Hippocampal neurogenesis has been implicated in the pathogenesis of and recovery from depression. However, most of the underlying studies were endpoint investigations in experimental animals yielding conflicting results, and it has been under debate to which extent these results could be transferred to human patients. Now, researchers have developed a powerful new tool to address these questions by a non‐invasive method in humans and animals in vivo, using magnetic resonance spectroscopy to detect a biomarker for proliferating progenitor cells that give (...) rise to new neurons.1 This makes it possible to study the role of neural progenitor cells in a wide variety of human brain disorders. BioEssays 30:806–810, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

. Each predicate of the Aristotelian square of opposition includes the word “is”. Through a twofold interpretation of this word the square includes both classical logic and non-classical logic. All theses embodied by the square of opposition are preserved by the new interpretation, except for contradictories, which are substituted by incommensurabilities. Indeed, the new interpretation of the square of opposition concerns the relationships among entire theories, each represented by means of a characteristic predicate. A generalization of the square of opposition (...) is achieved by not adjoining, according to two Leibniz’ suggestions about human mind, one more choice about the kind of infinity; i.e., a choice which was unknown by Greek’s culture, but which played a decisive role for the birth and then the development of modern science. This essential innovation of modern scientific culture explains why in modern times the Aristotelian square of opposition was disregarded. (shrink)

This volume gathers contributions on key concepts elaborated in the Platonic tradition (Proclus, Plotinus, Porphyry or Sallustius) and reconsidered by Arabic (e.g. Avicenna, the _Book of Causes_), Byzantine (e.g. Maximus the Confessor, Ioane Petritsi) and Latin authors (e.g. Albert the Great, Thomas Aquinas etc.).

L?intention de cet article est de présenter la critique et le remaniement de l?intentionnalité qu?implique l?élaboration d?une phénoménologie asub­jective chez Jan Pato?ka. À cette fin, nous exposerons d?abord les raisons qui amènent Pato?ka à prendre ses distances par rapport au subjectivisme de la phénoménologie husserlienne, et les conséquences de ce dépassement de l?horizon transcendantal de la subjectivité. Et dans un deuxième temps nous tâcherons de suivre les implications de cette destitution du subjectivisme relativement au statut et au sens de l?intentionnalité. (...) La nécessité d?élaborer une phénoménologie asubjective et de propo­ser par là une alternative au subjectivisme et à l?idéalisme implicite de la phénoménologie husserlienne découle chez Pato?ka d?une volonté de rendre compte plus authentiquement, c'est-à-dire plus phénoménologi­quement, de la structure et de la modalité de l?apparaître. En effet, c?est en s?interrogeant sur le comment de l?apparaître que Pato?ka est conduit à affirmer que celui-ci ne peut pas être expliqué à partir d?un sujet qui, avant tout, est lui-même quelque chose d?apparaissant. S?il apparaît à son tour, c?est qu?il est soumis lui-même à la légalité de l?apparaître, au lieu d?en être le principe. À partir de ces considérations, il devient possible de formuler une alternative tranchée entre deux types de phénoménologie, comme le. (shrink)

Even though Pietraszewski acknowledges the tentative nature of the theory and the multiple lines of adjacent research needed to flesh it out, he insists that the finite set of primitives he identified is necessary and sufficient for defining social groups in the context of conflict. In this commentary I expose three interrelated conundrums that cast doubt on this simplistic presumption.

The book is the proceeding of a conference in Pisa 12007 on the philosophy of Lanza del Vasto - the unique Western disciple of Gandhi - examined under the items: his thesis work in Philosophy (Fabris), his Greek and Christian methaphysics (Salmeri), his criticism of Hegel (Vigne), the relationship with Gandhi (Manara), Trinity (Vermorel) Indian philosophical traditioon (Trianni), his henologixcal thinking (Reale) his trinitarian metaphysics (Bertini), his mystical thinking (Vannini) a logicaL analysis of his thinking(Drago), his philosophy and theory of (...) non-violence(Cozzo) The relationship with Catholic Church (Tanzarella), Pedagogy (Butturini), sojourn in Pisa (Lanza). (shrink)

