The emphasis in human pluripotent stem cell (hPSC) technologies has shifted from cell therapy to in vitro disease modelling and drug screening. This review examines why this shift has occurred, and how current technological limitations might be overcome to fully realise the potential of hPSCs. Details are provided for all disease‐specific human induced pluripotent stem cell lines spanning a dozen dysfunctional organ systems. Phenotype and pharmacology have been examined in only 17 of 63 lines, primarily those that model neurological and (...) cardiac conditions. Drug screening is most advanced in hPSC‐cardiomyocytes. Responses for almost 60 agents include examples of how careful tests in hPSC‐cardiomyocytes have improved on existing in vitro assays, and how these cells have been integrated into high throughput imaging and electrophysiology industrial platforms. Such successes will provide an incentive to overcome bottlenecks in hPSC technology such as improving cell maturity and industrial scalability whilst reducing cost. (shrink)

William James and Education is a dynamic collection of original essays spotlighting William James as a role model for bringing philosophy to bear on the persistent issues of life and education. Using James's philosophical ideas, the contributors evade the polarization and superficiality that permeate the debate around such educational issues as standards versus diversity, cultural consensus versus multiculturalism, religion versus science, and individual freedom versus social determinism. The result is a synthetic collection of essays offering original, unique, (...) and useful insights. One of the most influential of American philosophers, William James is relevant today because he provides a way of understanding human behavior that is both rigorous and humane. James shows how we may soften and sometimes harmonize rigid ideological divisions, such as those plaguing contemporary education, with a pragmatic approach to issues of theory and practice. By reconsidering some of the roots of American thought in James's work, this volume points the way to valuing both uniqueness and universality, among other seemingly opposing concerns. The result is a lively weave of historical and contemporary thought, providing philosophical perspectives on the critical issues facing educators today. (shrink)

James Beattie was appointed professor of moral philosophy and logic at Marischal College, Aberdeen, Scotland at the age of twenty-five. Though more fond of poetry than philosophy, he became part of the Scottish 'Common Sense' school of philosophy that included Thomas Reid and George Campbell. In 1770 Beattie published the work for which he is best known, An Essay on Truth, an abrasive attack on 'modern scepticism' in general, and on David Hume in particular, subsequently and despite Beattie's attack, (...) Scotland's most famous philosopher. The Essay was a great success, earning its author an honorary degree from Oxford and an audience with George III. Samuel Johnson declared in 1772 that 'We all love Beattie'. Hume, on the other hand, described the Essay as 'a horrible large lie in octavo', and dismissed its author as a 'bigotted silly Fellow'. Although Beattie is no match for Hume as a philosopher, the success of the Essay suggests that, unlike Hume, Beattie voices the characteristic assumptions, and anxieties, of his age. The first part of this selection—the first ever made from Beattie's prose writings—includes several key chapters from the Essay on Truth, along with extracts from all of Beattie's other works on moral philosophy. The topics treated include memory, the existence of God, the nature of virtue, and slavery. The second part of the selection is devoted to Beattie's contributions to literary criticism and aesthetics. Beattie's studies of poetry, music, taste, and the sublime are vital to the understanding of the literary culture out of which developed the early Romanticism of Wordsworth and Coleridge. (shrink)

This is a big book, conceived on a grand scale. Sprigge does not fight shy of addressing the large central issues. He takes James and Bradley head on and expounds their philosophy without compromise and without assuming that the only way we can appreciate them is by making them more palatable to the modern mind by watering down what they wrote. While he relates their thought to modern philosophical concerns he does not presuppose that modern philosophical concerns as such (...) should act as the arbiter of what counts as philosophical good sense. In other words, we can learn from Bradley and James, whether or not they could also learn from us. (shrink)

This special issue arose from a joint conference of the History of Education Society, UK and the Australian and New Zealand History of Education Society, held in Malvern in Worcestershire, England in 2016 on the theme ‘sight, sound and text in the history of education’. The conference drew together media and educational historians, as well as archivists and museum professionals, to examine both methodological issues and a range of examples of sensory and textual histories. The three-day event, as well as (...) being enriching for its international character, proved that although much work has already been done in this area, there is so much more to consider and exploit when it comes to the study of the ‘new’ sonic and visual sources and their intertextual relationship with the documentary, as well as traditional understandings of ‘text’. (shrink)

William James had the courage to experience the collision of European and American ways of thinking head on, and to emerge from it with a new philosophy - one displaying a remarkable vitality for dealing with the transformative issues at the core of the human condition. This easy to read introduction to his life and work explains why James' work is overwhelmingly valuable to us today in getting to grips with the spiritual dimension of human experience.

