Vaccines and vaccination are richly explored areas of study within the history of science and medicine, connecting related fields of the history of science and technology, and spanning across subfields such as biomedical sciences, animal studies, colonial and postcolonial history, and the history of global health. Vaccination is a thoroughly political act that is at once an intimate and local issue and a transnational one, with its particular set of politics connecting stakes for the individual and the community. Vaccination also (...) maps on narratives and temporal frameworks of disease with an ultimate goal of ending epidemics. Therefore, the essay takes these three analytical entry points to discuss the historiography of vaccination: the geographical, the political, and the temporal. We argue that through these lenses we can gain a more nuanced understanding of historical narratives we privilege, and in return, this understanding can enable us to explore past and current questions of health inequalities, validation practices, power relations and resistance and vaccine diplomacy. (shrink)

Imogen Dickie develops an account of aboutness-fixing for thoughts about ordinary objects, and of reference-fixing for the singular terms we use to express them. Extant discussions of this topic tread a weary path through descriptivist proposals, causalist alternatives, and attempts to combine the most attractive elements of each. The account developed here is a new beginning. It starts with two basic principles, the first of which connects aboutness and truth, and the second of which connects truth and justification. These (...) principles combine to yield a third principle connecting aboutness and justification. Dickie uses the principle to explain how the relations to objects that enable us to think about them--perceptual attention; understanding of proper names; grasp of descriptions--do their aboutness-fixing and thought-enabling work. The book includes discussions of the nature of singular thought and the relation between thought and consciousness. (shrink)

Here is one argument against realism. (1) Realists are committed to the classical rules for negation. But (2) legitimate rules of inference must conserve evidence. And (3) the classical rules for negation do not conserve evidence. So (4) realism is wrong. Most realists reject 2. But it has recently been argued that if we allow denied sentences as premisses and conclusions in inferences we will be able to reject 3. And this new argument against 3 generates a new response to (...) the antirealist argument: keep 1 and 2, avoiding 4 by rejecting 3. My aim in this paper is to see how much work in the fight against anti-realism this new response can really do. I argue that there is a powerful objection to the response: 2 is in tension with the claim that denied sentences can be premisses and conclusions in inferences. But I show that, even given this objection, the new response has an important role to play. (shrink)

This article explores the social benefits and moral arguments in favour of women and couples freezing eggs and embryos for social reasons. Social IVF promotes equal participation by women in employment; it offers women more time to choose a partner; it provides better opportunities for the child as it allows couples more time to become financially stable; it may reduce the risk of genetic and chromosomal abnormality; it allows women and couples to have another child if circumstances change; it offers (...) an option to women and children at risk of ovarian failure; it may increase the egg and embryo pool. There are strong arguments based on equal concern and respect for women which require that women have access to this new technology. Freezing eggs also avoids some of the moral objections associated with freezing embryos. (shrink)

This paper develops a new account of reference-fixing for proper names. The account is built around an intuitive claim about reference fixing: the claim that I am a participant in a practice of using α to refer to o only if my uses of α are constrained by the representationally relevant ways it is possible for o to behave. §I raises examples that suggest that a right account of how proper names refer should incorporate this claim. §II provides such an (...) account. (shrink)

I propose an amendment to Sosa’s virtue reliabilism. Sosa’s framework assigns a central role to sophisticated, conceptual, motivational states: ‘intentions to affirm aptly’. I argue that the suggestion that ordinary knowers in fact are motivated by such intentions in everyday belief-forming situations is at best problematic, and explore the possibility of an alternative virtue reliabilist framework. In this alternative framework, the role Sosa assigns to ‘intentions to affirm aptly’ is played instead by non-conceptual motivational states, which I call ‘needs’. The (...) first part of the paper sketches Sosa’s framework. The second develops the need-based alternative. I close by comparing the two proposals, concluding that the onus is at least on Sosa to say why his intention-based framework should be preferred. (shrink)

