We recently examined gene expression during Xenopus tadpole tail appendage regeneration and found that carbohydrate regulatory genes were dramatically altered during the regeneration process. In this essay, we speculate that these changes in gene expression play an essential role during regeneration by stimulating the anabolic pathways required for the reconstruction of a new appendage. We hypothesize that during regeneration, cells use leptin, slc2a3, proinsulin, g6pd, hif1α expression, receptor tyrosine kinase (RTK) signaling, and the production of reactive oxygen species (ROS) to (...) promote glucose entry into glycolysis and the pentose phosphate pathway (PPP), thus stimulating macromolecular biosynthesis. We suggest that this metabolic shift is integral to the appendage regeneration program and that the Xenopus model is a powerful experimental system to further explore this phenomenon.Also watch the Video Abstract. (shrink)

The articles presents my journey with "Live Poetry" a participatory poetry methods created by Luis Enrique Amaya in Perù. This journey is marked by three encounters I had, that convinced me of the depth of the beauty and healing this journey can bring. The first occurs in Cali, Colombia, in a vast set of working-class neighbourhoods called Distrito de Agua Blanca. This area is dominated by drug trafficking and invisible borders between rival gangs. Teenagers experience a daily life (...) of violence and neglect. In this neighbourhood, I meet Luis Enrique Amaya, poet and social activist from Lima, Peru. Today, Luis will lead a poetry workshop with teenagers in the neighbourhood. It is based on a community poetry method he created years before with his collaborators. The workshop today will have two phases. In the first phase, the poet interviews a passer-by, a member of the community, and asks them to talk about someone important to her or him (a family member, a friend, a lover). In the second phase, the poet asks the interviewee to wait for few minutes. Then the poet sits alone for about ten minutes and composes a poem dedicated to the person chosen by the interviewee. When he has finished, the poet gives the poem to the interviewee as a gift saying: “After listening to you, I composed this poem and I give it to you as a gift. But beware: it is not for you. It is to invite you give it as a gift to the person you told me about”. (shrink)

ENRIQUE BONETE: Neuroética práctica, Desclée de Brouwer, 2011, 192 pp.; JOSÉ MANUEL GIMÉNEZ AMAYA y SERGIO SÁNCHEZ-MIGALLÓN: De la Neurociencia a la Neuroética, Navarra, EUNSA 2010, 192 pp.; KATHINKA EVERS: Neuroética. Cuando la materia se despierta, Argentina- España, Katz, 2011, 208 pp.

This volume gathers papers by many of the best-known philosophers now at work on issues of realism and relativism across the field of philosophy.

La educación tiene un objetivo principal según las principales regulaciones educativas estatales e internacionales: la consecución de una serie de competencias. Aunque quepa piensar de competencias sociales, cívicas o éticas, la idea central de esta perspectiva es que la educación debe servir en primer lugar para el desempeño de una profesión, que definirá el éxito social de los educandos. El objetivo principal de este artículo es cuestionar filosóficamente la validez de ese objetivo. Sostenemos que la adquisición de competencias debe permanecer, (...) pero basarse y quedar supeditada a la adquisición de las virtudes. Esta respuesta remite al pensamiento de Leonardo Polo y permite una comprensión de la educación basada en su cultivo. (shrink)

El artículo analiza el discurso de S. Kierkegaard “Todo buen don y toda dádiva perfecta viene de arriba” y lo articula con otros dos Discursos edificantes. La articulación procura, primero, elucidar por qué el sí mismo auténtico es aquel que asume que no puede nada. Segundo, muestra silencio, obediencia y alegría como las actitudes fundamentales sobre cuya base el sí mismo auténtico es en el mundo y caracteriza la fe originaria implícita en ellas como su condición de posibilidad. Finalmente, explicita (...) el mundo en el que es el sí mismo auténtico como sitio justo abierto a la espera del reino. (shrink)

A Steiner triple system (STS) is a set S together with a collection B of subsets of S of size 3 such that any two elements of S belong to exactly one element of B. It is well known that the class of finite STS has a Fraïssé limit M_F. Here, we show that the theory T of M_F is the model completion of the theory of STSs. We also prove that T is not small and it has quantifier elimination, (...) TP2, NSOP1, elimination of hyperimaginaries and weak elimination of imaginaries. (shrink)

Esta ponencia presenta un avance parcial de la investigación sobre la democracia en los municipios colombianos desde la adopción de la elección popular de los alcaldes. A partir de una conceptualización básica y operacional de la democracia se determinan sus principales dimensiones y se presentan los resultados obtenidos para algunas variables significativas que se han procesado, aplicando técnicas de análisis multivariado. El objetivo final (aún en elaboración) es generar un índice de calidad democrática que permita comparar y explicar los avances (...) y retrocesos de la democracia en los muy diversos municipios colombianos. (shrink)

