Henri Lefebvre has considerable claims to be the greatest living philosopher. His work spans some sixty years and includes original work on a diverse range of subjects, from dialectical materialism to architecture, urbanism and the experience of everyday life. The Production of Space is his major philosophical work and its translation has been long awaited by scholars in many different fields. The book is a search for a reconciliation between mental space and real space. In the course of his (...) exploration, Henri Lefebvre moves from metaphysical and ideological considerations of the meaning of space to its experience in the everyday life of home and city. He seeks, in other words, to bridge the gap between the realms of theory and practice, between the mental and the social, and between philosophy and reality. In doing so, he ranges through art, literature, architecture and economics, and further provides a powerful antidote to the sterile and obfuscatory methods and theories characteristic of much recent continental philosophy. This is a work of great vision and incisiveness. It is also characterized by its author's wit and by anecdote, as well as by a deftness of style which Donald Nicholson-Smith's sensitive translation precisely captures. (shrink)

. Lamarck and Darwin agreed on the inconstancy of species and on the exclusive gradualism of evolution. Darwinism, revived as neo-Darwinism, was almost generally accepted from about 1930 till 1960. In the sixties the evolutionary importance of selection has been called in question by the neutralists. The traditional conception of the gene is disarranged by recent molecular-biological findings. Owing to the increasing confusion about the concept of genotype, this concept is reconsidered. The idea of the genotype as a cluster of (...) genes is replaced by a cybernetical interpretation of the genotype. As nature does jump, exclusive gradualism is dismissed. Saltatory evolution is a natural phenomenon, provoked by a sudden collapse of the thresholds which resist against evolution. The fossil record and the taxonomic system call for a macromutational interpretation. As Lamarck and Darwin overlooked the resistance of evolutionary thresholds, an alternative evolution model is needed, the first to be constructed on a palaeontological and taxonomic basis. (shrink)

Si la vie est une évolution, alors elle doit expliquer jusqu'à la connaissance, l'intelligence, la science et la technique de l'homme, l'homo faber ; si il y a en elle de la création, alors ce n'est pas un postulat extérieur, mais dans son histoire et dans notre vie même qu'on doit l'expérimenter. dans L'évolution créatrice, Bergson pousse ainsi la théorie de l'évolution et l'expérience de la " durée " jusqu'au bout, sans admettre ni une création transcendante ni une vie sans (...) émergence ou nouveauté. Les conséquences traversent toute la science, la théorie de la connaissance, et la philosophie, de 1907 à aujourd'hui. La première édition critique des œuvres de Bergson, dans laquelle s'inscrit le présent volume, répond à un double principe : offrir d'abord le texte intégral du livre tel que l'a publié Bergson, dans sa pagination de référence inchangée ; le compléter ensuite par un dossier comportant des notes historiques et philosophiques ainsi que les variantes éventuelles du texte, une table analytique de l'ouvrage, une série originale d'index, une anthologie des " lectures " majeures et une bibliographie commentée. (shrink)

Given a 4-tuple of Boolean variables (a, b, c, d), logical proportions are modeled by a pair of equivalences relating similarity indicators ( \({a \wedge b}\) and \({\overline{a} \wedge \overline{b}}\) ), or dissimilarity indicators ( \({a \wedge \overline{b}}\) and \({\overline{a} \wedge b}\) ) pertaining to the pair (a, b), to the ones associated with the pair (c, d). There are 120 semantically distinct logical proportions. One of them models the analogical proportion which corresponds to a statement of the form “a (...) is to b as c is to d”. The paper inventories the whole set of logical proportions by dividing it into five subfamilies according to what they express, and then identifies the proportions that satisfy noticeable properties such as full identity (the pair of equivalences defining the proportion hold as true for the 4-tuple (a, a, a, a)), symmetry (if the proportion holds for (a, b, c, d), it also holds for (c, d, a, b)), or code independency (if the proportion holds for (a, b, c, d), it also holds for their negations \({{(\overline{a},\overline{b}, \overline{c}, \overline{d})}}\) ). It appears that only four proportions (including analogical proportion) are homogeneous in the sense that they use only one type of indicator (either similarity or dissimilarity) in their definition. Due to their specific patterns, they have a particular cognitive appeal, and as such are studied in greater details. Finally, the paper provides a discussion of the other existing works on analogical proportions. (shrink)

Networks for the exchange and/or sharing of genetic data are developing in many countries. We focus here on the situations in the US and France. We highlight some recent and remarkable differences between these two countries concerning the mode of access to, and the storage and use of genetic data, particularly as concerns two-sided markets and dynamic consent or dynamic electronic informed consent. This brief overview suggests that, even though the organization and function of these two-sided markets remain open to (...) criticism, dynamic e-IC should be more widely used, especially in France, if only to determine its real effectiveness. (shrink)

The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine”. The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision (...) of care. Molecular tumor boards are one response to these changes and are now providing better access to next-generation sequencing and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent documents at all academic medical centers and to introduce dynamic and electronic informed consent. (shrink)

Dieu trompeur et malin génie. La valeur de l’évidence liée au problème de l’origine de l’homme. Le malin génie comme artifice méthodologique qui disparaît après avoir rempli son office. Le rôle de la véracité divine lié à la thèse de la création des vérités éternelles.

