In order to improve our understanding of the components that reflect functionally important processes during reward anticipation and consumption, we used principle components analyses (PCA) to separate and quantify averaged ERP data obtained from each stage of a modified monetary incentive delay (MID) task. Although a small number of recent ERP studies have reported that reward and loss cues potentiate ERPs during anticipation, action preparation, and consummatory stages of reward processing, these findings are inconsistent due to temporal and spatial overlap (...) between the relevant electrophysiological components. Our results show three components following cue presentation are sensitive to incentive cues (N1, P3a, P3b). In contrast to previous research, reward‐related enhancement occurred only in the P3b, with earlier components more sensitive to break‐even and loss cues. During feedback anticipation, we observed a lateralized centroparietal negativity that was sensitive to response hand but not cue type. We also show that use of PCA on ERPs reflecting reward consumption successfully separates the reward positivity from the independently modulated feedback‐P3. Last, we observe for the first time a new reward consumption component: a late negativity distributed over the left frontal pole. This component appears to be sensitive to response hand, especially in the context of monetary gain. These results illustrate that the time course and sensitivities of electrophysiological activity that follows incentive cues do not follow a simple heuristic in which reward incentive cues produce enhanced activity at all stages and substages. (shrink)

We wholeheartedly agree with Schmidt and colleagues’ efforts to promote equity in intensive care unit triage. We also take issue with their characterisation of the New Jersey allocation framework for ICU beds and ventilators, which is modelled after the multi-principle allocation framework we developed early in the pandemic. They characterise it as a two-criterion allocation framework and claim—without evidence—that it will ‘compound disadvantage for black patients’. However, the NJ triage framework—like the model allocation policy we developed—actually contains four allocation criteria: (...) the two criteria that the authors mentioned and two criteria that they failed to mention which we included to promote equity: giving priority to frontline essential workers and giving priority to younger patients. These omissions are problematic both for reasons of factual accuracy and because the two criteria they failed to acknowledge would likely mitigate rather than exacerbate racial disparities during triage. (shrink)

Popper and Eccles present two different notions of Interactionism. Popper's arguments arise out of the traditional philosophical debate, whereas Eccles' arguments arise out of a mixture of neurophysiology and personal belief. Popper's three-world ontology is the philosophical foundation of both their positions. However, it is precisely against the background of the three Worlds that the considerable differences between their positions are apparent. Despite these defects, Interactionism is a productive notion since it does not place the Self beyond experimental investigation. Indeed, (...) both Popper and Eccles have made implicit suggestions as to experimental procedure which might contribute to the investigation of the Self. (shrink)

ABSTRACT This paper reports on a multidisciplinary meeting held to discuss ethical issues in medical research in the developing world. Many studies, including clinical trials, are conducted in developing countries with a high burden of disease. Conditions under which this research is conducted vary because of differences in culture, public health, political, legal and social contexts specific to these countries. Research practices, including standards of care for participants, may vary as a result. It is therefore not surprising that ethical issues (...) emerge. This meeting sought to identify and discuss these issues from the perspectives of the many actors in such research, including community representatives, with a view to finding ethical and pragmatic solutions to these issues. Dialogue between these actors was also promoted, with a view to identifying the need to develop such dialogue in future. Drawing from the experiences of the speakers, the colloquium attempted to outline some answers to several key questions characterising the field today. Experiences related to epidemiologic research, vaccine trials, drug trials, diagnostic tests and to some fundamental ethical issues in health research. Speakers were from different countries, disciplines and professions. The meeting provided a forum for consultation and debate between different ethics actors. Both encouraging findings and challenges emerged. (shrink)

We appreciate the opportunity to respond to Schneiderman and colleagues’ opinions on the recent Multiorganization Policy Statement, “An Official ATS/AACN/ACCP/ESICM/SCCM Policy Statement: Responding to Requests for Potentially Inappropriate Treatments in Intensive Care Units”. We will first point out three areas in which Schneiderman and colleagues seem to perceive a disagreement where there is none, then we will respond to their main criticisms of the Multiorganization Policy Statement. In doing so, we will point out areas in which we believe Schneiderman and (...) colleagues have either misunderstood or misrepresented the statement. First, we agree with Schneiderman and... (shrink)

