The Type VI secretion system is a multiprotein and mosaic apparatus that delivers protein effectors into prokaryotic or eukaryotic cells. Recent data on the enteroaggregative Escherichia coli T6SS have provided evidence that the TssA protein is a key component during T6SS biogenesis. The T6SS comprises a trans-envelope complex that docks the baseplate, a cytoplasmic complex that represents the assembly platform for the tail. The T6SS tail is structurally, evolutionarily and functionally similar to the contractile tails of bacteriophages. We have shown (...) that TssA docks to the membrane complex, recruits the baseplate complex and initiates and coordinates the polymerization of the inner tube with that of the sheath. Here, we review these recent findings, discuss the variations within TssA-like proteins, speculate on the role of EAEC TssA in T6SS biogenesis and propose future research perspectives. In the environment, bacteria have to cope with other microbial species and therefore have evolved anti-microbial mechanisms. The bacterial Type VI secretion system transports toxins into bacterial and/or eukaryotic cells using a contractile mechanism. At the architectural level, the T6SS could be viewed as a nano-speargun assembled in the bacterial cytoplasm and anchored to a trans-envelope complex. We describe and speculate on recent findings demonstrating that the TssA subunit is involved in the different stages of T6SS biogenesis. (shrink)

Can large language models produce expert‐quality philosophical texts? To investigate this, we fine‐tuned GPT‐3 with the works of philosopher Daniel Dennett. To evaluate the model, we asked the real Dennett 10 philosophical questions and then posed the same questions to the language model, collecting four responses for each question without cherry‐picking. Experts on Dennett's work succeeded at distinguishing the Dennett‐generated and machine‐generated answers above chance but substantially short of our expectations. Philosophy blog readers performed similarly to the experts, while ordinary (...) research participants were near chance distinguishing GPT‐3's responses from those of an “actual human philosopher”. (shrink)

Depuis les années 1960, Gilbert Durand a fondé et développé une méthodologie et une épistémologie novatrices de l'étude des imaginaires individuels et culturels qui ont inspiré une Ecole de Grenoble, qui n'a cessé d'essaimer à travers un grand nombre de centres de recherches en France et dans le monde. Sa pensée, connue à travers la mythocritique et la mythanalyse, enrichie par une vaste culture historique et pluriculturelle, a été appliquée dans les domaines les plus divers des sciences humaines et (...) sociales. Loin d'être un système clos, son oeuvre a inspiré une épistémologie ouverte qui a permis, sur la base des acquis fondamentaux, de se préciser, de s'adapter à des champs nouveaux, de recevoir les apports d'autres écoles, courants ou traditions culturelles. Les contributions ici rassemblées permettront de mieux situer l'émergence de la problématique de l'imaginaire dans différentes disciplines ou champs d'études, de présenter les innovations théoriques apportées par l'anthropologie de l'imaginaire de G Durand, d'illustrer les innovations qu'elles auront permises, d'amorcer des éléments de prospective pour les chantiers actuellement en cours d'exploration. (shrink)

This paper examines the relationship between simulation and experiment. Many discussions of simulation, and indeed the term "numerical experiments," invoke a strong metaphor of experimentation. On the other hand, many simulations begin as attempts to apply scientific theories. This has lead many to characterize simulation as lying between theory and experiment. The aim of the paper is to try to reconcile these two points of viewto understand what methodological and epistemological features simulation has in common with experimentation, while at the (...) same time keeping a keen eye on simulation's ancestry as a form of scientific theorizing. In so doing, it seeks to apply some of the insights of recent work on the philosophy of experiment to an aspect of theorizing that is of growing philosophical interest: the construction of local models. (shrink)

My dissertation asks how we affect conversational context and how it affects us when we participate in any conversation—including philosophical conversations. Chapter 1 argues that speakers make pragmatic presuppositions when they use proper names. I appeal to these presuppositions in giving a treatment of Frege’s puzzle that is consistent with the claim that coreferential proper names have the same semantic value. I outline an explanation of the way presupposition carrying expressions in general behave in belief ascriptions, and suggest that substitutivity (...) failure is a special case of this behavior. Chapter 2 develops a compositional probabilistic semantics for the language of subjective uncertainty, including epistemic adjectives scoped under quantifiers. I argue that we should distinguish sharply between the effects that epistemically hedged statements have on conversational context, and the effects that they have on belief states. I also suggest that epistemically hedged statements are a kind of doxastic advice, and explain how this hypothesis illuminates some otherwise puzzling phenomena. Chapter 3 argues that ordinary causal talk is deeply sensitive to conversational context. The principle that I formulate to characterize that context sensitivity explains at least some of the oddness of ‘systematic causal overdetermination,’ and explains why some putative overgenerated causes are never felicitously counted, in conversation, as causes. But the principle also makes metaphysical theorizing about causation rather indirectly constrained by ordinary language judgments. (shrink)

