The viral and cellular forms of the Src protein tyrosine kinases take a prototypic role in oncology and signal transduction research, by virtue of being holders of an impressive number of ‘firsts’. Our understanding of the biochemistry and physiology of Src has therefore always been used as a reference for our general advancement in the field of protein phosphorylation and growth control. The recent solution of the crystal structure of two members of the Src family(1,2) represents a milestone in these (...) disciplines and, as usual, provides a general lookout post for developments to come. (shrink)

There is increasing evidence to suggest that cytoplasmic tyrosine kinases of the Src family have a pivotal role in the regulation of a number of cellular processes. Members of this family have been implicated in cellular responses to a variety of extracellular signals, such as those arising from growth factors and cell‐cell interactions, as well as in differentiative and developmental processes in both vertebrates and invertebrates. A better understanding of the regulation and of the structure‐function relationships of these enzymes might (...) aid in the development of specific ways to interfere with their action, as well as serving as a paradigm for regulation of other protein tyrosine kinases that have SH2 and SH3 domains. In this review we will first discuss the regulation of Src family protein tyrosine kinases, with particular emphasis on their SH2 and SH3 domains. We will then briefly review other non‐receptor protein tyrosine kinases that have SH2 and SH3 domains. (shrink)

In juxtaposition with the myth and tragedy of Ovid’s Medea, this paper investigates the possibility within the Kantian conception of agency of understanding moral evil as acting against one’s better judgment. It defends the thesis that in Kant self-deception, i. e. the intentional untruthfulness to oneself, provides the fundamental structure for choosing against the moral law. I argue that, as Kant’s thought progresses, self-deception slowly proceeds to become the paradigmatic case of moral evil. This is discussed with regard to two (...) important topics in his later moral philosophy: the doctrine of radical evil and the crucial role of the duty of truthfulness in ethics. The inquiry into Kant’s theory of conscience unfolds both against this theoretical background and in light of its historical roots in the polemic against casuistry and probabilism. This contribution closes with a brief look at the tools Kant implements to counter this tendency to self-deception in moral judgment and particularly at the role casuistry plays within his conception of moral education. (shrink)

In this paper, in line with the general framework of value-sensitive design, we aim to operationalize the general concept of “Meaningful Human Control” in order to pave the way for its translation into more specific design requirements. In particular, we focus on the operationalization of the first of the two conditions investigated: the so-called ‘tracking’ condition. Our investigation is led in relation to one specific subcase of automated system: dual-mode driving systems. First, we connect and compare meaningful human control with (...) a concept of control very popular in engineering and traffic psychology, and we explain to what extent tracking resembles and differs from it. This will help clarifying the extent to which the idea of meaningful human control is connected to, but also goes beyond, current notions of control in engineering and psychology. Second, we take the systematic analysis of practical reasoning as traditionally presented in the philosophy of human action and we adapt it to offer a general framework where different types of reasons and agents are identified according to their relation to an automated system’s behaviour. This framework is meant to help explaining what reasons and what agents play a role in controlling a given system, thereby enabling policy makers to produce usable guidelines and engineers to design systems that properly respond to selected human reasons. In the final part, we discuss a practical example of how our framework could be employed in designing automated driving systems. (shrink)

The brains of higher mammals are extraordinary integrative devices. Signals from large numbers of functionally specialized groups of neurons distributed over many brain regions are integrated to generate a coherent, multimodal scene. Signals from the environment are integrated with ongoing, patterned neural activity that provides them with a meaningful context. We review recent advances in neurophysiology and neuroimaging that are beginning to reveal the neural mechanisms of integration. In addition, we discuss concepts and measures derived from information theory that lend (...) a theoretical basis to the notion of complexity as integration of information and suggest new experimental tests of these concepts. (shrink)

