A recent paper(1) describing the stage‐specific loss of ubiquitin (UBQ) and ubiquitinated proteins (UBQ‐Ps) during pollen development has raised some interesting questions regarding our understanding of the regulation of protein turnover during cellular differentiation and the specialized development of the pollen grain. The authors, Callis and Bedinger(1), describe experiments in which the profiles of free and protein‐conjugated ubiquitin were examined during pollen development. UBQ and UBQ‐Ps were immunologically detected in extracts of microspores and maturing pollen of maize at six developmental (...) stages. Their results remarkably demonstrate that UBQ and UBQ‐Ps decline to barely detectable levels during the final stages of pollen development. (shrink)

The contemporary design practice known as data sonification allows us to experience information in data by listening. In doing so, we understand the source of the data in ways that support, and in some cases surpass, our ability to do so visually. -/- In order to assist us in negotiating our environments, our senses have evolved differently. Our hearing affords us unparalleled temporal and locational precision. Biological survival has determined that the ears lead the eyes. For all moving creatures, in (...) situations where sight is obscured, spatial auditory clarity plays a vital survival role in determining both from where the predator is approaching or to where the prey has escaped. So, when designing methods that enable listeners to extract information from data, both with and without visual support, different approaches are necessary. -/- A scholarly yet approachable work by one of the recognized leaders in the field of auditory design, this book will -/- - Lead you through some salient historical examples of how non-speech sounds have been used to inform and control people since ancient times. -/- - Comprehensively summarize the contemporary practice of Data Sonification. -/- - Provide a detailed overview of what information is and how our auditory perceptions can be used to enhance our knowledge of the source of data. -/- - Show the importance of the dynamic relationships between hearing, cognitive load, comprehension, embodied knowledge and perceptual truth. -/- - Discuss the role of aesthetics in the dynamic interplay between listenability and clarity. -/- - Provide a mature software framework that supports the practice of data sonification design, together with a detailed discussion of some of the design principles used in various examples. -/- David Worrall is an internationally recognized composer, sound artist and interdisciplinary researcher in the field of auditory design. He is Professor of Audio Arts and Acoustics at Columbia College Chicago and a former elected president of the International Community for Auditory Display (ICAD), the leading organization in the field since its inception over 25 years ago. -/- Code and audio examples for this book are available at -/- https:// github. com/david-worrall/springer/. (shrink)

Worrall :99–124, 1989) famously claimed that structural realism is the best of both worlds; it enables one to endorse the best arguments for scientific realism and antirealism. In this paper, I argue that structural realism also enables one to combine two other seemingly inconsistent positions: realism and pluralism. Indeed, the very features which form the basis of the structural realist’s reply to the problem of theory change may be applied synchronically to allow for a pluralist structural realism. The resulting (...) position incorporates a robust variety of scientific pluralism unavailable to the traditional realist and thereby allows the structural realist to take seriously the pluralism apparent in scientific practice. (shrink)

The newest addition to the successful Oxford Readings in Philosophy series, this collection contains the most important contributions to the recent debate on the philosophy of science. The contributors crystallize the often heated arguments of the last two decades, assessing the skeptical attitudes within philosophy of science and the counter-challenges of the scientific realists. Contributors include Nancy Cartwright, Brian Ellis, Arthur Fine, Clark Glymour, Larry Laudan, Peter Lipton, Alan Musgrave, Wesely C. Salmon, Lawrence Sklar, Bas C. van Fraassen, and John (...) Worrall. (shrink)

Experimental balance is usually understood as the control for the value of the conditions, other than the one under study, which are liable to affect the result of a test. We discuss three different approaches to balance. ‘Millean balance’ requires identifying and equalizing ex ante the value of these conditions in order to conduct solid causal inferences. ‘Fisherian balance’ measures ex post the influence of uncontrolled conditions through the analysis of variance. In ‘efficiency balance’ the value of the antecedent conditions (...) is decided ex ante according to the efficiency they yield in the estimation of the treatment outcome. Against some old arguments by Worrall, we show that in both Fisherian and efficiency balance there are good reasons to randomize the allocation of treatments, in particular when there is no agreement among experimenters as to the antecedent conditions to be controlled for. (shrink)

