Mucopolysaccharidosis VI is an autosomal recessive lysosomal storage disorder associated with severe disability and premature death. The presence of a mucopolysaccharidosis-like disease in indigenous ethnic groups in Colombia can be inferred from archaeological findings. There are several indigenous patients with mucopolysaccharidosis VI currently receiving enzyme replacement therapy. We discuss the ethical and economic considerations, regarding both direct and indirect costs, of a high-cost orphan disease in a marginalised minority population in a developing country.

I : PETRARCH'S BRITAIN 1: Piero Boitani: Petrarch and the barbari Britanni II: PETRARCH AND THE SELF 2: Jennifer Petrie: Petrarch solitarius 3: Zygmunt G. Baranski: The Ethics of Ignorance: Petrarch's Epicurus and Averroes and the Structures of the De Sui Ipsius et Aliorum Ignorantia 4: Jonathan Usher: Petrarch's Second Death III: PETRARCH IN DIALOGUE 5: Francesca Galligan: Poets and Heroes in Petrarch's Africa: Classical and Medieval Sources 6: Enrico Santangelo: Petrarch reading Dante: the Ascent of Mont Ventoux 7: John (...) Took: Petrarch and Cino da Pistoia: A Moment in the Pre-history of the Canzoniere IV: PETRARCHISM AND ANTIPETRARCHISM IN ITALY 8: Abigail Brundin: Petrarch and the Italian Reformation 9: Hilary Gatti: Petrarch, Sidney, Bruno 10: Diego Zancani: Renaissance Misogyny and the Rejection of Petrarch 11: Letizia Panizza: Impersonations of Laura in Sixteenth and Seventeenth Century Italy V: PETRARCHISM: ENGLISH AND SCOTTISH CONNECTIONS 12: Michael Wyatt: Other Petrarchs in Early Modern England 13: Stephen Clucas: Thomas Watson's Hekatompathia and European Petrarchism 14: John Roe: The Comedy of Astrophil: Petrarchan Motifs in Sidney's Astrophil and Stella 15: Syrithe Pugh: Sidney, Spenser and Political Petrarchism 16: R. D. S. Jack: Petrarch and the Scottish Renaissance Sonnet VI: PETRARCH AND THE MODERNS: ITALY AND BRITAIN 17: Pamela Williams: Leopardi and Petrarch 18: Ela Tandello: Between Tradition and Transgression: Amelia Rosselli's Petrarch 19: Martin McLaughlin: Nineteenth-century British Biographies of Petrarch 20: Peter Hainsworth: Translating Petrarch. (shrink)

Nuevos espacios de participación de los afrodescendientes en América y el Caribe.

Kevin Liggieri, »Anthropotechnik«. Zur Geschichte eines umstrittenen Begriffs, Konstanz: Konstanz University Press 2020.

This paper approaches the current epistemological debate on peer disagreement from a neo-Pyrrhonian perspective, thus adopting a form of skepticism which is more radical than those discussed in the literature. It makes use of argumentative strategies found in ancient Pyrrhonism both to show that such a debate rests on problematic assumptions and to block some maneuvers intended to offer an efficacious way of settling a considerable number of peer disputes. The essay takes issue with three views held in the peer (...) disagreement debate: there is an objective fact of the matter about at least most controversial questions; we possess theory-neutral evidence bearing on those questions which grants us access to the truth of the matter; and many peer controversies are resolved by attending to which disputant has correctly evaluated the objective evidence. With respect to the first two views, it is argued that the belief in both objective facts and theory-neutral evidence is subject to fierce dispute, and should not therefore be taken for granted in the discussion of peer disagreement. As for the third view, it is argued that from either a first- or a third-person perspective, there seems to be epistemic symmetry between the disputants which makes it necessary to suspend judgment. (shrink)

Durante la última década del siglo XX y los primeros años del nuevo milenio, las instituciones públicas y/o de gobierno han pasado por un proceso de ajuste y cambio debido al arribo de las técnicas gerenciales provenientes del sector privado conocidas como Nueva Gestión Pública. Dichas técnicas han generado, por un lado, una modificación sustantiva en la forma de organizar, estructurar y operar los servicios públicos y, por otro, algunos cambios en la conducta de los servidores públicos pero desviándose de (...) la esencia de servicio público original. Ante este panorama, éste artículo se plantea reflexionar sobre si hay alguna alternativa a esta situación. (shrink)

