The Type VI secretion system is a multiprotein and mosaic apparatus that delivers protein effectors into prokaryotic or eukaryotic cells. Recent data on the enteroaggregative Escherichia coli T6SS have provided evidence that the TssA protein is a key component during T6SS biogenesis. The T6SS comprises a trans-envelope complex that docks the baseplate, a cytoplasmic complex that represents the assembly platform for the tail. The T6SS tail is structurally, evolutionarily and functionally similar to the contractile tails of bacteriophages. We have shown (...) that TssA docks to the membrane complex, recruits the baseplate complex and initiates and coordinates the polymerization of the inner tube with that of the sheath. Here, we review these recent findings, discuss the variations within TssA-like proteins, speculate on the role of EAEC TssA in T6SS biogenesis and propose future research perspectives. In the environment, bacteria have to cope with other microbial species and therefore have evolved anti-microbial mechanisms. The bacterial Type VI secretion system transports toxins into bacterial and/or eukaryotic cells using a contractile mechanism. At the architectural level, the T6SS could be viewed as a nano-speargun assembled in the bacterial cytoplasm and anchored to a trans-envelope complex. We describe and speculate on recent findings demonstrating that the TssA subunit is involved in the different stages of T6SS biogenesis. (shrink)

This book offers a state-of-the-art introduction to the basic techniques and results of neighborhood semantics for modal logic. In addition to presenting the relevant technical background, it highlights both the pitfalls and potential uses of neighborhood models – an interesting class of mathematical structures that were originally introduced to provide a semantics for weak systems of modal logic. In addition, the book discusses a broad range of topics, including standard modal logic results ; bisimulations for neighborhood models and other model-theoretic (...) constructions; comparisons with other semantics for modal logic ; neighborhood semantics for first-order modal logic, applications in game theory ; applications in epistemic logic ; and non-normal modal logics with dynamic modalities. The book can be used as the primary text for seminars on philosophical logic focused on non-normal modal logics; as a supplemental text for courses on modal logic, logic in AI, or philosophical logic ; or as the primary source for researchers interested in learning about the uses of neighborhood semantics in philosophical logic and game theory. (shrink)

Depuis les années 1960, Gilbert Durand a fondé et développé une méthodologie et une épistémologie novatrices de l'étude des imaginaires individuels et culturels qui ont inspiré une Ecole de Grenoble, qui n'a cessé d'essaimer à travers un grand nombre de centres de recherches en France et dans le monde. Sa pensée, connue à travers la mythocritique et la mythanalyse, enrichie par une vaste culture historique et pluriculturelle, a été appliquée dans les domaines les plus divers des sciences humaines et (...) sociales. Loin d'être un système clos, son oeuvre a inspiré une épistémologie ouverte qui a permis, sur la base des acquis fondamentaux, de se préciser, de s'adapter à des champs nouveaux, de recevoir les apports d'autres écoles, courants ou traditions culturelles. Les contributions ici rassemblées permettront de mieux situer l'émergence de la problématique de l'imaginaire dans différentes disciplines ou champs d'études, de présenter les innovations théoriques apportées par l'anthropologie de l'imaginaire de G Durand, d'illustrer les innovations qu'elles auront permises, d'amorcer des éléments de prospective pour les chantiers actuellement en cours d'exploration. (shrink)

Whole Brain Emulation has been championed as the most promising, well-defined route to achieving both human-level artificial intelligence and superintelligence. It has even been touted as a viable route to achieving immortality through brain uploading. WBE is not a fringe theory: the doctrine of Computationalism in philosophy of mind lends credence to the in-principle feasibility of the idea, and the standing of the Human Connectome Project makes it appear to be feasible in practice. Computationalism is a popular, independently plausible theory, (...) and Connectomics a well-funded empirical research program, so optimism about WBE is understandable. However, this optimism may be misplaced. This article argues that WBE is, at best, no more compelling than any of the other far-flung routes to achieving superintelligence. Similarly skeptical conclusions are found regarding immortality. The essay concludes with some positive considerations in favor of the Biological Theory of consciousness, as well as morals about the limits of Computationalism in both artificial intelligence and the philosophy of mind more generally. (shrink)

This paper examines the relationship between simulation and experiment. Many discussions of simulation, and indeed the term "numerical experiments," invoke a strong metaphor of experimentation. On the other hand, many simulations begin as attempts to apply scientific theories. This has lead many to characterize simulation as lying between theory and experiment. The aim of the paper is to try to reconcile these two points of viewto understand what methodological and epistemological features simulation has in common with experimentation, while at the (...) same time keeping a keen eye on simulation's ancestry as a form of scientific theorizing. In so doing, it seeks to apply some of the insights of recent work on the philosophy of experiment to an aspect of theorizing that is of growing philosophical interest: the construction of local models. (shrink)

