Genetic research into ageing, longevity and late-onset disease is becoming increasingly common. Yet, there is a paucity of knowledge related to clinical actionability and the return of pathogenic variants to otherwise healthy elderly individuals. Whether or not genetic research in the elderly should be managed differently from standard practices adapted for younger populations has not yet been defined. In this article, we provide an overview of ethical and practical challenges in preparing for a genetic study of over 14 000 healthy (...) Australians aged 70 years or older enrolled in the ASPirin in Reducing Events in the Elderly Healthy Ageing Biobank. At the time of consent, all participants in this study were free of life-threatening illness, cardiovascular disease or cognitive impairment. ASPREE is thus a cohort of healthy elderly individuals with seemingly minimal burden of genetic disease recruited without ascertainment bias. The cohort presents a unique opportunity to address the penetrance of known pathogenic variants in a population without disease symptoms; however, it also raises a number of ethical concerns regarding the interpretation and disclosure of variants with known clinical actionability. Some of the challenges include how to manage the interpretation, disclosure and actioning of pathogenic variants found in otherwise healthy elderly adults without disease symptoms, whether or not to disclose findings for the benefit of family members rather than elderly consented donors themselves, how to manage the return of genetic findings to the elderly individuals who are now in severe cognitive decline or terminal illness, how to ensure quality of information and clinical service upon disclosure of results to this demographic and how to prepare for the insurance implications of disclosing genetic information under Australian law. We discuss these and other dilemmas and propose a defensible plan of management. Trial registration number ISRCTN83772183. (shrink)

“Is something beautiful because we like it, or is it likable because it is beautiful?” This was how (in De vera religione 59: ideo pulchra sint, quia delectant; an ideo delectent, quia pulchra sunt...

