Similar to parasites, cancer cells depend on their hosts for sustenance, proliferation and reproduction, exploiting the hosts for energy and resources, and thereby impairing their health and fitness. Because of this lifestyle similarity, it is predicted that cancer cells could, like numerous parasitic organisms, evolve the capacity to manipulate the phenotype of their hosts to increase their own fitness. We claim that the extent of this phenomenon and its therapeutic implications are, however, underappreciated. Here, we review and discuss what can (...) be regarded as cases of host manipulation in the context of cancer development and progression. We elaborate on how acknowledging the applicability of these principles can offer novel therapeutic and preventive strategies. The manipulation of host phenotype by cancer cells is one more reason to adopt a Darwinian approach in cancer research. -/- . (shrink)

This book contributes to the environmental humanities field by offering an analysis of the Anthropocene fantasy: the idea that the Anthropocene is an opportunity to remake our terrestrial environment thanks to the power of technology. The author argues that the earth always escapes the human desire to remake and master it.

Although being generally safe, the use of Deep Brain Stimulation has been associated with a significant number of patients experiencing postoperative psychological and neurological harm within experimental trials. A proportion of these postoperative severe adverse effects have lead to the decision to medically prescribe device deactivation or removal. However, there is little debate in the literature as to what is in the patient’s best interest when device removal has been prescribed; in particular, what should be the conceptual approach to ethically (...) guide the decision to remove or maintain implants. The purpose of this article is to examine the ethical issues raised when patients refuse brain device explantation despite medical prescription. In order to illustrate these issues, we report and discuss a clinical case involving a patient suffering from treatment resistant depression who experienced forms of postoperative self-estrangement, as well as suicidal attempts, but who resists giving consent to device explantation. (shrink)

Haeusermann et al. (Citation2023) draw three overall conclusions from their study on closed loop neuromodulation and self-perception in clinical treatment of refractory epilepsy. The first is that closed-loop neuromodulation devices did not substantially change epileptic patient’s personalities or self-perception postoperatively. The second is that some patients and caregivers attributed observed changes in personality and self-perception to the epilepsy itself and not to the DBS treatments. The third is that the devices provided participants with novel ways to make sense of their (...) illness. These findings further demonstrate a misalignment between some neuroethicists’ concerns about putative postoperative changes to personality, and the empirical evidence for such changes. Haeusermann et al. nonetheless concede that “neurotechnology directed at persisting rather than episodic clinical phenomena could have greater implications for personality or self-perception, either because they operate more continuously or are directed at clinical phenomena that are more stably integrated into patients’ self-concepts” (41). We acknowledge that the hypothesis that participants did not report changes because they were only episodically and not continually stimulated offers an interesting line for future investigation. Nonetheless, we would like to propose that potential postoperative personality changes might be correlated with the pathophysiology itself, rather than the stimulation effects of the technology. Generally, we advance the view that unintended effects solely induced by the technology cannot be excluded per se. Regardless, this comment aims to highlight that ethicists’ starting premise should be that patients suffering from diverse pathophysiology, or patients who are treated with stimulation in different brain regions and with differing parameters, would likely not react in the same way to treatment. (shrink)

The Histories of Anthropology Annual presents diverse perspectives on the discipline’s history within a global context, with a goal of increasing awareness and use of historical approaches in teaching, learning, and conducting anthropology. The series includes critical, comparative, analytical, and narrative studies involving all aspects and subfields of anthropology. Volume 11, Historicizing Theories, Identities, and Nations, examines the work and influence of scholars, including Franz Boas, Ruth Benedict, John Dewey, Randolph Bourne, A. Irving Hallowell, and Edward Westermarck, and anthropological practices (...) and theories in Vietnam and Ukraine as well as the United States. Contributions also focus on the influence of Western thought and practice on anthropological traditions, as well as issues of relativism, physical anthropology, language, epistemology, ethnography, and social synergy. (shrink)

In their article, Herrera-Ferra et al. (2023) highlight how the progress and implementation of neurotechnology, especially in conjunction with artificial intelligence, have revealed potential impli...

Although a number of microfinance initiatives have improved financial inclusion in various regions of developing countries, the transferability of their foundations from one context to another is still a challenge. This study proposes an innovative process-based model targeting the initial stages of the transfer process that links three interconnected categories: local contextual conditions, transferring practices, and initial developmental consequences. The results were produced through a longitudinal study of the implementation of three community development banks on the periphery of Sao Paulo (...) based on a highly successful Brazilian model known as Banco Palmas. In addition to the process-based model, our findings contribute to the microfinance and bottom of the pyramid literatures, showing a cross-fertilization that has been insufficiently explored. (shrink)

An argument opposing the unrestricted use of quantification in modal logic has been put forward by Quine. Central to this argument are the two phrases, The Morning Star, The Evening Star.One form of the argument is obtained by considering the following two statements: It is necessary that the Morning Star is identical with the Morning Star. It is not necessary that the Evening Star is identical with the Morning Star.

