Since their discovery over two decades ago, the molecular and cellular functions of the NIPSNAP family of proteins (NIPSNAPs) have remained elusive until recently. NIPSNAPs interact with a variety of mitochondrial and cytoplasmic proteins. They have been implicated in multiple cellular processes and associated with different physiologic and pathologic conditions, including pain transmission, Parkinson's disease, and cancer. Recent evidence demonstrated a direct role for NIPSNAP1 and NIPSNAP2 proteins in regulation of mitophagy, a process that is critical for cellular health and (...) maintenance. Importantly, NIPSNAPs contain a 110 amino acid domain that is evolutionary conserved from mammals to bacteria. However, the molecular function of the conserved NIPSNAP domain and its potential role in mitophagy have not been explored. It stands to reason that the highly conserved NIPSNAP domain interacts with a substrate that is ubiquitously present across all species and can perhaps act as a sensor for mitochondrial health. (shrink)

Karim Fathi liefert erstmalig einen Überblick über die unterschiedlichen Diskurse und Strategien der Komplexitätsbewältigung auf der Ebene von Teams, Organisationen und Gesellschaften. Unter der Leitdifferenz kommunikativer Komplexitätsbewältigung untersucht er Fragen wie: Welche Strategien und Methoden ergeben sich im Umgang mit komplexen, vieldimensionalen und unvorhersehbaren Problemen? Wie können Kommunikationsprozesse so gestaltet werden, dass sie höhere kollektive Intelligenz ermöglichen? Sein universell anwendbarer Ansatz unterstützt komplexe Problemlöseprozesse auf allen Ebenen und fördert transdisziplinäres Denken in Zeiten globalen strukturellen Wandels.

Background The increasing prevalence of moral distress in the stressful environment of the intensive care unit (ICU) provides grounds for nursing error and endangers patients’ health, safety, and even life. One of the most important reasons for this distress is the treatment team’s second victim syndrome (SVS), especially nurses, following errors in the treatment system. Objectives The present study aimed to determine the relationship between moral distress and SVS in ICUs. Research design This cross-sectional study involved a sample size of (...) 96 ICU nurses working in hospitals affiliated with Tehran University of Medical Sciences, Iran, in the 2021–2022 period, who were selected via a simple random sampling method. Data were collected using the Demographic Questionnaire, the second victim experience and support tool (SVEST) and Moral Distress Scale-Revised (MDS-R). Descriptive statistics (percentage, frequency, mean, and SD) and analytical tests (Spearman correlation coefficient test, independent t-test, and ANOVA) were employed for data analysis. Participants and research context This study used a sample size of 96 intensive care unit nurses working in hospitals affiliated to Tehran University of Medical Sciences selected by simple random sampling. Ethical considerations The study obtained research ethics approval, and all participants were informed of the voluntary and anonymous nature of their participation. Findings The results showed that 59.4% of nurses suffered a low level of moral distress, and 40.6% suffered from a moderate level of moral distress. The SVS score of 86.5% of the nurses was moderate. There was no significant and direct correlation between moral distress and SVS in nurses; however, there was a significant and inverse correlation between the moral distress intensity and SVS ( p = 0.011). Conclusion Despite no significant correlation between moral distress and SVS, these variables were at moderate levels. Accordingly, it is suggested to provide a proper ground for expressing morally stressful situations, counseling and training strategies to deal with moral distress, creating support resources for those suffering from SVS, and implementing empowerment programs. (shrink)

The extended neoteric ranked set sampling plan proposed by Taconeli and Cabral has proven to outperform many one stages and two stages ranked set sampling plans when estimating the mean and the variance for different populations. Therefore, in this paper, the likelihood function based on ENRSS is proposed and used for estimation of the parameters of the inverted Nadarajah–Haghighi distribution. An extensive Monte Carlo simulation study is conducted to assess the performance of the proposed likelihood function, and the efficiency of (...) the estimated parameters based on ENRSS is compared with the well-known ranked set sampling plan and some of its modifications. These modifications include the extended ranked set sampling plan and the neoteric ranked set sampling plan. The results as foreseeable were very satisfactory and gave similar results to Taconeli and Cabral’s 2019 results. (shrink)

Philosophy; Arab countries; political and social conditions.

