This article reviews recent findings that bear on the mechanism(s) of tumor‐specific Lyt‐1+2− T cell‐mediated tumor eradication in vivo A tumor‐immune Lyt‐1+2− T cell subset has been identified which is distinct from T cells mediating in vitro cytotoxicity (Lyt‐1+2+/1−2+). The Lyt‐1+2− cells have a crucial role in rejecting tumor cells when adoptively transferred into T cell‐deprived B cell mice. This indicates that Lyt‐1+2− T cells do not necessarily require recruitment of the host's cytotoxic T cell precursors for implementation of in (...) vivo immunity. Instead, this T cell subset exerts its anti‐tumor effect in collaboration with macrophages as shown with an in vivo tumor cell culture system utilizing a diffusion chamber. A pathway of Lyt‐1+2− T cell‐macrophage interaction leading to tumor cell killing is discussed in terms of its probable relevance to the eradication of tumor cell masses consisting of tumor cells expressing quantitatively and/or qualitatively different tumor antigens. (shrink)

The word sautrāntika is known to designate one of the philosophical schools in later documents, but its earlier phase remains uncertain. The discovery of this term in the Mahāparinirvāṇa-mahāsūtra thus brings forward new evidence essential for solving the problem of sautrāntika. In this paper, I will attempt to establish the interpretation of the context, in which the phrase vinayadharaḥ sautrāntikaḥ appears.

日本史・日本思想史・日本文学から葉隠の歴史に迫る。現代人が無意識に前提としてきた「日本」「武士道」の認識枠組みを問う初の書。.

Disruptions in chromatin regulator genes are frequently the cause of neurodevelopmental and neuropsychiatric disorders. Chromatin regulators are widely expressed in the brain, yet symptoms suggest that specific circuits can be preferentially altered when they are mutated. Using Drosophila allows targeted manipulation of chromatin regulators in defined neuronal classes, lineages, or circuits, revealing their roles in neuronal precursor self‐renewal, dendrite and axon targeting, neuron diversification, and the tuning of developmental signaling pathways. Phenotypes arising from chromatin regulator disruption are context dependent – (...) defined by interaction networks between the regulators, transcription factors, and chromatin remodeling complex partners. Future challenges are to determine the complexity of partner interactions, and to ascertain the degree to which cognitive deficits are due to loss of chromatin regulator activity in building a circuit or in maintaining homeostasis and activity within it. (shrink)

This paper demonstrates that recent changes in the mass media, especially TV programs, change democratic practice. I argue that this theory is applicable not only to the US, but also to Japan after the 1990s. This paper is organized as follows: the first section confirms that the increase in TV news after the 1980s is driven by an increase in or political news. The second section describes the changes in political practice – elections, policy processes, and party organization brought about (...) by this change in the mass media, using both quantitative and qualitative methods. (shrink)

江戸時代、喧嘩をした者は、喧嘩両成敗法により両成敗になったという通念は、従来「理非を論ぜず」を「理由の如何を問わず」と解釈されてきたことによる。しかし、実際の裁判記録では、理不尽な実力行使に対する自己 防衛の場合は無罪とされることも多く、異なる身分の喧嘩では武士により重い罰が与えられていた。一方、百姓・町人に対する武士の横暴として見られがちな無礼討ちは、武士にとっては名誉と身分秩序を守るための義務で あった。武士による喧嘩・敵討・無礼討ちの豊富な事例を通して、近世社会の身分秩序意識、「家」の名誉、武士が考える武士道を再考する。.

The Commission for Religious Relations with the Jews produced The Gifts and Calling of God Are Irrevocable, in which supersessionism is firmly rejected. In this document, the term fulfillment occurs frequently to describe the relationship between the Old and New Covenant. It implies an evolutionary development from old to new, or from promise to fulfillment. Therefore, the use of this term may lead one to suspect that it is merely a synonym for supersession or a progression from good to better. (...) To avoid this connotation, I redefine this term by locating it within the Israelite cult. Through a study of Aaron’s ordination to the high priesthood in Leviticus and the claims for Jesus’s high priesthood in the Epistle to the Hebrews, I show that fulfillment already occurs in the Old Covenant by relating the historical, earthly cult to the eternal, heavenly cult. (shrink)

