The neural cell adhesion molecule (N‐CAM) is believed to be a key regulator of adhesive events in the nervous system and skeletal muscle. The recent isolation of N‐CAM cDNAs from different tissues has identified a high degree of diversity in primary amino acid sequence between different isoforms. In this article, we review these recent studies and discuss methods for unravelling the functional consequences of the generation of multiple N‐CAM polypeptides using gene transfection approaches.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Søren Kierkegaard and the Word(s): Essays on Hermeneutics and CommunicationGeorge ConnellPoul Houe and Gordon D. Marino. editors. Søren Kierkegaard and the Word(s): Essays on Hermeneutics and Communication. Copenhagen: C. A. Reitzel, 2003. Pp. 299. Paper, kr. 375,–Though many associate Kierkegaard with isolated individuality, Kierkegaard scholars are rather gregarious. Four times since 1985, Kierkegaard devotees from all the inhabited continents have gathered at St. Olaf College for several days (...) of intense paper reading. Since it is difficult to keep a handle on so much material presented orally and because many were not able to attend, it is a commendable service that Houe and Marino have edited and published many of the papers delivered at the 2001 conference, just as they had previously published essays from 1998 conference and C. Stephen Evans and I had published essays from the 1989 conference.This volume reflects its origins in several ways. First, the essays are unusually brief compared to most journal articles (around ten pages each). While this is an agreeable format when listening to many papers in a single day, I do think that many of these essays are rather rushed and less than fully developed. Accordingly, the reader of these essays may well feel stimulated by interpretive suggestions rather than satisfied by thoroughly worked out treatments.Second, the essays are quite diverse, as conference papers tend to be, even when, as in this case, a preferred theme—hermeneutics and communication—was stated in advance. Since, as Alastair Hannay notes in the opening keynote essay, "hermeneutics" is used in a wide variety of ways, this theme really did not limit participants to any significant degree. Essays in this volume look variously at Kierkegaard's practice of hermeneutics (especially in reference to the Bible), at our predicament of interpreting Kierkegaard's notoriously elusive and cryptic pseudonymous works, at hermeneutics as our existential disposition as sense-making creature thrust into an ambiguous world, at hermeneutics as a quasi-Hegelian project of engulfing particularity without remainder in a totalizing whole, and, in contrast, at radical hermeneutics (a term coined by John Caputo and applied to Kierkegaard) as an interpretive approach that refuses the consolations and consonances of its Gadamerian cousin. As the use of "hermeneutics" varies, we hear that Kierkegaard is both an exemplary hermeneuticist and "the ultimate non-hermeneuticist." And in a number of essays, the issue of hermeneutics only seems to come up in the vacuous sense that the author offers a reading of some Kierkegaardian text or texts.The wide variety of essays included here reflects itself in the unsatisfactory final article in which Poul Houe makes a thoroughly desultory attempt at pulling the various articles together. I've tried my hand at writing such a piece, so I feel empathy for Houe's plight. But the paragraph per essay tour of the book is so hurried and so perfunctory that I wonder what purpose it really serves in this case.Though widely varying in topic and approach, most of the essays in the volume are quite good, if tantalizingly short. Given that there are twenty-five essays in the volume, it is not possible to summarize them here. But several observations are in order. First, it is especially nice to see five essays by Danish scholars included in this book. The community of Kierkegaard scholars has increasingly come to appreciate that viewing him in terms of his local context can be quite illuminating. American scholars have done excellent work along these lines, but clearly Danes have a crucial role to play in this interpretive task. Second, there have been heated disagreements in Kierkegaard circles over how to place Kierkegaard in reference to philosophical postmodernism. That polemic is in evidence in this volume as well. Several essays, most notably that of David Goicoechea, affiliate [End Page 502] Kierkegaard with postmodernist refusals of the totalizing understandings. In contrast, Sylvia Walsh juxtaposes Kierkegaard's "erotic hermeneutics," which treats its phenomenon with amorous tenderness, with Derrida's deconstructive approach to interpretation, which Walsh sees as a violent expression of the will to power. Christopher Simpson tries to reconcile these divisions by reading Kierkegaardian faith as an attractive... (shrink)