In april 1872, with the caisson at a depth of seventy-odd feet and still no bedrock, two men died. The strain for Roebling was nearly unbearable, as his wife later said. On May 18, a third man died, and that same day Roebling made the most difficult and courageous decision of the project. Staking everything — the success of the bridge, his reputation, his career - he ordered a halt. The New York tower, he had concluded, could stand where it (...) was, at a depth of 78 feet 6 inches, not on bedrock, but on “hardpack” sand. From examinations of the strata he had determined to his own satisfaction that no movement had occured at the level since the time of deposit millions of years in the geologic past; so, he said, it was “good enough to found upon”. (shrink)

From a reliabilist point of view, our inferential practices make us into instruments for determining the truth value of hypotheses where, like all instruments, reliability is a central virtue. I apply this perspective to second-order inductions, the inductive assessments of inductive practices. Such assessments are extremely common, for example whenever we test the reliability of our instruments or our informants. Nevertheless, the inductive assessment of induction has had a bad name ever since David Hume maintained that any attempt to (...) justify induction by means of an inductive argument must beg the question. I will consider how the inductive justification of induction fares from the reliabilist point of view. I will also consider two other wellknown arguments that can be construed as inductive assessments of induction. One is the miracle argument, according to which the truth of scientific theories should be inferred as the best explanation of their predictive success; the other is the disaster argument, according to which we should infer that all present and future theories are false on the grounds that all past theories have been found to be false. (shrink)

John Worrall recently provided an account of epistemic structural realism, which explains the success of science by arguing for the correct mathematical structure of our theories. He accounts for the historical failures of science by pointing to bloated ontological interpretations of theoretical terms. In this paper I argue that Worrall’s account suffers from five serious problems. I also show that Pierre Cruse and David Papineau have developed a rival structural realism that solves all of the problems faced (...) by Worrall. This Ramsey-sentence realism is a significant advance in the debate, but still ultimately fails for its incomplete account of reference. (shrink)

This book aims to reinvigorate discussions of moral arguments for God's existence.

Is it possible for a liberal society to have an established church? After outlining the conditions for liberal establishment, I take from David Hume a secular argument in its favour that points to the moderating effect of establishment on religious discourse and practice. I examine the claim that state support for religion violates liberal equality, and argue that, with respect to state-provided public goods generally, what matters is that the whole package should be of roughly equal benefit to each (...) citizen; it is not required that every citizen should value each distinct good. I claim that religious establishment can have valuable effects for both believers and non-believers, and thereby count as a public good. I then examine the charge that establishment always conveys a message of disparagement to those outside the favoured church, making them into second-class citizens, as both Martha Nussbaum and Cécile Laborde have claimed. Understood as a claim about the experience of minority groups, however, it is unsupported by empirical evidence. Understood as an interpretative claim about the meaning of establishment, it fails to distinguish between privileging an institution and privileging the people attached to it. Finally, I point out that religious minorities may favour an established church as a shield against the pervasive secularism of most modern liberal societies. (shrink)

Introduction -- The commercialisation of science and the construction of the knowledge-based bio-economy -- The KBBE reality--the case of agriculture -- Intellectual property rights and the global commodification of knowledge -- Privatizing Chinese science : national development vs. neoliberal financialization -- Critical realism and the importance of ontological attention -- Critical realism and beyond in economics -- The realist transcendental argument.

Quantum theory plays an increasingly significant role in contemporary early-universe cosmology, most notably in the inflationary origins of the fluctuation spectrum of the microwave background radiation. I consider the two main strategies for interpreting standard quantum mechanics in the light of cosmology. I argue that the conceptual difficulties of the approaches based around an irreducible role for measurement - already very severe - become intolerable in a cosmological context, whereas the approach based around Everett's original idea of treating quantum systems (...) as closed systems handles cosmological quantum theory satisfactorily. Contemporary cosmology, which indeed applies standard quantum theory without supplementation or modification, is thus committed - tacitly or explictly - to the Everett interpretation. (shrink)

Introduction / David F. Wright -- The natural ethic / Oliver O'Donovan -- Using the Bible in ethics / Howard Marshall -- From Christendom to pluralism / John Briggs -- Towards a theology of the state / Haddon Wilmer -- The challenge of Marxism / David Lyon -- Man in society / E. David Cook -- Human rights / John Gladwin -- Epilogue : tasks which await us / John Stott.