In 1896 William James published an essay entitled The Will to Believe, in which he defended the legitimacy of religious faith against the attacks of such champions of scientific method as W.K. Clifford and Thomas Huxley. James's work quickly became one of the most important writings in the philosophy of religious belief. James Wernham analyses James's arguments, discusses his relation to Pascal and Renouvier, and considers the interpretations, and misinterpretations, of James's major critics. Wernham shows (...) convincingly that James was unaware of many destructive ambiguitities in his own doctrines and arguments, although clear and consistent in his view that our obligation to believe in theism is not a moral but a prudential obligation -- a foolish-not-to-believe doctrine, rather than a not-immoral-to-believe one. Wernham also shows that the doctrine is best read as affirming the wisdom of gambling that God exists, a notion which James failed to distinguish from believing and which, among other things, he explicitly identified with faith. James's pragmatism, a theory concerning the meaning of truth, is shown to be quite distinct from the doctrine of The Will to Believe. In concentrating on a careful analysis of this doctrine of the will-to-believe, Wernham not only makes a major contribution to understanding James's philosophy, but also clarifies issues in the philosophy of religion and in the analysis of belief and faith. (shrink)

it is easy to think that he did. Clifford certainly had one. In a celebrated essay he argued for the thesis that “it is wrong always, everywhere and for anyone to believe anything upon insufficient evidence“; and his title was “The Ethics of Belief.” Clifford was not alone, for Huxley, also, was of that same opinion. For him, such belief was not just wrong: it was “the lowest depth of immorality.” With that opinion, and with those advocates of it, (...) class='Hi'>James was locked in a struggle throughout his life; and it is a reasonable suspicion that the opponent of one ethics of belief is himself an ethicist with a rival ethics of belief of his own. That suspicion, moreover, appears to be confirmed by James's best known essay. He himself came to the view that his The Will to Believe would have been better named The Right to Believe, and it is a commonplace that “right” is a word of the ethical vocabulary. In short, there are obvious signs pointing to a positive answer to our question. (shrink)

This paper explores the question of whether all or most explanations in biology are, or ideally should be, ‘mechanistic’. I begin by providing an account of mechanistic explanation, making use of the interventionist ideas about causation I have developed elsewhere. This account emphasizes the way in which mechanistic explanations, at least in the biological sciences, integrate difference‐making and spatio‐temporal information, and exhibit what I call fine‐tunedness of organization. I also emphasize the role played by modularity conditions in mechanistic explanation. I (...) will then argue, in agreement with John Dupré, that, given this account, it is plausible that many biological systems require explanations that are relatively non‐mechanical or depart from expectations one associates with the behaviour of machines. (shrink)

Presents the American philosopher and experimental psychologist's study of such spiritual phenomena as conversion, repentance, mysticism, saintliness, the hope for reward, and the fear of punishment.

Estudio preliminar, por L. M. Ravagnán--Compendio de psicología--Problemas de la filosofía.--Ensayo sobre empirismo radical.--La voluntad de creer.--El pragmatismo.--Fases del sentimiento religioso.--Los ideales de la vida.--Cuadro cronológico.--Bibliografía (p. 116-118).

First published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.

The identity and diversity of individual objects may be grounded or ungrounded, and intrinsic or contextual. Intrinsic individuation can be grounded in haecceities, or absolute discernibility. Contextual individuation can be grounded in relations, but this is compatible with absolute, relative or weak discernibility. Contextual individuation is compatible with the denial of haecceitism, and this is more harmonious with science. Structuralism implies contextual individuation. In mathematics contextual individuation is in general primitive. In physics contextual individuation may be grounded in relations via (...) weak discernibility. (shrink)

William James has long been recognized as a central figure in the American philosophic tradition, and his ideas continue to play a significant role in contemporary thinking. Yet there has never been a comprehensive exploration of the thought of this seminal philosopher and psychologist. In Experiencing William James, renowned scholar James Campbell provides the fuller and more complete analysis that James scholarship has long needed. Commentators typically address only pieces of James's thought or aspects of (...) his vision, often in an attempt to make the task of understanding James seem easier than it is or else to dismiss him as a philosophically unprepared if well-meaning amateur. The isolated nature of these examinations, too often divorced from the original contexts, badly hinders and even distorts their conclusions. Focusing on James's own ideas rather than his critiques of others, and drawing from a wealth of scholarship that includes the completed editions of his writings and correspondence, Experiencing William James provides an invaluable, comprehensive view of James as he participates in and advances the pragmatic spirit that is at the core of American philosophy. Taking the whole of the man's thinking into account, this book offers the richest perspective so far on this great but not fully comprehended intellectual. (shrink)

First published in 1997. Routledge is an imprint of Taylor & Francis, an informa company.