RationaleSurrogates of critically ill patients often have inaccurate expectations about prognosis. Yet there is little research on how intensive care unit clinicians should discuss prognosis, and existing expert opinion-based recommendations give only general guidance that has not been validated with surrogate decision makers.ObjectiveTo determine the perspectives of key stakeholders regarding how prognostic information should be conveyed in critical illness.MethodsThis was a multicenter study at three academic medical centers in California, Pennsylvania, and Washington. One hundred eighteen key stakeholders completed in-depth semistructured (...) interviews. Participants included 47 surrogates of adult patients with acute respiratory distress syndrome; 45 clinicians working in study ICUs, including physicians, nurses, social workers, and spiritual care providers; and 26 experts in health communication, decision science, ethics, family-centered care, geriatrics, healthcare disparities, palliative care, psychology, psychiatry, and critical care.Measurements and main resultsThere was broad support among surrogates for existing expert recommendations, including truthful prognostic disclosure, emotional support, tailoring the disclosure strategy to each family's needs, and checking for understanding. In addition, stakeholders offered suggestions that add specificity to existing recommendations, including: In addition to conveying prognostic estimates, clinicians should help families "see the prognosis for themselves" by showing families radiographic images and explaining the clinical significance of physical manifestations of severe disease at the bedside. Many physicians did not support using numeric estimates to convey prognosis to families, whereas many surrogates, clinicians from other disciplines, and experts believed numbers could be helpful. Clinicians should conceptualize prognostic communication as an iterative process that begins with a preliminary mention of the possibility of death early in the ICU stay and becomes more detailed as the clinical situation develops. Although prognostic information should be initially disclosed by physicians, other members of the multidisciplinary team-nurses, social workers, and spiritual care providers-should be given explicit role responsibilities to reinforce physicians' prognostications and help families process a poor prognosis emotionally.ConclusionsFamily members, clinicians, and experts identified specific communication behaviors that clinicians should use to discuss prognosis in the critical care setting. These findings extend existing opinion-based recommendations and should guide interventions to improve communication about prognosis in ICUs. (shrink)

Douglas Sturm, a major ethical thinker, here presents ten intriguing essays that lay the groundwork for a communitarian political theory. Drawing on the work of Alfred North Whitehead and Bernard E. Meland, Sturm brings the implications of process thought, especially its principle of internal relations, to bear on the interpretation and evaluation of our social and political life. He argues that American individualism, including its curious transmutations into the forms of corporativism, racism, and nationalism is a constraint that (...) deprives us of a deeper, more complex understanding of ourselves and a richer sense of the goodness of our lives. The essays contrast a communitarian political theory with alternative traditions of social thought, particularly those forms of individualism generated by Hobbes, Locke, and Bentham. Political realities of power, rights, and interests are not to be dismissed, according to Sturm, but they need to be cast within a concept of politics that sustains a community as a whole; thus public good and justice are defined as the central principles of public life. He isolates alternative theoretical perspectives and demonstrates how they deal with several current social and political dilemmas. Sturm applies the principles of the communitarian political theory to a broad range of contemporary concerns: the character and legitimacy of the modern business corporation; the idea of democratic capitalism; legal realism as the prevailing jurisprudence of the practicing lawyer; the scope and focus of bioethics as a discipline. In doing so, he affirms both the inescapability of public life in our existence and the radical character of the evil that it often creates. (shrink)

This letter to the editor responds to commentaries in the September‐October 2021issue of the Hastings Center Report by Douglas B. White and Bernard Lo, by Govind Persad, and by Virginia A. Brown, which were themselves responding, in part, to the article “Life‐Years and Rationing in the Covid‐19 Pandemic: A Critical Analysis,” by MaryKatherine Gaurke, Bernard Prusak, Kyeong Yun Jeong, Emily Scire, and Daniel P. Sulmasy.