La bibliographie Platon 1990-1995 prend concretement la suite du travail bibliographique (couvrant la periode 1950-1990) deja paru dans la revue Lustrum publiee a Gottingen et qui preserve, pour l'essentiel, la presentation materielle. Pour la periode ici consideree (1990-1995), on denombre plus de 70 entreprises d'edition et de traduction, et surtout pres de 1800 travaux d'interpretation, livres ou articles eux-memes publies dans des periodiques, actes de congres, melanges ou recueils. Ces travaux, ecrits en une dizaine de langues differentes, sont ici accompagnes (...) pour la plupart d'une notice et analyses dans un index tres detaille. Le chercheur dispose ainsi d'une sorte de carte geographique lui permettant de s'orienter facilement dans cet immense territoire de litterature secondaire et d'aller rapidement d'un point a un autre en evitant les detours fastidieux et les impasses. (shrink)

Postmortem evidence of chronic traumatic encephalopathy (CTE) in the brains of American National Football League players who suffered concussions while playing have intensified concerns about the risks of concussion in sport.1 Concussions are frequently sustained by amateur and professional players of Australia’s three most popular football codes (Australian football, rugby league, and rugby union) and, to a lesser extent, other contact sports such as soccer. This raises major concerns about possible long-term neurological damage, cognitive impairment and mental health problems in (...) players of these sports. (shrink)

In their article published in Nanoethics, “Ethical, Legal and Social Aspects of Brain-Implants Using Nano-Scale Materials and Techniques”, Berger et al. suggest that there may be a prima facie moral obligation to improve neuro implants with nanotechnology given their possible therapeutic advantages for patients [Nanoethics, 2:241–249]. Although we agree with Berger et al. that developments in nanomedicine hold the potential to render brain implant technologies less invasive and to better target neural stimulation to respond to brain impairments in the near (...) future, we argue against presenting the development of nanobionic clinical devices in terms of a moral obligation to conduct this research. In the first part of the paper, we consider what a duty to pursue new technologies might mean, and in the second we explore some of the negative consequences of defending such development as a moral obligation based on potential benefit. We argue that promoting the advances available to brain implants through developments in nanotechnology and bionics could contribute to medical rhetoric that indirectly increases the risk of exposing patients to harm when participating in clinical trials. We argue that rather than there being a moral obligation to improve nanobionics implants because of their potential benefit, the pursuit of improved neuro implants must be balanced against the prima facie obligations to protect patients against harm and to promote and protect patient autonomy. (shrink)

The idea of creation as the free, spontaneous, and joyous play (līlā) of the gods has been a pervasive motif in Indian thought since Vedic times. In the tradition of Advaita Vedānta, however, where the sole Reality is Brahman alone, divine playfulness is given an illusionistic interpretation and līlā becomes an expression of the deceptive power of māyā.

Introduction -- The serenity of the wise man -- The seventh day of history -- The guarantor-state -- Biosecurity -- Conclusion -- Appendix -- Index.

Some writers have noted that valuation is often focused on foreseen changes. They say that we often don't value situations in terms of what we would have in them only but also in terms of the gains or losses that they offer us — that we then focus on departures from our status quo. They argue that such thinking conflicts with basic economic analysis, and also that it violates logic: they say that it is irrational. I agree that it seems (...) to be common. But is such a way of setting one's values a challenge to economics? And does it conflict with being rational? (shrink)

L’article met à jour un désaccord très peu connu entre les PP. Gaston Fessard (1897-1978) et Henri de Lubac (1896-1991), à propos du discernement à poser sur le communisme et le progressisme chrétien entre 1945 et 1950. Après avoir dégagé les deux périodes qui marquent l’histoire de ce différend – publication de France, prends garde de perdre ta liberté (1945-1946) aux éditions du Témoignage chrétien (I) ; conférence du P. de Lubac sur « La conception de l’homme » aux Semaines (...) Sociales de juillet 1947 (II) – l’auteur analyse les raisons du désaccord, en pointant notamment le fait que le P. Fessard avait développé une véritable méthode de discernement des événements et des idéologies, là où le P. de Lubac ne disposait pas d’instrument équivalent (III). (shrink)