Für den interkulturellen Dialog zwischen den europäischen Ländern und ihren muslimischen Nachbarn spielen die Künste eine zentrale Rolle. Jede Kunst hat eine ihr eigene Sprache entwickelt, die den Menschen hilft, in Beziehung zueinander zu treten und sich auszutauschen. Die Künste geben den Kulturen die Möglichkeit sich auszudrücken und tragen zur Entstehung kultureller Identität bei. Sie formen die Wahrnehmungen, Erinnerungen, Vorstellungen und damit das individuelle und kollektive Imaginäre. In ihnen erfahren die Menschen die Alterität anderer Kulturen und ihrer selbst und werden (...) dadurch gebildet. Die Künste sind nicht nur den Angehörigen ihrer Kultur, sondern allen Menschen zugänglich. Sie vermitteln heterologische Erfahrungen und haben daher für die Verständigung zwischen den verschiedenen Kulturen eine große Bedeutung. Zu den Autoren gehören Kulturwissenschaftler und Philosophen aus europäischen und muslimischen Ländern: Radwa Ashour, Hans Belting, Benmeziane Bencherki, Roland Bernecker, Christina von Braun, Paolo Fabbri, Lydia Goehr, Gertrud Koch, Klaus Krüger, Mustapha Larissa, Reyés Mate, Hamdi Mehrez, Marie-José Mondzain, Angelika Neuwirth, Ludgar Schwarte, Antoine Seif, Philippe Tancelin, Jacques Poulain, Fathi Triki, Rachida Triki, Hassan Wahibi,Christoph Wulf, Mohamed Zouzi-Chebbi. (shrink)

L’individu peine à émerger dans les sociétés musulmanes qui vivent toujours sous l’impérium de la communauté. La dignité du vivre-ensemble ne devient réelle que dans la mesure où l’individu se libère et choisit son mode de vie. La dignité implique la liberté et la liberté conduit à la dignité. La question est de savoir si l’islam est un obstacle à cette libération de l’individu et s’il englobe en son sein le communautarisme. Est-il vrai que l’Islam est une religion de l’identité, (...) de la communauté et donc de l’exclusion de la dignité individuelle? (shrink)

Home and place are two interrelated concepts that have overlapping meanings. They are both referring to physical spaces that have meanings and feelings, spaces where common experiences shape and identities are formed. The concepts of home and place are intrinsically linked and are used interchangeably but the most important line that ties these two together is through the notion of belonging and attachment that bind individuals to meaningful spaces. However, there is a gap in the home and place literature about (...) understanding these meanings through negative attributes. This chapter explores the similarities and differences of home and place through negative experiences of two groups of vulnerable people: homeless people and migrants. In this chapter we examine how a lack of physical attachments leads to a lack of belonging and how, together, they create ruptures that ironically help to understanding of the meanings of home and place by separating them from the notion of space. The chapter acknowledges that not all places are called home and not all spaces have the capacity to be made into meaningful places, but that one must focus on the theoretical distinctions underpinning the two terms. The authors suggest that focusing on two vulnerable populations (migrants and homeless people) can offer a pathway towards a theoretical understanding of these two generic concepts. By examining the negative experiences of marginalization and exclusion, in relation to the meanings of home and place, the chapter discusses how negative experiences of displacement and homelessness can offer valuable insights into further theorization of the concepts of home and place. (shrink)

Disintegration is the most important step for drug bioavailability because after, the disintegration process, the ingredients of solid dosage forms dissolve and become bioavailable. Generally, the tablets and capsules should be taken with a glass of water otherwise the manufacturer gives instructions to use the proper beverage. Several drugs are taken with different forms of beverages to ensure easy swallowing of the tablet, masking the bad taste of the drug and overcoming the drug aftertaste, these beverages can influence the disintegration (...) of the solid dosage form. The most common cold beverages consumed by the Libyan population are juice, milk, and Coca-Cola. These beverages are consumed without awareness of the possible effect of these beverages on drugs, especially over-the-counter drugs such as analgesic, antipyretic, and anti-inflammatory drugs that are taken without a prescription. This study aimed to evaluate the influence of three beverages, namely: orange juice, milk, and Coca-Cola on the disintegration time of four over-the-counter-drugs: Panadol, Congestal, Brufen, and Reality Extra using disintegration test of drugs in 0.1 N HCL and in hybrid medium prepared by combination of 150 ml 0.1 N HCL and 550 ml of beverage to simulate in vivo condition. The findings show that the orange juice significantly increases the disintegration time of all the investigated drugs. Coca-Cola significantly increases the disintegration time of Reality Extra, and slightly increases the disintegration time of Brufen, Congestal, and Panadol and the full-fat milk significantly increases the disintegration time of Reality Extra and Panadol while slightly increasing the disintegration time for Brufen and Congestal. It is concluded that commonly used beverages affect the disintegration time of the examined over-the-counter drugs. Patients should be advised to take these medications without beverages which may delay the disintegration and the onset of action of the drug. (shrink)

