DNA double‐strand breaks (DSBs) are one of the most deleterious forms of DNA damage and can result in cell inviability or chromosomal aberrations. The Mre11‐Rad50‐Nbs1 (MRN) ATPase‐nuclease complex is a central player in the cellular response to DSBs and is implicated in the sensing and nucleolytic processing of DSBs, as well as in DSB signaling by activating the cell cycle checkpoint kinase ATM. ATP binding to Rad50 switches MRN from an open state with exposed Mre11 nuclease sites to a closed (...) state with partially buried nuclease sites. The functional meaning of this switch remained unclear. A new study shows that ATP binding to Rad50 promotes DSB recognition, tethering, and ATM activation, while ATP hydrolysis opens the nuclease active sites to promote processing of DSBs. MRN thus emerges as functional switch that may coordinate the temporal transition from signaling to processing of DSBs. (shrink)

Die Teilhabe an der lateinischen res publica litterarum der frühneuzeitlichen Fakultäten und Universitäten wurde mittels gemeinsamer literarischer Ausdrucksformen reguliert - zuweilen in Gestalt feingeistiger philologischer Kontroverse, zuweilen als wüste Polemik oder tosender Jubel. In Fallstudien zu Humanisten aus drei Jahrhunderten geht der Band der Frage nach, wie kollegiale Beziehungen literarisch inszeniert und innerhalb der Gelehrtengemeinschaft instrumentalisiert wurden. Diskursregeln und Kommunikationsbedingungen kommen dabei ebenso zur Sprache wie die Anwendung literarischer Modelle aus antiker und nachantiker Invektive, Satire und Panegyrik.

The question of sociological truth-finding is posed in the light of the view that logical formalizations, along with other arguments, only acquire relevance in illocutionary contexts, where it is not so much the abstract correctness of a sentence as the stating of it that counts. In order to become a counterfactual an argument requires its antecedent to be recognized as being contrary to the 'facts'. To this extent there is a clear link with 'reality' or with a view of the (...) world that is taken as factually given. Social science develops on the basis not only of generalizations but also of historical facts and political requirements. The question arises: in terms of what world-view or purpose can we unambiguously declare a conditional to be a counterfactual - and a significant or non-trivial one at that? Further, can Elster's clarifications help identify political agents and the proper entities within and through which political action is performed? Finally, the problem-solving capacity of the concept of closeness of one possible world to another or to the actual world, especially with regard to counterfactuals and causality, is questioned. (shrink)

Romano Guardini gilt als einer der massgeblichen christlichen Denker des 20. Jahrhunderts. Seine Schriften, philosophische und theologische Abhandlungen, aber auch zahlreiche meditative und spirituelle Texte, haben eine weltweite Verbreitung gefunden und pragen ungebrochen bis heute Generationen von Leserinnen und Lesern. Der vorliegende Band, der aus Anlass des 50. Todestages Romano Guardinis am 1. Oktober 2018 sowie zur Eroffnung des Seligsprechungsprozesses erscheint, versammelt Beitrage namhafter Autorinnen und Autoren. Aus unterschiedlichen Perspektiven widmen sie sich insbesondere Guardinis Buch "Der Herr" uber Person und (...) Botschaft Jesu Christi, aber beispielsweise auch Aspekten der Gottesfrage, der Ethik oder des Gebets. Eine Fundgrube fur alle, die sich der Person und dem Denken Guardinis neu nahern mochten. Mit Beitragen von Hanna-Barbara Gerl-Falkovitz, Jean Greisch, Karl Kardinal Lehmann (+), Peter Reifenberg, Marius Reiser, Peter Schallenberg, P. Kosmas Lars Thielmann OCist, Karl-Heinz Wiesemann. (shrink)

One task of religion is delivering human beings from evil within and between themselves. Defining good as well-being or functioning well, evil as impaired functioning, and doing evil as impairing the functioning of others, this essay explores how religions in consort with other social institutions might understand and respond to evil in light of contemporary scientific knowledge. To understand evil I use a multicausal approach that includes both biological and sociocultural environmental causes. I illustrate the use of this approach by (...) analyzing how we might understand and respond to human rage and violence. (shrink)

. This paper outlines an evolutionary theory of knowledge involving not only conceptual but also behavioral and experiential knowledge. It suggests human knowledge is continuous at the behavioral and experiential level with that of nonhuman animals. By contrasting an evolutionary understanding of ultimate reality with the more traditional, personalistic understanding, the paper shows how an evolutionary epistemology applies to religion in terms of both general and special revelation. Finally, the paper explores how one might respond to the problem of religious (...) knowledge in a pluralistic age and how a nonpersonal, evolutionary understanding of God might be religiously adequate. (shrink)

In my summary lecture at the IRAS 1997 Star Island Conference on the Evolution of Morality, I reflected on the thinking of other speakers in light of my own personal experience. My remarks were organized around five questions: (1) Do worldviews matter, and how do we decide if some matter more than others? (2) What does it mean to be moral? (3) What is the relation between biology and culture? (4) How does a scientific, sociobiological description of how we have (...) become moral fit with our own personal quest for meaning and moral guidance toward richer and fuller lives? (5) How do we test evolutionary views of the biological conditions of morality scientifically? (shrink)