Background Japanese people have become increasingly interested in the expression and enhancement of their individual autonomy in medical decisions made regarding medical treatment at and toward the end of life. However, while many Western countries have implemented legislation that deals with patient autonomy in the case of terminal illness, no such legislation exists in Japan. The rationale for this research is based on the need to investigate patient's preferences regarding treatment at the end of life in order to re-evaluate advance (...) directives policy and practice. Methods We conducted a cross-sectional survey with 418 members of the general middle-aged and senior adults (aged between 40 and 65) in Tokyo, Japan. Respondents were asked about their attitudes toward advance directives, and preferences toward treatment options. Results Over 60% of respondents agreed that it is better to express their wishes regarding advance directives (treatment preferences in writing, appointment of proxy for care decision making, appointment of legal administrator of property, stating preferences regarding disposal of one's property and funeral arrangements) but less than 10% of them had already done so. About 60% of respondents in this study preferred to indicate treatment preferences in broad rather than concrete terms. Over 80% would like to decide treatment preferences in consultation with others (22.2% with their proxy, 11.0% with the doctor, and 47.8% with both their proxy and the doctor). Conclusion This study revealed that many Japanese people indicate an interest in undertaking advance directives. This study found that there is a range of preferences regarding how advance directives are undertaken, thus it is important to recognize that any processes put into place should allow flexibility in order to best respect patients' wishes and autonomy. (shrink)

This study aimed to: (1) develop and evaluate the Moral Distress Scale for Psychiatric nurses (MDS-P); (2) use the MDS-P to examine the moral distress experienced by Japanese psychiatric nurses; and (3) explore the correlation between moral distress and burnout. A questionnaire on the intensity and frequency of moral distress items (the MDS-P: 15 items grouped into three factors), a burnout scale (Maslach Burnout Inventory — General Survey) and demographic questions were administered to 391 Japanese psychiatric nurses in 2007—2008. These (...) nurses experienced relatively low levels of moral distress despite the fact that they were commonly confronted by morally distressing situations. All the circumstances in which the participants experienced moral distress were included in the ‘low staffing’ factor, which reflects the characteristics of Japanese psychiatric care. The frequency score of the low staffing factor was a significant predictor of burnout. (shrink)

Artificial intelligence (AI) has become indispensable in our lives. The development of a quantitative scale for AI ethics is necessary for a better understanding of public attitudes toward AI research ethics and to advance the discussion on using AI within society. For this study, we developed an AI ethics scale based on AI-specific scenarios. We investigated public attitudes toward AI ethics in Japan and the US using online questionnaires. We designed a test set using four dilemma scenarios and questionnaire items (...) based on a theoretical framework for ethics, legal, and social issues (ELSI). We found that _country_ and _age_ are the most informative sociodemographic categories for predicting attitudes for AI ethics. Our proposed scale, which consists of 13 questions, can be reduced to only three, covering ethics, tradition, and policies. This new AI ethics scale will help to quantify how AI research is accepted in society and which area of ELSI people are most concerned with. (shrink)

Perceptual grouping has traditionally been thought to be governed by innate, universal principles. However, recent work has found differences in Japanese and English speakers' non-linguistic perceptual grouping, implicating language in non-linguistic perceptual processes (Iversen, Patel, & Ohgushi, 2008). Two experiments test Japanese- and English-learning infants of 5-6 and 7-8 months of age to explore the development of grouping preferences. At 5-6 months, neither the Japanese nor the English infants revealed any systematic perceptual biases. However, by 7-8 months, the same age (...) as when linguistic phrasal grouping develops, infants developed non-linguistic grouping preferences consistent with their language's structure (and the grouping biases found in adulthood). These results reveal an early difference in non-linguistic perception between infants growing up in different language environments. The possibility that infants' linguistic phrasal grouping is bootstrapped by abstract perceptual principles is discussed. (shrink)