RESUMENLa analogía de Ortega del actor arrojado a un escenario no supone, como se ha sugerido en distintos trabajos, la inclusión de su metafísica en el entorno del tópico que entiende el mundo como un teatro. La identificación del individuo con un actor que debe transformarse en el personaje que perfila su vocación implica una concepción de mi vida, entendida como creación propia, opuesta a la del theatrum mundi, donde al actor le es asignado un papel ya escrito que debe (...) representar dócilmente. Con todo, su definición del actor como metáfora corporizada converge –o puede llegar a converger- con su noción metafísica del hombre como existencial metáfora. Aunque Ortega no es explícito en este punto.PALABRAS CLAVE«IDEA DEL TEATRO», THEATRUM MUNDI, VOCACIÓN, RES DRAMÁTICA, METÁ- FORA CORPORIZADAABSTRACTOrtega’s analogy of the actor who is thrown into a scenario does not imply the inclusion of his metaphysics in the literary topic that understands the world as a theatre. Ortega identifies the person as an actor who must become the character that his vocation writes. This implies a conception of «my life», understood as my creation, which is contrary to the Theatrum Mundi’s, in which the actor is assigned a previously written role. However his definition of the actor as embodied metaphor could converge with its metaphysical notion of man as an existential metaphor. Ortega is not explicit on this point, though.KEYWORDS«THE IDEA OF THEATRE», THEATRUM MUNDI, VOCATION, RES DRAMATICA, EMBODIED METAPHOR. (shrink)

Automated Guided Vehicles (AGV) are an essential element of transport in industry 4.0. Although they may seem simple systems in terms of their kinematics, their dynamics is very complex, and it requires robust and efficient controllers for their routes in the workspaces. In this paper, we present the design and implementation of an intelligent controller of a hybrid AGV based on fuzzy logic. In addition, genetic algorithms have been used to optimize the speed control strategy, aiming at improving efficiency and (...) saving energy. The control architecture includes a fuzzy controller for trajectory tracking that has been enhanced with genetic algorithms. The cost function first maximizes the time in the circuit and then minimizes the guiding error. It has been validated on the mathematical model of a commercial hybrid AGV that merges tricycle and differential robot components. This model not only considers the kinematics and dynamics equations of the vehicle but also the impact of friction. The performance of the intelligent control strategy is compared with an optimized PID controller. Four paths were simulated to test the approach validity. (shrink)

Dynamic Theodicy (DT) is a broad concept we bring up to designate some modern Philosophical Theology attempts to reconcile the necessary and perfect existence of God with the contingent characteristics of human life. In this paper we analyze such approaches and discuss how they have become incomprehensible because the metaphysical assumptions implicit in these explanations have lost their intrinsic relation to the natural human desire for salvation. In the first part we show Charles Hartshorne's DT-model, arising from the modal logic (...) of perfection, and the modern rational problems of this position in making infinite-necessary Being (God) and finite-contingent being (human) compatible. We note that at the heart of the contradictions in this DT account is a dialectical mode of thinking that makes it difficult to find a correct solution to this dichotomy, and to assume a human desire that could be considered related to lifelong goals. In the second part, supported by the proposal of Hans Urs von Balthasar's DT, we develop the concepts of bodily vulnerability, corporeal intentionality, and natural desire for salvation, which come from an Aristotelian-Thomistic thought. This theory is established in order to build an argument, following Alasdair MacIntyre’s ethical framework, on how to make possible the recovery of a metaphysical and anthropological desire that transcends natural aging and goes beyond death. We conclude that both human dependence and the virtues that arise naturally when human beings decide to seek the good of their transcendent condition, make it possible to recover the natural desire for salvation through divine and human love. (shrink)