In my response to the comments of Charley Hardwick, Ann Pederson, and Greg Peterson, I continue the narrative, confessional mode of my writing in Dancing with the Sacred. First, I sketch some methodological decisions underlying my naturalistic, evolutionary, practical theology. I then respond to the encouraging suggestions of my commentators by further developing my ideas about naturalism, mystery, creativity as God, the place of ecological responsibility in my thinking, sin, and eschatology. I offer suggestions as to how I might widen (...) the practical applications of my theology beyond environmental and medical ethics to other areas of moral responsibility in relation to the creative process. I do all this with much appreciation for the care and careful critical reflection that my commentators have devoted to my thinking. (shrink)

Developing a scientifically grounded philosophy of cosmic evolution, and using the moral norm of completeness as dynamic harmony, this paper argues that humans are a part of nature in both its conserving and emergent aspects. Humans are both material and cultural, instinctual‐emotional and rational, creatures and creators, and carriers of stability and change. To ignore any of the multifaceted aspects of humanity in relation to the rest of nature is to commit one of a number of fallacies that are grounded (...) in a dualistic‐conquest mentality. Examples of some new developments in philosophy and theology, metaphorical images, and ritual show how to overcome dualism in favor of a dynamic harmony of humanity within nature. (shrink)

This editorial statement describes the purpose of Zygon and the need for such a journal. It then sketches the history of the journal and of its financial affairs. Next it proposes some development projects to expand the impact of the journal around the world, to develop Zygon leadership, and to establish more firmly Zygon's financial base. The statement opens and closes with the news of Zygon's receiving a Gift Subscription Challenge Grant.

Human cooperation is highly unusual. We live in large groups composed mostly of non-relatives. Evolutionists have proposed a number of explanations for this pattern, including cultural group selection and extensions of more general processes such as reciprocity, kin selection, and multi-level selection acting on genes. Evolutionary processes are consilient; they affect several different empirical domains, such as patterns of behavior and the proximal drivers of that behavior. In this target article, we sketch the evidence from five domains that bear on (...) the explanatory adequacy of cultural group selection and competing hypotheses to explain human cooperation. Does cultural transmission constitute an inheritance system that can evolve in a Darwinian fashion? Are the norms that underpin institutions among the cultural traits so transmitted? Do we observe sufficient variation at the level of groups of considerable size for group selection to be a plausible process? Do human groups compete, and do success and failure in competition depend upon cultural variation? Do we observe adaptations for cooperation in humans that most plausibly arose by cultural group selection? If the answer to one of these questions is “no,” then we must look to other hypotheses. We present evidence, including quantitative evidence, that the answer to all of the questions is “yes” and argue that we must take the cultural group selection hypothesis seriously. If culturally transmitted systems of rules (institutions) that limit individual deviance organize cooperation in human societies, then it is not clear that any extant alternative to cultural group selection can be a complete explanation. (shrink)

This paper examines Thomas Aquinas’s condemnation of usury. In the first section, the details of Thomas’s teaching are examined with special attention to the so-called “extrinsic titles” discussed in the Middle Ages as qualifications of the moral and legal strictures concerning moneylending. The reminder of the paper examines the particular extrinsic title of Lucrum Cessans (compensation for lost profit), which Thomas rejects, and attempts to square that rejection with other texts implying that compensation for lost profit is a requirement of (...) justice when taken outside the context of moneylending. The paper concludes with some possible modern applications of Thomas’s position. (shrink)

Outlining the characteristics of “wicked” and “super‐wicked” problems, climate change is considered as a global super‐wicked problem that is primarily about the future. Being global‐ and future‐oriented makes climate change something we have to learn to live with but cannot expect to solve. Because the Institute on Religion in an Age of Science (IRAS) is a multidisciplinary society that yokes the natural and social sciences with values, it is in a position to explore strategies for living with climate change—exemplified by (...) the articles in this section. Finally, asking “who/what is in charge,” it is suggested that in a dynamically interrelated and evolving world no one is. It is important to distinguish between good that is already created and the creative interactions that give rise to new good. In order to live with climate change, our primary orientation should be to live with the creativity that has created and continues to create our life on Planet Earth—since we are not able to know what the future holds. (shrink)

This essay briefly examines the original visions of Zygon , how they helped explain the publication of a new journal, and what they imply for where we might be going today.

Since Zygon: Journal of Religion and Science was founded 49 years ago and since one of its co-publishers, the Institute on Religion in an Age of Science (IRAS), was founded 60 years ago, there have been significant developments in their various cultural contexts—in science, in religion, in culture, in academia, and in the science and religion dialogue. This article is a personal remembrance and reflection that compares the context of IRAS in 1954 when it was first organized with the context (...) of IRAS and Zygon today. It considers the contemporary niche of IRAS in relation to the developments that have occurred over the past 60 years. (shrink)

Through cultivating my thinking, along with that of many others, Ralph Burhoe taught me to understand myself in relational terms. He helped me to appreciate religious traditions on scientific grounds and to see how religion adapts to changing conditions even as it continues to provide meaning and guidance to the wider culture. He restored my belief in an ever‐present sovereign God when God is understood in terms of function and system.