This paper offers a novel argument for superspace substantivalism. _Superspace_ is a modified spacetime represented formally through combining ordinary spatial dimensions with anticommuting dimensions whose coordinates are labelled in Grassmann numbers rather than real numbers. At supersymmetric worlds, physical laws exhibit _supersymmetry_—viz., a symmetry that transforms bosons into fermions and vice versa. _Superspace substantivalism_ is the thesis that, at supersymmetric worlds, among the most fundamental structures is superspace. Initially, the focus will be on a prevalent doctrine in the philosophy of (...) physics literature which I call the _mimetic ideal_. On the mimetic ideal, interpreting physical theories aims primarily at specifying their _ontology_, namely at achieving accurate _reference_ (in natural-language accounts of those theories) or _representation_ (in model-theoretic portrayals of those theories) with respect to aspects of physical reality. However, I show that the mimetic ideal doesn’t seem able to account for important aspects of physics practice (Sect. 2 ). In Sect. 3, therefore, I articulate and defend a new, _diegetic ideal_, according to which the interpretation of physical theories should aim at _perspectival coordination_ between interpreters and practising physicists. Perspectival coordination, in the context of interpreting physical theories, means that interpreters and practising physicists share a perspective or a point of view on some aspect of physical reality described by that theory. In Sect. 4, I apply this analysis to the study of supersymmetric quantum field theories (QFTs): reframing the realist framework which underlies Baker’s (2020) agnosticism, I examine the exciting upshot that superspace substantivalism is true. I conclude with some reflections on what perspectival coordination means for realism (Sect. 5 ). (shrink)

This article is about the theoretical life of `the abject'. It focuses on the ways in which Anglo-American and Australian feminist theoretical accounts of maternal bodies and identities have utilized Julia Kristeva's theory of abjection. Whilst the abject has proved a compelling and productive concept for feminist theory, this article cautions against the repetition of the maternal (as) abject within theoretical writing. It argues that employing a Kristevan abject paradigm risks reproducing, rather than challenging, histories of violent disgust towards maternal (...) bodies. In place of the Kristevan model of the abject, it argues for a more thoroughly social and political account of abjection. This entails a critical shift from the current feminist theoretical preoccupation with the `transgressive potentiality' of `encounters with the abject' to a consideration of consequences of being abject within specific social and political locations. (shrink)

: ‘Sortalism about demonstrative reference’ is the view that the capacity to refer to things demonstratively rests on the capacity to classify them according to their kinds. This paper argues for one form of sortalism. Section 1 distinguishes two sortalist views. Section 2 argues that one of them is false. Section 3 argues that the other is true. Section 4 uses the argument from Section 3 to develop a new response to the objection to sortalism from examples where we seem (...) to succeed in referring even though we get sortal classification wrong, or do not attempt to classify at all. (shrink)

A hypothesis on the evolutionary origin of the genetic pathway of sex determination in the nematode Caenorhabditis elegans is presented here. It is suggested that the pathway arose in steps, driven by frequency‐dependent selection for the minority sex at each step, and involving the sequential acquisition of dominant negative, neomorphic genetic switches, each one reversing the action of the previous one. A central implication is that the genetic pathway evolved in reverse order from the final step in the hierarchy up (...) to the first. The possible applicability of the model to the other well‐characterized sex determination pathway, that of Drosophila melanogaster, and to sex determination in mammals, is discussed, along with some potential implications for pathway evolution in general. Finally, the specific molecular and population genetic questions that the model raises are described and some tests are proposed. (shrink)

Human tissue and body parts have been used in one way or another for millennia. They have been preserved and displayed, both in museums and public shows. Real human hair is used for wigs, while some artists even use human tissue in their works. Blood, bone marrow, whole organs and a host of other structures and human substances are all transplanted into living persons to treat illness. New life can be created from gametes through in vitro fertilisation , while the (...) creation of cell lines keeps tissue alive indefinitely. These uses create significant challenges for the legal system in the UK. The major challenge for the law is to balance the competing demands of those groups who have vested interests in human tissue—researchers, medical practitioners, patients, families, the community and the police, among many others. It must provide sufficient control to users of tissue, but also take account of the fact that our bodies hold psychological importance for us while we live and, after we die, for those we leave behind. To some degree the law has been successful, but we still lack a comprehensive, coherent approach to the regulation of human tissue. Partially as a reaction to this lack of a comprehensive approach, some commentators have turned to applying the concept of property to human tissue means to achieve regulatory outcomes they support. (shrink)

The UK Medical Research Council (MRC) takes the issue of conflict of interest very seriously. The overall aim is to preserve a climate in which personal and organisational innovation can flourish while ensuring that potential conflicts are disclosed and identified and conflicts are either avoided or managed with integrity. The approach needs to encompass the MRC’s various responsibilities and the levels at which conflicts might arise: MRC staff (scientists and administrators); the governing Council; research Boards and committees; external peer-reviewers; and (...) applicants for funding. To achieve its goals, the MRC has issued practical guidance on various aspects of conflict of interest. For the future, the MRC has identified the continuing commercialisation of science and the increasing involvement of lay people in scientific decision-making as special challenges in this area. (shrink)