We propose four policies of ethical design of human-grade Artificial Intelligence. Two of our policies are precautionary. Given substantial uncertainty both about ethical theory and about the conditions under which AI would have conscious experiences, we should be cautious in our handling of cases where different moral theories or different theories of consciousness would produce very different ethical recommendations. Two of our policies concern respect and freedom. If we design AI that deserves moral consideration equivalent to that of human beings, (...) that AI should be designed with self-respect and with the freedom to explore values other than those we might impose. We are especially concerned about the temptation to create human-grade AI pre-installed with the desire to cheerfully sacrifice itself for its creators’ benefit. (shrink)

My dissertation asks how we affect conversational context and how it affects us when we participate in any conversation—including philosophical conversations. Chapter 1 argues that speakers make pragmatic presuppositions when they use proper names. I appeal to these presuppositions in giving a treatment of Frege’s puzzle that is consistent with the claim that coreferential proper names have the same semantic value. I outline an explanation of the way presupposition carrying expressions in general behave in belief ascriptions, and suggest that substitutivity (...) failure is a special case of this behavior. Chapter 2 develops a compositional probabilistic semantics for the language of subjective uncertainty, including epistemic adjectives scoped under quantifiers. I argue that we should distinguish sharply between the effects that epistemically hedged statements have on conversational context, and the effects that they have on belief states. I also suggest that epistemically hedged statements are a kind of doxastic advice, and explain how this hypothesis illuminates some otherwise puzzling phenomena. Chapter 3 argues that ordinary causal talk is deeply sensitive to conversational context. The principle that I formulate to characterize that context sensitivity explains at least some of the oddness of ‘systematic causal overdetermination,’ and explains why some putative overgenerated causes are never felicitously counted, in conversation, as causes. But the principle also makes metaphysical theorizing about causation rather indirectly constrained by ordinary language judgments. (shrink)

The question “are garden snails conscious?” or equivalently “is there something it’s like to be a garden snail?” admits of three possible answers: yes, no, and denial that the question admits of a yes-or-no answer. All three answers have some antecedent plausibility, prior to the application of theories of consciousness. All three answers retain their plausibility after the application of theories of consciousness. This is because theories of consciousness, when applied to such a different species, are inevitably question-begging and rely (...) crucially on dubious extrapolation from the introspections and verbal reports of a single species. (shrink)

In the philosophy of climate science, debate surrounding the issue of variety of evidence has mostly taken the form of attempting to connect these issues in climate science and climate modeling with philosophical accounts of what has come to be known as “robustness analysis.” I argue that an “explanatory” conception of robustness is the best candidate for understanding variety of evidence in climate science. I apply the analysis to both examples of model agreement, as well at to the convergence of (...) evidence from both model and non-model sources. (shrink)

On an intellectualist approach to belief, the intellectual endorsement of a proposition (such as “The working poor deserve as much respect as the handsomely paid”) is sufficient or nearly sufficient for believing it. On a pragmatic approach to belief, intellectual endorsement is not enough. Belief is behaviorally demanding. To really, fully believe, you must also “walk the walk.” This chapter argues that the pragmatic approach is preferable on pragmatic grounds: It rightly directs our attention to what matters most in thinking (...) about belief. (shrink)

Number words seemingly function both as adjectives attributing cardinality properties to collections, as in Frege’s ‘Jupiter has four moons’, and as names referring to numbers, as in Frege’s ‘The number of Jupiter’s moons is four’. This leads to what Thomas Hofweber calls Frege’s Other Puzzle: How can number words function as modifiers and as singular terms if neither adjectives nor names can serve multiple semantic functions? Whereas most philosophers deny that one of these uses is genuine, we instead argue that (...) number words, like many related expressions, are polymorphic, having multiple uses whose meanings are systematically related via type shifting. (shrink)

A successful theory of the language of subjective uncertainty would meet several important constraints. First, it would explain how use of the language of subjective uncertainty affects addressees’ states of subjective uncertainty. Second, it would explain how such use affects what possibilities are treated as live for purposes of conversation. Third, it would accommodate 'quantifying in' to the scope of epistemic modals. Fourth, it would explain the norms governing the language of subjective uncertainty, and the differences between them and the (...) norms governing the language of subjective certainty. Neither truth conditional nor traditional force modfier theories of the language of subjective uncertainty look adequate to the task of satisfying all four of these constraints. (shrink)

