Este trabajo se propone calcular la pobreza de tiempo en la Provincia de Santa Fe en el tercer trimestre de 2013 a partir de la encuesta sobre trabajo no remunerado y uso de tiempo del Indec, utilizando la metodología cuantitativa de Zacharías, Antonopoulos y Masterson (2012). Los objetivos específicos son, en primer lugar, estimar la pobreza de tiempo individual; en segundo lugar, calcular la pobreza de tiempo según la estructura demográfica de los hogares; y en tercer lugar, analizar cómo se (...) distribuye el trabajo remunerado y no remunerado según el sexo. Entre los resultados del trabajo, se encontró que las mujeres de 18 años o más dedicaban más tiempo que los varones al trabajo doméstico y de cuidados no remunerado, mientras que ocurría lo inverso con el trabajo remunerado. Respecto de la pobreza de tiempo, se observó que el 20,2% de las personas de 18 años o más eran pobres de tiempo, de las cuales el 75,7% eran mujeres. Asimismo, el 40,4% de los hogares encuestados eran pobres de tiempo. Por último, se encontró que de todas las personas de 17 años o menos, el 80,6% pertenecían a un hogar pobre de tiempo. (shrink)

Nursing research using concept analysis plays a critical role for knowledge development, particularly when concerning to broad and foundational concepts for nursing practice, such as dignity. This study aimed to synthesize research concerning concept analysis of dignity in nursing care. Based on a literature review, electronic databases were searched using the terms “dignity,” “human dignity,” “concept analysis,” and nurs*. Papers in Portuguese or English were included. The research synthesis was conducted independently by two reviewers. A total of 35 citations were (...) identified and seven papers were included. Six studies were elected using Walker and Avant concept analysis methodology while one applied the Beth Rodgers evolutionary model. The concept of dignity has been studied by nurses, and its attributes, antecedents, consequences, and similar concepts were synthesized into a definition. Dignity emerged as a fundamental concept in nursing ethics and the main attributes synthesized were personhood, sociability, respect, and autonomy. The antecedents identified were: facilitators—patient focus care, recognition, education, and ethical competence; threats—vulnerability and organizational environment. The consequences were positive coping, empowerment, and dignity preservation. The synthesis of these seven studies using concept analysis provided a clear definition of dignity. These findings challenge future research and education, particularly for the study of undergraduate and postgraduate nursing education programs to enhance skills for preserving patient dignity in clinical practice. (shrink)

Any living organism interacts with and responds specifically to environmental molecules by expressing specific olfactory receptors. In this paper, this specificity will be first examined in causal terms with particular emphasis on the mechanisms controlling olfactory gene expression, cell-to-cell interactions and odor-decoding processes. However, this type of explanation does not entirely justify the role olfactory receptors have played during evolution, since they are also expressed ectopically in different organs and/or tissues. Homologous olfactory genes have in fact been found in such (...) diverse cells and/or organs as spermatozoa, testis and kidney where they are assumed to act as chemotactic sensors or renin modulators. To justify their functional diversity, homologous olfactory receptors are assumed to share the same basic role: that of conferring a self-identity to cells or tissues under varying environmental conditions. By adopting this standpoint, the functional attribution as olfactory or chemotactic sensors to these receptors should not be seen either as a cause conditioning receptor gene expression, or as a final effect resulting from genetically predetermined programs, but as a direct consequence of the environmental conditions olfactory receptor genes have explored during evolution. The association of odorant patterns with specific environmental or contextual situations makes their relationship semiotically triadic, due to the emergence of an interpretant capable of perceiving odorants as meaningful signs out of a noisy background. This perspective highlights the importance of odorant-receptor relationships as respect to the properties of the interacting partners. It is our contention that only when taken together can these different explanatory strategies provide a realistic account of how olfactory receptor genes have been structurally and functionally modified during evolution. (shrink)

This article motivates a shift in certain strands of the debate over legitimate roles for nonepistemic values in scientific practice from investigating what is involved in taking cognitive attitudes like acceptance toward an empirical hypothesis to looking at a social understanding of assertion, the act of communicating that hypothesis. I argue that speech act theory’s account of assertion as a type of doing makes salient legitimate roles nonepistemic values can play in scientific practice. The article also shows how speech act (...) theory might provide a framework for fruitfully extending aspects of the social and pragmatic turns in the philosophy of science. (shrink)