Nuclear War, edited by Fox and Groarke, is one of five recent anthologies containing new essays by philosophers on the subject of nuclear war. The Blake and Pole volumes, containing essays mainly by British philosophers, are distinguished by unrelenting and comprehensive opposition to British and American policy, and by the fame of the contributors, which include Anthony Kenny, Michael Dummett, and Bernard Williams. The Chicago volume contains a number of excellent papers by philosophers and the added bonus of nine (...) papers by established specialists in national security issues; it attempts, with partial success, to cover the full range of strategic nuclear options. The Cohen and Lee and the Fox and Groarke volumes consist largely of papers by strategic outsiders far from the centres of political power; the debate in these volumes is not between the principal versions of nuclear deterrence but between nuclear deterrence in any form and some scheme that transcends the present arrangement of mutually deterring superpowers. Of these last two books, Cohen and Lee contains relatively longer and more detailed essays. (shrink)

In his book Economics as a Moral Science , Bernard Hodgson argues that economics is not value neutral as is often claimed, but is a value-laden discipline. In the long argument for this in his book, Hodgson never discusses or even mentions corporations. This article explains that corporations are absent from Hodgson’s discussion because he considers only the consumption side of general equilibrium theory (GET), and it shows that if Hodgson had included corporations and the production side, his overall (...) argument would have been more complete and convincing. This article shows that Hodgson’s methodology, when applied to the production side of GET, has value implications for CEOs of large corporations, for shareholders and members of Boards of Directors, and for legislators and regulators of business. Hodgson’s claim that economics must consider the ability of economic agents to create or change the institutional, cultural, and organizational conditions of their own economic actions is supported and expanded. (shrink)

In redefining logic, philosophers need to go back to the Aristotelian roots of the subject, to expand the boundaries of the subject to include informal logic and to give up false oppositions between informal and formal logic.

It used to be that everyone read the "notorious" Bernard Mandeville (1670-1733). He was a great satirist and come to have a profound impact on economics, ethics and social philosophy. "The Fable of the Bees" begins with a poem and continues with a number of essays and dialogues. It is all tied together by the startling and original idea that "private vices" (self-interest) lead to "publick benefits" (the development and operation of society).

The French sociological tradition has long regarded the ‘individual’ as a reality situated outside its area of intellection and investigation. According to Durkheim, the individual is a psychological object par excellence. Sociology has thus long favored the study of collectives (groups, classes, categories, institutions, microcosms), suggesting that the individual was a reality which, in itself, fell short of the social. The article discusses a method from the mid-1990s of researching sociology at an individual scale. This approach is essentially embedded in (...) the French sociological tradition, from Durkheim to Bourdieu via Halbwachs, despite the inflections and criticisms it might have of this tradition, while also drawing on the main theoretical knowledge of Norbert Elias’ relational and process-focused sociology. From empirical realization in methodological and theoretical reflexivity, this research program has progressed in dialog with various types of scientific knowledge more classically oriented toward the individual and their mental realities, such as cultural psychology, psychoanalysis, cognitive psychology or the neurosciences. (shrink)

Several diagrams and tables from review articles during the Ox-Phos Controversy serve as an occasion to assess the nature of competition in models of theory choice in science. Many models follow "Super-Bowl" principles of polar, either-or, winner-take-all competition. A significant alternative highlighted by this episode, however, is the differentiation of domains. Incommensurability and the partial divergence of overlapping domains serve both as signals and context for shifting frameworks of competition. Appropriate strategies may thus help researchers diagnose the status of competition (...) and shape their research accordingly. (shrink)

The aim of this paper is to make it clear how and why begging the question should be seen as a pragmatic fallacy which can only be properly evaluated in a context of dialogue. Included in the paper is a review of the contemporary literature on begging the question that shows the gradual emergence over the past twenty years or so of the dialectical conception of this fallacy. A second aim of the paper is to investigate a number of general (...) problems raised by the pragmatic framework. (shrink)

In this paper, I try to make a bundle theory of objects consistentwith a temporal parts theory of object persistence. To that end,I propose that such bundles are made up of tropes includingthe co-instantiation relation.

