Halley and colleagues highlight important aspects of advocacy and justice in rare disease and provide recommendations for stakeholders to encourage progress toward equity and justice. In the rare d...

The promise of genomic medicine lies in the opportunity to improve health outcomes via a personalized approach to management, grounded in genetic and genomic variation unique to an individual. However, disparities and inequities mar this remarkable landscape of genomic innovation. Prior efforts to understand these inequities have focused on populations for which genetic testing is relatively protocolized or where test utility varies greatly by ancestry groups, where equitable outcomes are more clearly defined. We therefore consider the current landscape of rare (...) disease genomics, in which diagnostic approaches vary widely and utility remains to be fully understood, and suggest a path forward: how ecosocial theory may be used to guide novel equity‐focused initiatives that incorporate illness narratives to improve population health. We present examples of narrative medicine in rare disease and reimagine the role this discipline may play in genomic sequencing studies, toward incorporation of the unique illness narrative into clinical genetics and genomics practice. Approaches that broaden the definitions of disease and of outcomes of interest will force the field to grapple with its racist history and begin to advance health equity and promote justice so that genomic medicine may truly deliver on its promise. (shrink)

Purpose This systematic review aims to identify factors that influence parents’ decisions regarding pediatric diagnostic and predictive genetic testing (DT/PT). Factors are integrated into a conceptual model of decision-making. Implications for genetic counseling, research, and ethics are derived. Methods PubMed, PsychInfo, WebofScience and references of related reviews were searched for original publications between 2000 and 2023. Extracted factors were categorized into an existing model. Results Of 5843 publications, 56 met inclusion criteria. The included studies differentiate between DT, traditional, and expanded (...) PT and describe factors impacting parental decisions on both to have the child genetically tested and to be informed about additional findings. Factors included: 1. benefits/hopes, 2. worries/concerns, 3. values and beliefs, 4. individual circumstances, and 5. emotional states. Conclusion Our work extends an existing empirical decision model of family decisions about genome sequencing to genetic testing in pediatrics in general, adding the categories “individual circumstances” and “emotional states”. The factors can be further integrated into the Health Belief Model; the importance of emotional states is reflected in dual-process theories, such as Fuzzy Trace Theory. Research is required on emotional states, differences between DT and PT, parents’ decisions about result disclosure, and dyadic variables as decision-making predictors. (shrink)

Responding to volatile criticisms frequently leveled at Leo Strauss and those he influenced, the prominent contributors to this volume demonstrate the profound influence that Strauss and his students have exerted on American liberal democracy and contemporary political thought. By stressing the enduring vitality of classic books and by articulating the theoretical and practical flaws of relativism and historicism, the contributors argue that Strauss and the Straussians have identified fundamental crises of modernity and liberal democracy.

Third-party intervention has been the focus of recent debate in self-defense theory. When is it permissible for third-parties to intervene on behalf of an innocent victim facing an unjustified attack or threat? In line with recent self-defense theory, if an attacker is morally responsible for their actions and does not have an acceptable excuse then it is permissible for third-parties to use proportionate violence against them.

Fodor's and Pylyshyn's stand on systematicity in thought and language has been debated and criticized. Van Gelder and Niklasson, among others, have argued that Fodor and Pylyshyn offer no precise definition of systematicity. However, our concern here is with a learning based formulation of that concept. In particular, Hadley has proposed that a network exhibits strong semantic systematicity when, as a result of training, it can assign appropriate meaning representations to novel sentences (both simple and embedded) which contain words (...) in syntactic positions they did not occupy during training. The experience of researchers indicates that strong systematicity in any form is difficult to achieve in connectionist systems.Herein we describe a network which displays strong semantic systematicity in response to Hebbian, connectionist training. During training, two-thirds of all nouns are presented only in a single syntactic position (either as grammatical subject or object). Yet, during testing, the network correctly interprets thousands of sentences containing those nouns in novel positions. In addition, the network generalizes to novel levels of embedding. Successful training requires a, corpus of about 1000 sentences, and network training is quite rapid. The architecture and learning algorithms are purely connectionist, but classical insights are discernible in one respect, viz, that complex semantic representations spatially contain their semantic constituents. However, in other important respects, the architecture is distinctly non-classical. (shrink)