With his new riddle of induction, Goodman raised a problem for enumerative induction which many have taken to show that only some ‘natural’ properties can be used for making inductive inferences. Arguably, however, (i) enumerative induction is not a method that scientists use for making inductive inferences in the first place. Moreover, it seems at first sight that (ii) Goodman’s problem does not affect the method that scientists actually use for making such inferences—namely, classical statistics. Taken together, this would indicate (...) that (iii) ‘naturalness’ is not such a relevant concept for the problem of induction, after all. I have no objections against (i) and (iii). But, contrary to (ii), I argue that classical statistics does face a version of Goodman’s problem, which I call the statistical riddle of induction. Given that his problem merely is an instance of the more general problem of underdetermination, this is hardly surprising. Perhaps more importantly, I also show how my riddle can be used for exposing a common fallacy in probabilistic reasoning, without relying on Bayesian assumptions. (shrink)

We present evidence that mainstream Anglophone philosophy is insular in the sense that participants in this academic tradition tend mostly to cite or interact with other participants in this academic tradition, while having little academic interaction with philosophers writing in other languages. Among our evidence: In a sample of articles from elite Anglophone philosophy journals, 97% of citations are citations of work originally written in English; 96% of members of editorial boards of elite Anglophone philosophy journals are housed in majority-Anglophone (...) countries; and only one of the 100 most-cited recent authors in the Stanford Encyclopedia of Philosophy spent most of his career in non-Anglophone countries writing primarily in a language other than English. In contrast, philosophy articles published in elite Chinese-language and Spanish-language journals cite from a range of linguistic traditions, as do non-English-language articles in a convenience sample of established European-language journals. We also find evidence that work in English has more influence on work in other languages than vice versa and that when non-Anglophone philosophers cite recent work outside of their own linguistic tradition it tends to be work in English. (shrink)

The mainstream tradition in recent Anglophone Zhuangzi interpretation treats spontaneous skillful responsiveness – similar to the spontaneous responsiveness of a skilled artisan, athlete, or musician – as a, or the, Zhuangzian ideal. However, this interpretation is poorly grounded in the Inner Chapters. On the contrary, in the Inner Chapters, this sort of skillfulness is at least as commonly criticized as celebrated. Even the famous passage about the ox-carving cook might be interpreted more as a celebration of the knife’s passivity than (...) as a celebration of the cook’s skillfulness. (shrink)

Neuroethics is an interdisciplinary field that arose in response to novel ethical challenges posed by advances in neuroscience. Historically, neuroethics has provided an opportunity to synergize different disciplines, notably proposing a two-way dialogue between an ‘ethics of neuroscience’ and a ‘neuroscience of ethics’. However, questions surface as to whether a ‘neuroscience of ethics’ is a useful and unified branch of research and whether it can actually inform or lead to theoretical insights and transferable practical knowledge to help resolve ethical questions. (...) In this article, we examine why the neuroscience of ethics is a promising area of research and summarize what we have learned so far regarding its most promising goals and contributions. We then review some of the key methodological challenges which may have hindered the use of results generated thus far by the neuroscience of ethics. Strategies are suggested to address these challenges and improve the quality of research and increase neuroscience's usefulness for applied ethics and society at large. Finally, we reflect on potential outcomes of a neuroscience of ethics and discuss the different strategies that could be used to support knowledge transfer to help different stakeholders integrate knowledge from the neuroscience of ethics. (shrink)

Conjoined twinning is said to show that the number of human people—the number of us—can differ from the number of human organisms, and hence that we are not organisms. The paper shows that these arguments either assume the point at issue, rely on dubious and undefended assumptions, or add nothing to more familiar arguments for the same conclusion.

In the 1950s, dream researchers commonly thought that dreams were predominantly a black and white phenomenon, although both earlier and later treatments of dreaming assume or assert that dreams have color. The first half of the twentieth century saw the rise of black and white film media, and it is likely that the emergence of the view that dreams are black and white was connected to this change in film technology. If our opinions about basic features of our dreams can (...) change with changes in technology, it seems to follow that our knowledge of the experience of dreaming is much less secure than we might at first have thought it to be. (shrink)

ABSTRACTMany philosophers say that the nature of personal identity has to do with narratives: the stories we tell about ourselves. While different narrativists address different questions of personal identity, some propose narrativist accounts of personal identity over time. The paper argues that such accounts have troubling consequences about the beginning and end of our lives, lead to inconsistencies, and involve backwards causation. The problems can be solved, but only by modifying the accounts in ways that deprive them of their appeal.

b>: This article explains the concept of multiple realizability and its role in the philosophy of mind. In particular, I consider what is required for the multiple realizability of psychological kinds, the relevance of multiple realizability to the reducibility and autonomy of psychology, as well as further refinements of the concept that would prove helpful.

