Following extensive examination of published and unpublished materials, we provide a history of the use of dexamethasone in pregnant women at risk of carrying a female fetus affected by congenital adrenal hyperplasia (CAH). This intervention has been aimed at preventing development of ambiguous genitalia, the urogenital sinus, tomboyism, and lesbianism. We map out ethical problems in this history, including: misleading promotion to physicians and CAH-affected families; de facto experimentation without the necessary protections of approved research; troubling parallels to the history (...) of prenatal use of diethylstilbestrol (DES); and the use of medicine and public monies to attempt prevention of benign behavioral sex variations. Critical attention is directed at recent investigations by the U.S. Food and Drug Administration (FDA) and Office of Human Research Protections (OHRP); we argue that the weak and unsupported conclusions of these investigations indicate major gaps in the systems meant to protect subjects of high-risk medical research. (shrink)

The “binding problem” has been a central question in vision science for some 30 years: When encoding multiple objects or maintaining them in working memory, how are we able to represent the correspondence between a specific feature and its corresponding object correctly? In this letter we argue that the boundaries of this research program in fact extend far beyond vision, and we call for coordinated pursuit across the broader cognitive science community of this central question for cognition, which we dub (...) “Binding Problem 2.0”. (shrink)

Research on the cognitive consequences of bilingualism typically proceeds by labeling participants as “monolingual” or “bilingual” and comparing performance on some measures across these groups. It is well-known that this approach has led to inconsistent results. However, the approach assumes that there are clear criteria to designate individuals as monolingual or bilingual, and more fundamentally, to determine whether a communication system counts as a unique language. Both of these assumptions may not be correct. The problem is particularly acute when participants (...) are asked to classify themselves or simply report how many languages they speak. Participants' responses to these questions are shaped by their personal perceptions of the criteria for making these judgments. This study investigated the perceptions underlying judgments of bilingualism by asking 528 participants to judge the extent to which a description of a fictional linguistic system constitutes a unique language and the extent to which a description of a fictional individual's linguistic competence qualifies that person as bilingual. The results show a range of responses for both concepts, indicating substantial ambiguity for these terms. Moreover, participants were asked to self-classify as monolingual or bilingual, and these decisions were not related to more objective information regarding the degree of bilingual experience obtained from a detailed questionnaire. These results are consistent with the notion that bilingualism is not categorical and that specific language experiences are important in determining the criteria for being bilingual. The results impact interpretations of research investigating group differences on the cognitive effects of bilingualism. (shrink)

Metaphors abound in descriptions of the COVID-19 pandemic: it is described, among other things, as a war, a flood, and a marathon. However, not all metaphors may resonate equally well with members...

The thought of contemporary North American theologian and ethicist Wendy Farley is an unflinching clarion call to justice and compassion. Farley invites us to discover ways of embodying the deep compassion capable of resisting pernicious distortions and traumatizing injustices that harm and dehumanize us all. This volume of essays embodies her invitation to awaken as beloved community. And when we are overwhelmed by the magnitude of struggle and despair, Farley reminds us that the powerful longing of hope, at times against (...) all evidence, refuses to give up on seeking justice and wholeness. Compassionate justice, radical hospitality, creative liberation, and deep listening emerge as more than ethical values for Farley; they are expressions of erotic faith, a praxis of faithfulness born of divine desire. These writings explore transformative perspectives and practices that have the capacity to help us recover and author our identity as the "god-bearers" we are. Erotic faith embodies the love-seeking persistence of divine faithfulness necessary to transform us from within; it meets the truth of human harm, vulnerability, and suffering by offering a complex, struggling, unscripted creativity capable of remaking us, and our world, until the beloved community is whole. (shrink)

The mutual interaction and interdependence of race, class, and gender create profound political dilemmas for feminist activists. How can we create coherent, inclusive political movements when the very oppressions we seek to dismantle also divide us internally? This article seeks answers to this question by exploring the history of the Southeast Women's Employment Coalition, which throughout the 1980s sought to unify working-class women in the South across the divide of race. The article concludes that gender is insufficient to effect political (...) unity among racially diverse women, but that a “politics of solidarity,” based on an appreciation of the intersections of race, gender, and class, is possible. (shrink)

In this Chapter I present early Mesopotamian philosophical views and contrast them to En Hedu’Anna’s account of metaphysics, epistemology, ontology, philosophy of religion and her views on several socio-political issues. Through her writings we see her views of the cosmos, of deities, of women’s nature, gender fluidity, justifications for violence, and other significant concepts. Lastly, I summarize her influence and suggest that her work marks a new dawn, a first, for Philosophy.

