster analyses of an Artificial Neural Network output.Methodology: Two hundred and thirty participants completed an online survey which included (...) the following questionnaires: Toronto alexithymia scale; Acceptance and Action Questionnaire 2 ; Positive and Negative Affect Scale, Depression, Anxiety, and Stress Scale 21 ; Multidimensional Assessment of Interoceptive Awareness ; and the Self-as-Context scale. A stepwise backwards linear regression and mediation analysis were performed, as well as a cluster analysis of the non-linear ANN upper hidden layer output.Results: Higher levels of alexithymia were associated with increased psychological inflexibility, lower positive affect scores, and lower interoception for the subscales of “not distracting” and “attention regulation.” SAC mediated the relation between emotional regulation and total alexithymia. The ANNs accounted for more of the variance than the linear regressions, and were able to identify complex and varied patterns within the participant subgroupings.Conclusion: The findings were discussed within the context of developing a SAC processed-based therapeutic model for alexithymia, where it is suggested that alexithymia is a complex and multi-faceted condition, which requires a similarly complex, and process-based approach to accurately diagnose and treat this condition. (shrink)

There is currently a lively debate about whether there are practical reasons for belief, epistemic reasons for belief, or both. I will argue that the intuitions on all sides can be fully accounted for by applying an independently motivated contextualist semantics for normative terms. Specifically, normative terms must be relativized to a goal. One possible goal is epistemic, such as believing truly and not believing falsely, while another possible goal is practical, such as satisfying desires, or maximizing value. I will (...) argue that we have practical reasons given the practical goal and epistemic reasons given the epistemic goal. Disagreement disappears when we make the context explicit. The result is an independently motivated version ofpluralism. (shrink)

Psychology has benefited from an enormous wealth of knowledge about processes of cognition in relation to how the brain organizes information. Within the categorization literature, this behavior is often explained through theories of memory construction called exemplar theory and prototype theory which are typically based on similarity or rule functions as explanations of how categories emerge. Although these theories work well at modeling highly controlled stimuli in laboratory settings, they often perform less well outside of these settings, such as explaining (...) the emergence of background knowledge processes. In order to explain background knowledge, we present a non-similarity-based post-Skinnerian theory of human language called Relational Frame Theory (RFT) which is rooted in a philosophical world view called functional contextualism (FC). This theory offers a very different interpretation of how categories emerge through the functions of behavior and through contextual cues, which may be of some benefit to existing categorization theories. Specifically, RFT may be able to offer a novel explanation of how background knowledge arises, and we provide some mathematical considerations in order to identify a formal model. Finally, we discuss much of this work within the broader context of general semantic knowledge and artificial intelligence research. (shrink)

An attractive picture of the world is that some features are metaphysically fundamental and others are derivative, with the derivative features grounded in the fundamental features. But how do we have justified beliefs about which features are fundamental? What is the epistemology of fundamentality? I sketch a response in this paper. The guiding idea is that the same properties cause the same experiences. I argue that a probabilistic connection between epistemic fundamentality and metaphysical fundamentality is sufficient for justified beliefs about (...) the metaphysically fundamental. (shrink)

It is widely acknowledged that hoping is an integral part of what it is to be human. The present article strives to make sense of the myriad competing conceptions of hope that have emerged over the past half-century. Two problems with the literature are highlighted. First, discussions of hope tend to take place within rather than between disciplines. Second, hope is often taken to be an undifferentiated experience. In order to address the first problem, the article takes an interdisciplinary approach, (...) drawing on research from the fields of philosophy, anthropology, psychology, theology and politics. In order to address the second problem, the article proposes that hope be regarded as a human universal that can be experienced in different modes. A variety of theories and models of hope are discussed, including those offered by Marcel, Dauenhauer, Bloch, Moltmann, Bovens, Pettit, Snyder, Rorty and Gutiérrez. While many of these claim to have identified the characteristics of hope, it is argued that each captures something about a particular mode of hoping. The theories and models are integrated into a framework comprising five modes of hoping: patient, critical, estimative, resolute and utopian. Examining hope in this way, as a human universal that can be experienced in different modes, may help us see the varying conceptions that presently exist within the human sciences not as conflicting, nor even as competing, but rather as complementary. (shrink)