Demokratische Lebensbedingungen sind nur möglich, wenn Menschen mit Hilfe von Erziehung und Bildung über die Fähigkeit verfügen, ihre gesellschaftlichen, sozialen und kulturellen Verhältnisse so zu gestalten, dass sie sich an den menschlichen Grundrechten orientieren. Erziehung und Bildung dürfen nicht auf die Maximierung von Leistungsfähigkeit, Demokratie und gesellschaftliches Zusammenleben nicht auf die bloße Befolgung von Gesetzen und Regeln reduziert werden. Erziehung und Bildung umfassen wissen lernen, handeln lernen, zusammenleben lernen und sein lernen. Gelingende Demokratie zielt auf Lebens-, Interaktions-, Kommunikationsverhältnisse, die sich (...) an den Werten gesellschaftliche Sicherheit, soziale Gerechtigkeit und Nachhaltigkeit orientieren und zugleich für neue individuelle und soziale Entwicklungen offen sind. Infolge der Globalisierung und des Neoliberalismus sind Demokratien und ihre Bildungssysteme in den europäischen, muslimischen und arabischen Ländern in Gefahr, den Reichtum und die Vielfalt ihrer Werte und Lebensformen auf die Realisierung enger religiöser Vorstellungen, die Durchsetzung politischer und ökonomischer Herrschaft und die Überbetonung zweckrationalen Denkens und Handelns zu reduzieren. Dagegen bestehen die Autoren und Autorinnen dieses Bandes auf der Notwendigkeit partizipatorischer Erziehungs- und Bildungsprozesse, die die Entwicklung von Subjekten und Gemeinschaften fördern und in denen Menschen lernen, ihre individuellen und gesellschaftlichen Lebensbedingungen in kultureller Diversität demokratisch zu gestalten. (shrink)

While most chemists agree on what is a metal and what is a non-metal there is a disagreement with respect to what is a metalloid and what is a transition metal. It is believed that this problem can be solved if two new terms are adopted: typical and less typical metals. These new terms will also help reconcile the European Periodic Table versus the North American regarding numbering of groups as well as the IUPAC numbering which could be as well (...) abandoned in favour of group names as will be shown in the manuscript. (shrink)

Diabetic ketoacidosis is a serious, medical emergency that can be fatal but treatable, we aimed to evaluate the clinical profile of patients admitted with diabetic ketoacidosis. This case series study enrolled 213 non-pregnant adult and adolescent patients admitted with diabetic ketoacidosis at Tripoli Diabetes Hospital from January to September 2023. Demographic data, clinical characteristics, laboratory findings, precipitating factors, and patient outcomes were extracted from medical records and analyzed. Type 1 diabetes mellitus was present in 187 (87.8%) of patients, the age (...) range 11-84 years, (30.26±13.28), with 130 patients ≤30 years old (61.0%), females accounting for 110 of the patients (51.6%), 109 had a diabetes duration of less than 10 years (51.2%). The most common precipitating factor was insulin omission 92 (43.2%) in patients with known diabetes mellitus, whereas, diabetic ketoacidosis as the first presentation of diabetes mellitus in 24 patients (11.7%), systolic blood pressure ranged 50-160 mmHg (112.82±16.19), diastolic blood pressure varied 30-100 mmHg (70.24±11.32). Plasma glucose at presentation ranged 183-1494 mg/dl (462.92±169.85), with Eu-glycemic diabetic ketoacidosis 100-249 mg/dl were in nine patients (4.2%), whereas most of cases (135 patients, 63.4%) present with plasma glucose 250-500 mg/dl, while hyperosmolar status (≥701 mg/dl) were present in 13 patients (6.1%). Venous pH varied from 6.7-7.42 (7.13±0.14), 132 (62.0%) patients presented with pH <7.24, while severe acidosis was pH < 7 in 32 of patients (14.6%), serum bicarbonate with 10.93±4.95, severe (<5 mmol) in 91 patients (42.7%) and moderate (5-10 mmol) were in 79 patients (37.08%). The mean length of hospital stay was 3.33 days, with an average of 2.11 days spent in the high-dependent unit. Serum potassium varied from 2.4-6.7 meq/L with 3.66± 0.63, most common complications of diabetic ketoacidosis treatment were hypokalemia observed in 82 (35.7%) of cases, and hypoglycemia was detected in 41 patients (19.2%). 170 patients were discharged in good condition (79.8%), and 17.8% of patients were transferred to another hospital to receive further management for co-morbid diseases with diabetes after controlling their hyperglycemic crises. The majority of patients presented with the critical status of diabetic ketoacidosis. The findings emphasize the importance of patient education about prevention measures prompt presentation to the hospital, and clinicians' awareness for early and aggressive treatment of hyperglycemic crises. (shrink)