This paper argues for the need of philosophical translator-advocates to overcome the (would-be) limitations produced by the linguistic narrowness of analytic philosophy. It draws on a model used to analyze epistemic communities in order to characterize a form of linguistic injustice. In particular it does so by treating language as an epistemic barrier to entry of ideas and people and by treating philosophical translator-advocates as engaged in a form of arbitrage. Along the way I specify some necessary and jointly sufficient (...) characteristics of a philosophical translator-advocate. My argument is illuminated and vivified with examples from the history of analytic philosophy and other episodes from the history of philosophy. (shrink)

The theory and practice of history and its relevance to the modern world, by Britains greatest radical historian.

In this paper, we outline and critically evaluate Thomas Hofweber’s solution to a semantic puzzle he calls Frege’s Other Puzzle. After sketching the Puzzle and two traditional responses to it—the Substantival Strategy and the Adjectival Strategy—we outline Hofweber’s proposed version of Adjectivalism. We argue that two key components—the syntactic and semantic components—of Hofweber’s analysis both suffer from serious empirical difficulties. Ultimately, this suggests that an altogether different solution to Frege’s Other Puzzle is required.

In his original semantics for counterfactuals, David Lewis presupposed that the ordering of worlds relevant to the evaluation of a counterfactual admitted no incomparability between worlds. He later came to abandon this assumption. But the approach to incomparability he endorsed makes counterintuitive predictions about a class of examples circumscribed in this paper. The same underlying problem is present in the theories of modals and conditionals developed by Bas van Fraassen, Frank Veltman, and Angelika Kratzer. I show how to reformulate all (...) these theories in terms of lower bounds on partial preorders, conceived of as maximal antichains, and I show that treating lower bounds as cutsets does strictly better at capturing our intuitions about the semantics of modals, counterfactuals, and deontic conditionals. (shrink)

It is possible to survey humankind and be proud, even to smile, for we accomplish great things. Art and science are two notable worthy human accomplishments. Consonant with art and science are some of the ways we treat each other. Sacrifice and heroism are two admirable human qualities that pervade human interaction. But, as everyone knows, all this goodness is more than balanced by human depravity. Moral corruption infests our being. Why?

Cartesian or substance dualism is the view that concrete substances come in two basic kinds. There are material things, such as biological organisms. These may be either simple or composed of parts. And there are immaterial things--minds or souls--which are always simple. No material thing depends for its existence on any soul, or vice versa. And only souls can think.

Animalism is the view that you and I are animals. That is, we are animals in the straightforward sense of having the property of being an animal, or in that each of us is identical to an animal-not merely in the derivative sense of having animal bodies, or of being "constituted by" animals. And by 'animal' I mean an organism of the animal kingdom." Sensible though it may appear, animalism is highly contentious. The most common objection is that it conflicts (...) with widespread and deep beliefs about our identity over time. These beliefs are brought out in reactions to fictional cases. Suppose, for instance, that your brain is transplanted into my head. The being who ends up with that organ, everyone assumes, will remember your life and not mine. More generally, he will have your beliefs, preferences, plans, and other mental properties, for the most part at least. Who would he be-you, me, or someone else? (shrink)

Should we understand the biological philosophy of Hans Jonas as a phenomenology for unveiling the phenomenon of life or as a kind of Hegelian metaphysics that presents life as a substantial principle? To answer that question, we need to deal first with the question of our access to other living beings and then with the problem of the spiritualization of the concept of evolution. This article will use an essay called “Organism and Freedom: An Essay in Philosophical Biology.”.