In this paper I defend epistemic circularity by arguing that the “No Self-Support” principle (NSS) is false. This principle, ultimately due to Fumerton ( 1995 ), states that one cannot acquire a justified belief in the reliability of a source of belief by trusting that very source. I argue that NSS has the skeptical consequence that the trustworthiness of all of our sources ultimately depends upon the trustworthiness of certain fundamental sources – sources that we cannot justifiably believe to be (...) reliable. This is a problem, I claim, because if the trustworthiness of all of our sources depends upon sources that we should not believe to be reliable, then a reflective individual should not trust any of his sources at all. The hidden cost of rejecting epistemic circularity is thus the unacceptable skeptical thesis that reflective individuals like you and I have no justified beliefs whatsoever. (shrink)

This book uncovers the lost history of Christianity's encounters with Pythagorean ideas before the Renaissance. David Albertson skillfully examines ancient and medieval theologians, particularly Thierry of Chartres and Nicholas of Cusa, who successfully reconceived the Trinity and the Incarnation within the framework of Greek number theory. David Albertson challenges modern assumptions about the complex relationship between religion and science.

Figures of Thought looks at how mathematical works can be read as texts and examines their textual strategies. David Reed offers the first sustained and critical attempt to find a consistent argument or narrative thread in mathematical texts. Reed selects mathematicians from a range of historical periods and compares their approaches to organizing and arguing texts, using an extended commentary on Euclid's Elements as a central structuring framework. He develops fascinating interpretations of mathematicians' work throughout history, from Descartes to (...) Hilbert, Kronecker, Dedekind, Weil and Grothendieck. Reed traces the implications of this approach to the understanding of the history and development of mathematics. (shrink)

I aim to show that standard theories of counterfactuals are mistaken, not in detail, but in principle, and I aim to say what form a tenable theory must take. Standard theories entail a categorical interpretation of counterfactuals, on which to state that, if it were that A, it would be that C is to state something, not relative to any supposition or hypothesis, but categorically. On the rival suppositional interpretation, to state that, if it were that A, it would be (...) that C is to state that it would be that C relative to the supposition that it were that A. The two interpretations make incompatible predictions concerning the correct evaluation of counterfactuals. I argue that the suppositional interpretation makes the correct prediction. (shrink)

This chapter contains sections titled: Abstract Introduction The Tacit ‐ Agreement Approach to Morality as Social Construction Speaker Relativism What it Might Mean for Morality to be Constructed as Part of Human Culture Explaining Moral Commonalities and Differences Across Cultures Relativism and the Meaning of Moral Terms Explaining Intra ‐ Group Disagreement Why Fundamental Intragroup Disagreement Might Be Inevitable References.

Background: Current practice relies on patient-designated and next-of-kin surrogates, in consultation with clinicians, to make treatment decisions for patients who lose the ability to make their own decisions. Yet there is a paucity of data on whether this approach is consistent with patients' preferences regarding who they want to make treatment decisions for them in the event of decisional incapacity. Methods: Self-administered survey of patients at a tertiary care center. Results: Overall, 1169 respondents completed the survey (response rate = 59.8%). (...) Of the 229 respondents who had previously designated a surrogate, 78.2% wanted their surrogate to make treatment decisions in the event of decisional incapacity, whereas 21.8% wanted their doctors to make treatment decisions. Of the 822 respondents who had not designated a surrogate, 66.1% wanted their family to make treatment decisions, whereas 33.9% wanted their doctors to make treatment decisions. The most common explanation provided for why respondents wanted their surrogate or family to make treatment decisions for them in the event of decisional incapacity was the belief that loved ones knew the patient's treatment preferences. Conclusions: Contrary to current practice, 33.9% of respondents who had not designated a surrogate and 21.8% of those who had designated a surrogate indicated that they wanted their doctors to make treatment decisions for them in the event of decisional incapacity. Moreover, many of those who wanted their surrogates or family members to make treatment decisions explained this preference by citing a belief that loved ones knew the patient's treatment preferences. This belief is undermined by prior research that suggests that surrogates and family members frequently are unable to predict which treatments their charges would want. Future research should assess these two concerns with current practice and, where necessary, identify approaches to address them. (shrink)