The culmination of a lifetime's design practice and environmental study, Natural Energy and Vernacular Architecture presents a master architects' extraordinary insights into the vernacular wisdom of indigenous architectural forms that have evolved in hot arid climates.

Ethical decision making is a complex issue because it strongly depends on the religion, beliefs, traditional laws and moral views of each society. The purpose of this study was to explore the experience of Iranian family caregivers of end stage cancer patients about ethical decision making. This qualitative study is based on van Manen’s method of hermeneutic phenomenology. In-depth interviews were carried out to collect data. Participants were 12 caregiver. Audiotapes were transcribed and analyzed for common themes that represented the (...) participants’ experiences. Trustworthiness of the findings was established using the Lincoln and Guba’s criteria. Three themes reflected the essence of caregivers’ lived experience including; fluctuating between hope and despair, wandering dilemma, and ethical decision making. Each of these themes consisted of several subthemes. The present study revealed that, the caregivers of terminally ill cancer patients need different information about prognosis and end of life decision making process. Our perception of how families negotiate ethical issues in their decision-making is still developing. Opportunities should be created to empowering caregivers to talk about their uncertainties and concerns. (shrink)

Because of the exacting nature of teaching, identifying factors affecting teachers’ mental health and psychological wellbeing are of paramount importance. Parallel with this line of inquiry, the goal of this project was to test a model of psychological wellbeing based on teacher self-efficacy and emotion regulation in an EFL context. To this end, 276 Iranian English teachers participated in this survey. First, the measurement models for the three latent constructs were verified through performing Confirmatory Factor Analysis. Then Structural Equation Modeling (...) was used to test the hypothesized model. SEM outcomes evince that both teacher self-efficacy and emotion regulation were the significant predictors of teachers’ psychological wellbeing, with teacher self-efficacy being a stronger correlate than emotion regulation. The findings offer significant implications for English as a Foreign Language teachers. (shrink)

Une sorte de dialogue entre un "acteur" (Jacques Derrida) et un "auteur" (Safaa Fathy), croisant leur mémoire (notamment sur l'Algérie) et leur réflexion. Deux autobiocinématographies réalisées à partir d'un film produit pour la série "Profils" d'Arte et consacré au philosophe : D'ailleurs, Derrida. Au-delà du méta-discours sur le cinéma, il s'agit ici de tenter une cinématographie de la parole.

The current study aimed to verify the multidimensional factor structure of teacher reflection and to examine the psychometric properties of a widely used teacher reflection scale using a large-scale representative dataset of 1,611 practicing Iranian English as a Foreign Language teachers. Furthermore, the measurement invariance of the hypothesized, a priori six-factor model of teacher reflection as measured by the adapted scale was assessed across gender and educational degree in Mplus program. In addition, the differences in latent factor means of the (...) same groups were examined. The result of confirmatory factor analysis revealed that teacher reflection was a multidimensional construct, encompassing six underlying factors. Overall, the adapted teacher reflection scale based on the 6-factor model showed an overall good fit. The results also indicated metric and scalar invariance which manifests that the factors underlying the adapted scale had an identical theoretical structure across educational degree/gender groups. Finally, there were significant factor mean differences in reflection components across gender and educational degree groups. A discussion of the results and their implications ensue. (shrink)

Pentecostal Republic: Religion and the Struggle for State Power in Nigeria By ObadareEbenezer, xviii + 214 pp. Price PB £16.99. EAN 978–1786992376.