Sometimes analogy researchers talk as if the freshness of an experience of analogy resides solely in seeing that something is like something else -- seeing that the atom is like a solar system, that heat is like flowing water, that paint brushes work like pumps, or that electricity is like a teeming crowd. But analogy is more than this. Analogy isn't just seeing that the atom is like a solar system; rather, it is seeing something new about the atom, an (...) observation enabled by 'looking' at atoms from the perspective of one's understanding of solar systems. The question for analogy researchers then is this: Where does this new knowledge about atoms come from? How can an analogy provide new knowledge and new understanding? (shrink)

Hegel remarked in his discussion of the nothing in the Science of Logic that: “It is well known that in oriental systems, and essentially in Buddhism, nothing, or the void, is the absolute principle.” Schopenhauer commented in a discussion of the joy of death in The World as Will and Representation: “The existence which we know he willingly gives up: what he gets instead of it is in our eyes nothing, because our existence is, with reference to that, nothing. The (...) Buddhist faith calls it Nirvana, i.e., extinction.” It is striking how nineteenth-century German philosophical discourses (from Hegel and Schopenhauer to Mainländer, von Hartmann, and Nietzsche) concerning negativity, nihility, and nothingness explicitly refer to Buddhism, which was initially conceived by Christian missionaries as a “cult of nothingness” and became entangled with European debates concerning pessimism (the Pessimismusstreit) and nihilism. In this article, I reconsider how the interpretation of negativity and nothingness in Schopenhauer and nineteenth-century German thought informed the reception of Buddhism as a philosophical and religious discourse, and trace the ways in which Buddhist emptiness was reinterpreted in the context of the Western problematic of being and nothingness. (shrink)

Rights-oriented libertarian theory asserts the existence of robust individual rights - including robust rights of property. If these property rights are absolute, then it seems that all taxation is theft. However, it also seems that, if an individual is (faultlessly) in dire straits, it is permissible for him to seize or trespass in order to escape from those straits. It does seem that in this sense property rights are non-absolute. This essay examines what contribution this non-absoluteness of rights makes to (...) the justification of taxation for the sake of rescuing individuals from their dire straits. The essay investigates how dire an individual's circumstances have to be for him to have a dispensation from the normal obligation to respect property. It distinguishes among different dispensations that individuals in dire enough circumstances may have. And it emphasizes how precarious is the path from the premise that sometimes individuals possess one or another of these dispensations to the conclusion that taxation to rescue people from dire straits is justified. Footnotesa I thank Ellen Paul, the other contributors to this volume, and Mary Sirridge for their helpful comments. (shrink)

ABSTRACTIn this paper I argue that Kant’s complex argument against materialism involves not only his generic commitment to the existence of non-spatio-temporal and thus non-material things in themselves, but also considerations pertaining to reason and the subject of our thoughts. Specifically, I argue that because Kant conceives of reason in such a way that it demands a commitment to the existence of the unconditioned so that we can account for whatever conditioned objects we encounter in experience, our thoughts, which are (...) also conditioned, require something unconditioned that, because it is unconditioned, cannot be material. In this way, Kant’s attitude towards materialism is based not only on abstract features of his metaphysics and epistemology, but also on specific features that were under serious discussion in the early modern period. (shrink)

Though whistleblowing is quickly becoming an accepted means of addressing wrongdoing, whistleblower protection laws and the relevant case law are either awkwardly silent, unclear or mutually inconsistent concerning public disclosures of classified government information. I remedy this problem by first arguing that such disclosures constitute a pro tanto wrong as they violate (1) promissory obligations, (2) role obligations and (3) the obligation to respect the democratic allocation of power. However, they may be justified if (1) the information disclosed concerns grave (...) government wrongdoing, (2) alternative channels of disclosure are first exhausted and (3) steps are taken to minimize harm. (shrink)

Many philosophical theories make comparisons between objects, events, states of affairs, worlds, or systems, and many such theories deliver plausible verdicts only if some of the elements they compare are ranked as ‘best.’ When the relevant ordering does not have such ‘best’ or ‘tied for best’ elements the theory wrongly falls silent or gives badly counterintuitive results. This paper develops ordering supervaluationism---a very general technique that allows any such theory to handle these problematic cases. Just as ordinary supervaluation helps us (...) save and generalize ‘uniqueness assuming’ theories, ordering supervaluationism helps us save and generalize ‘limit assuming’ theories. With so many otherwise attractive limit assuming theories, this is a sensible, methodologically conservative approach. (shrink)

While the concept of multiple realizability is widely used, it is seldom rigorously characterized. This paper defends a liberal conception of multiple realizability as sameness of type through _any_ differences in the (lower-level) conditions that give rise to instances of that type. This kind of “sameness through difference” is contrasted with another type of asymmetric dependency relation between properties, multiple _specification_. This liberal conception is then defended from objections, and it is augmented by a concept of relativized multiple realizability. The (...) last section presents a survey of the ontological, explanatory, and methodological consequences of this analysis of multiple realizability. (shrink)

Bioethics, Volume 36, Issue 1, Page 63-70, January 2022.