John Woods' The Logic of Fiction, now thirty-five years old, is a ground-breaking event in the establishment of the semantics of fiction as a stand-alone research programme in the philosophies of language and logic. There is now a large literature about these matters, but Woods' book retains a striking freshness, and still serves as a convincing template of the treatment options for the field's key problems. The book now appears in a second edition with a new Foreword by Nicholas (...) Griffin and an extended bibliography covering the period 1969-2009. As Griffin notes in his Foreword, it is "surprising on looking back to discover how little was written on the semantics of fiction before John Woods' The Logic of Fiction was published in 1974. The surprise is the greater because Woods' book appeared after almost a quarter century of fierce philosophical debate about reference Fictional discourse, one would have thought, would be an important testing ground for philosophical theories of referential expressions and one, moreover, in which the standard theories would likely be tested to destruction. " " One of the great merits of Woods' book is that it takes seriously the wide-ranging demands that fiction imposes on logic and semantics, and does not try to force fiction into some pre-conceived logical mould. but thanks to Woods' pioneering efforts, we are much closer to one now than we were when he set out to write his book. His book was not the last word on the logic of fiction; it was much more important: it was nearly the first." NICHOLAS GRIFFIN is Canada Research Chair in Philosophy at McMaster University. Recent publications include Russell vs Meinong: The Legacy of "On Denoting," edited with Dale Jacquette. JOHN WOODS is Director of the Abductive Systems Group at the University of British Columbia and Charles S. Peirce Visiting Professor of Logic in the Group on Logic and Computational Science, King's College London. He has two forthcoming books on fiction - an edited volume, Fictions and Models: New Essays, and a research monograph, Sherlock's Member: New Perspectives on the Semantics of Fiction, both to appear in 2010. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BALTHASAR AND ECKHART: THEOLOGICAL PRINCIPLES AND CATHOLICITY CYRIL O'REGAN Yale University New Haven, Connecticut Or pleas'd to wound, and yet afraid to strike, Just hint a Fault, and hesitate Dislike; Alike reserv'd to blame or to commend, A tim'rous Foe and a suspitious Friend 1 THE TENDENCY to avoid exclusion is a mark of the thought of Hans Urs von Balthasar. It represents an identifying habit, an incorrigible feature (...) of style and sensibility. His texts in which theologians, philosophers, poets, dramatists, and saints are christianly praised give testimony to a catholicity that barely brooks limits. Not only in true Gospel fashion are a multitude invited to the eschatological banquet, they constitute the vast medium of tradition, in which Maximus the Confessor rubs shoulders with Plato, in the company of Claudel, Calderon, and Therese of Lisieux. At different times Balthasar thinks of the tradition as one huge symphony in which notes sound only to be transcended and as a conversation between particular perspectives on the great mystery of redemption, no one of which is final and which meet only in the infinity of their object. The decision for plurality and variety in the tradition certainly validates difference and counts against its reduction.2 Yet at the same time tradition, precisely as a matter of variety, exhibits a measure of coherence or concordance that pro1 These couplets are from Alexander Pope's poem Atticus. See Minor Poems, ed. Norman Ault, completed by John Butt (London: Methuen & Co. Ltd.; New Haven: Yale University Press, 1954), p. 143. 2 See, for example, The Theology of Karl Barth, trans. Edward T. Oakes, S.J. (San Francisco: Ignatius Press, 1992), pp. 39, 187, 251. 203 204 CYRIL O'REGAN hibits difference from becoming truly excessive. It is this prohibition of excessive difference in Balthasar's reading of tradition that I would like to examine here. I take as my case study of Balthasar's rhetoric of reading his conflicted response to Meister Eckhart, about whose inclusion in the Christian tradition Balthasar expresses no doubts, yet whose theological message is such as to cause anxiety. We shall occupy ourselves in this paper with the way in which Eckhart's nonnegotiable inclusion within the tradition serves to repress the account of those features that present a fundamental challenge, that represent difference that would make the Christian field radically heterogeneous. In the first two sections, focusing mainly on the fifth volume of The Glory of the Lord (=GL),3 I shall offer outlines of both the positive and negative contributions Eckhart is deemed to have made to the theological tradition. Though I do not wish to give the impression of Scholastic pro and contra, Balthasar's positive remarks being imbricated with the negative and vice versa, it will be suggested that the elements adduced in both cases constitute mirror images of each other. Balthasar takes a bifocal, though not stereoscopic, view of a group of five elements: aesthetic disposition, the sameness of Being and God, the whylessness of the divine, Gelassenheit, and Gottesgeburt. This group is in effect read twice, once in a way that affirms and confirms Eckhart's unproblematic inclusion in the tradition (section 1), and again in a way that, in the light of basic Christian principles, raises serious questions about such inclusion (section 2). In a final section the question is raised whether the conflict in interpretation suggests a deeper underlying conflict between Balthasarian commitment to Catholic theological principles and catholicity. I. BALTHASAR'S AFFIRMATIVE RENDERING OF ECKHART On the surface there is little reservation about the approbation Eckhart receives in the fifth volume of The Glory of the 3 The Glory ofthe Lord: A Theological Aesthetics, vol. S, The Realm ofMetaphysics in the Modern Age, trans. Oliver Davies, Andrew Louth, Brian McNeil, C.R.V., John Saward, and Rowan Williams, ed. Brian McNeil, C.R.V. and John Riches (San Francisco: Ignatius Press, 1991). BALTHASAR AND ECKHART 205 Lord. If the depths of Balthasar's analyses of the medievals in his volumes on metaphysics (vols. 4 & 5) never reach the level of his account of Anselm and Bonaventure in volume two, it would be caviling to suggest that his intention at the... (shrink)

Includes bibliographical references and index. isbn 0-226-97861-3 (alk. paper) — isbn 0-226-97862-1 (pbk. : alk. paper) 1. Science — Philosophy. 2. Science — History. 3. Progress. I. Title. Q175 .Z25 2004 501 — dc2i 200301 1970 ...

This book addresses one of the fundamental topics in philosophy: the relation between appearance and reality. John Yolton draws on a rich combination of historical and contemporary material, ranging from the early modern period to present-day debates, to examine this central philosophical preoccupation, which he presents in terms of distinctions between phenomena and causes, causes and meaning, and persons and man. He explores in detail how Locke, Berkeley and Hume talk of appearances and their relation to reality, and offers (...) illuminating connections and comparisons with the work of contemporary philosophers such as Paul Churchland and John McDowell. He concludes by offering his own proposal for a 'realism of appearances', which incorporates elements of both Humean and Kantian thinking. His important study will be of interest to a wide range of readers in the history of philosophy, the history of ideas, and contemporary philosophy of mind, epistemology and metaphysics. (shrink)