La pregunta por el sentido general del ser emerge, en situaciones críticas, como una indagación noética y existencial que descubre la condición finita y vulnerable del ser ahí. La pandemia Covid19 se ha convertido en el contexto social la oportunidad para pensar en la importancia del cuidado en donde, a raíz del confinamiento y el aislamiento preventivo, se ha modificado de forma infranqueable los ritmos de vida. La rapidación del mundo social de producción y consumo ha constituido el modus vivendi-operandi (...) de nuestras sociedades capitalistas. Por eso, los ritmos de vida acelerados han constituido la forma habitual del ser ahí en la carrera social hacia el éxito, consumada en una vida aparentemente feliz, sujeta a las tendencias del mercado y convirtiéndose, este imaginario colectivo, en el paradigma globalizado al cual aspira cualquier persona desde el nivel de vida o estrato social en que se encuentra. Los relegados del sistema, por su parte, quiénes no están a la altura de la competencia del capitalismo salvaje, se convierten en excedentes sociales postergados hacia el inevitable destino del desecho. Si queremos reivindicar el discurso del ser es en orden al fortalecimiento del cuidado de la vida, como un asunto primordial del ser ahí, para reconocer la raíz humana de la crisis ecológica porque, a la base de esta indagación fundamental se encuentra una deficiente cultura del cuidado que no es otra cosa que el descuido mismo del ser. El objetivo de este artículo, derivado de un proceso de investigación documental, es proponer, a la luz de los aportes de Martín Heidegger, la estructura fundamental de la cura como elemento consustancial de la vida en orden al cuidado de sí, de los otros y del ambiente natural como una respuesta oportuna a la crisis actual. (shrink)

The reorganization of taxation within the territory under the Crown of Aragon, which was undertaken alfter the War of Succession, was performed at a period of economic difficulties and coincided with radical political change. It was therefore not unopposed. The study of the Peñiscola Revolt in 1715 is important for three main reasons: the opposition to taxation which fuelled it; the demands for a retum to the municipal organization of the period of the "fuero"; and the fact that it arose (...) in one of the Valencian towns which had proved most loyal to Philip V during the War of Succession. (shrink)

El artículo analiza desde una perspectiva fenomenológica y hermenéutica el modo originario de donación del mundo y el origen del mundo en el pensamiento de Jan Patočka posterior a 1965. Primero muestra en qué sentido tanto la donación del mundo como horizonte, cuanto los movimientos de la existencia humana, implican un vínculo esencial entre el modo originario de darse del mundo y la noción de infinito, concebido como lo indefinido e inagotable. Finalmente explicita por qué el vínculo del mundo con (...) lo infinito reposa sobre un impulso creativo divino que constituye el fundamento cosmológico de la religiosidad humana. (shrink)

El mundo del ensueño y el mundo de la vigilia raras veces se oponen o se excluyen de manera tajante; más bien, una de las características de tal relación es la posibilidad de una inminente irrupción de uno en el otro. La tesis general de este artículo es que la tradición filosófica de Aristóteles a Husserl no cuenta con una orientación para acceder al fenómeno de los sueños que no privilegie la vigilia. Esta dificultad está detrás de una serie de (...) problemas y paradojas que se pueden explicitar ejemplarmente mediante una aproximación a la teoría aristotélica sobre el dormir (hýpnon) y el soñar (enýpnion), en los tres tratados dedicados al tema en Parva naturalia. La tematización aristotélica es analizada y criticada de cara a una posible fenomenología de los sueños, de la cual ya hay algunos vestigios en Husserl y Heidegger, pero que se desarrolló sistemáticamente en Fink. El artículo propone que al reelaborar las “piezas faltantes” del acercamiento aristotélico, así como la prioridad que la primera persona tiene en la fenomenología, sería posible abrir una vía de exploración que lleve a pensar el sueño en la realidad de su efectuación concreta. Este enfoque permite evidenciar tres requerimientos fundamentales para pensar la fenomenalización del ensueño, a saber: el entrecruzarse de los mundos de la vigilia y del ensueño, la maximización y la móvil ordenación de las sensaciones durante el sueño y, finalmente, el afloramiento del reino afectivo. Estos tres fondos problemáticos ponen sobre la mesa la pregunta por los límites de la manifestación (de los ensueños) y, en ese sentido, abren un posible diálogo con la fenomenología francesa contemporánea. (shrink)

Augustine’s teaching on wealth and poverty, on the relations between the poor and the rich has been extensively studied in the past few decades. However, much attention has not been given to his considerations on the prosperity of the wicked and the tendency of the faithful to serve God for an immediate material reward. In this paper, I examine the bishop of Hippo’s preaching on this question. Predominantly, in his Sermones ad populum and Enarrationes in Psalmos, Augustine constantly calls his (...) flock to acknowledge the author of prosperity and of all good things as the Supreme Good, and to prefer him to all the ephemerous possessions they may have in this world. Above all, he encourages the faithful to despise the prosperity of the wicked which is only apparent and to hope for God himself their reward for serving him. (shrink)