Quel est le rôle de Galilée dans la naissance séculaire de la science moderne? Je réponds à la question ci-dessus à la lumière de deux nouveaux éléments. Dès le xvie siècle, Nicolas de Cues, quoiqu’il ne pratiquât pas la science expérimentale, a anticipé une partie substantielle de la révolution copernicienne et de la naissance de la méthodologie galiléenne. Le deuxième élément est l’introduction d’une nouvelle conception des fondements de la science ; ils sont définis comme constitués de trois dialectiques. Après (...) cette définition, la naissance de la science moderne correspond à un très long processus historique qui se conclut à notre époque. Sur cette longue période, Galilée ne fut pas seulement le premier à recourir à une méthodologie scientifique, mais aussi presque le seul à jamais avoir été conscient de l’ampleur des enjeux intellectuels de l’entreprise scientifique. (shrink)

Cohen’s “Logic of Pure Knowledge” marks a transformation of transcendental philosophy through its new and radical interpretation of pure thinking. For Cohen, thought is in its essence creative and needs no external elements in order to produce knowledge. This study is an attempt to reconstruct the way in which Cohen understands how thinking can create its pure content from nothing. My thesis is that Kant’s distinction between the determinable and the determining I offers the theoretical context in which the productivity (...) of thinking in Cohen’s system can be understood. Thinking creates its pure content by questioning the nothing that stands before it. (shrink)

Pierre Hadot famously claimed that, between Antiquity and German Idealism, Western philosophy had lost its practical role of guiding the life of the practitioner. Scholars who challenged this view focused on two medieval models. This article argues that the overlooked work Colliget principiorum iuris naturalis, divini et humani philosophice doctrinalium by Heymericus de Campo postulates a third model. On the basis of St. Paul’s teaching about the “inner man,” Heymericus reconsiders the Aristotelian doctrines of abstraction and of being as such (...) in relation to the Neoplatonic model of intellectual progression and interior conversion. In a realist conceptual framework, he holds that only metaphysics reflects the true nature of the human being inasmuch as it presupposes a way of life that assumes both the interaction with and withdrawal from the sensible world. However, Heymericus’ theory is neither limited to nor conditioned by Christian principles, but by Peripatetic philosophy. (shrink)

Ce livre est consacré aux auteurs qui ont repris la pensée d’Averroès dans le monde latin entre 1250 et 1350. De nouvelles remarques sur la polysémie du terme averroista précèdent les grands thèmes abordés : le retour numériquement identique au corps corrompu, le rapport entre matière et puissance, la nécessité et la contingence, l’intellect agent et possible. Des manuscrits et des textes inédits jusqu’à ce jour sont au coeur des discussions qui apportent la preuve que des doctrines puisées dans l’œuvre (...) d’Averroès circulaient entre les Universités de Paris, Oxford, Bologne et Padoue. Sans prétendre aborder tous les aspects de l'averroïsme latin de cette période, le livre reprend sur nouveaux frais des questions considérées comme résolues et propose de nouvelles perspectives de recherche. (shrink)

An amendment to this paper has been published and can be accessed via the original article.

(1997). Information science as a paradigmatic instance of a problem‐based theory. World Futures: Vol. 49, The Quest for a Unified Theory of Information, pp. 251-273.

Recent years have witnessed a search for new sources for archaeological inspiration within areas which until recently have not been imagined as a source for science. Archaeology has become more â oeanthropologizedâ, and, as such, is becoming increasingly influenced by the Zeitgeist, although some European schools are yet to recognize this. The process of scientific research that archaeologists have always considered to be an objective approach has been revealed to be the result of different subjective cognitive processes, forming part of (...) the contemporary humanistic paradigm, a fact confirmed by new tendencies in contemporary archaeology. Consequently, this book considers the question: how does the archaeologist think today? Beginning with simple analogies issued from archaeological experiments or from ethnography, the structure of the contemporary archaeological thought is increasingly complex, working today with concepts that only yesterday were a subject of study. This book considers these new types of approaches, through a series of personal narratives provided by archaeologists, describing their working methods in the process of imagining the past. (shrink)

The contribution by De Dreu and Gross oversimplifies the complexity of the topic. I provide counterarguments that undermine the two sweeping contentions on which the article's argument depends, and I argue that asymmetric conflict is best understood at the finer-grained level of studying the sequences of strikes and counterstrikes that the rival actors have in store for one another.