Those familiar with the life and work of James Hayden Tufts tend to associate him with John Dewey, with whom he wrote both the 1908 and 1932 editions of _Ethics. _Yet as James Campbell here demonstrates, Tufts played a singular and important role in American philosophy from 1892, when he began teaching at the newly opened University of Chicago, until his retirement in 1930. During this period, he, along with Dewey and George Herbert Mead, was instrumental in the (...) birth of a new school of philosophy, the Chicago School, which developed a powerful and compelling social pragmatism. Campbell presents selected writings covering Tufts’s long and productive career. Arranged chronologically, they represent the full range of Tufts’s thought, from his concept of justice as the key value for harmonious community life to his views on religion and the question of evolution. A carefully annotated bibliography of all of Tufts’s writings completes the volume. (shrink)

This is a study of all the recent literature on william james written from a phenomenological perspective with the purpose of showing that william james made fundamental contributions to the phenomenological theory of the intentionality of consciousness, To the phenomenological theory of self-Identity, And to the phenomenological conception of noetic freedom as the basic concept of ethical theory.

William James is notorious for the large number of inconsistencies and at least apparent contradictions in his writings. Many readers conclude that he should be appreciated more for his profound but erratic insights than for any coherent philosophical perspective. Ellen Kappy Suckiel disagrees. She argues that James is far more careful and systematic than many readers realize. Her work on James is guided by the attempt to lay bare his coherent philosophical vision and the consistent philosophical methodology (...) underlying it. As a result of this approach, Suckiel's work on James is both sympathetic to his philosophical insights and carefully argued. In her first book, The Pragmatic Philosophy of William James (1982), Suckiel applies this approach to James's philosophy as a whole. The result is a work of remarkable clarity and insight that serves as a wonderful introduction to James's thought. In her more recent book, Suckiel applies this approach specifically to James's philosophy of religion, with similar felicitous results. Heaven's... (shrink)

v. 1. Interpretation and theology -- v. 2. Biblical studies.

James Tully: To Think and Act Differently collects classic, contemporary, and previously unpublished examples of public philosophy in action from across James Tully's four decades of scholarship. The book provides readers with a perspicuous representation of public philosophy as an ongoing experiment with reconstructing the practice of political theory as a democratizing and diversifying dialogue between scholars and citizens. This volume offers an overview of this participatory mode of political philosophy and political change by reconstructing the arc of (...) Tully's intellectual trajectory in contexts, illuminating moments of clarification and transformation, and the ways it continues to shed new insights into the challenges of citizenship in the present. Topics discussed include approaches to the history of political though, constitutionalism, democratic theory, comparative political theory, intercultural dialogue and translation; Indigenous political thought; settler colonialism and empire; climate change and sustainability; modernity; nonviolence; and mutual aid. It will be of interest to scholars of political philosophy, political theory, constitutional law, Indigenous studies, intellectual history, and ecological humanities. It will be of interest to scholars of political philosophy, political theory, constitutional law, Indigenous studies, intellectual history, and ecological humanities. (shrink)

Donald Capps and John Capps's James and Dewey on Belief and Experience juxtaposes the key writings of two philosophical superstars. As fathers of Pragmatism, America's unique contribution to world philosophy, their work has been enormously influential, and remains essential to any understanding of American intellectual history. In these essays, you'll find William James deeply embroiled in debates between religion and science. Combining philosophical charity with logical clarity, he defended the validity of religious experience against crass forms of scientism. (...) Dewey identified the myriad ways in which supernatural concerns distract religious adherents from pressing social concerns, and sought to reconcile the tensions inherent in science's dual embrace of common sense and the aesthetic. James and Dewey on Belief and Experience is divided into two sections: the former showcases James, the latter is devoted to Dewey. Two transitional passages in which each reflects on the work of the other bridge these two main segments. Together, the sections offer a unique perspective on the philosophers' complex relationship of influence and interdependence. An editors' introduction provides biographical information about both men, an overview of their respective philosophical orientations, a discussion of the editorial process, and a brief commentary on each of the selections. Comparing what these foremost pragmatists wrote on both themes illumines their common convictions regarding the nature of philosophical inquiry and simultaneously reveals what made each a distinctive thinker. (shrink)

William James répond le 19 mars 1902 à la proposition que lui a faite Joseph Segond de traduire les Principles of Psychology. Il l’invite à se mettre en relation avec d’autres candidats à cette traduction et suggère de traduire plutôt le Briefer Course dont il prépare une nouvelle édition.

Part of the Longman Library of Primary Sources in Philosophy," this edition of William James' "Selected Essays" is framed by a pedagogical structure designed to make this important work of philosophy more accessible and meaningful for readers. A General Introduction includes the work's historical context, a discussion of historical influences, and biographical information on William James. Annotations and notes from the editor clarify difficult passages for greater understanding, and a bibliography gives the reader additional resources for further study.

William James’s theory of emotion has been controversial since its inception, and a basic analysis of Cannon’s critique is provided. Research on the impact of facial expressions, expressive behaviors, and visceral responses on emotional feelings are each reviewed. A good deal of evidence supports James’s theory that these types of bodily feedback, along with perceptions of situational cues, are each important parts of emotional feelings. Extensions to James’s theory are also reviewed, including evidence of individual differences in (...) the effect of bodily responses on emotional experience. (shrink)