Stephen Nathanson's clear-sighted abridgment of Principles of Political Economy, Mill's first major work in moral and political philosophy, provides a challenging, sometimes surprising account of Mill's views on many important topics: socialism, population, the status of women, the cultural bases of economic productivity, the causes and possible cures of poverty, the nature of property rights, taxation, and the legitimate functions of government. Nathanson cuts through the dated and less relevant sections of this large work and includes significant material omitted in (...) other editions, making it possible to see the connections between the views Mill expressed in Principles of Political Economy and the ideas he defended in his later works, particularly On Liberty. Indeed, studying Principles of Political Economy, Nathanson argues in his general Introduction, can help to resolve the apparent contradiction between Mill's views in On Liberty and those in Utilitarianism, making it a key text for understanding Mill’s philosophy as a whole. (shrink)

1. Introduction: memory and interdisciplinarity (footnote 1) Memory is studied at a bewildering number of levels, in a daunting range of disciplines, and with a vast array of methods. Is there any sense at all in which memory theorists - from neurobiologists to narrative theorists, from the developmental to the postcolonial, from the computational to the cross-cultural - are studying the same phenomena? This exploratory review paper sketches the bare outline of a positive framework for understanding current work on memory, (...) both within the various cognitive sciences and across the gulfs between the cognitive and the social sciences. (shrink)

Nowadays, science is treated an instrument of policy, serving the material interests of government and commerce. Traditionally, however, it also has important non-instrumental social functions, such as the creation of critical scenarios and world pictures, the stimulation of rational attitudes, and the production of enlightened practitioners and independent experts. The transition from academic to ‘post-academic’ science threatens the performance of these functions, which are inconsistent with strictly instrumental modes of knowledge production. In particular, expert objectivity is negated by entanglement with (...) political and commercial interests. We cannot go back to the old academic model for science, but need to consider how to maintain its vital non-instrumental roles. (shrink)

This book encapsulates John Beebe’s influential work on the analytical psychology of consciousness. Building on C. G. Jung’s theory of psychological types and on subsequent clarifications by Marie-Louise von Franz and Isabel Briggs Myers, Beebe demonstrates the bond between the eight types of consciousness Jung named and the archetypal complexes that impart energy and purpose to our emotions, fantasies, and dreams. For this collection, Beebe has revised and updated his most influential and significant previously published papers and has introduced, (...) in a brand new chapter, a surprising theory of type and culture. Beebe’s model enables readers to take what they already know about psychological types and apply it to depth psychology. The insights contained in the fifteen chapters of this book will be especially valuable for Jungian psychotherapists, post-Jungian academics and scholars, psychological type practitioners, and type enthusiasts. (shrink)

This book shows otherwise. John Martin rehabilitates Neoplatonism, founded by Plotinus and brought into Christianity by St. Augustine.

Sequence on modern ontology -- From theology to philosophy -- The four pillars of modern philosophy -- Modern philosophy : a theological critique -- Analogy versus univocity -- Identity versus representation -- Intentionality and embodiment -- Intentionality and selfhood -- Reason and the incarnation of the logos -- The passivity of modern reason -- The baroque simulation of cosmic order -- Deconstructed representation and beyond -- Passivity and concursus -- Representation in philosophy -- Actualism versus possibilism -- Influence versus concurrence (...) -- Transition -- Sequence on political ontology -- Cosmos, law and morality -- Metaphysics and modern politics -- The fate of the rational animal -- The irony of representation -- On legal concurrence -- The fate of the social animal -- Representation and mixed government -- Bureaucracy and the formal distinction -- Form, matter and contract -- The antiquity of historicism -- The sovereignty of the artist -- Eucharistic creativity and political power -- The conundrum of kingship -- The truth of political fiction -- The two rival constructions -- Creativity and mixed constitution -- Christological constitutionalism -- The fate of the fabricating animal -- The fate of the beast-angel -- The death of charity -- Augustine's three cities -- Church as cosmopolis -- Aquinas and kingship -- The theology of ruling -- The ecumenico-political problem -- Supernatural charity and global order -- Socialism beyond the left -- Critique of all materialisms. (shrink)