Abstract Drawing upon evolutionary theory and the work of Daniel Dennett and Nicholas Agar, I offer an argument for broadening discussion of the ethics of disenhancement beyond animal welfare concerns to a consideration of animal “biopreferences”. Short of rendering animals completely unconscious or decerebrate, it is reasonable to suggest that disenhanced animals will continue to have some preferences. To the extent that these preferences can be understood as what Agar refers to as “plausible naturalizations” for familiar moral concepts like beliefs (...) and desires, then they can make moral claims on us and provide support for intuitive opposition to disenhancement. Content Type Journal Article Category Original Paper Pages 1-6 DOI 10.1007/s11569-012-0142-6 Authors John Hadley, School of Humanities and Communication Arts, University of Western Sydney, 7.G.10b, Bankstown Campus, Locked Bag 1797, Penrith, NSW 2751, Australia Journal NanoEthics Online ISSN 1871-4765 Print ISSN 1871-4757. (shrink)

Much of traditional AI exemplifies the explicit representation paradigm, and during the late 1980''s a heated debate arose between the classical and connectionist camps as to whether beliefs and rules receive an explicit or implicit representation in human cognition. In a recent paper, Kirsh (1990) questions the coherence of the fundamental distinction underlying this debate. He argues that our basic intuitions concerning explicit and implicit representations are not only confused but inconsistent. Ultimately, Kirsh proposes a new formulation of the distinction, (...) based upon the criterion ofconstant time processing.The present paper examines Kirsh''s claims. It is argued that Kirsh fails to demonstrate that our usage of explicit and implicit is seriously confused or inconsistent. Furthermore, it is argued that Kirsh''s new formulation of the explicit-implicit distinction is excessively stringent, in that it banishes virtually all sentences of natural language from the realm of explicit representation. By contrast, the present paper proposes definitions for explicit and implicit which preserve most of our strong intuitions concerning straightforward uses of these terms. It is also argued that the distinction delineated here sustains the meaningfulness of the abovementioned debate between classicists and connectionists. (shrink)

This book presents a theory of habitat rights for wild animals, positioning animal property rights within the existing institution of property and discussing the practical implications of giving property rights to animals.

The past decade has witnessed the emergence of a novel stance on semantic representation, and its relationship to context sensitivity. Connectionist-minded philosophers, including Clark and van Gelder, have espoused the merits of viewing hidden-layer, context-sensitive representations as possessing semantic content, where this content is partially revealed via the representations'' position in vector space. In recent work, Bodén and Niklasson have incorporated a variant of this view of semantics within their conception of semantic systematicity. Moreover, Bodén and Niklasson contend that they (...) have produced experimental results which not only satisfy a kind of context-based, semantic systematicity, but which, to the degree that reality permits, effectively deals with challenges posed by Fodor and Pylyshyn (1988), and Hadley (1994a). The latter challenge involved well-defined criteria for strong semantic systematicity. This paper examines the relevant claims and experiments of Bodén and Niklasson. It is argued that their case fatally involves two fallacies of equivocation; one concerning ''semantic content'' and the other concerning ''novel test sentences''. In addition, it is argued that their ultimate construal of context sensitive semantics contains serious confusions. These confusions are also found in certain publications dealing with "latent semantic analysis". Thus, criticisms presented here have relevance beyond the work of Bodén and Niklasson. (shrink)

abstract Most moral philosophers accept that we have obligations to provide at least some aid and assistance to distant strangers in dire need. Philosophers who extend rights and obligations to nonhuman animals, however, have been less than explicit about whether we have any positive duties to free‐roaming or ‘wild’ animals. I argue our obligations to free‐roaming nonhuman animals in dire need are essentially no different to those we have to severely cognitively impaired distant strangers. I address three objections to the (...) view that we have positive duties to free‐roaming nonhuman animals, and respond to the predation objection to animal rights. (shrink)

In their provocative 1988 paper, Fodor and Pylyshyn issued a formidable challenge to connectionists, i.e. to provide a non‐classical explanation of the empirical phenomenon of systematicity in cognitive agents. Since the appearance of F&P's challenge, a number of connectionist systems have emerged which prima facie meet this challenge. However, Fodor and McLaughlin (1990) advance an argument, based upon a general principle of nomological necessity, to show that one of these systems (Smolensky's) could not satisfy the Fodor‐Pylyshyn challenge. Yet, if Fodor (...) and McLaughlin's analysis is correct, it is doubtful whether any existing connectionist system would fare better than Smolensky's. In the view of Fodor and McLaughlin, humans and classical architectures display systematicity as a matter of nomological necessity (necessity by virtue of natural law), but connectionist architectures do not. However, I argue that the Fodor‐Pylyshyn‐McLaughlin appeal to nomological necessity is untenable. There is a sense in which neither classical nor connectionist architectures possess nomological (or‘nomic’) necessity. However, the sense in which classical architectures do possess nomic necessity applies equally well to at least some connectionist architectures. Representational constituents can have causal efficacy within both classical and connectionist architectures. (shrink)

Recent social science research indicates that animal rights philosophy plays the functional role of a religion in the lives of the most committed animal rights advocates. In this paper, I apply the functional religion thesis to the recent debate over the place of direct action animal rights advocacy in democratic theory. I outline the usefulness of the functional religion thesis and explain its implications for theorists that call for deliberative theories to be more inclusive of coercive forms of activism.