Contemporary brain reading technologies promise to provide the possibility to decode and interpret mental states and processes. Brain reading could have numerous societally relevant implications. In particular, the private character of mind might be affected, generating ethical and legal concerns. This paper aims at equipping ethicists and policy makers with conceptual tools to support an evaluation of the potential applicability and the implications of current and near future brain reading technology. We start with clarifying the concepts of mind reading and (...) brain reading, and the different kinds of mental states that could in principle be read. Subsequently, we devise an evaluative framework that is composed of five criteria-accuracy, reliability, informativity, concealability and enforceability-aimed at enabling a clearer estimation of the degree to which brain reading might be realistically deployed in contexts where mental privacy could be at stake. While accuracy and reliability capture how well a certain method can access mental content, informativity indicates the relevance the obtainable data have for practical purposes. Concealability and enforceability are particularly important for the evaluation of concerns about potential violations of mental privacy and civil rights. The former concerns the degree with which a brain reading method can be concealed from an individual’s perception or awareness. The latter regards the extent to which a method can be used against somebody’s will. With the help of these criteria, stakeholders can orient themselves in the rapidly developing field of brain reading. (shrink)

The property of fundamental mechanical theories which allows to treat compound objects as particles under suitable conditions is considered. It is argued that such a property, called compoundation invariance, is a nonreleasable property of any mechanical theory not declaring to which elementary constituents it applies. Compoundation invariance is discussed in the framework of Bohmian mechanics. It is found that standard Bohmian mechanics satisfies the requirement of compoundation invariance, with some reservation in the case of compound objects with spin. On the (...) contrary that requirement is violated when additional terms are added to the standard velocity. (shrink)

ABSTRACT This article analyses the abbé de Saint-Pierre as a mediator of ideas between France and England. The political proposal of the Projet pour rendre la paix perpétuelle en Europe circulated in Great Britain just before the signing of the peace treaties of Utrecht and Aachen, attesting the influence that Saint-Pierre’s proposal exerted on British thought and politics. The abbé was engaged in dialogue with Quaker pacifists and, in particular, with the projects put forward by William Penn and John Bellers, (...) both theorists of a ‘European State’. After examining the relationship between Penn’s Essay and Saint-Pierre’s ideas, the article will demonstrate how elements of Bellers’s Some Reasons found their way into the Projet with numerous convergences of lexicon and content suggesting that the abbé had drawn inspiration from Bellers. Quaker ideas on politics had a greater effect on Saint-Pierre’s conception of peace and international relations than is commonly recognized. In fact, there was a constant intellectual exchange between the abbé and British political, economic and philosophical thought. (shrink)

This paper discusses a recent puzzle concerning the notions of boundary parthood and dependence, and offers a new solution. The puzzle was originally presented by Jeroen Smid and successively elaborated upon by Claudio Calosi. I first reformulate some of the troublesome premises. Particularly, whereas Smid and Calosi discuss the puzzle in terms of an underspecified notion of dependence, I propose to construe it in terms of the notion of grounding. In this manner, the dependence relation inherently carries an asymmetry, and (...) we can effectively utilize its four places. The solution I advance precisely takes advantage of this feature of dependence. My proposal avoids the contradiction while still respecting the intuitions driving the original premises. It is also fully compatible with boundaries being only generically dependent on their wholes. (shrink)

In “Engineering Transcendence” (Prisco 2004) I argued that science may someday develop the capability to resurrect the dead and build (and/or become) God(s), and proposed to base a “transhumanist1 religion” on this idea. I also argued that the ultra‐rationalist, aseptic engineering language dear to most technophiles does not seem able to have an emotional impact on the majority of other people.

v. 1. Empirismo logico, epistemologia e logica.--v. 2. Storia della logica e storiografia filosofica.

The capabilities approach is the theory according to which, in order to assess people's quality of life and reflect on the basic political entitlements, we should consider what people are capable of doing and being. Focusing mostly on Nussbaum's account, a number of scholars analysed the metaethical structure underlying the approach, showing her Aristotelian and Kantian sources. This article explores another aspect of Nussbaum's theory which has so far been somewhat overlooked: the role of emotions in the justification and motivational (...) support of the approach. After showing the importance Nussbaum places on compassion (and other benevolent emotions) to warrant her moral theory, I argue that – assuming her own cognitive account of compassion – her argument begs the question. I will then contend that Nussbaum's case does not have the inner tools to overcome such a circularity, trying to suggest, in conclusion, a possible way out which is consistent with it. (shrink)