The paper begins with an overview of the historical roots of philosophical hermeneutics grounded in the work of Husserl and Heidegger. It goes on to explore the philosophical hermeneutics of Hans Georg Gadamer as a philosophy useful to nursing research. The four concepts of prejudice, the fusion of horizons, the hermeneutic circle and play are discussed, as are the implications these concepts have for nursing research. These concepts have been utilized in the author's own research and examples from this research (...) are given to illuminate how these concepts can be shaped to the purposes of nursing research. While the concepts discussed stem from the work of Gadamer, the ways they have been utilized by the author do not represent a Gadamerian method. Gadamer's project is purely philosophical. (shrink)

R. Kevin Hill argues that while Walsh is correct in urging caution regarding Rand's polemical characterizations of Kant, interpreting her charitably reveals surprising insights into the underlying structure of Kant's thought. Rand's objections to Kant's epistemology, psychology and metaphysics are truer to Kant's intentions than revisionist attempts to save him from himself. Her objections to Kantian ethics contain promising critiques of both Kant's rational reconstructive-methodology and his misuse of the concept of agent-neutral reasons. Lastly, though she paints too broadly (...) in her account of Kant's influence, two questionable tendencies in contemporary thought are traceable to him. (shrink)

George S. Counts was a_ _major figure in American education for almost fifty years. Republication of this early work draws special attention to Counts’s role as a social and political activist. Three particular themes make the book noteworthy because of their importance in Counts’s plan for change as well as for their continuing contem­porary importance: _ _Counts’s crit­icism of child-centered progressives; _ _the role Counts assigns to teachers in achieving educational and social re­form; and Counts’s idea for the re­form (...) of the American economy. (shrink)

The opening lines of Franz Delitzsch's Babel und Bibel offer an unusually frank confession of the personal and psychological motives that animated German orientalism in the nineteenth and early twentieth centuries. For Delitzsch and countless others like him, orientalist scholarship provided an opportunity not just to expand their knowledge of the Near East and India, but also to explore the world of the Bible and, in doing so, effect a reckoning with the religious beliefs of their childhoods. In German Orientalism (...) in the Age of Empire, Suzanne Marchand opens up this scholarly world, exploring the criss-crossing forces and interests that shaped it, while effecting her own reckoning with orientalism as a historical and historiographical phenomenon. (shrink)