In vitro fertilisation and other assisted reproductive technologies (ART) now enable many women to have children, who would otherwise have remained childless. The most obvious application for these technologies is to help physically infertile, but otherwise healthy young women to have children. However, increasingly, other groups are seeking access to ART to conceive, raising ethical questions about who should be allowed to use these technologies to bear children. In particular, the question of access to ART by lesbian couples and single (...) women has roused considerable ethical, legal and public debate.This paper examines the perhaps less often considered issue of older and postmenopausal women, who are infertile due to age, using ART to conceive. A range of objections have been made to allowing these women access to ART, including concerns about their ability to care for the child, the risk of birth defects and the ‘unnaturalness’ of extending childbearing capacity beyond the menopause. This paper examines these objections and provides some responses. (shrink)

The terrorist threat remains a disturbing issue for the early 1990s. This book explores whether terrorism can ever be morally justifiable and if so under what circumstances. Professor Burleigh Taylor Wilkins suggests that the popular characterisation of terrorists as criminals fails to acknowledge the reasons why terrorists resort to violence. It is argued that terrorism cannot be adequately understood unless the collective responsibility of organised groups, such as political states, for wrongs allegedly done against the groups which the terrorists (...) represent is taken into account. Terrorism and Collective Responsibility provides an analysis of various models of collective responsibility, and it takes into account recent discussions of military responsibility and business ethics. The book also explores the problems that terrorism poses for the just war tradition. The arguments of prominent philosophers against terrorism are critically examined and the claim that terrorism necessarily violates the rights of innocent persons is considered. Wilkins sets forth an original definition of terrorism that is sure to provoke controversy. (shrink)

This paper uses a puzzle arising from cases of felicitous underspecification in uses of demonstratives to motivate a new model of communication using singular terms.

The contributions in this volume represent a detailed exploration of the salient legal and theoretical puzzles arising out of the body-as-property question, and a collation of the broad spectrum of analyses on offer.

This special issue, Withholding artificial nutrition and hydration, comprises several papers, commentaries and responses centred largely around the issues raised by the 2011 decision of the English Court of Protection in W v M.i In that case, the mother of an adult patient applied for the withdrawal of life-sustaining treatment . In 2003, the patient, M, had contracted viral encephalitis and suffered irreparable brain damage as a result. She fell into a coma, and when she emerged appeared to be in (...) a vegetative state and for 8 years was entirely dependent on life-sustaining care.Following her mother's application, M was held to lack capacity and hence in accordance with section 4 of the Mental Capacity Act 2005 , the matter turned on whether it was in her best interests for the treatment to be withdrawn. It was made clear in the 1993 decision of Airedale NHS Trust v Bland that life-sustaining treatment could be withdrawn from a patient in a permanent vegetative state if, on balance, it was not in his or her interest to continue treatment.ii The MCA also allows for withdrawal of treatment, although the approach to best interests is slightly different. However, the case of W v M is importantly different from the Bland case, because M was found not to be in a PVS, but instead was minimally conscious . Much evidence was presented of her capacity to respond to stimuli, seemingly express emotion and occasionally speak.In the first of his papers in this issue , Julian Sheather provides an overview of the case, particularly illuminating the discussions of M's interests and the views of her …. (shrink)

(2013). A History of the Electron: J. J. and G. P. Thomson. International Studies in the Philosophy of Science: Vol. 27, No. 1, pp. 104-107. doi: 10.1080/02698595.2013.783973.

The UK’s Medical Research Council (MRC) introduced a specific policy and procedure for inquiring into allegations of scientific misconduct in December 1997; previously cases had been considered under normal disciplinary procedures. The policy formally covers staff employed in MRC units, but those in receipt of MRC grants in universities and elsewhere are expected to operate under similar policies. The MRC’s approach is stepwise: preliminary action; assessment to establish prima facie evidence of misconduct; formal investigation; sanctions; and appeal. Strict time limits (...) apply at all stages. The procedure will be evaluated after two years. The indications so far are that the procedure is robust, and its clarity and transparency have been an asset to all parties. The MRC is also convinced that it is equally important to achieve a working culture that fosters integrity. Thus education and training in good research practices are fundamental to the prevention of research misconduct. (shrink)