The heristic argument with which Meno questions the possibility of inquiry and knowledge is tackled by Socrates through the reference to an archaic and religious doctrine, according to which the soul is immortal and has seen all things. Through this reference Socrates actually wants to affirm the affinity between the soul and the world of forms. So behind the myth of the prenatal vision of forms by the soul Plato intends to assert the ontological condition of the soul, that is, (...) its affinity to forms. (shrink)

I explore three points about the relationship between C.I. Lewis’s conceptual pragmatism and W.V. Quine’s naturalized epistemology inspired by Robert Sinclair’s Quine, Conceptual Pragmatism, and the Analytic-Synthetic Distinction. First, I highlight Lewis’s long-standing commitment to Platonism about meaning and its connection to his reflective philosophical method and rejection of a linguistic account of analyticity. Second, I consider Sinclair’s claim that “Lewis’s epistemology provides no indication concerning how, despite different sensory experiences, we still come to agree on what we are talking (...) about and what counts as evidence” (2022, 113). I find more hints, especially in Lewis’s account of how we verify that two people share meaning in common. However, some of the pragmatic and broadly empirical factors Lewis appeals to are not part of Quine’s naturalized epistemology. Finally, I relate these points to Quine’s (1953/1980) claim to advance a more “thorough pragmatism” than Lewis. Quine does not say much about action, value, and ethics, but these are central parts of Lewis’s conceptual pragmatism and a source of his reluctance to abandon those parts of his epistemology that Sinclair argues Quine found dispensable. (shrink)

Receptor oligomerization plays a key role in maintaining genome stability and restricting protein mutagenesis. When properly folded, protein monomers assemble as oligomeric receptors and interact with environmental ligands. In a gene-centered view, the ligand specificity expressed by these receptors is assumed to be causally predetermined by the cell genome. However, this mechanism does not fully explain how differentiated cells have come to express specific receptor repertoires and which combinatorial codes have been explored to activate their associated signaling pathways. It is (...) our contention that the plasma membrane acts as the locus where several contextual cues may be integrated. As such it allows the semiotic selection of those receptor configurations that provide cells with the minimum essential requirements for agency. The occurrence of protein misfolding makes it impossible for receptor monomers to assemble along the membrane and to sustain meaningful relationships with environmental ligands. How could a cell lineage deal with these loss-of-function mutations during evolution and restrain gene redundancy accordingly? In this paper, we will be arguing that the easiest way for bacteria clones to accomplish this goal is by getting rid of cells expressing mutated receptor proteins. The mechanism sustaining this cell selection is also occurring in many somatic tissues and its function is currently believed to counteract in vivo protein mutagenesis. Our discussion will be mainly focused on the significance and semiotic nature of the interplay between membrane receptors and the epigenetic control of gene expression, as mediated by the control of mismatched repairing and protein folding mechanisms. (shrink)

This article replies to the critical note by Trabattoni («Elenchos», xxxiii (2012) pp. 69-107). The author defends his interpretation of Plato's Theaetetus against Trabattoni's objections, arguing that the maieutic and peirastic character of the dialogue explains its negative or aporetic conclusion. For the failure of all the attempts to define knowledge in the dialogue doesn't mean that, according to Plato, knowledge is not possible for men or that it can be identified with doxa; on the contrary, Plato clearly states that (...) the philosopher, i.e. the dialectician, is absolutely able to attain the perfect knowledge of the forms. The subsequent failures in the Theaetetus, particularly the last two, depend on the admission of an "additive model'' according to which knowledge is "doxa plus something'', an epistemological attitude that is explicitly rejected in the Meno. (shrink)

In the proem that precedes the account of the generation of the world, Timaeus provides very important elements for understanding the discourse he is about to delivery. It is a complex text that displays at least three different levels: dialectical, analogical (or metaphorical) and epistemological. In the dialectical section, Timaeus establishes that the sensible universe is a generated reality and as such has a cause; in the metaphorical section, he indicates the analogical schemes he will use to explain the genesis (...) of the cosmos (technical and biological) and the causes on which it depends. Finally, in the epistemological section he explains the reason why this exposition cannot achieve truth but must be content with likeness. (shrink)