An attractor network was trained to compute from word form to semantic representations that were based on subject‐generated features. The model was driven largely by higher‐order semantic structure. The network simulated two recent experiments that employed items included in its training set (McRae and Boisvert, 1998). In Simulation 1, short stimulus onset asynchrony priming was demonstrated for semantically similar items. Simulation 2 reproduced subtle effects obtained by varying degree of similarity. Two predictions from the model were then tested on human (...) subjects. In Simulation 3 and Experiment 1, the items from Simulation 1 were reversed, and both the network and subjects showed minimally different priming effects in the two directions. In Experiment 2, consistent with attractor networks but contrary to a key aspect of hierarchical spreading activation accounts priming was determined by featural similarity rather than shared superordinate category. It is concluded that semantic‐similarity priming is due to featural overlap that is a natural consequence of distributed representations of word meaning. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A Second Copy Thesis in Hume? George S. Pappas The copy thesis which applies to simple ideas andimpressionsin Hume is well known; every simple idea is supposed to be a copy of, that is, to exactly resemble, some simple impression. Or very nearly so, at any rate, for there is the famous missing shade ofblue to take into account. There seems to be another copy thesis in Hume, (...) however, and one on which Hume places a great deal ofweight. We find it expressed early on in the Treatise, incorporated into Hume's discussion of space and time. He says: Wherever ideas are adequate representations of objects, the relations, contradictions and agreements of the ideas are all applicable to the objects; and this we may in general observe to be the foundation of all human knowledge. But our ideas are adequate representations of the most minute parts of extension; and thro' whatever divisions and subdivisions we may suppose these parts to be arriv'd at, they can never become inferior to some ideas, which we form. The plain consequence is, that whatever appears impossible and contradictory upon the comparison of these ideas, must be really impossible and contradictory, without any farther FogeUn has recently described this as a "remarkable passage," one which is "a match for anything found in the writings of the rationalists."2 Perhaps it is such a match, perhaps not, but Fogelin is certainly right to regard this as a remarkable passage, at least for Hume. After all, Hume here seems to be endorsing some form of representationalism, a doctrine we typically do not associate with Hume's philosophy. Two important questions emerge from this passage:just what are these adequate ideas ofwhich Hume speaks; and, in what sense can it be true that they form the foundation ofall ofour knowledge? I believe that a correct answer to each of these questions has some strong imphcations for our understanding ofHume's philosophy. I. Humean Adequate Ideas So far as I can discover, the above-quoted passage is the Only place where Hume talks about adequate ideas. The only text which I have Volume XVII Number 1 51 GEORGE S. PAPPAS found which even suggests the same sentiments occurs in "Of the Passions" where Hume discusses ideas and truth (T 448-49), but no mention is made there of adequate ideas. So I think we have to concentrate on the passage from the Treatise in the attempt to understand what Hume is telling us. Hume seems to refer to adequacy as a feature ofindividual ideas, and also to groups or systems ofideas. The latter is suggested by his reference to relations, contradictions, and agreements between ideas, while the former is indicated by the first clause ofthe quoted passage, where Hume mentions adequacy but makes no reference to relations between ideas. Instead, adequacy in the relationsbetween ideas seems to be a consequence of adequacy of individual ideas. Moreover, that individual ideas are supposed to be adequate is made clear from the argument Hume immediately gives regarding the alleged infinite divisibility of space. He writes: I first take the least idea I can form ofa part ofextension, and beingcertainthatthereis nothingmoreminute than thisidea, I conclude, that whatever I discover by its means must be a real quality ofextension. (T 29) Hume's reasoning here can be interpreted in two different ways, but both rest on the adequacy of individual ideas. He might be read as saying that one starts with a least-sized idea, and infers that there are bits of extension which are the same size as the least-sized idea. The inference from the feature of the idea to the feature of the bit of extension rests on the claimed adequacy ofthe idea. The other reading of Hume's reasoning is that one starts with the least-sized idea and then infers that there is (a) a bit ofextended matter that small, and (b) that there is no smaller bit of extended matter. Ofthese two readings, I think the second is the right way to understand Hume here, for only it supports the argument's conclusion that space is not infinitely divisible.3 But notice that this second version ofHume... (shrink)

This fourth edition of one of the classic logic textbooks has been thoroughly revised by John Burgess. The aim is to increase the pedagogical value of the book for the core market of students of philosophy and for students of mathematics and computer science as well. This book has become a classic because of its accessibility to students without a mathematical background, and because it covers not simply the staple topics of an intermediate logic course such as Godel's Incompleteness Theorems, (...) but also a large number of optional topics from Turing's theory of computability to Ramsey's theorem. John Burgess has now enhanced the book by adding a selection of problems at the end of each chapter, and by reorganising and rewriting chapters to make them more independent of each other and thus to increase the range of options available to instructors as to what to cover and what to defer. (shrink)

The Most Important Book on Money You'll Ever Read Also Includes Acres of Diamond The Richest Man in Babylon is a transformative book that has changed the way millions of people think about money since it was first published in 1926. Through light, entertaining parables author George S. Clason shares profound truths about wealth and success that will revolutionize the way you relate to money and interact with your finances. Clason's wisdom has inspired countless readers to gain, grow, and (...) maintain their wealth, making this one of the most beloved finance books of all time. This special edition also includes the bonus book Acres of Diamond by Russell Conwell, a powerful exploration of the nature of true wealth. The Richest Man In Babylon is part of the GPS (Good, Practical, Simple) Guides to Life Series, which brings classic success books to a modern audience. Each edition features new modern design while staying true to the text of the original editions. (shrink)