The paper applies Christian Humanism to management highlighting the role of relations in business and the entrepreneurial life. The claim is that such a dimension is important for everybody even from a secular point of view regardless of one’s belief. The first part shows how Biblical tradition inspired a rereading of relation in the first Christian thinkers, who had to recognize it in God. But this made possible to perceive that the relationships can be a real source of being, as (...) the example of a family shows. The thesis proposed is that within every Gesellschaft there is a Gemeinschaft, that is constituted by its relational dimensions, connecting the common good and profit also to relational goods. The second part draws consequences for management, recognizing through the example of the Inner Game three relational dimensions relevant for management: the one interior to the person; the relationships between coworkers; the interaction with the culture of the company. All of them should be considered to improve the Gemeinschaft dimension within the Gesellschaft. The last part of the article explains how Christian Humanism helps also to avoid an idealistic reading of the proposal, which always has to take into account the demands of confrontation with the external system intrinsic to the Gesellschaft, as the very etymology of management reveals. (shrink)

(2014). The economic debate on power: a Marxist critique. Journal of Economic Methodology: Vol. 21, No. 2, pp. 175-192. doi: 10.1080/1350178X.2014.907440.

We propose that sleep is linked to synaptic homeostasis. Specifically, we propose that: (1) Wakefulness is associated with synaptic potentiation in cortical circuits; (2) synaptic potentiation is tied to the homeostatic regulation of slow wave activity; (3) slow wave activity is associated with synaptic downscaling; and (4) synaptic downscaling is tied to several beneficial effects of sleep, including performance enhancement.

This book provides the first unified overview of the burgeoning research area at the interface between Quantum Foundations and Quantum Information. Topics include: operational alternatives to quantum theory, information-theoretic reconstructions of the quantum formalism, mathematical frameworks for operational theories, and device-independent features of the set of quantum correlations. Powered by the injection of fresh ideas from the field of Quantum Information and Computation, the foundations of Quantum Mechanics are in the midst of a renaissance. The last two decades have seen (...) an explosion of new results and research directions, attracting broad interest in the scientific community. The variety and number of different approaches, however, makes it challenging for a newcomer to obtain a big picture of the field and of its high-level goals. Here, fourteen original contributions from leading experts in the field cover some of the most promising research directions that have emerged in the new wave of quantum foundations. The book is directed at researchers in physics, computer science, and mathematics and would be appropriate as the basis of a graduate course in Quantum Foundations. (shrink)

Rights proclamations are often alleged to be meaningless – ‘nonsense upon stilts’. But what makes a rights proclamation meaningful? In general, I argue, meaningful rights proclamations presuppose the existence of both a duty – directed from some party to another – and an interest whose protection is at least a non-redundant element in the justification of why the duty exists. Further conditions of meaningfulness apply for specifically moral rights proclamations. Here, the interest must be of such moral relevance to ground, (...) by itself, the duty and the duty must be demonstrably compatible with other mandatory components of morality. Neither of these conditions applies to rights proclamations in the legal realm. For a legal right proclamation to be meaningful, it is sufficient that there is or there ought to be, in the legal community at stake, a legal obligation whose justification includes, as a non-redundant element, the interest of some party. (shrink)

Any progress in shaping up an externalist psychiatry, so previous discussion suggested, must begin from questions about the ontology of social causation. So far, research and theory have adhered to a naturalistic approach to the social causes of illness, concentrating mostly on the ‘social determinants of mental health’ (inequality, discrimination, housing insecurity, etc.). The paper starts with an assessment of ‘social determinants’ through the lens of epidemiology and critical psychiatry. It illustrates existing practical and political approaches that fight these constraints (...) and it highlights their therapeutic value. It argues, though, that a focus on social determinants is not sufficient for fully realizing externalism because a great portion of sociogenic illness remains causally indeterminate. Alongside political action, externalism requires a social etiology that is established by virtue of the meaning that it holds for patients, rather than by virtue of its capacity to identify objective social causes of illness. This entails abandoning naturalism about social causation and embracing constructivism. The paper shows that this methodological shift is less contradictory and more effective than it is commonly imagined. Drawing from further anthropological evidence, it concludes that only by lending support to projects that balance a focus on constraints with social construction will psychiatry be truly externalist. At stake is a prospect of effective treatment for sociogenic illness for the countless in struggle. (shrink)