Dual-ranking act-consequentialism (DRAC) is a rather peculiar version of act-consequentialism. Unlike more traditional forms of act-consequentialism, DRAC doesn’t take the deontic status of an action to be a function of some evaluative ranking of outcomes. Rather, it takes the deontic status of an action to be a function of some non-evaluative ranking that is in turn a function of two auxiliary rankings that are evaluative. I argue that DRAC is promising in that it can accommodate certain features of commonsense morality (...) that no single-ranking version of act-consequentialism can: supererogation, agent-centered options, and the self-other asymmetry. I also defend DRAC against three objections: (1) that its dual-ranking structure is ad hoc, (2) that it denies (putatively implausibly) that it is always permissible to make self-sacrifices that don’t make things worse for others, and (3) that it violates certain axioms of expected utility theory, viz., transitivity and independence. (shrink)

This article addresses the question whether companies benefit from their commitment to corporate social responsibility. The authors argue that firms which score high on CSR activities build investor confidence and find evidence that they benefit from lower information asymmetry. The authors measure information asymmetry by insider trading, which is defined as the trading of a company’s shares by corporate insiders who have an information advantage with the aim to reap gains or avoid losses. Using a sample of U.S. firms listed (...) in the MSCI World Index during the period 2004 to 2013 and the firm- and industry-level CSR rating from Global Engagement Service, the authors show that insider transactions in firms with a high score on CSR activities lead to lower abnormal returns. This investigation extends current literature on the business case for CSR by explaining the influence of CSR activities on asymmetric information. (shrink)

The scholastic philosopher is interested in definition for a different reason than the lexicographer and linguist. The philosopher is trying to learn things. Fe defines, after investigating reality, in an attempt to describe reality clearly and to sum up some aspect of his understanding of reality. Hence, we find our scholastic philosophers adopting as a main feature of their method this insistence on defining, on precise and detailed explanation of their definitions, and on proving that their definitions da correctly express (...) what a nature or activity is. A dictionary of the language of scholastic philosophy fitted to the needs of beginners and of undergraduate students of the subject is not available in English. (shrink)

I highlight a category of experiment-what I am calling 'demonstrations'-that differs in justificatory mode and argumentative role from the more familiar 'crucial tests'. 'Tests' are constructed such that alternative results are equally and symmetrically informative; they help discriminate between alternative solutions within a problem-field, where questions are shared. 'Demonstrations' are notably asymmetrical (for example, "failures" are often not telling), yet they are effective, if not "crucial," in interparadigm dispute, to legitimate questions themselves. The Ox-Phos Controversy in bioenergetics serves as an (...) integral case study. (shrink)

This chapter contains sections titled: A Method of Inquiry Doubt, Intuition, and Certainty Peirce's Reconstruction of the “method for guiding one's reason” A Transformed Ontology.

Abduction was first introduced in the epistemological context of scientific discovery. It was more recently analyzed in artificial intelligence, especially with respect to diagnosis analysis or ordinary reasoning. These two fields share a common view of abduction as a general process of hypotheses formation. More precisely, abduction is conceived as a kind of reverse explanation where a hypothesis H can be abduced from events E if H is a good explanation of E. The paper surveys four known schemes for abduction (...) that can be used in both fields. Its first contribution is a taxonomy of these schemes according to a common semantic framework based on belief revision. Its second contribution is to produce, for each non-trivial scheme, a representation theorem linking its semantic framework to a set of postulates. Its third contribution is to present semantic and axiomatic arguments in favor of one of these schemes, ordered abduction, which has never been vindicated in the literature. (shrink)

ABSTRACTDrawing on my own work and experience, this paper brings together the various connections between critical realism and ethics. It argues that, against both determinism and physicalist...