In a recent paper Samir Okasha has suggested an application of Arrow’s impossibility theorem to theory choice. When epistemic virtues are interpreted as ‘voters’ in charge of ranking competing theories, and there are more than two theories at stake, the final ordering is bound to coincide with the one proposed by one of the voters, provided a number of seemingly reasonable conditions are in place. In a similar spirit, Jacob Stegenga has shown that Arrow’s theorem applies to the amalgamation of (...) evidence; the ‘voters’ here are the different sources of evidence. As with Okasha’s proposal, it is not clear how to avoid Arrow’s pessimistic conclusion.In this paper we develop a novel argument that purports to show that, in typical examples, Arrow’s result does not obtain when dealing with evidence amalgamation. The reason is that we cannot escape the well-known Duhem problem: the evidence actually confirms complex conjunctions that include various auxiliary hypotheses. We argue that confirmational holism induces us to restrict the domain of a reasonable amalgamation function, thus violating one of Arrow’s conditions. The upshot is that we are now able to see the Duhem problem under a different, positive light – namely, as a phenomenon that makes the aggregation of the evidence possible in the first place, when there are at least three options on the table. (shrink)

This paper addresses the role of the notion of sacrifice in Kant’s theoretical philosophy, practical philosophy, and in his account of religion. First, I argue that kenotic sacrifice, or sacrifice as ‘withdrawal’, plays a hidden and yet important role in the development of Kant’s transcendental philosophy. Second, I focus on Kant’s practical philosophy, arguing that the notion of sacrifice that is both implied and explicitly analyzed by Kant is mainly suppressive sacrifice. However, Kant’s account is fundamentally ambiguous, as sometimes the (...) kenotic meaning of sacrifice seems to resurface, especially in the context of Kant’s discussion of the happiness of others as an end in itself. Because religious notions are regarded by Kant as necessary transitional forms (Darstellungen) to be used to make moral ideas applicable to the world, I then scrutinize Kant’s view of sacrifice as an improper symbol, and I analyze Kant’s arguments for such a dismissal and discuss the subject matter in recent literature. Finally, I examine the role of sacrifice in Kant’s account of Christ as the prototype of pure moral disposition. I conclude by arguing that Kant indeed grasped the importance of including kenotic dynamics in practical philosophy but was somehow unable or unwilling to integrate it into the formal grounding of his ethics. This tension, however, effectively provides an entry point for features that can be found in the post-Kantians. (shrink)

Microbes can influence host physiology and behavior in many ways. Here we review evidence suggesting that some microbes can contribute to host stress (and other microbes can contribute to increased resilience to stress). We explain how certain microbes, which we call “stress microbes,” can potentially benefit evolutionarily from inducing stress in a host, gaining access to host resources that can help fuel rapid microbial replication by increasing glucose levels in the blood, increasing intestinal permeability, and suppressing the immune system. Other (...) microbes, which we term “resilience microbes,” can potentially benefit from making hosts more resilient to stress. We hypothesize that “stress microbes” use a fast life history strategy involving greater host exploitation while “resilience microbes” use a slow life history strategy characterized by more aligned evolutionary interests with the host. In this paper, we review the evidence that microbes affect host stress and explain the evolutionary pressures that could lead microbes to manipulate host stress, discuss the physiological mechanisms that are known to be involved in both stress and microbial activity, and provide some testable predictions that follow from this hypothesis. (shrink)

People tend to overestimate emotional responses to future events. This study examined whether such affective forecasting errors occur for feelings of regret, as measured by self-report and subsequent decision-making. Some participants played a pricing game and lost by a narrow or wide margin, while others were asked to imagine losing by such margins. Participants who experienced a narrow loss reported more regret than those who imagined a narrow loss. Furthermore, those experiencing a narrow loss behaved more cautiously in a subsequent (...) gambling task. Thus, the study provides self-report and behavioral evidence for a reversal of the affective forecasting phenomenon for feelings of regret. (shrink)

The article delves into two closely intertwined notions that have increasingly taken centre stage in Gianni Vattimo’s thought since the mid-eighties: secularisation and kenosis. The significance of these themes in Vattimo’s late work is such that, it is argued, it amounts to an actual Kehre, or turn. However, akin to Heidegger, Vattimo’s Kehre is not a radical break but a shift in research and reflection towards themes that, although already present in his philosophy, have assumed more distinctly religious nuances and (...) have progressively developed up to the point where they have formed an organic perspective. The article traces this development, commencing with the notion of secularisation to then explore its interweaving with themes of emancipation and the violence of metaphysics. It concludes with a reflection on the central role of kenosis and its significance in Vattimo’s thought. (shrink)