The article has as point of departure the idea that for Saint Augustine biological life is intimately linked with spiritual life; moreover, biological life itself is nothing but a metaphor of the real life. It is also presented that for Saint Augustine life is ultimately a Christological matter. The basic Augustinian anthropological idea of the human being as mendicus Dei is also developed, starting from the text of 1 Cor 4, 7, and developing the image of the human being as (...) vilicus, as a simple administrator of God’s gifts. On the other hand, the issue of abortion is addressed according to the Augustinian ideas, to highlight that despite the fact that in the time of Saint Augustine a subtle distinction was made between a formed and an unformed embryo, according to the number of days of gestation, following the Aristotelian theories illuminated by the text of Ex 21, 22-23, according to the LXX, Saint Augustine opposes abortion in all cases, considering it a homicide, because whoever will become a person, is already so in the very womb of their mother. Three sources of human dignity according to Saint Augustine are also presented. In the first place, the fact that the human being has been created in the image and likeness of the Triune God. Second, the fact of Christ’s incarnation and redemption, presenting the Augustinian argument that the price of each man is none other than the blood of Christ. A third Augustinian argument is also presented, which is his condition as a son of God through the sacrament of baptism. It also presents the point of view of Saint Augustine on the death penalty, specifically in relation to the circumcelliones and the ep. 133 and the slave traders and ep. 10*. (shrink)

Ahora más que nunca es necesario el resurgimiento del cosmopolitismo en la forma de una ética cosmopolita y global. Probablemente ésta sea la única vía para enfrentar la crisis ecosocial de dimensiones planetarias, causada por el acelerado desarrollo tecnocientífico, la violencia y la guerra sistemá..

This Volume contains main papers from a conference on epistemology and, in addition, especially invited papers on that topic. The volume contains twenty-three substantial papers by leading figures, who have vcontribut3d papers representative of their current work, plus a book symposium on Knowledge and Lotteries by John Hawthorne.

This book collects cutting edge essays on epistemic agency and related topics by distinguished senior contributors to epistemology, as well as rising figures in the field. The assembly of scholars is impressive, as is reflected by the quality and range of their contributions.

This volume represents the main papers delivered by both prominent and rising philosophers at the 1999 SOFIA conference in Mazatlan, Mexico. The volume contains twenty substantial papers spanning important issues of current interest including sexuality and consent, rights and scarcity, democracy and individualism, and the nature of law and the value of punishment.

Some recent researches in experimental philosophy have posed a problem for philosophers’ appeal to intuition (hereinafter referred to as PAI); the aim of this paper is to offer an answer to this challenge. The thesis against PAI implies that, given some experimental results, intuition does not seem to be a reliable epistemic source, and —more importantly— given the actual state of knowledge about its operation, we do not have sufficient resources to mitigate its errors and thus establish its reliability. That (...) is why PAI is hopeless. Throughout this paper I will defend my own conception of PAI, which I have called the Deliberative Conception, and consequently, I will defend intersubjective agreement as a means to mitigate PAI errors, offering empirical evidence from recent studies on the Argumentative Theory of Reason that favor the conception I defend here. Finally, I will reply to some objections that might arise against the Deliberative Conception, which will lead me to discuss some metaphilosophical issues that are significantly relevant for the future of the dispute about the appeal to intuition. (shrink)

The objective of this research work was to determine what are the factors that condition the labor insertion of graduates of the 14 Study Programs of the Faculty of Technology, in the Technical Variant Educational Institutions, the Productive Technical Centers and in the Higher Institutions. Technological, in the year 2023, with its two dimensions of employability and occupancy; The methodology applied was quantitative, type of applied research, non-experimental research method, simple descriptive design, 13 questions were prepared for the employability dimension (...) and 12 questions for the employability dimension, this questionnaire was developed through Google form and It was applied through virtual social networks to graduates who obtained their degrees in the years 2019, 2020 and 2021. The sample consisted of 160 graduates. The statistical process of reliability and validity of the instruments was carried out using the SPSS V-27 statistical package, the following result was reached, of the 160 respondents, 16.88 % indicate that insertion is low, another 28.75 % respond which is medium and 54.37 %, which is equivalent to 87 graduates surveyed, specify that it is high. (shrink)

La filosofía judía contemporánea, particularmente la surgida de la historia herida del pensador lituano Emmanuel Levinas, presenta de modo exclusivista la reducción de la relación religiosa a relación ética. No sólo queda ahí su propuesta sino que este filó-sofo judío considera la experiencia mística una degeneración o peligro para la religiosidad auténtica. En cambio, el mayor especialista español en los estudios de fenomenología de la religión, el pensador cristiano Juan Martín Velasco, considera la experiencia mística como la culminación de la (...) experiencia religiosa. (shrink)