A central aim of cognitive science is to understand the fundamental mechanisms that enable humans to navigate and make sense of complex environments. In this letter, we argue that computational complexity theory, a foundational framework for evaluating computational resource requirements, holds significant potential in addressing this challenge. As humans possess limited cognitive resources for processing vast amounts of information, understanding how humans perform complex cognitive tasks requires comprehending the underlying factors that drive information processing demands. Computational complexity theory provides a (...) comprehensive theoretical framework to achieve this goal. By adopting this framework, we can gain new insights into how cognitive systems work and develop a more nuanced understanding of the relation between task complexity and human behavior. We provide empirical evidence supporting our argument and identify several open research questions and challenges in applying computational complexity theory to human decision‐making and cognitive science at large. (shrink)

ABSTRACTThis paper analyses the discourses produced on their websites by the two organisations that conducted the official ‘leave’ and ‘remain’ campaigns in the Brexit referendum. The analysis, whi...

Germ cells are cross-roads of development and evolution. They define the origin of every new generation and, at the same time, represent the biological end-product of any mature organism. Germ cells are endowed with the following capacities: to store a self-descriptive program, to accumulate a protein-synthesizing machinery, and to incorporate enough nourishment to sustain embryonic development. To accomplish this goal, germ cells do not simply unfold a pre-determined program or realize a sole instructive role. On the contrary, due to the (...) complexity of their cytoarchitecture and the nature of the soma-to-germ interactions, they are heavily involved in processes of sign recognition and meaningful tissue exploration. At each stage of their inward migration, germ plasma membranes act as semiotic interfaces allowing cells to interact with the surrounding extracellular milieu and experience the compatibility of selected developmental sequences. The question of which signaling pathways are activated at each developmental stage does not result from a strictly predetermined program instructing germ cell stemness. Rather, each developmental sequence is an open-ended semiotic relationship explored and gradually defined during evolution by the context-dependency of specific cell-to-cell interactions. In this way, any structural and functional novelty that has emerged in the course of germ cell interactions may be interpreted as an exaptation fixed in the species genome in response to specific environmental constraints. (shrink)

The egg behaves as a prospective cell sustaining the developmental processes of the future embryo. In biosemiotic terms, this apparent teleonomic behaviour can be accounted for without referring to the exclusive causal role played by its genetic makeup. We envision two different processes that are uniquely found in the oocyte: (1) the first involves the mechanisms by which large amounts of mRNA accumulate in the ooplasm to establish the embryo axes prior to fertilization; (2) the second involves transfer of an (...) excess of maternally supplied ribosomes to the oocyte to provide the future embryo with newly synthesized proteins. In this paper, we argue that the information required to sustain embryonic development is not due to any physical properties of the zygotic DNA and the maternal mRNAs, but to their spatially and temporally ordered relationship in the zygote’s internal space. (shrink)

Volume 16, Issue 4, September 2019, Page 381-388.

Este artículo analiza tres cuentos de Edgar Allan Poe (El demonio de la perversidad, El gato negro y El corazón delator). Estos cuentos tienen en común el tema de la perversidad hacia cuya elucidación pretendemos avanzar desde la premisa deleuziana según la cual es preciso volver al espacio literario donde fueron nombradas las perversidades, con el fin de obtener algunas claves de comprensión sobre las causas y consecuencias de la perversidad, así como sobre la naturaleza de estos personajes literarios que, (...) en los tres cuentos citados, se autodefinen como víctimas de esta condición que se encarna en los seres humanos bajo la forma de un demonio. Nos acompañarán en este recorrido los aportes teóricos de Julia Kristeva, Gilles Deleuze, Michel Foucault, François Delaporte y Claude-Olivier Doron. (shrink)

An Innovating approach to Plato’s philosophy Through a careful survey of several significant Platonic texts, mainly focussing on the nature of knowledge, Essays on Plato’s Epistemology offers the reader a fresh and promising approach to Plato’s philosophy as a whole. From the very earliest reception of Plato’s philosophy, there has been a conflict between a dogmatic and a sceptical interpretation of his work and thought. Moreover, the two sides are often associated, respectively, with a metaphysical and an anti-metaphysical approach. This (...) book, continuing a line of thought that is nowadays strongly present in the secondary literature – and also followed by the author in over thirty years of research –, maintains that a third way of thinking is required. Against the widespread view that an anti-dogmatic philosophy must go together with an anti-metaphysical stance, Trabattoni shows that for Plato, on the contrary, a sober and reasonable assessment of both the powers and limits of human reason relies on a proper metaphysical outlook. (shrink)