According to several late medieval logicians, the use the universal quantifier ‘omnis’ creates the requirement that the sentence refers to at least three items—the principle of sufficientia appellatorum. The commitment is such that, when the quota is not fulfilled, one has to import the missing items from the realm of the nonexistent. While the central argument for this principle, whose origin is Aristotle’s De Caelo, stems from the contrast between unrestricted universal quantifiers and binary quantifiers, the discussion is often mixed (...) with another issue, concerning the requirement of a plurality of referents for universals. In this paper, we try to distinguish those different issues and map the reactions of xiii th authors to the principle of sufficientia appellatorum. (shrink)

Although the meaning of «phenomenology» significantly differs from Fichte to Henry, it is nonetheless a similar problem that both thinkers encounter since they both can be read as conceiving of the absolute as life, i.e. as that which essentially and necessarily escapes the power of the concept as well as that of sight. If life is according to its very essence invisible, then it must remain outside the realms of intuition and discourse. On the other hand, life is precisely what (...) a phenomenology of life as a philosophical discourse is aiming at. By placing the recognition of the absolute in the center of their approach, both Henry’s material phenomenology and Fichte’s phenomenology – presented in his 1804 Wissenschaftslehre Zweiter Vortrag – raise the question of the conditions of possibility enabling such knowing and recognition. From an ethical point of view, however, the decisive question, that of the existential form that this recognition could take in the realm of action, remains open. (shrink)

Cet article étudie la présence de la valeur humaniste de "douceur" chez Montaigne et Descartes, dans le champ de l'éducation, des relations humaines, mais aussi de la méthode cartésienne pour bien conduire son entendement. Ainsi, la méthode doit faire preuve de douceur dans la culture de l'âme, et Descartes dans l'Epître à Voet décrit la douceur comme une composante essentielle des "lois de l'amitié" entre les hommes. Il s'agit donc de proposer une interprétation nouvelle et humaniste de la pensée cartésienne, (...) qui porte à la fois sur la morale et la recherche de la vérité. (shrink)

According to Thagard and Stewart :1–33, 2011), creativity results from the combination of neural representations, and combination results from convolution, an operation on vectors defined in the holographic reduced representation framework. They use these ideas to understand creativity as it occurs in many domains, and in particular in science. We argue that, because of its algebraic properties, convolution alone is ill-suited to the role proposed by Thagard and Stewart. The semantic pointer concept allows us to see how we can apply (...) the full range of HRR operations while keeping the modal representations so central to Thagard and Stewart’s theory. By adding another combination operation and using semantic pointers as the combinatorial basis, this modified version overcomes the limitations of the original theory and perhaps helps us explain aspects of creativity not covered by the original theory. While a priori reasons cast doubts on the use of HRR operations with modal representations :5039–5054, 1987) such as semantic pointers, recent models point in the other direction, allowing us to be optimistic about the success of the revised version. (shrink)

Clinical cases of frontal lobe lesions have been significantly associated with acquired aggressive behaviour. Restoring neuronal and cognitive faculties of aggressive individuals through invasive brain intervention raises ethical questions in general. However, more questions have to be addressed in cases where individuals refuse surgical treatment. The ethical desirability and permissibility of using intrusive surgical brain interventions for involuntary or voluntary treatment of acquired aggressiveness is highly questionable. This article engages with the description of acquired aggressiveness in general, and presents a (...) rare clinical case to illustrate the difficulties of treating this population. To expand the debate further, this article explores the ethics related to invasive brain surgery in three parts: a) it examines coercive involuntary invasive brain surgery for the benefit of protecting others on individuals suffering from acquired aggressiveness who lack decision-making capacities to consent; b) it addresses voluntary psychosurgery on individuals suffering from acquired aggressiveness who are competent to consent; and, c) it questions whether acquired aggressive individuals, who are legally competent, have a duty to consent to invasive brain surgery, in order to maintain their autonomy by reducing or even eliminate their aggressive drives. Ensuring the safety and efficacy of surgical brain interventions could increase the ethical permissibility of voluntary treatment, but it would not necessarily entail ethical justification for proceeding with invasive brain surgery for treatment of intractable acquired aggressive behaviour. (shrink)

The hypothesis that every class of facts has an explanation is never refuted by evidence, But is confirmed every time any hypothesis is confirmed. Hence, It is the most highly confirmed hypothesis of all, And, Therefore, Should be considered to be true. If it is true, Then there is an explanation of the class of all facts, And this explanation may be identified with god.