Most readers of Louis Althusser first enter his work through his writings on ideology. In an important new essay Étienne Balibar, friend and colleague of Althusser, offers an original reading of Althusser’s idea of ideology, drawing on both recently published posthumous writing and Althusser's work on the Piccolo Teatro di Milano. Balibar’s essay uncovers the intricate workings of interpellation through Althusser’s essays on the theater. If debates on dialectical materialism belong to a distant history, Balibar suggests, the question of ideology (...) remains crucial for thinking the present. The issue includes commentaries on Balibar’s essay from five influential scholars who engage critically with Althusser’s philosophy: Judith Butler, Banu Bargu, Adi Ophir, Warren Montag, and Bruce Robbins. This issue reanimates Althusser’s concept of ideology as an analytic tool for contemporary cultural and political critique. (shrink)

Ellen Meiksins Wood is a leading contemporary political theorist who has elaborated an innovative approach to the history of political thought, the social history of political theory .

Based on the conception of life and semiosis as co-extensive an attempt is given to classify cognitive and communicative potentials of species according to the plasticity and articulatory sophistication they exhibit. A clear distinction is drawn between semiosis and perception, where perception is seen as a high-level activity, an integrated product of a multitude of semiotic interactions inside or between bodies. Previous attempts at finding progressive trends in evolution that might justify a scaling of species from primitive to advanced levels (...) have not met with much success, but when evolution is considered in the light of semiosis such a scaling immediately catches the eye. The main purpose of this paper is to suggest a scaling of this progression in semiotic freedom into a series of distinct steps. The elleven steps suggested are: 1) molecular recognition, 2) prokaryote-eukaryote transformation, 3) division of labor in multicellular organisms, 4) from irritability to phenotypic plasticity, 5) sense perception, 6) behavioral choice, 7) active information gathering, 8) collaboration, deception, 9) learning and social intelligence, 10) sentience, 11) consciousness. In light of this, the paper finally discusses the conceptual framework for biosemiotic evolution. The evolution of biosemiotic capabilities does not take the form of an ongoing composition of simple signs into composite wholes. Rather, it takes the shape of the increasing subdivision and control of a primitive, holophrastic perception-action circuit already committed to “proto-propositions” reliably guiding action already in the most primitive species. (shrink)

Journal Name: Semiotica - Journal of the International Association for Semiotic Studies / Revue de l'Association Internationale de Sémiotique Volume: 2014 Issue: 198 Pages: 11-31.

The threshold from unicellularity to multicellularity has been crossed only in three major living domains in evolution with any lasting success. The hard problem was to create a multicellular self. Such a self is vulnerable to breakdown due to the unavoidable appearance of mutant anarchistic cells, and stringent semiotic scaffoldings had to emerge to prevent this. While a unicellular self may go on to live practically forever, the multicellular self most often must run through an individuation process ending in the (...) death of the individual. Due to basic differences in cells of plants, fungi and animals this individuation process poses very different challenges in the three kingdoms of plants, fungi and animals, and the solutions found to these differences are discussed. In the same time as multicellularity ushered life into the epoch of mortality it logically also led to the appearance of fertilization and thereby the need for a whole new set of elaborate semiotic scaffoldings. Multicellularity also opened the door to the formation symbiotic relations where cells with different genomes might collaborate or at least coexist inside the same body. All in all multicellularity led to an enormous diversification both of morphology space and the space of sensomotoric elaborations. New means for scaffolding of this expansion and diversification of possible life forms into functional patterns called for a corresponding growth in the space of semiotic tools and initiated a growth in semiotic freedom, that has continued to our days. (shrink)