Nella storia della metafisica è stato un grande problema come chiarire l’idea della coincidentia oppositorum (la coincidenza degli opposti) di Cusano, il quale è riconosciuto comunque da Cassirer come il primo epistemologo del pensiero moderno, in particolare come colui che ha saputo conquistare l’infinito alla mente umana. Dopo alcuni secoli, ha avuto una grande importanza una idea simile a quella di Cusano, la dialettica di Hegel, la quale aggiunge una negazione ad una prima frase negata per ottenere una sintesi in (...) termini generali. Ma poi queste idee sono state sempre meno seguite, eccetto che nel XX secolo da un filosofo non accademico, Lanza del Vasto che ha criticato Hegel e si è ricondotto a Cusano. Nello scritto esamino questa tematica mediante gli strumenti recentemente forniti dalla logica matematica, già verificati sugli scritti di altri scienziati; essi sono capaci di distinguere con precisione che cosa, negli scritti di uno studioso, è un passaggio logico formale e che cosa è una semplice illazione, derivata dalla conoscenza comune o dalla sua creatività; e se è un passaggio logico, decidere di che tipo di logica è. Per mezzo di questo metodo formale, i) presento alcune caratteristiche del ragionare di Cusano; ii) critico il metodo di Hegel; il risultato si accorda con la analisi critica di Hegel che Lanza del Vasto ha compiuto in maniera intuitva; iii) dimostro che la relazione tra Cusano e Lanza del Vasto è più forte di quanto dichiara quest’ultimo; iv) suggerisco una spiegazione della coincidentia oppositorum, chiarendo che la novità di ragionare in logica non classica è stata così innovativa che il tentativo di Cusano di precisarne il metodo è risultato in una scorciatoia, non errata ma valida solo in alcune situazioni; mentre è stato deviante il tentativo di Hegel; Lanza del Vasto, che ha portato un contributo al metodo di Cusano, si è comunque reso conto che occorreva arrivare a formalizzare un nuovo tipo di logica, che oggi risulta essere quella non classica. In definitiva, occorre attribuire a Cusano il merito di aver suggerito una nuova maniera di razionalità logica, quella capace di ragionare in logica non classica e di averne dato, sia pure in maniera imprecisa ed oscura, una prima formalizzazione. (shrink)

“Conflict” in the Works of Michel de Montaigne The “philosophical” style specific to Montaigne’s Essays, totally devoid of demonstration and system, gives the reader the possibility of “essaying” an experience of his own reading, based on the idea that “Words belong half to the speaker, half to the hearer” (III, 13). Following Montaigne’s idea that selfishness is the basis of solidarity between men (the basis of society), we can detect two levels in this political conception: 1) on the one hand, (...) the relationship between the individual subject and his own complex state; 2) on the other hand, the relationship of the individual to otherness. For Montaigne, the first level is a priority and, as his own political experience shows, the individual subject has above all the duty to remain true to himself and to his own temperament. The duty to serve others is secondary, occasional and moderate. To complete the ideas that can constitute a “map” of Montaigne’s political philosophy, we have analyzed – quantitatively and qualitatively – the contexts in which the French philosopher used the word “conflict”. The examples confirm the predominance of the interior level of the individual subject and less of the relationship of the individual to otherness. To be active in the public sphere, the individual needs modesty and moderation in the expression of his opinions, as well as a rational evaluation when he wishes major changes; otherwise, they risk doing more harm than good to others. The individual must struggle internally with the weapons of reason, so as not to give in to irrational desires – such as revenge or carnal desires – which would affect others, which is virtue. An inner balance is necessary, and the others will gain from this. (shrink)