This review of 122 research reports (184 independent samples, 14,900 subjects) found average r ϭ .274 for prediction of behavioral, judgment, and physiological measures by Implicit Association Test (IAT) measures. Parallel explicit (i.e., self-report) measures, available in 156 of these samples (13,068 subjects), also predicted effectively (average r ϭ .361), but with much greater variability of effect size. Predictive validity of self-report was impaired for socially sensitive topics, for which impression..

How do you know what you want? Philosophers have lately developed sophisticated accounts of the practical and doxastic knowledge that are rooted in the point of view of the subject. Our ability to just say what we are doing or what we believe—that is, to say so authoritatively, but not on the basis of observation or evidence—is an aspect of our ability to reason about the good and the true. However, no analogous route to orectic self-knowledge is feasible. Knowledge of (...) desire is distinctive in being a matter of our affective response to imagined prospects. An examination of this idea yields the following thesis: I know what I want just in case the object pursued in anticipation of a certain pleasure actually yields the anticipated pleasure. (shrink)

The Conceptual Mind’s twenty-four newly commissioned essays cover the most important recent theoretical developments in the study of concepts, identifying and exploring the big ideas that will guide further research over the next decade. Topics include concepts and animals, concepts and the brain, concepts and evolution, concepts and perception, concepts and language, concepts across cultures, concept acquisition and conceptual change, concepts and normativity, concepts in context, and conceptual individuation.

This article defends the existence of _borderline consciousness._ In borderline consciousness, conscious experience is neither determinately present nor determinately absent, but rather somewhere between. The argument in brief is this. In considering what types of systems are conscious, we face a quadrilemma. Either nothing is conscious, or everything is conscious, or there’s a sharp boundary across the apparent continuum between conscious systems and nonconscious ones, or consciousness is a vague property admitting indeterminate cases. Assuming mainstream naturalism about consciousness, we ought (...) to reject the first three options, which forces us to the fourth, indeterminacy. Standard objections to the existence of borderline consciousness turn on the inconceivability of borderline cases. However, borderline cases are only inconceivable by an inappropriately demanding standard of conceivability. I conclude with some plausible cases and applications. (shrink)

Standard microbial evolutionary ontology is organized according to a nested hierarchy of entities at various levels of biological organization. It typically detects and defines these entities in relation to the most stable aspects of evolutionary processes, by identifying lineages evolving by a process of vertical inheritance from an ancestral entity. However, recent advances in microbiology indicate that such an ontology has important limitations. The various dynamics detected within microbiological systems reveal that a focus on the most stable entities (or features (...) of entities) over time inevitably underestimates the extent and nature of microbial diversity. These dynamics are not the outcome of the process of vertical descent alone. Other processes, often involving causal interactions between entities from distinct levels of biological organisation, or operating at different time scales, are responsible not only for the destabilisation of pre-existing entities, but also for the emergence and stabilisation of novel entities in the microbial world. In this article we consider microbial entities as more or less stabilised functional wholes, and sketch a network-based ontology that can represent a diverse set of processes including, for example, as well as phylogenetic relations, interactions that stabilise or destabilise the interacting entities, spatial relations, ecological connections, and genetic exchanges. We use this pluralistic framework for evaluating (i) the existing ontological assumptions in evolution (e.g. whether currently recognized entities are adequate for understanding the causes of change and stabilisation in the microbial world), and (ii) for identifying hidden ontological kinds, essentially invisible from within a more limited perspective. We propose to recognize additional classes of entities that provide new insights into the structure of the microbial world, namely “processually equivalent” entities, “processually versatile” entities, and “stabilized” entities. (shrink)

A successful theory of the language of subjective uncertainty would meet several important constraints. First, it would explain how use of the language of subjective uncertainty affects addressees’ states of subjective uncertainty. Second, it would explain how such use affects what possibilities are treated as live for purposes of conversation. Third, it would accommodate 'quantifying in' to the scope of epistemic modals. Fourth, it would explain the norms governing the language of subjective uncertainty, and the differences between them and the (...) norms governing the language of subjective certainty. Neither truth conditional nor traditional force modfier theories of the language of subjective uncertainty look adequate to the task of satisfying all four of these constraints. (shrink)