An Inquiry into the first principles of morals and justice: This book restores to us an understanding that was once settled in the 'moral sciences': that there are propositions, in morals and law, which are not only true but which cannot be ...

In this paper I extend orthodox just-war terrorism theory to the phenomenon of extremist violence on behalf of nonhuman animals.I argue that most documented cases of so-called animal rights extremism do not quality as terrorism.

Hadley Arkes argues that it is necessary to move "beyond the Constitution", to the principles that stood antecedent to the text, if we are to understand the text and apply the Constitution to the cases that arise every day in our law.

In this paper data from a Tanzanian horticultural population are used to assess whether mother’s kin network size predicts several measures of children’s health and well-being, and whether any kin effects are modified by household socioeconomic status. This hypothesis is further tested with a questionnaire on maternal attitudes towards kin. Results show small associations between measures of maternal kin network size and child mortality and children’s growth performance. Together these results suggest that kin positively influence child health, but the effects (...) are small and it is unlikely that the high prevalence of undernutrition observed in this setting is influenced by the availability of kin. (shrink)

In this paper I bring together self-defense theory and animal rights theory. The extension of self-defense theory to animals poses a serious problem for proponents of animal rights. If, in line with orthodox self-defense theory, a person is a legitimate target for third-party self-defensive violence if they are responsible for a morally unjustified harm without an acceptable excuse; and if, in line with animal rights theory, people that consume animal products are responsible for unjustified harm to animals, then many millions, (...) if not billions, of otherwise law abiding and decent people will be legitimate targets for third-party self-defense violence on behalf of animals. I call this problem: the multiple inappropriate targets problem for animal rights. (shrink)

At present, the prevailing Connectionist methodology forrepresenting rules is toimplicitly embody rules in neurally-wired networks. That is, the methodology adopts the stance that rules must either be hard-wired or trained into neural structures, rather than represented via explicit symbolic structures. Even recent attempts to implementproduction systems within connectionist networks have assumed that condition-action rules (or rule schema) are to be embodied in thestructure of individual networks. Such networks must be grown or trained over a significant span of time. However, arguments (...) are presented herein that humanssometimes follow rules which arevery rapidly assignedexplicit internal representations, and that humans possessgeneral mechanisms capable of interpreting and following such rules. In particular, arguments are presented that thespeed with which humans are able to follow rules ofnovel structure demonstrates the existence of general-purpose rule following mechanisms. It is further argued that the existence of general-purpose rule following mechanisms strongly indicates that explicit rule following is not anisolated phenomenon, but may well be a common and important aspect of cognition. The relationship of the foregoing conclusions to Smolensky''s view of explicit rule following is also explored. The arguments presented here are pragmatic in nature, and are contrasted with thekind of arguments developed by Fodor and Pylyshyn in their recent, influential paper. (shrink)

In this paper I extend liberal property rights theory to nonhuman animals.I sketch an outline of a nonhuman animal property rights regime and argue that both proponents of animal rights and ecological holism ought to accept nonhuman animal property rights. To conclude I address a series of objections.

This paper addresses the question of whether Medicaid is in fact a high-cost program after adjusting for the health of the people it covers. We compare and simulate annual per capita medical spending for lower-income people (families with incomes under 200% of poverty) covered for a full year by either Medicaid or private insurance. We first show that low-income privately insured enrollees and Medicaid enrollees have very different socioeconomic and health characteristics. We then present simulated comparisons based on multivariate statistical (...) models that estimate the effects of private and Medicaid coverage on the likelihood of using services, and the level of expenditures, given any use, holding constant demographic, economic, and health status characteristics. The simulations demonstrate that if people with Medicaid coverage—with their health status, disability, and chronic conditions—were given private coverage, they would cost considerably more than they do today. Conversely, if the privately insured were given Medicaid coverage, spending would be lower. We find no evidence that spending differences between Medicaid and private coverage for low-income people are due to lower service use by Medicaid beneficiaries. We conclude that most of the difference in expenditures is due to differences in provider payment rates. (shrink)