One can know how to ride a bicycle, play the cello, or collect experimental data. But who can know how to properly ride a tandem bicycle, perform a symphony, or run a high-energy physics experiment? Reductionist analyses fail to account for these cases strictly in terms of the individual know-how involved. Nevertheless, it doesn't follow from non-reductionism that groups possess this know-how. One must first show that epistemic extension cannot obtain. This is the idea that individuals can possess knowledge even (...) when others possess some of the epistemic materials generating it. I show that only knowledge-that can be epistemically extended, not knowledge-how. Appeal to epistemic extension is a viable way of avoiding group knowledge-that ascriptions but not group knowledge-how ascriptions. Therefore, groups can know how. (shrink)

According to the transcendental Aesthetic of the Critique of pure reason, there are two properties of time that cannot be intellectualized: passage and infinitude. This study tries to show that these essential properties of time come to light in Kant’s Critique of Judgment. The contemplation of beauty will be understood as a non-successive time and the wonder that we experience in seeing the sublime will be understood through Kant’s concept of infinite moment. These two aesthetic concepts of time will be (...) integrated into Kant’s broader view of time as developed in the first Critique. (shrink)

Nicolas d’Autrécourt (c. 1298-1369) est l’un des penseurs les plus audacieux de l’histoire de la philosophie, et Zénon Kaluza, qui lui a consacré près de trente ans d’études, nous le fait découvrir par ses sources, ses doctrines et ses manuscrits. Ce livre propose notamment des analyses sur des thèmes importants (tels que la perception, la causalité finale, les catégories ou l’éternité du monde) ainsi qu’une nouvelle édition des Prologues de l’Exigit ordo, enrichie d’un commentaire suivi. Les études—dont certaines sont parues (...) mais difficiles d’accès et d’autres sont inédites—dévoilent la figure d’un philosophe désirant de libérer la philosophie des contraintes institutionnelles et de critiquer la métaphysique d’Aristote, au risque de bouleverser les traditions, de contredire les dogmes de la foi et se voir condamner par les autorités théologiques de son temps. Nicolas d'Autrécourt (c. 1298-1369) is one of the most daring thinkers in the history of philosophy, and Zénon Kaluza, who has devoted to him nearly thirty years of study, presents him to us through his sources, his doctrines and his manuscripts. The reader will find studies on some of the most relevant philosophical doctrines (such as perception, the final causality, the categories and the eternity of the world) as well as a new edition of the Prologues of the _Exigit ordo_, enriched with a running commentary. The texts gathered here—some of which have been published previously but are difficult to access and others which have been unpublished until now—reveal a philosopher who wished to free philosophy from institutional constraints and dared to criticize Aristotle's metaphysics, at the risk of upsetting traditions and contradicting the dogmas of the faith, and who was condemned by the theological authorities of his time. (shrink)

_Reading Proclus and the_ Book of Causes: _Western Scholarly Networks and Debates, Volume 1_ provides a fresh account, based on previously unknown documents, of the diffusion of Hellenic and Islamic thought in the Latin West (12th -16th centuries).

Current developments in fields such as quantum physics, fine arts, robotics, cognitive sciences or defense and security indicate the emergence of creative systems capable of producing new and innovative solutions through combinations of machine learning algorithms. These systems, called machine invention systems, challenge the established invention paradigm in promising the automation of – at least parts of – the innovation process. This paper’s main contribution is twofold. Based on the identified state-of-the-art examples in the above mentioned fields, key components for (...) machine invention systems and their relations are identified, creating a conceptual model as well as proposing a working definition for machine invention systems. The differences and delimitations to other concepts in the field of machine learning and artificial intelligence, such as machine discovery systems are discussed as well. Furthermore, the paper briefly addresses the social and societal implications and limitations that come with the adoption of the technology. Because of their revolutionizing potential, there are widespread implications to consider from ethical and moral implications to policymaking and societal changes, like changes in the job structure. The discussion part approaches some of these implications, as well as solutions to some of the proposed challenges. The paper concludes by discussing some of the systemic benefits that can be accessed through machine invention. (shrink)