Taking a new look at the language of ‘religious experience’, the authors in this contribution take into review this aspect in the current theological discussion, and in the church pew, asking the question: Does George Lindbeck’s criticism of the experiential-expressive model of religion still have something to say to us? Firstly, Lindbeck is reviewed and recouped. Then, religious experience and its commodification are discussed, at the hand also of the heritage from Schleiermacher onwards on experience. Taking a position within the (...) post-modern, relativist, critical realist and pragmatist possibilities, a community-embedded sense of truth is concluded to without sacrificing the possibility of universalising claims. Is it possible, though, within the cultural reflex towards psychologised faith to retain a historically oriented depth? (shrink)

AtRepublic9, 583b1–587a2, Socrates argues that the pleasure of the philosophical life is the truest pleasure. I will call this the ‘true pleasure argument’. The true pleasure argument is divisible into two parts: 583b1–585a7 and 585a8–587a2. Each part contains a sub-argument, which I will call ‘the misperception argument’ and ‘the true filling argument’ respectively. In the misperception argument Socrates argues that it is characteristic of irrational men to misperceive as pleasant what in fact is a condition of neither having pleasure nor (...) being pained. In the true filling argument Socrates argues that in so far as pleasure entails somatic or psychic filling and there are more and less true fillings, there are more and less true pleasures. Philosophical filling is the truest filling and thus the truest pleasure. The misperception argument critically contributes to the true pleasure argument by clarifying what pleasure is not: merely an appearance or merely the absence of pain. The misperception argument thereby clears the ground for the constructive contribution of the true filling argument. (shrink)

I examine Bernard Williams’s forceful challenge that evolutionary science has done away with the sort of teleological worldview that is needed in order to make sense of an Aristotelian virtue ethic perspective. I also consider Rosalind Hursthouse’s response to Williams and argue that it is not sufficient. My main task is to show what is needed in order to meet Williams’s challenge. First, I argue that we need a deeper exploration of the first-personal evaluative standpoint from within our human form (...) of life than we find in Hursthouse’s ethical naturalist perspective. In particular, we need to recognize the important role of “strong evaluation” for identifying what is noblest and best about us as human beings, for this will enable us to address the “mixed bag” problem of human nature. Second, I argue—contra John McDowell’s quietism—that in order to make sense of such a normative account of human nature we must overcome Williams’s tragic cosmic outlook according to which human life is seen as ultimately without meaning and purpose. (shrink)

This is a review article about John Searle's most recent book The Rediscovery of the Mind, which criticizes it for not going far enough in its departure from orthodox materialistic views of the brain and mind. It argues that Searle's two central propositions, consciousness is irreducible and consciousness cannot cause anything that cannot be explained by the causal behaviour of neurons, are incompatible; and suggests that it is reasonable and scientifically respectable to reject the latter rather than the former.

Case presentations, esthetics, insurance considerations, communicable diseases, referral questions, dental phobia, and legal concerns all play a role in doctor-patient relationships. These topics, and many others, are the subject of this one-of-a-kind resource, designed to show dental students and practitioners how to approach patient relationships.