Les décideurs du 21e siècle héritent d'un monde en crise. Comme cela s'est passé plusieurs fois dans l'histoire de l'Occident, un grand système politique, philosophique et culturel est en train de disparaître. Ce qui tombe, c'est un monde construit autour de l'idéologie libérale postmoderne : monde de démocratie médiatique, de capitalisme financier, d'individualisme arbitraire et de constructions internationales trop artificielles. Ce libéralisme idéologique postmoderne est ce qu'est devenu le grand libéralisme politique des Lumières, une fois qu'il a abandonné la Raison (...) et le Devoir. Pour une nouvelle génération de décideurs, il faut une philosophie nouvelle. Celle-ci apprend à retrouver la pensée classique, en se replongeant dans les trois grandes sources de la pensée occidentale, que sont l'antiquité gréco-romaine, la religion chrétienne et la grande philosophie des Lumières. Le but de cette philosophie est de reconstruire une culture capable d'équilibrer les principes conservateurs et les principes de liberté, de refonder la légitimité du pouvoir politique, et de dépasser tout ce qui reconduit la société civilisée à l'état de nature. C'est le travail de tout décideur, dans ces périodes troublées précédant les périodes de renaissance, d'avoir médité sur ces grandes problématiques philosophiques, politiques et morales. (shrink)

The ArgumentThe status of the person is analyzed as represented by the life sciences under the influence of modern physico–chemical and molecular biology.At the same time the linguistic structure of reality as seen through formalized scientific discourse is not that of a language, but rather that of operational symbolisms, so that the judeo–Greek tradition of Verb as creating and Logos as procreating — which is probably at the origin of the surprising confidence in the possibility of dominating nature through words (...) and formulae — could be suc–cessful only through the depersonalization of language.Notwithstanding appearances, the phenomena of structural and functional self–organization do not really change this situation.In this context the question of the status of the person and of the intentional subject has to be dealt with pragmatically, giving up the notion of a unified scientific theory that would take into consideration at the same time the experi–mental sciences and the human sciences as linking subjectivity and intentionality. (shrink)

The objective of this study is to analyze the measurability and interfirm comparability of sustainability performance through the qualitative content analysis of 12 sustainability reports of mining firms using the Global Reporting Initiative guidelines. The systematic comparison of information disclosed in 92 GRI indicators sheds light on the reasons underlying the impossibility of rigorously measuring and comparing the sustainability performance of firms from the same sector, which are supposed to be strictly following the same reporting guideline. These reasons include qualitative (...) aspects of sustainability, lack of compliance with GRI protocols, indicator contingency, ambiguous or incomplete information, data heterogeneity, and report opacity. The study makes it possible to return to the very notion of sustainability, its meaning, and flexible application by organizations. The results are discussed from three different theoretical perspectives, each of which proposes possible and complementary explanations of the main findings. (shrink)

Excerpt from Immanuel Kants Transzendentale Deduktion Die Bedeutung der transzendentalen Deduktion ist erst in der neueren Zeit klar erkannt und zum Gegenstand eingehenderer philosophischer Untersuchungen gemacht worden. Die grossen Denker, welche im Zeitalter des deutschen Idealismus mehr oder weniger von Kant beeinfluBt ihre eigenen Systeme aufgestellt haben, scheinen an Kants transzendentaler Deduktion das wenigste Interesse genommen zu haben. Auch in Schopenhauers Kritik der Kantischen Philosophie findet man keine Anzeichen dafur, dass er die von Kant selbst so betonte Wichtigkeit dieses Abschnittes (...) der Vernunftkritik zu erkennen vermocht habe. Wie es nun erlaubt ist, zu vermuten, dass die von Kant ebenfalls wiederholt zugestandene Schwierigkeit und Dunkelheit dieses Gebietes diejenigen, welche wir im Auge haben, von einer tiefer eindringenden Beschaftigung mit demselben abgehalten hat, so kann es andererseits nicht Wunder nehmen, dass die Bedeutung der Deduktion erst von solchen Forschern er kannt werden konnte, welche - von dem methodischen Grund satze ausgehend, da Beine als Fortschritt gelten sollende Philosophie die genaue Kenntnis der fruheren Systeme zur unnachlassigen Bedingung habe - der Aufforderung Kants getreu sich durch keine Schwierigkeit und Dunkelheit der Darstellung abhalten lieben. in ihre Tiefen einzudringen, um so das andere Wort Kants von der Wichtigkeit dieser Untersuchung bestatigt zu finden. Ist man nun auch neuerdings einstimmig von der Wichtigkeit und Bedeutsamkeit der Deduktion uberzeugt, so werden doch ihre Lehren von den verschiedenen Forschern in sehr verschiedenem Sinne interpretiert. Ist man nun auch neuerdings einstimmig von der Wichtigkeit und Bedeutsamkeit der Deduktion uberzeugt, so werden doch ihre Lehren von den verschiedenen Forschern in sehr verschiedenem Sinne interpretiert. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.". (shrink)