Abstract This paper attempts to clarify the debate between those philosophers who hold that the development of science is governed by objective standards of rationality and those sociologists of science who deny this. In particular it focuses on the debate over the ?symmetry thesis?. Bloor and Barnes argue that a properly scientific approach to science itself demands that an investigator should seek the same general type of explanation for all decisions and actions by past scientists, quite independently of whether or (...) not she or he happens to agree with those decisions or approve those actions as ?correct? or ?rational?. I try to improve on previous treatments of the ?rationalist? position (by Lakatos, Laudan, Newton?Smith and Brown) and clarify the exact asymmetries to which the ?rationalist? is, and is not, committed. (shrink)

Yolton insists that Locke's Essay concerning Human Understanding marks the beginning of the great empirical tradition in British philosophy.

Frances Kamm sets out to draw and make plausible distinctions that would show how and why it is, in some circumstances, permissible to kill some to save many more, but is not so in others. To do so she draws on a famous, and famously artificial, example of Judith Thomson, which illustrates the fact that people intutitively reject some instances of such killings but not others. The irrationality, implausibility and in many cases the self-defeating nature of such distinctions I had (...) attempted to expose in my 'The Survival Lottery' over 25 years ago. I still think these distinctions irrational and implausible and I will try, in this response, to show why this remains the case and why doctrines of additional effects, to however many powers they are taken, remain unhelpful in ethics. (shrink)

Barack Obama has called him “one of my favorite philosophers.” John McCain wrote that he is “a paragon of clarity about the costs of a good war.” Andrew Sullivan has said, “We need Niebuhr now more than ever.” For a theologian who died in 1971, Reinhold Niebuhr is maintaining a remarkably high profile in the twenty-first century. In _Why Niebuhr Now?_ acclaimed historian John Patrick Diggins tackles the complicated question of why, at a time of great uncertainty about (...) America’s proper role in the world, leading politicians and thinkers are turning to Niebuhr for answers. Diggins begins by clearly and carefully working through Niebuhr’s theology, which focuses less on God’s presence than his absence—and the ways that absence abets the all-too-human sin of pride. He then shows how that theology informed Niebuhr’s worldview, leading him to be at the same time a strong opponent of fascism and communism and a leading advocate for humility and caution in foreign policy. Turning to the present, Diggins highlights what he argues is a misuse of Niebuhr’s legacy on both the right and the left: while neoconservatives distort Niebuhr’s arguments to support their call for an endless war on terror in the name of stopping evil, many liberal interventionists conveniently ignore Niebuhr’s fundamental doubts about power. Ultimately, Niebuhr’s greatest lesson is that, while it is our duty to struggle for good, we must at the same time be wary of hubris, remembering the limits of our understanding. The final work from a distinguished writer who spent his entire career reflecting on America’s history and promise, _Why Niebuhr Now? _is a compact and perceptive book that will be the starting point for all future discussions of Niebuhr. (shrink)

John Granville's first book is unique on several counts. First, it's not simply a history of science, but rather a history of our evolving unerstanding of motion. It's unique in the detailed explanations given to common scientific riddles-explanations aimed to help students avoid catastrophic collisions with these concepts in college. It's unique in that it resents the philosophies on which the major scientific paradigm shifts rest. It's unique in its presentation from Thomas Kuhn's point of view (i.e., his concept (...) of world view and paradigm shifts as presented in his classic work The Structure of Scientific Revolutions). The book begins with an informal discussion of Kuhn's notion of world view, and various concepts relevant to his thesis concerning the nature of scientific revolutions; but, the Discovery of Motion proper begins with ancient Egyptian and Greek preparations for Aristotle (here the dialectic of Parmenides and Plato are given special attention). A survey of Aristotle and his science of motion follows (i.e., his theory of nature and natural philosophy). Included in this part of the book are the works of such notables as Archimedes and Ptolemy. The Copernican revolution, including the works of Galileo, Kepler and Newton is, of course, presented from the viewpoint of Kuhn's paradigm shift. Four chapters concerning Newtonian motion are the highlight of the first half of the book. It is here Granville's original aim, of explaning puzzling scientific phenomena to young students, is realized-but now this material serves another purpose. These chapters not only clarify Newton's world view but expose phenomena that were virtually invisible to the peripatetics...and will eventually expose reasons for the ambivalence and frustration that accompany scientific revolutions. Granville then turns to philosophical developments that led to our modern view of the world. This part of the book covers the evolution of empiricism from Bacon to Hume (with Descartes' rationalism thrown in for contrast). Kant's epistemology concludes this philosophical survey, deliberately leading the plot back toward the classical viewpoint. Finally, developments of the nineteenth century that led to the so-called Second Scientific Revolution are considered. The final chapter is a unique presentation of Einstein's relativity theory, where the incompatibility of this theory with Newtonian physics, and the reason why relativity must take precedence, are discussed. Granville compares the opposition to the Copernican revolution with twentieth century opposition to the Einsteinian revolution. The book reveals that, after building detailed understanding of classical Newtonian phenomena, opposition to a shift of world view is an understandable human reaction. (shrink)