We show that the modal prepositional logicILM (interpretability logic with Montagna's principle), which has been shown sound and complete as the interpretability logic of Peano arithmetic PA (by Berarducci and Savrukov), is sound and complete as the logic ofπ 1-conservativity over eachbE 1-sound axiomatized theory containingI⌆ 1 (PA with induction restricted tobE 1-formulas). Furthermore, we extend this result to a systemILMR obtained fromILM by adding witness comparisons in the style of Guaspari's and Solovay's logicR (this will be done in a (...) separate continuation of the present paper). (shrink)

We live in an age of impotence. Stuck between global war and global finance, between identity and capital, we seem to be incapable of producing the radical change that is so desperately needed. Is there still a way to disentangle ourselves from a global order that shapes our politics as well as our imagination? In his most systematic book to date, renowned Italian theorist Franco Berardi tackles this question through a solid yet visionary analysis of the three fundamental concepts (...) of Possibility, Potency, and Power. Characterizing Possibility as the content, Potency as the energy, and Power as the form, Berardi suggests that the road to emancipation unravels from the awareness that the field of the possible is only limited, and not created, by the power structures that implement it. Other futures and other worlds are always already inscribed within the present, despite power's attempt at keeping them invisible. Overcoming any temptation of giving in to despair or nostalgia, Berardi proposes the notion of 'futurability' as a way to remind us that even within the darkness of our current crisis lies dormant the horizon of possibility. (shrink)

Infants initiate joint attentional exchanges by pointing relevant referents out to addressees. Over the second year of life, the functional meaning of the pointing gesture develops from declarative (sharing a referent) to informational (giving some information that is new to the addressee). This chapter analyzes this transition in the development of pointing based on experimental evidence about its production contexts and, in particular, of variables concerning the visibility of referents for infant and addressee. Further evidence is reported concerning the association (...) of pointing with vocalizations and visual checking towards the addressee in different temporal sequencing. It is argued that shared attention initiated by pointing plays a pivotal role in the intersection between social cognition and language development. (shrink)

This analysis presents an epistemological and moral examination of suffering. It addresses the specific questions: (1) What is suffering? (2) Can one's suffering be assessed by another? and (3) What is the moral significance of suffering? The epistemological analysis is orientated by Peter Hacker's framework for the investigation of emotions, demonstrating that suffering is an emotion. This leads to a discussion of whether suffering is a phenomenon that can be evaluated objectively by another person who is not experiencing the suffering, (...) questioning the validity of some decisional models for limiting life-sustaining therapies with the aim of preventing suffering. This analysis highlights that understandings of suffering are value laden. It is conventionally implied that suffering is `bad' and that it should be eliminated. Suffering is commonly regarded as a moral wrong that needs to be made right by health care. This article concludes with a recommendation for a paradigm shift in how suffering can be better understood, through the practice of empathic attunement. (shrink)

Nos mais recentes debates críticos acerca da filosofia de Platão, a doutrina da reminiscência tem suscitado um interesse comparativamente menor em relação aos outros temas tratados na obra do pensador ateniense. Grande parte dos estudiosos modernos tende a considerar a reminiscência um método de pesquisa, bem como a marginalizar a referência a dois mundos e o trânsito da alma entre eles. O que pretendo demonstrar neste artigo é que não só a teoria da reminiscência é a condição de possibilidade necessária (...) das nossas operações cognitivas, como também o é apenas e só em virtude da sua valência metafísica. (shrink)

Attention and adaptation are both mechanisms that optimize visual performance. Attention optimizes performance by increasing contrast sensitivity for and neural response to attended stimuli while decreasing them for unattended stimuli; adaptation optimizes performance by increasing contrast sensitivity for and neural response to changing stimuli while decreasing them for unchanging stimuli. We investigated whether and how the adaptation state and the attentional effect on contrast sensitivity interact. We measured contrast sensitivity with an orientation-discrimination task, in two adaptation conditions—adapt to 0% or (...) 100% contrast—in focused, distributed, and withdrawn attentional conditions. We used threshold and asymptotic performance to index the magnitude of the attentional effect—enhancement or impairment in contrast sensitivity—before and after adapting to high-contrast stimuli. The results show that attention and adaptation affect the contrast psychometric function in a similar but opposite way: Attention increases stimulus salience, whereas adaptation reduces stimulus salience. An interesting finding is that the adaptation state does not modulate the magnitude of the attentional effect. This suggests that attention affects the normalized signal once the effect of contrast adaptation has taken place and that these two mechanisms act separately to change contrast sensitivity. Attention can overcome adaptation to restore contrast sensitivity. (shrink)