La recepción durante el siglo XX se preguntó si la filosofía nietzscheana era a-, im- o anti-política, es decir, si podía ser asimilada por la democracia, o si era antimoderna, elitista y reaccionaria. El italiano Roberto Esposito ha propuesto leerla como formando e informando el paradigma de la biopolítica. Se discuten cuatro lecturas de esa biopolítica: como formadora del paradigma de la inmunidad, como tanatopolítica, como liberal y neoliberal, y como biopolítica afirmativa. Twentieth-century readers wondered if Nietzschean philosophy was apolitical, (...) impolitic, or anti-political; that is, if it could be assimilated by democracy or if it was antimodern, elitist, and reactionary. The Italian philosopher Robert Esposito has proposed reading Nietzsche's philosophy as forming and informing the biopolitical paradigm. Four readings of these biopolitics are discussed: as part of the paradigm of immunity, as thanatopolitics, as liberal and neoliberal, and as affirmative biopolitics. (shrink)

A function is algebraic on an algebra if it can be implicitly defined by a system of equations on. In this note we give a semantic characterization for algebraic functions on quasiprimal algebras. This characterization is applied to obtain necessary and sufficient conditions for a quasiprimal algebra to have every one of its algebraic functions be a term function. We also apply our results to particular algebras such as finite fields and monadic algebras.

The aim of this paper is to offer a phenomenological interpretation of Aristotle’s approach to the sense of touch. The first part of this text deals with the role of touch in De Anima and states the central point of the argument to be developed: to show that touch has an ontological function insofar as it is the condition of possibility for accessing objects as objects. Some methodological considerations are required in order to delineate the overall context in which the (...) present contribution has to be understood. Not dealing with a philological reconstruction, nor with a perspective focusing on the history of philosophy, this text aims at a systematic approach to the question, taking Aristotle as its starting point. (shrink)

l nostro obiettivo è di rintracciare l'origine dell'autocoscienza attraverso una indagine filosofica che, a partire dalle ricerche di Darwin, segue il filo che lega lo scienziato inglese alle concezioni pragmatiste sviluppate da Mead e Wright, i quali hanno messo in evidenza alcuni aspetti chiave che sviluppiamo poi in una ricostruzione sistematica e genealogica condotta con l'aiuto della fenomenologia classica e della filosofia di Carlo Sini.

Movies can serve valuable didactic purposes teaching clinical ethics to medical students. However, using film sequences as means to develop critical thinking is not a straightforward task. There is a significant gap in the literature regarding how to analyse the ethical content embedded in these clips systematically, in a way that facilitates the students’ transition from anecdotal reflections to abstract thinking. This article offers a pedagogical proposal to approach the ethical analysis of film sequences in a systematic fashion. This structured (...) stepwise method encourages students to identify the main ethical problem of a selected scene and to reflect on the theoretical principles involved, emphasizing the application of these norms and values in a contextually situated analysis. We believe this method in film studies both reinforces the students’ comprehension of the theoretical framework of an ethical topic, and casts light on its pertinence and limitations under the circumstances of the scene, thus proving a constructive tool to strengthen the bridge between the theoretical teaching of clinical ethics and clinical practice. (shrink)

Morphological EvoDevo is a field of biological inquiry in which explicit relations between evolutionary patterns and growth or morphogenetic processes are made. Historically, morphological EvoDevo results from the coming together of several traditions, notably Naturphilosophie, embryology, the study of heterochrony, and developmental constraints. A special feature binding different approaches to morphological EvoDevo is the use of formalisms and mathematical models. Here we will introduce anatomical network analysis, a new approach centered on connectivity patterns formed by anatomical parts, with its own (...) concepts and tools specifically designed for the study of morphological EvoDevo questions. Riedl’s concept of burden is tightly related to the use of anatomical networks, providing a nexus between the evolutionary patterns and the structural constraints that shape them. (shrink)

Understanding the mechanisms underlying the formation of cultural traits is an open challenge. This is intimately connected to cultural dynamics, which has been the focus of a variety of quantitative models. Recent studies have emphasized the importance of connecting those models to empirically accessible snapshots of cultural dynamics. In particular, it has been suggested that empirical cultural states, which differ systematically from randomized counterparts, exhibit properties that are universally present. Hence, a question about the mechanism responsible for the observed patterns (...) naturally arises. This study proposes a stochastic structural model for generating cultural states that retain those robust empirical properties. One ingredient of the model assumes that every individual’s set of traits is partly dictated by one of several universal “rationalities,” informally postulated by several social science theories. The second, new ingredient assumes that, apart from a dominant rationality, each individual also has a certain exposure to the other rationalities. It is shown that both ingredients are required for reproducing the empirical regularities. This suggests that the effects of cultural dynamics in the real world can be described as an interplay of multiple, mixing rationalities, providing indirect evidence for the class of social science theories postulating such a mixing. (shrink)