If we accept that Kandinsky developed a systematic theory of the fundamentals of painting, we must ask what is the central concept underlying this attempt. This paper argues for the thesis that objectless vibration plays a central role in the reconstruction proposed Kandinsky’s first book, ”Concerning the Spiritual in Art”. This kind of vibration includes as a virtual field both shapes, sounds and colors. All these “fall” in an organized way from the virtual vibrations, and the purpose of abstract painting (...) is to lift the mind beyond the specific distinctions of the visible world of objects to the abstract level of primordial vibrations. The article examines the origin, functions, and the effect this concept has on color theory. (shrink)

I characterize Bishop's constructive mathematics as an alternative to classical mathematics, which makes use of the actual infinity. From the history an accurate investigation of past physical theories I obtianed some ones - mainly Lazare Carnot's mechanics and Sadi Carnot's thermodynamics - which are alternative to the dominant theories - e.g. Newtopn's mechanics. The way to link together mathematics to theoretical physics is generalized and some general considerations, in particualr on the geoemtry in theoretical physics, are obtained.that.

I connect two increasingly popular ideas in social epistemology—group knowledge and epistemic extension—both departures from mainstream epistemological tradition. In doing so, I generate a framework for conceptualizing and organizing contemporary epistemology along several core axes. This, in turn, allows me to delineate a largely unexplored frontier in group epistemology. The bulk of extant work in group epistemology can be dubbed intra-group epistemology: the study of epistemically salient happenings within groups. I delineate and attempt to motivate what I dub inter-group epistemology: (...) the study of epistemically salient happenings between groups and other subjects and entities. (shrink)

BackgroundThis paper highlights the issues that one of the 90 Italian Research Ethics Committees (RECs) might encounter during the approval phase of a clinical trial to identify corrective and preventive actions for promoting a more efficient review process and ensuring review quality. Publications on the subject from Italy and the rest of Europe are limited; encouraging constructive debate can improve RECs’ service to the subject of the clinical trial.MethodsWe retrospectively reviewed a cohort of 822 clinical trial protocols, initially reviewed by (...) REC, from June 2014 to December 2018. Data collected for each protocol were type of trial, sample size, use of placebo, number and kind of revisions requested by the REC before approval, and time taken for approval. Data for each protocol were collected by a trained clinical research assistant using the REC’s files and electronic archives.ResultsAlmost 45% of the reviewed studies (374/822) required clarifications, significant changes to the documentation, or minor changes before final approval.ConclusionsPreventive measures are needed to reduce the number of requested corrections and thus also the time required for approval, while maintaining review quality. All critical points and proposals presented in this paper require harmonization through updates to European regulations, as regulatory harmonization produces better compliance with rules and reduces the number of changes required before the trials’ final approval. Such updates include the development of standardized formats for informed consent, the verification of any evidence in favor of using off-label treatments over placebo as comparators, using multidisciplinary staff in clinical trials with children and adolescents, improving the legal definition of RECs to assign responsibilities and ensure independence, and providing guidance for RECs to engage clinical research assistants in internal audits. (shrink)

Kristina Rolin and Brad Wray agree with an increasing number of epistemologists that knowledge can sometimes be attributed to a group and to none of its individual members. That is, collective knowledge sometimes obtains. However, Rolin charges Wray with being too restrictive about the kinds of groups to which he attributes collective knowledge. She rejects Wray’s claim that only scientific research teams can know while the general scientific community cannot. Rolin forwards a ‘default and challenge’ account of epistemic justification toward (...) her argument that even the general scientific community can know because it’s sometimes the general scientific community, and none of its individual members, that attains epistemic justification. I argue that Rolin faces a dilemma: either she must herself be more restrictive about the kinds of groups to which she attributes collective knowledge or she must concede the general claim that collective knowledge obtains at all. (shrink)