Climate change's impact on investor behavior is a scantly investigated area in finance. This paper examines the performance of socially responsible exchange trade funds (ETFs) concerning conventional ETFs, in response to climate change events. We proxy climate change signals with a list of natural disaster events that NASA scientists relate to climate change. We contribute to existing literature, by using a very extensive information set of ETF strategies, not influenced by rating agencies' subjective evaluation policies, and covering almost 90% of (...) the universe of worldwide sustainability thematic-oriented ETFs. This sample allows us to identify the socially responsible investment behavior in response to unpredictable climate change shocks. Our identification strategy accounts for endogeneity concerns and relies on two-stage least square (2SLS) approach finding that responsible investors react to climate change events by purchasing socially responsible investments. The relationship between climate change signals and return of investment in themes linked to the development of sustainability is positive. Interestingly enough, the sign of this relationship is different, when we disentangle the empirical results according to the asset type, confirming that investors shift their investments from equity funds to bond funds when market sentiment worsens. Our results indicate that policymakers should increase the support of firms adopting environmentally conscious business practices, while managers should boost a sustainable business strategy. (shrink)

I explore one distinctive aspect of our relation to spaces which is particularly significant in our everyday aesthetic evaluations of cities (urban spaces): the frequent use of linguistic expressions referring to the sense of touch. We say that a space is oppressive or expansive, or warm or cold, or (more indirectly) cozy or desolate. Touching, as involved in these expressions, seems to refer, rather than to the contact of a physical object with our skin, to a sort of touching with (...) our life. To understand this, I try to make explicit both (a) what is being touched, i.e., the view of space behind these expressions; and (b) how and in which sense our life touches it. I propose to think about space as a plenum made of qualities (e.g., colors, smells, sounds, textures), some of which are penetrable and some of which are not. And as to how we touch spaces, I defend that we do so as we immerse ourselves in them. Once immersed in them, we are constantly both evaluating how well we fit in them as well as looking for a better-quality fitting. This is how we evaluate spaces aesthetically. Our embodied life fits better in a space when (a) we can realize more significant (for us, according to our ideal of life) possibilities in it, and (b) the felt quality of realizing those possibilities is enhanced by that space (“it feels better to read in this café”). (shrink)

This study investigates contemporary Mayan oral stories through the lens of Julian Jaynes's theory on the origin of consciousness, aiming to identify a potential connection between the literary elements of these narratives and traits of pre‐consciousness outlined by Jaynes. Jaynes's neuropsychological thesis argues that human consciousness emerged around 3000 years ago after a period of “bicameral mind,” characterized by auditory “hallucinations” that guided non‐habitual behavior. He claims that remnants of bicameral mentality linger to this day in all cultures. While his (...) theoretical framework has been applied to cultures in Europe, the Middle East, and Asia, this research uniquely surveys early Mayan texts and focuses on 78 oral narratives from Lake Atitlán, Guatemala. Our findings reveal traces of bicamerality, evident in the gradual fading of inner voices replaced by divination, anomalous mental states, encounters with the supernatural, and spiritual possession. Contrary to pathologizing these phenomena, the narratives often present them as abilities the Maya may not have felt culturally compelled to suppress to the extent presumed in other societies. (shrink)

The aim of this review is to identify and provide a structured overview of quantitative models in the pharmaceutical supply chain, a subject not exhaustively studied in the previous reviews on healthcare logistics related mostly to quantitative models in healthcare or logistics studies in hospitals. The models are classified into three categories of classification: network design, inventory models, and optimization of a pharmaceutical supply chain. A taxonomy for each category is shown describing the principal features of each echelon included in (...) the review; this taxonomy allows the readers to identify easily a paper based on the actors of the pharmaceutical supply chain. The search process included research articles published in the databases between 1984 and November 2016. In total 46 studies were included. In the review process we found that in the three fields the most common source of uncertainty used is the demand in the 56% of the cases. Within the review process we can conclude that most of the articles in the literature are focused on the optimization of the pharmaceutical supply chain and inventory models but the field on supply chain network design is not deeply studied. (shrink)