Resumo O propósito deste artigo é mostrar a contribuição de Nietzsche à revolução nas práticas da encenação que ocorreram no Século XX, bem como sua relevância como crítico apaixonado pelo potencial de uma forma de arte que ele sentia que era interpretada em sua época de forma diminuída. A partir de seu estudo do teatro grego na obraO nascimento da tragédia, sublinha a importância da encenação na tragédia antiga, a qual estava para além do texto escrito por seu autor. Oferece (...) com isso uma análise da ideia de teatro como arte, a qual é consubstancial realizar-se em três dimensões: a do ator, a do poeta ou escritor do texto e a do espectador. Nietzsche defende a especificidade desses três papéis para toda realização teatral e o sentido filosófico que tem o teatro como autêntica forma artística. Conclui-se o artigo mostrando a recepção do pensamento teatral de Nietzsche em autores como August Strindberg, George Bernard Shaw e Eugene O'Neill, que buscarão novas formas e novos significados para sua arte.The purpose of this article is to show the contribution of Nietzsche to the revolution in the practices of the scenario that takes place in the 20th century, as well as its relevance as a passionate critic for the potential of an art form that he felt was interpreted in his time in a diminished way. From his study of Greek theater in his workThe Birth of Tragedy,he underlines the importance that in the ancient tragedy had its staging, and that went beyond the text written by its author. It offers therefore an analysis of the idea of theater as art, which is consubstantial in three dimensions: the actor, the poet or writer of the text and the viewer. Nietzsche defends the specificity of these three roles for every theatrical enterprise and the philosophical sense that theater has as an authentic artistic form. The article concludes by showing the acceptance of Nietzsche's theatrical thought in authors such as August Strindberg, George Bernard Shaw or Eugene O'Neill, who sought new forms and new meanings for their art. (shrink)

Resumen: El artículo aborda uno de los modos de localización de entidades en situaciones espaciales estáticas: la deíxis espacial. Nuestro objetivo principal es describir la estructura y uso del sistema demostrativo en espacio de escala menor en la lengua hablada por los gitanos de Chile: el rromané jorajané. Para la obtención de los datos se utilizó The 1999 Demonstrative Questionnaire: ‘THIS’ and ‘THAT’ in comparative perspective. Los resultados del análisis destacan que los demostrativos espaciales del rromané jorajané constituyen un grupo (...) altamente simétrico, que combina un componente semántico deíctico, junto con contenidos gramaticales. Se trata de un sistema demostrativo binario en cuanto a la categoría de distancia respecto del centro deíctico. Se concluye también que la selección del demostrativo apropiado obedece al siguiente patrón: el demostrativo proximal tiene su área focal en la zona próxima al hablante, mientras que el demostrativo distal incluye en su campo de aplicación tanto la zona próxima al oyente como la zona distante al hablante.: This paper addresses one way of locating entities in static spatial situations: the spatial deixis. Our main purpose is to describe the structure and use of the demonstrative system in small-scale space in the language spoken by Gypsies in Chile: the rromané jorajané. Data collection was performed with “The 1999 Demonstrative Questionnaire: ‘THIS’ and ‘THAT’ in comparative perspective”. The analysis results highlight that spatial demonstratives in rromané jorajané are a highly symmetrical group combining a deictic semantic component with grammatical contents. It is a binary demonstrative system in terms of the category of distance from the deictic center. Additionally, it is concluded that choice of the suitable demonstrative proceeds according to the following pattern: the proximal demonstrative has its focal area in the speaker’s zone of proximity, while the distal demonstrative includes both the addressee’s zone of proximity and the speaker’s distal zone within its application field. (shrink)

We extend the construction of bad fields of characteristic zero to the case of arbitrary prescribed divisible green torsion.

Historicamente, as humanidades têm sido essenciais para a educação, uma vez que são consideradas como disciplinas fundamentais para a formação de cidadãos democráticos. A partir dessa conjectura, esse artigo visa refletir sobre a importância das competências no ensino de humanidades para a formação de cidadãos democráticos. Para isso, realizamos uma pesquisa de cunho bibliográfico, baseada no pensamento de Martha Nussbaum sobre as competências necessárias para o desenvolvimento de uma cidadania democrática (2015). O desenvolvimento de competências no ensino de humanidades promove (...) a autonomia do estudante no âmbito pessoal, profissional, intelectual e político para o enfrentamento dos desafios da sociedade. Essas competências permitem aos estudantes enfrentar a realidade e as necessidades humanas com senso crítico e consciência de sua responsabilidade como pessoa em um meio social, político e cultural. (shrink)