This article considers what can be learned regarding the ethical acceptability of intrusive interventions intended to halt the spread of infectious disease (‘Infection Control’ measures) from existing ethical discussion of intrusive interventions used to prevent criminal conduct (‘Crime Control’ measures). The main body of the article identifies and briefly describes six objections that have been advanced against Crime Control, and considers how these might apply to Infection Control. The final section then draws out some more general lessons from the foregoing (...) analysis for the ethical acceptability of different kinds of Infection Control. (shrink)

This article assesses what standards of safety and certainty of diagnosis need to be met in the determination of brain death. Recent medical, legal, and philosophical developments on brain death are summarized. It is argued that epistemologically adequate standards require the finding of whole-brain death rather than destruction of the cortex. Because of the possibility of positive error in misdiagnosing death, a tutioristic approach of being on the safe side is advocated. Given uncertainties in diagnosis of so-called vegetative states like (...) the apallic syndrome, anything less than whole-brain death, especially given the present state of diagnostic capability, should not qualify as an argument for removing therapy specifically on grounds that the patient is dead. (shrink)

Sustainability is typically viewed as consisting of three forces, economic, social, and ecological, in tension with one another. In this paper, we address the dangers posed to societal sustainability. The concern being addressed is the very survival of societies where the rights of individuals, personal and collective freedoms, an independent judiciary and media, and democracy, despite its messiness, are highly valued. We argue that, as a result of various technological innovations, a range of dysfunctional impacts are threatening social and political (...) stability. For instance, robotics and automation are replacing human labor and decision-making in a range of industries; search engines, monetized through advertising, have access to, and track, our interests and preferences; social media, in connecting us to one another often know more about us than we ourselves do, enabling them to profit in ways which may not coincide with our well-being; online retailers have not only acquired the ability to track and predict our buying choices, but also they can squeeze vendors based on their outsize bargaining power; and, in general, virtual technologies have changed both the way we think and our sense of self. With the rising deployment of the Internet of Things, and developments in machine learning and artificial intelligence, the threats to individual freedoms and rights, societal cohesion and harmony, employment and economic well-being, and trust in democracy are being ratcheted up. This paper lauds the benefits and addresses the harm wrought by the high tech giants in Information and Communication Technologies. The search for rapidly growing revenues drives firms to accelerate product innovation without fully investigating the entire gamut of their impacts. As greater wealth accrues to the leaders of tech firms, inequalities within firms and societies are widening, creating social tensions and political ferment. We explore the ethical nature of the challenge employing a simple utilitarian calculus, complemented by approaches rooted in rights, justice, and the common good. Various options to address the challenges posed by ICTs are considered and evaluated. We argue that regulation may do little more than slow down the damage to society, particularly since societal values and political preferences vary internationally. Firms need to establish ethical standards, imbuing the upholders of these standards with sufficient authority, while creating a culture of morality. User involvement and activism, and shareholders’ concerns for the sustainability of societies on whose continued prosperity they depend, are imperative to humanity’s ability to decide the future direction of technology. (shrink)

Do classical, contemplative philosophies have anything to teach which is relevant to life here and now? In the case of Plotinus, yes. While Platonic metaphysics is most often summarized as dualistic, where one sensible world stands apart from and in tension with an intelligible world, in the case of Plotinus this interpretation is incorrect. He does distinguish between sensibles and sense-experience, on one hand, and intelligibles and intelligible experience, on the other; but the two belong together intimately: both are located (...) in the same space, and the sensible is related to the intelligible as a shadow to its object or a reflection to what it reflects. Plotinus’ world is one. Given this picture, one rightly wonders at the status of the Plotinian exhortation for the soul to flee "alone to the Alone." Does not the journey of the soul to its source require a passing beyond of this world to some other? No, Plotinus exhortation should be understood as a reorientation, a reordering within the world here and now, not a rejection of one reality in favor of some other. This can be likened to Aesop’s fable, "The Dog and the Bone," where the dog had the choice between one real and one illusory bone, not two separate bones. Similarly, Plotinus’ world, though it can be perceived dualistically, is ontologically one; hence his metaphysics, far from otherworldly, offers a means of understanding life as it is to be lived here and now. (shrink)