In America today, the problem of achieving racial justice--whether through "color-blind" policies or through affirmative action--provokes more noisy name-calling than fruitful deliberation. In Color Conscious, K. Anthony Appiah and Amy Gutmann, two eminent moral and political philosophers, seek to clear the ground for a discussion of the place of race in politics and in our moral lives. Provocative and insightful, their essays tackle different aspects of the question of racial justice; together they provide a compelling response to our nation's most (...) vexing problem.Appiah begins by establishing the problematic nature of the idea of race. He draws on the scholarly consensus that "race" has no legitimate biological basis, exploring the history of its invention as a social category and showing how the concept has been used to explain differences among groups of people by mistakenly attributing various "essences" to them. Appiah argues that, while people of color may still need to gather together, in the face of racism, under the banner of race, they need also to balance carefully the calls of race against the many other dimensions of individual identity; and he suggests, finally, what this might mean for our political life.Gutmann examines alternative political responses to racial injustice. She argues that American politics cannot be fair to all citizens by being color blind because American society is not color blind. Fairness, not color blindness, is a fundamental principle of justice. Whether policies should be color-conscious, class conscious, or both in particular situations, depends on an open-minded assessment of their fairness. Exploring timely issues of university admissions, corporate hiring, and political representation, Gutmann develops a moral perspective that supports a commitment to constitutional democracy.Appiah and Gutmann write candidly and carefully, presenting many-faceted interpretations of a host of controversial issues. Rather than supplying simple answers to complex questions, they offer to citizens of every color principled starting points for the ongoing national discussions about race. (shrink)

This paper offers an interpretation of Plato's Cratylus 427d1-431c3 that supports a reading of the dialogue as a whole as concluding in favour of a conventionalist account of naming. While many previous interpretations note the value of this passage as evidence for Platonic investigations of false propositions, this paper argues that its demonstration that there can be false (or incorrect) naming in turn refutes the naturalist account of naming; that is, it shows that a natural relation between name and nominatum (...) is neither a necessary nor a sufficient condition for reference. Socrates secures this outcome by using demonstratives and their concomitants to show how any putative natural imitative link between name and object may be overridden. Furthermore, Socrates' employment of demonstratives and context-dependent statements in his case-studies of false naming speaks in favour of a reading of this passage as primarily focussing on naming rather than on propositions in general. (shrink)

This paper is about the claim that, necessarily, a subject who can think that a is F must also have the capacities to think that a is G, a is H, a is I, and so on (for some reasonable range of G, H, I), and that b is F, c is F, d is F, and so on (for some reasonable range of b, c, d). I set out, and raise objections to, two arguments for a strong version of (...) this claim (Gareth Evans' generality constraint). I present a new argument for a weaker version of the claim, and sketch some directions of enquiry which this new argument opens up. (shrink)

Long‐term potentiation (LTP) of excitatory synapses is a leading model to explain the concept of information storage in the brain. Multiple mechanisms contribute to LTP, but central amongst them is an increased sensitivity of the postsynaptic membrane to neurotransmitter release. This sensitivity is predominantly determined by the abundance and localization of AMPA‐type glutamate receptors (AMPARs). A combination of AMPAR structural data, super‐resolution imaging of excitatory synapses, and an abundance of electrophysiological studies are providing an ever‐clearer picture of how AMPARs are (...) recruited and organized at synaptic junctions. Here, we review the latest insights into this process, and discuss how both cytoplasmic and extracellular receptor elements cooperate to tune the AMPAR response at the hippocampal CA1 synapse. (shrink)

The Moral Media provides readers with preliminary answers to questions about ethical thinking in a professional environment. Representing one of the first publications of journalists' and advertising practitioners' response to the Defining Issues Test (DIT), this book compares thinking about ethics by these two groups with the thinking of other professionals. This text is divided into three parts: *Part I includes chapters that explain the DIT and place it within the larger history of three fields: psychology, philosophy, and mass communication. (...) It also provides both a statistical (quantitative) and narrative (qualitative) analysis of journalists' responses to the DIT. *Part II adds to scholarship theory building in these three disciplines and makes changes in the DIT that adds an element of visual information processing to the test. *Part III explores the larger meaning of this effort overall and links the results to theory and practice in these three fields. The Moral Media pursues connections among various intellectual disciplines, between the academy and the profession of journalism, and among those who believe that what journalists do is essential. As a result, this book is appropriate for aspiring journalists; scholars in journalism and mass communication; psychologists, particularly those interested in human development and behavior; and philosophers. (shrink)

This paper uses cases involving empty singular terms (on the one hand, cases of what I call “accidental aboutness-failure”; on the other, cases involving proper names occurring in fictions) to argue for a claim about the goal of ordinary belief-forming activity, and shows how this claim generates new foundations for the theory of reference.

In this paper I argue that in order to secure the commitment of believers in reasonable comprehensive doctrines to political liberalism a third principle of justice needs to be adopted in the Original Position. Rawls acknowledges that neutral legislation by the liberal state may negatively affect some reasonable comprehensive doctrines, and I offer a third principle of justice to help alleviate this problem. This principle, which I believe is in keeping with the United States constitutional history especially where church-state relations (...) are concerned, maintains that a constitutional regime should, insofar as possible, avoid adopting rules with harmful effects upon those comprehensive doctrines which satisfy the conditions of reasonable pluralism. (shrink)