The natural sciences are sometimes called "hard" sciences in contrast to the social sciences , which are thought to represent "soft" sciences. L. V. Hedges made an important effort to determine the empirical cumulativeness of various scientific research programs, with an eye toward assessing if this criterion is related to a discipline's "hardness" or "softness." This article discusses another criterion, a research program's predictive accuracy, that might also be considered along with a program's empirical cumulativeness. Finally, recent improvements in the (...) predictive accuracy of multifaceted psychological theories are discussed. 2012 APA, all rights reserved). (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Perception of the Self George S. Pappas Differences of detail aside, we may think ofboth Locke and Berkeley as accepting the same view of the mind. They agree that there are minds, and that each mind is a simple, immaterial substance. Sometimes the word 'soul' is used instead of'mind'; but in this context, the different terminology is not consequential. Moreover, Locke and Berkeley employ essentially the same argument (...) for their shared view about minds. More exactly, they use the same argument for the limited thesis that there is something distinct from perceptions and from ideas perceived, and that this somethingis aperceiver, or that which perceives. The argument, given in more detail below, claims that we are aware ofour own minds in, or while we are engaged in, perception. The kind ofawareness is said to be or to involve a reflex act, a concept we associate with Berkeley, though I think it is one he appropriated from Locke. Hume, ofcourse, rejects the view ofLocke and Berkeley. He rejects the very notion of an immaterial mind or soul, finding it to be meaningless. And he rejects as well the limited thesis that there is something which perceives and which is distinct from all perceptions. In this paper I will restrict attention to Hume's arguments for rejecting the limited thesis. 1. Rejection ofthe limited thesis Hume investigates the limited thesis of Locke and Berkeley in the well-known section ofthe Treatise which deals with personal identity (Treatise 1.4.6). Here is how he expresses the view of "some philosophers": Theke are some philosophers, who imagine we are every moment intimately conscious of what we call our SELF; that we feel its existence and continuance in existence; and are certain, beyond the evidence of a demonstration, both of its perfect identity and simplicity. The strongest sensation, the most violent passion, say they, instead of distracting us from this view, only fix it the more intensely, and make us consider their influence on selfeither by their pain or pleasure.1 Thus, Hume represents the argumentofthosehe opposes as containing two premises: Volume XVIII Number 2 275 GEORGE S. PAPPAS (1)In perception, one is aware ofone's self, and aware ofthe simplicity of the self. (2)In being thus aware of the self and its simplicity one gains an idea of a simple self. These premises, in turn, support a double conclusion: (3)There are simple selves (minds). (4)We have an idea of a simple self(mind). Hume does not take the trouble to cite the second premise given here in the passage I have quoted, butitis clear that he has it in mind, since he proceeds directly to a criticism of it. The criticism is quite familiar inform, encapsulatingwhat I call aderivabilityargument. Here is what Hume says: all these positive assertions are contrary to that very experience, which is pleaded for them, nor have we any idea of self, after the manner it is here explain'd. For from what impression cou'd this idea be deriv'd?... It must be some one impression, that givesrise toeveryreal idea. But selfor person is not any one impression, but that to which our severahmpressionsandideas are suppos'd to have areference. Ifany impression gives rise to the idea ofself, that impression must continue invariably the same, thro' the whole course of our lives; since self is suppos'd to exist after that manner. (T 251) He is also sharply critical ofthe first premise. Hume says: when I enter most intimately into what I call myself, I always stumble on some particularperception orother, ofheatorcold, light or shade, love or hatred, pain or pleasure. I never can catch myselfat any time without a perception, and never can observe any thing but the perception. (T 252) So, minimally, Hume's arguments amount to this: (1) is false; hence, we have nogroundforclaiming(3). Similarly, (2) is false, so that we have no ground for claiming (4). Actually, of course, Hume asserts stronger claims, maintaining that (3) and (4) arefalse, and not merely that we lack adequate support forthem. Buttoshowtheirfalsityrequires additional argumentbeyond whatis providedin the above-quoted passages. Here I will not consider those additional arguments, except to note... (shrink)

Suggests that the papers by B. D. Slife , M. Gergen , R. N. Williams , and M. S. Richardson demonstrated no simple solution to the free will problem. How humans achieve some limited exercise of FW in a world of nonagentic, coercive forces remains unclear, especially as human nature and lives represent complex phenomena in which the person who exercises FW is anything but omnipotent, ahistorical, self-contained, and acultural. 2012 APA, all rights reserved).

William James’s pluralism, when combined with his pragmatism and radical empiricism, is a complete and coherent philosophy of life. James provides an antidote to the excesses of both the extreme realist/objectivist and the extreme constructivist/relativist camps. In this paper, we demonstrate how this is so in a discussion of epistemology and ontology including several extended examples. These examples demonstrate the inescapability of context and background assumptions and the advantages of a pluralist worldview.