This study reports the findings of a survey of television news directors drawn from a Radio?Television News Directors Association (RTNDA) sample. Rationale for the study centers around an apparent trend in television news to extend its ethical boundaries to include high proportions of sensationalism, privacy invasion, deception, unfair reporting, and the like. Five principles of journalism ethics? truth, justice, freedom, humaneness, and stewardship?are used as the framework for discussing results of 34 ethical questions. Results show most news directors clearly favor (...) traditional ethical solutions to ethical questions related to truth, justice, freedom, and stewardship principles. There is more disagreement among news directors in responses related to humaneness. (shrink)

... or political office or scientific research tends to think everything small which does not visibly contribute to money-getting, or political influence, ...

In “Do Animals have an Interest in Liberty?” Alasdair Cochrane brings some much needed attention to the ethics of animal confinement (2009a). Of particular significance is the question of whether confinement in itself is bad for nonhuman animal (hereafter, animal) well-being. If confinement conditions cause animals to suffer or frustrate their preferences it is safe to assume that liberty or freedom (following Cochrane, I use the terms interchangeably) would be instrumentally good for them. But, what about seemingly benign conditions of (...) confinement in which animals are not suffering or having their preferences frustrated? Is confinement in such cases bad for their well-being? In other words, do animals have an .. (shrink)

In this paper I argue that the potentially environmentally destructive scope of a libertarian property rights regime can be narrowed by applying reasonable limits to those rights. I will claim that excluding the right to destroy from the libertarian property rights bundle is consistent with self-ownership and Robert Nozick’s interpretation of the Lockean proviso.

Within AI and the cognitively related disciplines, there exist a multiplicity of uses of belief. On the face of it, these differing uses reflect differing views about the nature of an objective phenomenon called belief. In this paper I distinguish six distinct ways in which belief is used in AI. I shall argue that not all these uses reflect a difference of opinion about an objective feature of reality. Rather, in some cases, the differing uses reflect differing concerns with special (...) AI applications. In other cases, however, genuine differences exist about the nature of what we pre-theoretically call belief. To an extent the multiplicity of opinions about, and uses of belief, echoes the discrepant motivations of AI researchers. The relevance of this discussion for cognitive scientists and philosophers arises from the fact that (a) many regard theoretical research within AI as a branch of cognitive science, and (b) even if theoretical AI is not cognitive science, trends within AI influence theories developed within cognitive science. It should be beneficial, therefore, to unravel the distinct uses and motivations surrounding belief, in order to discover which usages merely reflect differing pragmatic concerns, and which usages genuinely reflect divergent views about reality. (shrink)

In this paper I introduce the ‘changing the subject’ problem. When proponents of animal protection use terms such as dignity and respect they can be fairly accused of shifting debate from welfare to rights because the terms purportedly refer to properties and values that are logically distinct from the capacity to suffer and the moral significance of causing animals pain. To avoid this problem and ensure that debate proceeds in the familiar terms of the established welfare paradigm, I present an (...) expressivist analysis of animal rights vocabulary. When terms such as dignity and respect are understood in line with the theory of moral language use known as expressivism, proponents of animal protection that use these terms can escape the charge of changing the subject. Drawing upon Helm’s theory of love, I show how the usage of rights vocabulary can be respectable way for people to register their concern for the welfare of animals, even at times when it is unlikely that the animals concerned are suffering. Tying rights vocabulary to welfare via expressivism aligns the aims of animal rights with welfare without the theoretical problems associated with attempts to ‘reduce’ dignity or respect to natural behaviour or inherent value. (shrink)

In this paper we make an argument for limiting veterinary expenditure on companion animals. The argument combines two principles: the obligation to give and the self-consciousness requirement. In line with the former, we ought to give money to organisations helping to alleviate preventable suffering and death in developing countries; the latter states that it is only intrinsically wrong to painlessly kill an individual that is self-conscious. Combined, the two principles inform an argument along the following lines: rather than spending inordinate (...) amounts of money on veterinary care when a companion animal is sick or injured, it is better to give the money to an aid organisation and painlessly kill the animal. (shrink)