Recent technological advances have accelerated the use of artificial intelligence (AI) in the world. Public concerns over AI in ethical, legal, and social issues (ELSI) may have been enhanced, but their awareness has not been fully examined between countries and cultures. We created four scenarios regarding the use of AI: “voice,” “recruiting,” “face,” and “immigration,” and compared public concerns in Japan, the US, Germany, and the Republic of Korea (hereafter Korea). Additionally, public ELSI concerns in respect of AI were measured (...) using four items: ethics, tradition, law and social benefit. Respondents with AI knowledge tended to exhibit stronger concern about ELSI in various situations. In terms of law concerns, Japanese respondents displayed greater concerns. In contrast, the US, when compared Japan, expressed a relatively optimistic view of the current law landscape. Regarding social benefits, Korea, compared to Japan, exhibited a more positive outlook, whereas Germany, in comparison to Japan, expressed heightened concerns about it across different scenarios. (shrink)

The globalization in business and tourism becomes crucial more and more for the economical sustainability of local communities. In the presence of an epidemic outbreak, there must be such a decision on the policy by the host community as whether to accept visitors or not, the number of acceptable visitors, or the condition for acceptable visitors. Making use of an SIRI type of mathematical model, we consider the influence of visitors on the spread of a reinfectious disease in a community, (...) especially assuming that a certain proportion of accepted visitors are immune. The reinfectivity of disease here means that the immunity gained by either vaccination or recovery is imperfect. With the mathematical results obtained by our analysis on the model for such an epidemic dynamics of resident and visitor populations, we find that the acceptance of visitors could have a significant influence on the disease’s endemicity in the community, either suppressive or supportive. (shrink)

This paper reports the results of a survey of 842 undergraduate business students in four nations - the United States of America, the Peoples' Republic of China, Japan, and the Republic of Korea. This survey asked students to respond to four scenarios with potentially unethical business behavior and a string of questions related to the importance of ethics in business strategy and in personal behaviors. Based on arguments related to differences in recent historical experiences, the authors suggest that student responses (...) may be as different within the East Asian environment as they are between this environment as a whole and the USA. Survey results indicate a greater perception of ethical problems and more importance placed on ethics per se in business practices, as well as less of an emphasis on social harmony on the part of USA students. At the same time, substantial national differences in response are also witnessed within the set of East Asian students. A priori expectations as to the manner in which these East Asian responses should vary based on differences in recent historical experiences are partially, but not fully, supported. The authors argue that the key value of the reported research rests on a demonstration that national differences within a common cultural area can be as great as differences across cultural areas and that practitioners of global business must fine-tune their expectations as to acceptable business and personal actions to accommodate specific national historical experiences to be effective. (shrink)

In this paper, we will report annotation experiments which show the advantage of applying a formal ontological methodology for constructing a schema for semantic annotation to mark up terms in the...

Nisbett et al. claim that East Asians are likely to use holistic thought to solve problems, whereas Westerners use analytic thought more, and discuss the differences in the frame of the individualism/collectivism distinction. The holistic versus analytic distinction has been the greatest point of interest of dual process theories, which imply that human thinking has two sub processes. We apply a revised dual process model that proposes meme-acquired goals in both systems to explain cultural differences in thought. According to this, (...) gene-installed goals are universal across cultures, whereas meme-acquired goals depend upon culture. To introduce a dual process model means that we discuss adaptation both in terms of culture and natural selection. Hence, we propose an interactive view that supports an adaptive relation between mind and culture. (shrink)

In studies publishing identifying personal information, obtaining consent is regarded as necessary, as it is impossible to ensure complete anonymity. However, current journal practices around specific points to consider when obtaining consent, the contents of consent forms and how consent forms are managed have not yet been fully examined. This study was conducted to identify potential issues surrounding consent to publish identifying personal information.

While freedom has traditionally been discussed in philosophy and political theory, this paper proposes an anthropological approach to the study of freedom. The focus is on the Japanese word amae, which Takeo Doi calls the ‘key’ to Japanese culture and contrasts with the ‘Western’ concept of freedom. After discussing Doi’s influential work, meanings are reconstructed from interviews and group discussions with Japanese people about amae. The interviewees define amae literally in terms of social ‘non-independence’ and, unlike Doi, understand it in (...) a complex intertwining with freedom on the one hand and autonomy on the other. Overall, the paper argues that amae can hardly serve as a ‘key’ to understanding the Japanese, but can stimulate fruitful anthropological reflections not only on Japanese culture, but also on the concept of freedom. (shrink)