For many centuries, philosophers have debated this question: “Does God exist?” Surprisingly, they have paid rather less attention to this distinct – but also very important – question: “Would God’s existence be a good thing?” The latter is an axiological question about the difference in value that God’s existence would make (or does make) in the actual world. Perhaps the most natural position to take, whether or not one believes in God, is to hold that it would be a very (...) good thing if such a being were to exist. After all, God is traditionally thought to be perfectly powerful and good, and it might seem obvious that such a being’s existence would make things better than they would otherwise be. But this judgment has been contested: some philosophers have held that God’s existence would make things worse, and that, on this basis, one can reasonably prefer God’s non-existence. We first distinguish a wide array of axiological positions concerning the value of God’s existence which might be held by theists, atheists, and agnostics alike. We next construe these positions as comparative judgments about the axiological status of various possible worlds. We then criticize an important recent attempt to show that God’s existence would make things worse, in various ways, than they would otherwise be. (shrink)

Thomas Kuhn explicitly states that the paradigm shift implies a change of the world. This is because the paradigm is seen as constitutive of nature itself. In this paper, I will try to interpret this thesis by inscribing Kuhn's theory in the larger Kantian theoretical framework. As the last chapter of the „Critique of pure reason” shows, Kant thought that reason is inherently historical and evolves through revolutions. This dynamical perspective on reason comes clearly to light especially in the „Appendix” (...) to the „transcendental Dialectic”, where the Idea of reason is seen as an abstract theoretical framework that makes possible and guides the understanding. It will be shown that the Kuhnian paradigm and the Kantian transcendental Ideea function in similar ways. Both serve as an orientation for scientific research, they make rules possible, and constitute nature in a weak, indirect, way. The relation between Ideea and understanding in the first „Critique” parallels in many ways the kuhnian relation between paradigm and normal science. (shrink)

Reading Proclus and the Book of Causes, published in three volumes, is a fresh, comprehensive understanding of Proclus' legacy in the Hellenic, Byzantine, Islamic, Latin and Hebrew traditions. The history of the Book of Causes, an Islamic adaptation of mainly Proclus' Elements of Theology and Plotinus' Enneads, is reconsidered on the basis of newly discovered manuscripts. This first volume enriches our understanding of the diverse reception of Proclus' Elements of Theology and of the Book of Causes in the Western tradition (...) where universities and religious schools offered unparalleled conditions of diffusion. The volume sheds light on overlooked authors, texts, literary genres and libraries from all major European universities from the 12th to the 16th centuries. (shrink)

La notion d’ordre public trouve des expressions diverses dans la norme constitutionnelle. Tantôt norme d’habilitation, tantôt moyen de conciliation entre des principes constitutionnels antagonistes, l’ordre public est un objectif de valeur constitutionnelle qui s’impose au législateur et qui est susceptible de restreindre l’exercice de certaines libertés. Plus fondamentalement, la Constitution apparaît comme une règle, par nature, d’ordre public.

The paper examines the meaning of a Hegelian expression: “the ascension of the human spirit to God”, which was formulated in the philosopher’s 1829 summer course dedicated to the proofs of God’s existence. We argue that the Hegelian formula describes a double movement: the first one refers to the departure of thinking from the Phenomenon and its arrival to the Ideal, and the second one describes the opposite movement, in which thinking crosses the barrier between the Ideal and the Phenomenon.

This paper aims to show that Lessing develops in his aesthetics a pre-Kantian philosophy of consciousness. The concept of virtuality that the german writer puts forward in his essay Laocoon implies an interweaving of temporal dimensions similar to the threefold temporal synthesis described by Kant in the transcendental deduction of the Critique of Pure Reason. But whereas Kant thematizes an a priori of consciousness, Lessing is in search of an a priori of plastic art. It will be seen that perfect (...) sculpture presupposes the choice of that moment in time which can open the imagination to the past and the future in a way that enriches the present by transforming it into a "pregnant moment". The final aim of the article is to trace the genesis of the concept of simultaneity of temporal dimensions presupposed by the idea of the pregnant moment, and its implications for the idea of the temporality of consciousness. (shrink)