Most bodies in this world do not have brains and the minority of animal species that do have brained bodies are descendents from species with more distributed or decentralized nervous systems. Thus, bodies were here first, and only relatively late in evolution did the bodies of a few species grow supplementary organs, brains, sophisticated enough to support a psychological life. Psychological life therefore from the beginning was embedded in and served as a tool for corporeal life. This paper discusses the (...) semiotically controlled dynamics of bodily existence that has allowed the evolution of these seemingly ‘unnatural’ mental and even linguistic kinds of species. It is shown how the skin, on the one hand, makes us belong in the world, and on the other hand, is part of the huge landscape of membranes across which the semiotic self incessantly must be reconstituted. The discussion moves on to the intracellular world of signal transduction through which the activity of single cells are put to service for bodily needs. The paper further considers the mechanisms behind homeostasis and the semiotics of the psycho-neuro-endocrine integration in the body. The concept of semiotic emergence is introduced and a holistic marker hypothesis for why some animals may have an experiential life is suggested. (shrink)

In strict opposition to the prevailing positivist conception of nature as senseless and deprived of meaning Jakob von Uexküll claimed that a certain planmässigkeit was operative in nature. This idea however might be taken to mean that organic evolution is not itself a creative process but a gradual, if majestic, unfolding of Nature's own master plan. Such an idea would threaten to restore determinism in the center of biological theory, and this would seriously contradict the vision of biosemiotics shared by (...) most of its proponents. It lies at the heart of biosemiotics and of Peircean cosmological philosophy that indeterminacy is primary, that “habit taking” or interpretation are real processes in the world, and therefore that belief in the law of necessity is unfounded. It is suggested that Uexküllian planmässigkeit is in fact reconcilable with a modern non-deterministic understanding. In a certain sense the Umwelten of animals have indeed developed in accordance to a natural planmässigkeit, but this is a plan that incessantly traps life in certain strategic choices and in the same time diversifies the dimensionality of options for dealing with these choices, i. e. “the adjacent possible” in the terms of Stuart Kauffman. (shrink)

Introduction: Semiotic ScaffoldingA central idea in biosemiotic writings has been the idea of growth in semiotic freedom as a persistent trend in evolution . By semiotic freedom we mean the capacity of species or organisms to derive useful information by help of semiosis or, in other words, by processes of interpretation in the widest sense of this term. While even bacteria have a certain very limited ability to interpret cues in the medium this ability obviously becomes more developed in more (...) complex organisms, and is typically most developed in big-brained animals that are late arrivals at the evolutionary scene. The evolution of a richer semiotic capacity is of course only one among many strategies available in the evolutionary game. Yet, this particular strategy potentially ignites a self-perpetuating evolutionary dynamics, since each step taken by a species along this route potentially opens new agendas for further change:the more capable some species ar .. (shrink)

A 1999–2000 national study of U.S. hospitals raised concerns about ethics consultation (EC) practices and catalyzed improvement efforts. To assess how practices have changed since 2000, we administered a 105-item survey to “best informants” in a stratified random sample of 600 U.S. general hospitals. This primary article details the methods for the entire study, then focuses on the 16 items from the prior study. Compared with 2000, the estimated number of case consultations performed annually rose by 94% to 68,000. The (...) median number of consults per hospital was unchanged at 3, but more than doubled for hospitals with 400+ beds. The level of education of EC practitioners was unchanged, while the percentage of hospitals formally evaluating their ECS decreased from 28.0% to 19.1%. The gap between large, teaching hospitals and small, nonteaching hospitals widened since the prior study. We suggest targeting future improvement efforts to hospitals where needs are not being met by current approaches to EC. (shrink)

The belief in a world governed by natural law has meant that our ideas of good thinking have increasingly turned toward formalizable schemes, suitable to support ideas of consistency, accuracy, and disembodied clarity. The idea that thinking might be a bodily thing hasn't been much appreciated among philosophers of this tradition. Yet, we shall pursue this line of thought in this paper. It is suggested that knowledge is not something we have but something created in the very moment of use. (...) The same goes for other essential concepts such as for instance causality. Causality is seen as a human bodily experience. Causality is an experience, and from this fact follows that the Newtonian world must be turned upside down. The laws of gravity are not something "out-there" but something "in-here". (shrink)