: Claus Oetke, in his "Ancient Indian Logic as a Theory of Non-monotonic Reasoning," presents a sweeping new interpretation of the early history of Indian logic. His main proposal is that Indian logic up until Dharmakirti was nonmonotonic in character-similar to some of the newer logics that have been explored in the field of Artificial Intelligence, such as default logic, which abandon deductive validity as a requirement for formally acceptable arguments; Dharmakirti, he suggests, was the first to consider that a (...) good argument should be one for which it is not possible for the property identified as the "reason" (hetu) to occur without the property to be proved (sadhya)-a requirement akin to deductive validity. Oetke's approach is challenged here, arguing that from the very beginning in India something like monotonic, that is, deductively valid, reasoning was the ideal or norm, but that the conception of that ideal was continually refined, in that the criteria for determining when it is realized were progressively sharpened. (shrink)

Rate, John In this first Sunday of Advent we are reminded that our lives and our world are moving towards a great finale, as envisioned in our times by the great Teilhard de Chardin. While there are some terrifying aspects to this (our natural fear of death, and the apocalyptic descriptions of the end-times in Luke's Gospel), Luke calms us with his confident admonition: 'Stand erect, hold your heads high, because your liberation is near at hand.' As we allow (...) this truth to influence daily life, we will naturally want to 'stay awake' and 'practise honesty and integrity in the land' (first reading), and we will understand more fully the beautiful Alleluia verse prayer: 'Lord, show us your mercy and love, and grant us your salvation.'. (shrink)

In this paper I defend a pairing of the “Epistemic Criterion” and of the “Momentousness Criterion” from a critique in Clayton and Stevens’s advocacy of the “Acceptability Requirement.” I argue that where it is valuable for people to set their own ends, they can only fully meaningfully do this in light of facts and free of misinformation. It is the duty of educators to put them in this position; it is then students' prerogative to fail to live meaningfully. While children (...) have no duty to perfect themselves, they do have a right to invent themselves, but they cannot do this is ignorance: if their life is meaningless because they chose as well as they could without being informed, then they could not truly consent to the life they undertook, and did not have a realistic chance at a meaningful life. (shrink)

This second set of papers by John Rist is concerned with attempts by (mostly pagan) thinkers in Greco-Roman antiquity to understand the nature of morality against a background of wide-ranging debate about the relationship between soul and body and the necessity for a correct psychology and physiology if the 'good life for man' is to be revealed. Three papers are on Plato, whose elaborate mix of ethics, psychology and metaphysics sets the stage for most of the debate; one is (...) on Aristotle, five are on the Stoics and five on Plotinus. A further study deals with the general problem of the relationship between ethics, cosmology and biology, and the series concludes with the crisis among both pagans and Christians in late antiquity over whether man is naturally good enough to correct his own moral weakness. The set of difficulties recognised by Plato has now found a disturbing conclusion. (shrink)