Three recently published books, by Stavros Tombazos, Jonathan Martineau, and Harry Harootunian, join a now established body of literature that highlights the temporal aspects of Marx’s work. Their differences notwithstanding, these books are united by the conviction that, at its core, capitalism is an immense and complex organisation of time, and thus that the importance of Marx’s work is realised by its singular contribution to our understanding of this. Each book is centrally concerned with the historically specific character of capital’s (...) temporal order, such that each presents a new reading of the relationship between capitalism and historical time. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:167. ON McRAE' S HUME Professor McRae's interesting paper may be rather naturally divided into two parts. In the first part he explains what he takes Hume's account of time to be; in the second he advances the bold thesis that Hume's account of time, or perhaps of duration, provides a basis or foundation for his more widely discussed remarks on identity, substance, the self, the necessary connections. In (...) what follows I first reconstruct Professor McRae' s paper, and then I raise some problems, perhaps puzzles, about Hume's view on duration, time and fictions. According to McRae, some philosophers (Descartes, Spinoza, Leibniz) distinguish between time and duration, both of which are taken to be perfectly legitimate notions. Hume, by contrast, takes time and duration to be the same, viz., a succession of moments. What philosophers and the vulgar call 'duration' is something quite different, namely a single unbroken stretch of time which is not composed of successive parts. Of duration taken in this latter way, McRae says, Hume has four things to say, all of them negative: (1) we have no idea of duration; (2) no object has duration; (3) there is no such thing as duration; and (4) duration is a fiction. Properly understood as a succession of moments, however, time certainly exists and is thus not a fiction. Moreover, we have the or at least an idea of time, despite the fact that it is obtained without derivation from a precedent impression. And, while no object can be said to have time, Hume will nonetheless allow that objects exist at certain times and perhaps across a time span. In the second part of his paper, Professor McRae distinguishes two types of Humean fictions. The first arises when one idea is confused with another and mis-applied to some object. The second arises when the imagination creates an "idea" in the attempt to resolve a 168. contradiction which comes up when the first fiction is applied to an object. What I have called McRae' s "bold thesis" in the second part of his paper can now be stated. Duration, or the putative idea thereof, is a fiction of the first type, one that is attributed to what Hume calls "steadfast objects." However, such an object can be considered in two ways. One might consider the object at two stages of this duration and, McRae says, "...this will give us the idea of number" (p. 126); or, one might consider in turn a series of objects, each of them supposedly "steadfast," all along supposing that though time is changing, the objects are not, and "...in this way- we get the idea of unity" (Ibid.). But no object is both a unity and a multiplicity. So, to reconcile these conflicting considerations, the "idea" or fiction of identity is invented. As McRae says: "The idea of identity is a pure product of the imagination invented to mediate between unity and number" (Ibid. ). This invented "idea" is then mis-applied (a fiction of type one) to interrupted appearances of an object. To reconcile the supposed identity of an object with successive appearances of it, the fiction of substance is invented. Quoting both McRae and Hume, In order to reconcile the contradiction between identity and diversity, the imagination is apt to feign something unknown and invisible, which it supposes to continue the same under all these variations ; 2 and this unintelligible something it calls a substance... (p. 128). Related needs to resolve contradictions, on McRae' s account, lead to the fictions of the self (p. 128) and of necessary connections (p. 130), though the latter fiction is of type one. Hence, McRae' s "bold thesis" amounts to this: Duration is a fiction. In the attempt to apply this fiction, one is led to, logically led to, most, if not all, of the other famous Humean fictions. And, if we allow that there are mental acts, for Hume, as well as impressions and ideas, "...then a fictitious duration will be attributed to 169. objects and by a progressive compounding of fictitious mental actions will give the world the ontological structure which it has for the vulgar belief we all share. It... (shrink)

Although every emerging infectious disease occurs in a unique context, the behaviour of previous pandemics offers an insight into the medium- and long-term outcomes of the current threat. Where an informative historical analogue exists, epidemiologists and policymakers should consider how the insights of the past can inform current forecasts and responses.