A sign is something that refers to something else. Signs, whether of natural or cultural origin, act by provoking a receptive system, human or nonhuman, to form an interpretant (a movement or a brain activity) that somehow relates the system to this "something else." Semiotics sees meaning as connected to the formation of interpretants. In a biosemiotic understanding living systems are basically engaged in semiotic interactions, that is, interpretative processes, and organic evolution exhibits an inherent tendency toward an increase in (...) semiotic freedom. Mammals generally are equipped with more semiotic freedom than are their reptilian ancestor species, and fishes are more semiotically sophisticated than are invertebrates. The evolutionary trend toward the production of life forms with an increasing interpretative capacity or semiotic freedom implies that the production of meaning has become an essential survival parameter in later stages of evolution. (shrink)

This volume gathers scholars from ecology, biochemistry, evolutionary biology, cognitive science, anthropology and philosophy to discuss how Gregory Bateson's thinking might lead to a reframing of central problems in modern science.

To design effective strategies to improve ethics consultation (EC) practices, it is important to understand the views of ethics practitioners. Previous U.S. studies of ethics practitioners have overrepresented the views of academic bioethicists. To help inform EC improvement efforts, we surveyed a random stratified sample of U.S. hospitals, examining ethics practitioners’ opinions on EC in general, on their own EC service, on strategies to improve EC, and on ASBH practice standards. Respondents across all categories of hospitals had very positive perceptions (...) of their own ethics consultation service (ECS) and few concerns about quality. Our findings suggest that the ethics-related needs of small, rural, non-teaching hospitals may be very different from those of academic medical centers, and therefore, different approaches to addressing ethical issues might be warranted. (shrink)

To address the current lack of knowledge about clinical ethics fellowship programs (CEFPs), we surveyed all 36 programs in the U.S. and Canada. The number of CEFPs has grown exponentially over the last 40 years and far exceeds previous estimates. Commonalities among CEFPs include: 88.8% require an advanced degree or rarely accept applicants without one; 91.7% of programs do not restrict applicants to a specific background such as medicine or philosophy; and 88.9% of programs compensate fellows. CEFPs vary widely on (...) numbers of fellows trained in the last 3 years (1–111), numbers of consultations performed by each fellow (0–450), and salaries paid ($0-$95,000). Less than half of programs meet CEFP standards established by ABPD. Nonpaying programs and larger programs tend to have lower admission standards and lower expectations for fellows. We hope these data will help inform CEFP standards that promote quality and consistency without stifling desirable diversity and innovation. (shrink)

The development of form in living organisms continues to challenge biological research. The concept of biological information encoded in the genetic program that controls development forms a major part of the semiotic metaphor in biology. Development is here seen in analogy to an execution of a program, written in a formal language in the computer. Other versions of the semiotic or "nature-as-language" metaphor use other formal or informal aspects of language to comprehend the specific structural relations in nature as explored (...) by molecular and evolutionary biology. This intuitively appealing complex of related ideas, which has a long history in the philosophy of nature and biology, is critically reviewed. The general nature of metaphor in science is considered, and different levels of metaphorical transfer of signification is distinguished. It is argued, that the metaphors may be of considerable value, not only heuristically, but in order to comprehend the irreducible nature of living organisms. In arguing for a semiotic perspective on living nature, it makes a marked difference whether the departure is made from the tradition of F. de Saussure´s structural linguistics or from the tradition of general semiotics of C. S. Peirce. An agenda is made for a Peircean perspective on the semiotics of nature. (shrink)

Coverage error is an important type of error that occurs in survey studies when there is a mismatch between the target population and the sampling frame from which a sample is drawn. Coverage error...

Interest in teaching business ethics classes on college campuses has increased dramatically during the past decade. In the United States, virtually all graduate and undergraduate business programs teach business ethics in some form. While current pedagogy relies primarily on factual recounting of actual workplace incidents and actual and hypothetical case studies, calls for multidisciplinary approaches to teaching business ethics have not yet produced significant pedagogical change. We propose the use of fiction (novels, dramas, and short stories) to enrich current teaching (...) materials. This paper illustrates the tremendous power of stories which deal with ethical dilemmas in business to illuminate moral issues in ways that lead to a clearer understanding of ethical theory. The fiction cited in this paper is all drawn from American literature. It seems likely that similar sources could be found in the literature of other countries. (shrink)