With his new riddle of induction, Goodman raised a problem for enumerative induction which many have taken to show that only some ‘natural’ properties can be used for making inductive inferences. Arguably, however, (i) enumerative induction is not a method that scientists use for making inductive inferences in the first place. Moreover, it seems at first sight that (ii) Goodman’s problem does not affect the method that scientists actually use for making such inferences—namely, classical statistics. Taken together, this would indicate (...) that (iii) ‘naturalness’ is not such a relevant concept for the problem of induction, after all. I have no objections against (i) and (iii). But, contrary to (ii), I argue that classical statistics does face a version of Goodman’s problem, which I call the statistical riddle of induction. Given that his problem merely is an instance of the more general problem of underdetermination, this is hardly surprising. Perhaps more importantly, I also show how my riddle can be used for exposing a common fallacy in probabilistic reasoning, without relying on Bayesian assumptions. (shrink)

We present evidence that mainstream Anglophone philosophy is insular in the sense that participants in this academic tradition tend mostly to cite or interact with other participants in this academic tradition, while having little academic interaction with philosophers writing in other languages. Among our evidence: In a sample of articles from elite Anglophone philosophy journals, 97% of citations are citations of work originally written in English; 96% of members of editorial boards of elite Anglophone philosophy journals are housed in majority-Anglophone (...) countries; and only one of the 100 most-cited recent authors in the Stanford Encyclopedia of Philosophy spent most of his career in non-Anglophone countries writing primarily in a language other than English. In contrast, philosophy articles published in elite Chinese-language and Spanish-language journals cite from a range of linguistic traditions, as do non-English-language articles in a convenience sample of established European-language journals. We also find evidence that work in English has more influence on work in other languages than vice versa and that when non-Anglophone philosophers cite recent work outside of their own linguistic tradition it tends to be work in English. (shrink)

In recent years deflationary accounts of self-deception, under the banner of motivationalism, have proven popular. On these views the deception at work is simply a motivated bias. In contrast, we argue for an account of self-deception that involves more robustly deceptive unconscious processes. These processes are strategic, flexible, and demand some retention of the truth. We offer substantial empirical support for unconscious deceptive processes that run counter to certain philosophical and psychological claims that the unconscious is rigid, ballistic, and of (...) limited cognitive sophistication. (shrink)

Philip Kitcher has proposed a theory of explanation based on the notion of unification. Despite the genuine interest and power of the theory, I argue here that the theory suffers from a fatal deficiency: It is intrinsically unable to account for the asymmetric structure of explanation, and thus ultimately falls prey to a problem similar to the one which beset Hempel's D-N model. I conclude that Kitcher is wrong to claim that one can settle the issue of an argument's explanatory (...) force merely on the basis of considerations about the unifying power of the argument pattern the argument instantiates. (shrink)

I argue that zombies are inconceivable. More precisely, I argue that the conceivability-intuition that is used to demonstrate their possibility has been misconstrued. Thought experiments alleged to feature zombies founder on the fact that, on the one hand, they _must_ involve first-person imagining, and yet, on the other hand, _cannot_. Philosophers who take themselves to have imagined zombies have unwittingly conflated imagining a creature who lacks consciousness with imagining a creature without also imagining the consciousness it may or may not (...) possess. (shrink)

Neuroethics is an interdisciplinary field that arose in response to novel ethical challenges posed by advances in neuroscience. Historically, neuroethics has provided an opportunity to synergize different disciplines, notably proposing a two-way dialogue between an ‘ethics of neuroscience’ and a ‘neuroscience of ethics’. However, questions surface as to whether a ‘neuroscience of ethics’ is a useful and unified branch of research and whether it can actually inform or lead to theoretical insights and transferable practical knowledge to help resolve ethical questions. (...) In this article, we examine why the neuroscience of ethics is a promising area of research and summarize what we have learned so far regarding its most promising goals and contributions. We then review some of the key methodological challenges which may have hindered the use of results generated thus far by the neuroscience of ethics. Strategies are suggested to address these challenges and improve the quality of research and increase neuroscience's usefulness for applied ethics and society at large. Finally, we reflect on potential outcomes of a neuroscience of ethics and discuss the different strategies that could be used to support knowledge transfer to help different stakeholders integrate knowledge from the neuroscience of ethics. (shrink)