I defend that Cartesian passions are a function—in fact, the only function—of the mind-body union responsible for guiding us in the pursuit of our (natural) perfection, a perfection that we increase by joining goods that our nature deems to be so. This view is in conflict, on one hand, with those (a majority) who have emphasized either the epistemic or survival role of our passions and, on the other and more precisely, with a recent proposal according to which Cartesian passions (...) should not be even seen as guides for happiness. Against the latter, I will attempt to show that passions perform a guiding function (1) by discriminating what is “important” for us regarding the increase of our natural perfection (which includes informing the soul about the current state of perfection both of the body and of the mind-body union); and (2) by disposing us to act (which includes proposing to the will possible ways of action to increase or maintain our perfection). Our passions are, thus, both informative and motivational. Making explicit their informative role will require, negatively, showing that this does not mean they are reliable and, positively, undertaking a study—largely absent among commentaries—of their specific intentionality. (shrink)

La primera parte del artículo presenta un raro texto titulado "Avertissements aux Confesseurs", que se completa con otros dos fragmentos y las "Ordenances synodales" para los confesores. Se muestra como ejemplo de los efectos prácticos del Concilio de Trento en la diócesis de Ginebra, como había hecho San Carlos Borromeo en Milán. La segunda parte del artículo se refiere a los penitentes, y aunque se basa principalmente en "Introducción a la vida devota" y "Conversaciones espirituales", también tiene en cuenta algunos (...) extractos de sus cartas, traducidas ahora por primera vez al español, así como algunos de sus sermones. La tercera parte trata de tres de los capítulos del "Tratado del amor de Dios", en el que San Francisco de Sales presenta su hermosa doctrina de la contrición, rechazada por la Reforma, pero confirmada por el Concilio de Trento. (shrink)

This article compares the political philosophies of Michael Oakeshott and Isaiah Berlin, probably the two most important political philosophers in postwar Britain, who, strangely, had very little to do with one another during their illustrious careers. The article focuses on their respective critiques of rationalism and theories of liberal pluralism, arguing that Oakeshott provides the more consistent and philosophically satisfying account in both instances.

According to one of the most fundamental tenets in Indian Buddhist epistemology, there are only two means of knowledge - perception and inference - because there are only two objects of knowledge: the particular and the universal. This book deals with this tenet as it was expounded and substantiated in Dharmakirti's (7th c.) magnum opus, the Pramanavarttika, a work that has exerted lasting influence on Buddhist philosophy in India and Tibet up to the present day. (Series: Leipzig Studies on Culture (...) and History of South and Central Asia / Leipziger Studien zu Kultur und Geschichte Sud- und Zentralasiens - Vol. 5) [Subject: Buddhism, Religious Studies, Philosophy]. (shrink)

Abhinavagupta is undoubtedly the most famous Kashmirian medieval intellectual: his decisive contributions to Indian aesthetics, Saiva theology, and metaphysics, and to the philosophy of the subtle and original Pratyabhijna system, are well known. Yet so far his works have often been studied without fully taking into account the specific historical, social, artistic, religious, and philosophical context in which they are embedded. The purpose of this book is to show that this intellectual background is no less exceptional than Abhinavagupta himself. (Series: (...) Leipzig Studies on the Culture and History of South and Central Asia / Leipziger Studien zu Kultur und Geschichte Sud- und Zentralasiens, Vol. 6) [Subject: History, Abhinavagupta, India Studies, Religious Studies]. (shrink)

La teología sobre el Espíritu Santo en la obra de San Francisco de Sales no se expone en un texto ad hoc, sino que está diseminada por toda su obra, eminentemente pastoral y espiritual: sermones, cartas, conversaciones espirituales, etc. Sólo en su Tratado del amor de Dios se encuentra una exposición coherente sobre algunos aspectos de la presencia del Espíritu Santo en la vida del cristiano. La originalidad del autor de Teotimo reside en su visión del Espíritu Santo como Espíritu (...) de Amor. (shrink)