In this paper I examine the ethics of street photography. I firstly discuss the close-up ‘in-your-face’ style street photography made famous by American photographer, Bruce Gilden. In close-up street photography, the proximity of the camera to the subject and the element of surprise work in tandem to produce a striking and evocative picture. Close-up street photography is shown to be ethically contentious on wellbeing-related and autonomy-related grounds. I next examine the more orthodox ‘respectable distance’ kind of street photography. In orthodox (...) street photography, the photographer positions the camera some distance away from a nonconsenting subject that may or may not be aware a picture is to be taken. The main ethical problem with this form of street photography relates to the subject’s vanity and sense of self. When street photographers produce and publish images without the consent of subjects, they express their own creative freedom at the expense of the subject’s right to editorial control. I discuss the scope and potentially demanding practical implications of a right to editorial control. To conclude, I offer a workable solution to the ethical dilemma facing street photographers and discuss the implications of smart phones and photo-sharing social media platforms. (shrink)

: J. Baird Callicott's claim to have unified environmentalism and animal liberation should be rejected by holists and liberationists. By making relations of intimacy necessary for moral considerability, Callicott excludes from the moral community nonhuman animals unable to engage in intimate relations due to the circumstances of their confinement. By failing to afford moral protection to animals in factory farms and research laboratories, Callicott's biosocial moral theory falls short of meeting a basic moral demand of liberationists. Moreover, were Callicott to (...) include factory farm and research animals inside the moral community by affording them universal or non-communitarian rights, his theory would fall foul of environmentalists who seek to promote ecosystem stability and integrity via therapeutic hunting. If factory farm and research animals can have rights irrespective of their particular circumstances, then so can free- roaming animals from overabundant and exotic species. (shrink)

For too long, Spinoza's ethics was misread as an ethics of ideals, in which the most virtuous life possible was said to consist of the life of pure reasoning. The "free man," Spinoza's paragon of virtue, was understood to be the individual who is neither helped nor harmed by anything external. The goal, on this view, was to transcend the life of the body, of the material, and of the political, in order to focus solely on becoming like God by (...) increasing one's store of rational ideas.This, of course, is an impoverished understanding of Spinoza's aims. Not only does it cast virtue as something unattainable for actually existing, materially and socially embedded individuals, but it overlooks a vast swath of Spinoza's... (shrink)

A process-oriented model of belief is presented which permits the representation of nested propositional attitudes within first-order logic. The model (NIM, for nested intensional model) is axiomatized, sense-based (via intensions), and sanctions inferences involving nested epistemic attitudes, with different agents and different times. Because NIM is grounded upon senses, it provides a framework in which agents may reason about the beliefs of another agent while remaining neutral with respect to the syntactic forms used to express the latter agent's beliefs. Moreover, (...) NIM provides agents with a conceptual map, interrelating the concepts of knowledge, belief, truth, and a number of cognate concepts, such as infers, retracts, and questions. The broad scope of NIM arises in part from the fact that its axioms are represented in a novel extension of first-order logic, -FOL (presented herein). -FOL simultaneously permits the representation of truth ascriptions, implicit self-reference, and arbitrarily embedded sentences within a first-order setting. Through the combined use of principles derived from Frege, Montague, and Kripke, together with context-sensitive semantic conventions, -FOL captures the logic of truth inferences, while avoiding the inconsistencies exhibited by Tarski. Applications of -FOL and NIM to interagent reasoning are described and the soundness and completeness of -FOL are established herein. (shrink)

"Dialogue" is one of American religion's shopworn terms. Although we hear much talk about dialogue, very little of it actually takes place. Religious discourse - especially about politics and public affairs - is increasingly polarized, involving much contestation but little conversation. If truth are to be tested, however, there is no substitute for dialogue.

For James Schall, revelation becomes open to us, on the most important questions that revelation can address, when it is opened by people who “study politics,” as Samuel Johnson had it. For Plato, the best city, the best political order, was spun out in the world of speech. It is not a place we expect to inhabit. But Plato had Socrates say at the end of the Republic that, whether this City exists anywhere or not, it is the only city (...) in which the thoughtful man would wish to take part. But even so, as Schall says, revelation alerts us to the possibility that our true home will really be elsewhere. (shrink)

The city of Cincinnati, we know, can be an engaging place, but federal judge Arthur Spiegel also found, in the mid-'90s, that it could be quite a vexing place. The city council of Cincinnati had passed what was called the Human Rights Ordinance of 1992, which barred virtually all species of discriminationAppalachian origin.sexual orientation.minority status” in the law. The framers of the amendment objected to the tendency to treat gays and lesbians on the same plane as groups that have suffered (...) discrimination based on race, religion, or gender. The proposal, known as Issue 3, drew wide support and passed in a referendum in 1993. It was, of course, challenged in the courts, which is why it found its way into the hands of Judge Spiegel. (shrink)