In some contexts, not saying S generates a conversational implicature: that the speaker didn’t have sufficient reason, all things considered, to say S. I call this an omissive implicature. Standard ways of thinking about conversational implicature make the importance and even the existence of omissive implicatures somewhat surprising. But I argue that there is no principled reason to deny that there are such implicatures, and that they help explain a range of important phenomena. This paper focuses on the roles omissive (...) implicatures play in Quantity implicatures—in particular, in solving the symmetry problem for scalar implicatures—and on the political and social importance of omissions where apologies, objections, or other communicative acts are expected or warranted. (shrink)

Perceptual processes, in particular modular processes, have long been understood as being mandatory. But exactly what mandatoriness amounts to is left to intuition. This paper identifies a crucial ambiguity in the notion of mandatoriness. Discussions of mandatory processes have run together notions of automaticity and ballisticity. Teasing apart these notions creates an important tool for the modularist's toolbox. Different putatively modular processes appear to differ in their kinds of mandatoriness. Separating out the automatic from the ballistic can help the modularist (...) diagnose and explain away some putative counterexamples to multimodal and central modules, thereby helping us to better evaluate the evidentiary status of modularity theory. (shrink)

Conjoined twinning is said to show that the number of human people—the number of us—can differ from the number of human organisms, and hence that we are not organisms. The paper shows that these arguments either assume the point at issue, rely on dubious and undefended assumptions, or add nothing to more familiar arguments for the same conclusion.

In the 1950s, dream researchers commonly thought that dreams were predominantly a black and white phenomenon, although both earlier and later treatments of dreaming assume or assert that dreams have color. The first half of the twentieth century saw the rise of black and white film media, and it is likely that the emergence of the view that dreams are black and white was connected to this change in film technology. If our opinions about basic features of our dreams can (...) change with changes in technology, it seems to follow that our knowledge of the experience of dreaming is much less secure than we might at first have thought it to be. (shrink)

Is there an explanatory gap between raw feels and raw material? Some philosophers argue, and many other people believe, that scientific explanations of conscious experience cannot be as satisfying as typical scientific explanations elsewhere, even in our wildest dreams. The underlying philosophical claims are.

The cognitive science of belief is a burgeoning field, with insights ranging from detailing the fundamental structure of the mind, to explaining the spread of fake news. Here we highlight how new insights into belief acquisition, storage, and change can transform our understanding of psychiatric disorders. Although we focus on monothematic delusions, the conclusions apply more broadly. -/- .

ABSTRACTMany philosophers say that the nature of personal identity has to do with narratives: the stories we tell about ourselves. While different narrativists address different questions of personal identity, some propose narrativist accounts of personal identity over time. The paper argues that such accounts have troubling consequences about the beginning and end of our lives, lead to inconsistencies, and involve backwards causation. The problems can be solved, but only by modifying the accounts in ways that deprive them of their appeal.

In _On Empirically Equivalent Systems of the World_ from 1975, Quine formulated a thesis of underdetermination roughly to the effect that every scientific theory has an empirically equivalent but logically incompatible rival, one that cannot be discarded merely as a terminological variant of the former. For Quine, the truth of this thesis was an open question. If true, some would argue that it undermines any belief in scientific theories that is based purely on their empirical success. But despite its potential (...) significance, surprisingly little has been done by way of establishing or refuting it. My aim is to establish the thesis for as large a class of theories as possible. Under various precisifications of the concepts involved, I show that it holds for all consistent and recursively axiomatizable theories that postulate infinitely many theoretical entities. (shrink)

b>: This article explains the concept of multiple realizability and its role in the philosophy of mind. In particular, I consider what is required for the multiple realizability of psychological kinds, the relevance of multiple realizability to the reducibility and autonomy of psychology, as well as further refinements of the concept that would prove helpful.

This paper argues for the need of philosophical translator-advocates to overcome the (would-be) limitations produced by the linguistic narrowness of analytic philosophy. It draws on a model used to analyze epistemic communities in order to characterize a form of linguistic injustice. In particular it does so by treating language as an epistemic barrier to entry of ideas and people and by treating philosophical translator-advocates as engaged in a form of arbitrage. Along the way I specify some necessary and jointly sufficient (...) characteristics of a philosophical translator-advocate. My argument is illuminated and vivified with examples from the history of analytic philosophy and other episodes from the history of philosophy. (shrink)

The theory and practice of history and its relevance to the modern world, by Britains greatest radical historian.