RésuméCet article est une exégèse appréciative de l'article de Steven Burns intitulé « If a lion could talk ». Dans son essai, Burns clarifie la remarque énigmatique de Ludwig Wittgenstein, « Si un lion pouvait parler, on ne serait pas capables de le comprendre », en la situant dans le contexte plus large de l’œuvre de Wittgenstein en philosophie de la psychologie. Nous lisons l'interprétation de cette remarque par Burns comme ouvrant les questions wittgensteiniennes fondamentales au sujet du sens et (...) de la (mé)compréhension, et nous la situons dans le cadre du travail de l'enseignant de Burns, Peter Winch. Notre discussion est une exégèse étroite du contenu immédiat de la remarque sur le lion et elle met en lumière les liens avec les réflexions écrites de Wittgenstein sur The Golden Bough de James George Frazer. Nous montrons comment Burns et Winch utilisent les méthodes de Wittgenstein pour résoudre les énigmes philosophiques en attirant l'attention sur des cas familiers intermédiaires. Enfin, nous concluons par quelques remarques impressionnistes sur Socrate dans une brève discussion au sujet de la difficulté de la technique et de l'activité philosophiques que Burns déploie et recommande. (shrink)

This website is a supplement to Peter D. McDonald’s book The Literature Police: Apartheid Censorship and its Cultural Consequences, which was first published by Oxford University Press in February 2009. It is intended for anyone curious to know more about the subject and for those interested in doing further research into the vast topic of apartheid censorship.

This book challenges readers to rethink rural health ethics. Traditional approaches to health ethics are often urban-centric, making implicit assumptions about how values and norms apply in health care practice, and as such may fail to take into account the complexity, depth, richness, and diversity of the rural context. There are ethically relevant differences between rural health practice and rural health services delivery and urban practice and delivery that go beyond the stereotypes associated with rural life and rural health services. (...) This book examines key values in the rural context that have not been fully explored or taken into account when we examine health ethics issues, including the values of community and place, and a need to “revalue” relationships. It also advocates for a greater attention to meso and macro level analysis in rural health ethics as being critical to ethical analysis of rural health care. This book is essential reading for those involved in health ethics, rural health policy and governance, and for rural health providers. (shrink)

Ethical perspectives on regional, rural, and remote healthcare often, understandably and importantly, focus on inequities in access to services. In this commentary, we take the opportunity to examine the implications of normalizing metrocentric views, values, knowledge, and orientations, evidenced by the recent (2022) New South Wales inquiry into health outcomes and access to hospital and health services in regional, rural and remote New South Wales, for contemporary rural governance and justice debates. To do this, we draw on the feminist inspired (...) approach to rural health ethics involving analysis of power relationships developed by Simpson and McDonald and related ideas from critical health sociology. In presenting this analysis, we extend contemporary thought about spatial health inequities and structural violence. (shrink)

Peter Brössel and Franz Huber in 2015 argued that the Bayesian concept of confirmation had no use. I will argue that it has both the uses they discussed—it can be used for making claims about how worthy of belief various hypotheses are, and it can be used to measure the epistemic value of experiments. Furthermore, it can be useful in explanations. More generally, I will argue that more coarse-grained concepts can be useful, even when we have more fine-grained concepts available.

The Government in the UK is encouraging consumerism within health care and is requiring Health Authorities to consult with the public on prioritisation of resources. Public consultation within the National Health Service (NHS) has had limited success in the past. Many of the techniques used are flawed. Despite the limited scope of the public surveys conducted so far, a number of themes have emerged: — a willingness to pay for experimental, ‘high‐tech’ life‐saving treatments rather than more cost‐effective treatments which will (...) improve quality of life, which are more likely to maximise utility from the scarce resources available; — preference for treating the young rather than the old; — preference for treating patients with dependants (e.g. spouse, children) rather than those who have none; — a willingness to discriminate against those patients who were partially responsible for their illness due to choice of `unhealthy' lifestyle (e.g. smoking cigarettes, drinking excess alcohol). These public preferences raise ethical problems. For example, is it just to spend more on heroic treatments which are likely to fail? Is there a right to health care irrespective of whether you have had ‘a fair innings’ or whether a patient is in part responsible for their illness due to an unhealthy lifestyle? If there are ethical concerns about these preferences, should health authorities consult with the public at all? Is human life and suffering incommensurable, and hence is it impossible to prioritise anyway? Some of the ethical consequences of using empirical data on public preferences are discussed. (shrink)