Henry at Work invites readers to rethink how we work today by exploring an aspect of Henry David Thoreau that has often been overlooked: Thoreau the worker. John Kaag and Jonathan van Belle overturn the popular misconception of Thoreau as a navel-gazing recluse who was scornful of work and other mundanities. In fact, Thoreau worked hard—surveying land, running his family’s pencil-making business, writing, lecturing, and building his cabin at Walden Pond—and thought intensely about work in its many dimensions. And (...) his ideas about work have much to teach us in an age of remote work and automation, when many people are reconsidering what kind of working lives they want to have. -/- Through Thoreau, readers will discover a philosophy of work in the office, factory, lumber mill, and grocery store, and reflect on the rhythms of the workday, the joys and risks of resigning oneself to work, the dubious promises of labor-saving technology, and that most vital and eternal of philosophical questions, “How much do I get paid?” In ten chapters, including “Manual Work,” “Machine Work,” and “Meaningless Work,” this personal, urgent, practical, and compassionate book introduces readers to their new favorite coworker: Henry David Thoreau. (shrink)

Western thought since the seventeenth century has been dominated by methodological solipsism (Krieger, 1991). The famous sound-bite of René Descartes 'cogito, ergo sum': 'I think, therefore I am', became the starting point for most discourse on the nature of things. This dictum does not advocate idealism. It does not assert that everything is necessarily a construct of the human mind. But it assumes that the world of things and beings is surveyed and interpreted from the point of view of a (...) single individual. Nowhere is this stance more entrenched than in the philosophy of science. To a remarkable degree the scientist is represented as studying the natural world as if alone in it, served only by mindless assistants who might as well be replaced by machines. Scientific theories are presented as systems of thought conjured up and tested by that same individual in a further series of single-headed operations. Research results are formulated and treated philosophically as the independent findings of lone explorers, each reporting the evidence of their own eyes and their rational inferences concerning the hidden mechanisms by which these personal percepts might be generated. Our epistemological role models are Robinson Crusoe and Sherlock Holmes, self-sufficient intellectuals to whom their human companions, Friday and Watson, are mere stooges. (shrink)

This chapter contains sections titled: The Background Why is Science Special from the Epistemic Point of View? Accumulation in Science, Despite “Revolutions”? Other Issues.

Ankersmit's articulation of a postmodern theory of history takes seriously both the strengths of traditional historicism and the right of historians to decide what makes sense for disciplinary practice. That makes him an exemplary interlocutor. Ankersmit proposes a theory of historical "representation" which radicalizes the narrative approach to historiography along the lines of poststructuralist textualism. Against this postmodernism but invoking some of his own arguments, I defend the traditional historicist position. I formulate criticisms of the theory of reference entailed in (...) his notion of "narrative substance," of his master analogy of historiography with modern painting, and finally of his characterization of historical hermeneutics. In each case I find him guilty of the hyperbole which he himself cautions against. While it is true that historical narratives cannot be taken to be transparent, in taking them to be opaque Ankersmit puts himself in an untenable position. Finally, Ankersmit seeks to buttress his theoretical case by an interpretation of the new cultural historical texts of authors like Davis and Ginzburg. While this is a concreteness heartily to be welcomed in philosophers of history, I cannot find his construction of this new school's work plausible. (shrink)

Sir John Templeton challenges the reader to apply the same energy that has been devoted to scientific inquiry to the pursuit of spiritual information. The world is at a state of unprecedented technical expertise, but why has our knowledge and faith in our own spirituality stalled and become obsolete in recent times? Possibilities for Over One Hundredfold More Spiritual Information seeks to address this question. It points out that our spiritual knowledge would also have the capacity to increase dramatically (...) if we were to open our minds to the endless possibilities that await us in terms of our spiritual lives. These include altruistic love for all people, new knowledge of the Divine, and a greater sense of our place in the universe. In order for us as human beings to take advantage of all of the spiritual gifts that we have been given, we need to be open and receptive to our individual spiritual natures, and to open ourselves to the limitless spiritual possibilities available to us. The book acknowledges the ancient scriptures and thinkers who have guided us for centuries. Vastly expanded research and the use of scientific method would only enhance our understanding of the wisdom contained within these wise teachings. The benefits of extending our spiritual knowledge might, in fact, exceed the benefits we have realized thus far from scientific and medical advances. Possibilities seeks to reawaken our desire for spiritual knowledge pushed aside so long ago in our quest for scientific knowledge. When these fields work together, the world will reap greater rewards that we can ever imagine. (shrink)