In his original semantics for counterfactuals, David Lewis presupposed that the ordering of worlds relevant to the evaluation of a counterfactual admitted no incomparability between worlds. He later came to abandon this assumption. But the approach to incomparability he endorsed makes counterintuitive predictions about a class of examples circumscribed in this paper. The same underlying problem is present in the theories of modals and conditionals developed by Bas van Fraassen, Frank Veltman, and Angelika Kratzer. I show how to reformulate all (...) these theories in terms of lower bounds on partial preorders, conceived of as maximal antichains, and I show that treating lower bounds as cutsets does strictly better at capturing our intuitions about the semantics of modals, counterfactuals, and deontic conditionals. (shrink)

Recently, Doolittle and Inkpen formulated a thought provoking theory, asserting that evolution by natural selection was responsible for the sideways evolution of two radically different kinds of selective units (also called Domains). The former entities, termed singers, correspond to the usual objects studied by evolutionary biologists (gene, genomes, individuals, species, etc.), whereas the later, termed songs, correspond to re‐produced biological and ecosystemic functions, processes, information, and memes. Singers perform songs through selected patterns of interactions, meaning that a wealth of critical (...) phenomena might receive novel evolutionary explanations. However, this theory did not provide an empirical approach to study evolution in such a broadened context. Here, we show that analyzing songs and singers, using patterns of interaction networks as a common ontology for both, offers a novel, actionable, inclusive and mathematical way to analyze not only the re‐production but also the evolution and fitness of biological and ecosystemic interconnected processes. (shrink)

The law of desire has been proposed in several forms, but its essential claim is that agents always act on their strongest proximal action motivation. This law has threatening consequences for human freedom, insofar as it greatly limits agents’ ability to do otherwise given their motivational state. It has proven difficult to formulate a version that escapes counterexamples and some categorically deny its truth. Noticeable by its absence in the literature is any attempt to provide an argument for the law (...) of desire – I propose such an argument here. It is noted that Sripada's “divided mind” theory of willpower provides a counterexample to the version of the law of desire my argument defends, but I note that a reformulated version of the law of desire survives this critique. I conclude that there is a serious case for the law of desire, and note the broader implications of this. (shrink)

It is possible to survey humankind and be proud, even to smile, for we accomplish great things. Art and science are two notable worthy human accomplishments. Consonant with art and science are some of the ways we treat each other. Sacrifice and heroism are two admirable human qualities that pervade human interaction. But, as everyone knows, all this goodness is more than balanced by human depravity. Moral corruption infests our being. Why?

Cartesian or substance dualism is the view that concrete substances come in two basic kinds. There are material things, such as biological organisms. These may be either simple or composed of parts. And there are immaterial things--minds or souls--which are always simple. No material thing depends for its existence on any soul, or vice versa. And only souls can think.

Animalism is the view that you and I are animals. That is, we are animals in the straightforward sense of having the property of being an animal, or in that each of us is identical to an animal-not merely in the derivative sense of having animal bodies, or of being "constituted by" animals. And by 'animal' I mean an organism of the animal kingdom." Sensible though it may appear, animalism is highly contentious. The most common objection is that it conflicts (...) with widespread and deep beliefs about our identity over time. These beliefs are brought out in reactions to fictional cases. Suppose, for instance, that your brain is transplanted into my head. The being who ends up with that organ, everyone assumes, will remember your life and not mine. More generally, he will have your beliefs, preferences, plans, and other mental properties, for the most part at least. Who would he be-you, me, or someone else? (shrink)

Should we understand the biological philosophy of Hans Jonas as a phenomenology for unveiling the phenomenon of life or as a kind of Hegelian metaphysics that presents life as a substantial principle? To answer that question, we need to deal first with the question of our access to other living beings and then with the problem of the spiritualization of the concept of evolution. This article will use an essay called “Organism and Freedom: An Essay in Philosophical Biology.”.

Sometimes analogy researchers talk as if the freshness of an experience of analogy resides solely in seeing that something is like something else -- seeing that the atom is like a solar system, that heat is like flowing water, that paint brushes work like pumps, or that electricity is like a teeming crowd. But analogy is more than this. Analogy isn't just seeing that the atom is like a solar system; rather, it is seeing something new about the atom, an (...) observation enabled by 'looking' at atoms from the perspective of one's understanding of solar systems. The question for analogy researchers then is this: Where does this new knowledge about atoms come from? How can an analogy provide new knowledge and new understanding? (shrink)

The theory of explanatory unification was first proposed by Friedman (1974) and developed by Kitcher (1981, 1989). The primary motivation for this theory, it seems to me, is the argument that this account of explanation is the only account that correctly describes the genesis of scientific understanding. Despite the apparent plausibility of Friedman's argument to this effect, however, I argue here that the unificationist thesis of understanding is false. The theory of explanatory unification as articulated by Friedman and Kitcher thus (...) emerges as fundamentally misconceived. (shrink)