When Augustine condemns the Jews to eternal carnality, he draws a direct connection between anthropology and hermeneutics. Because the Jews reject reading “in the spirit,” they are therefore condemned to remain “Israel in the flesh.” Allegory is thus, in his theory, a mode of relating to the body. In another part of the Christian world, Origen also described the failure of the Jews as owing to a literalist hermeneutic, one that is unwilling to go beyond or behind the material language (...) and discover its immaterial spirit.1 This way of thinking about language has been initially stimulated in the Fathers by Paul’s usage of “in the flesh” and “in the spirit” respectively to mean literal and figurative. Romans 7:5-6 is a powerful example of this hermeneutic structure: “For when we were still in the flesh, our sinful passions, stirred up by the law, were at work on our members to bear fruit for death. But now we are fully freed from the law, dead to that in which we lay captive. We can thus serve in the new being of the Spirit and not the old one of the letter.” In fact, the exact same metaphor is used independently of Paul by Philo, who writes that his interest is in “the hidden and inward meaning which appeals to the few who study soul characteristics rather than bodily forms.”2 For both, hermeneutics becomes anthropology. 1. See Henri Crouzel, Origen, trans. A. S. Worrall , pp. 107-12.2. Philo, On Abraham, sec. 147, in vol. 6 of Philo, trans. and ed. F. H. Colson , p. 75. It is very important to note that Philo himself is just the most visible representative of an entire school of people who understood the Bible, and indeed the philosophy of language, as he did. On this see David Winston, “Philo and the Contemplative Life,” in Jewish Spirituality: From the Bible through the Middle Ages, ed. Arthur Green , pp. 198-231, esp. p. 211. Daniel Boyarin is Taubman Professor of Talmudic Culture in the department of Near-Eastern studies at the University of California, Berkeley. He is the author of Intertextuality and the Reading of Midrash , as well as the forthcoming Carnal Israel: Reading Sex in Talmudic Culture, from which the present essay is drawn. He is currently engaged in a project entitled The Politics of the Spirit: Paul as a Jewish Cultural Critic. (shrink)

Arguments, claims, and discussions about the “level of description” of a theory are ubiquitous in cognitive science. Such talk is typically expressed more precisely in terms of the granularity of the theory, or in terms of Marr’s three levels. I argue that these ways of understanding levels of description are insufficient to capture the range of different types of theoretical commitments that one can have in cognitive science. When we understand these commitments as points in a multi-dimensional space, we find (...) that we must also reconsider our understanding of intertheoretic relations. In particular, we should understand cognitive theories as constraining one another, rather than reducing to one another. (shrink)

Delirium, a common syndrome in terminally ill people, presents specific challenges to a good death in end‐of‐life care. This paper examines the relational engagement between hospice nurses and their patients in a context of end‐of‐life delirium. Ethnographic fieldwork spanning 15 months was conducted at a freestanding residential hospice in eastern Canada. A shared value system was apparent within the nursing community of hospice; patients’ comfort and dignity were deemed most at stake and therefore commanded nurses’ primary attention. This overarching commitment (...) to comfort and dignity shaped all of nursing practice in this hospice, including practices related to end‐of‐life delirium. The findings of this study elaborate the ways in which hospice nurses interpreted and responded to the discomfort of their patients in delirium, as well as the efforts they made to understand their patients’ subjective experiences and to connect with them in supportive ways. In addition to what is already known about clinical assessment and treatment of delirium in palliative care settings, the findings of this study offer points of reflection for nurses anywhere who are contending with the relational challenges that delirium presents in end‐of‐life care. (shrink)

David Brown explores the ways in which the symbolic associations of the body and what we do with it have helped shape religious experience and continue to do so. A Church narrowly focused on Christ's body wracked in pain needs to be reminded that the body as beautiful and sexual has also played a crucial role not only in other religions but also in the history of Christianity itself. Dance was one way in which the connection was expressed. The (...) irony is not that such a connection has gone but that it now exists almost wholly outside the Church. Much the same could be said about music more generally, and Brown writes excitingly about the spiritual potential of not just classical music but also pop, jazz, musicals, and opera. Like Brown's much-praised earlier volumes, God and Enchantment of Place, Tradition and Imagination, and Discipleship and Imagination, the present book will enlarge horizons and challenge the narrowness of much theological thinking. (shrink)