Background HIV prevention trials conducted among disadvantaged vulnerable at-risk populations in developing countries present unique ethical dilemmas. A key concern in bioethics is the validity of informed consent for trial participation obtained from research subjects in such settings. The purpose of this study was to investigate the effectiveness of a continuous informed consent process adopted during the MDP301 phase III vaginal microbicide trial in Mwanza, Tanzania. Methods A total of 1146 women at increased risk of HIV acquisition working as alcohol (...) and food vendors or in bars, restaurants, hotels and guesthouses have been recruited into the MDP301 phase III efficacy and safety trial in Mwanza. During preparations for the trial, participatory community research methods were used to develop a locally-appropriate pictorial flipchart in order to convey key messages about the trial to potential participants. Pre-recorded audio tapes were also developed to facilitate understanding and compliance with gel-use instructions. A comprehension checklist is administered by clinical staff to all participants at screening, enrolment, 12, 24, 40 and 50 week follow-up visits during the trial. To investigate women's perceptions and experiences of the trial, including how well participants internalize and retain key messages provided through a continuous informed consent process, a random sub-sample of 102 women were invited to participate in in-depth interviews conducted immediately after their 4, 24 and 52 week follow-up visits. Results 99 women completed interviews at 4-weeks, 83 at 24-weeks, and 74 at 52 weeks. In all interviews there was evidence of good comprehension and retention of key trial messages including that the gel is not currently know to be effective against HIV; that this is the key reason for conducting the trial; and that women should stop using gel in the event of pregnancy. Conclusions Providing information to trial participants in a focussed, locally-appropriate manner, using methods developed in consultation with the community, and within a continuous informed-consent framework resulted in high levels of comprehension and message retention in this setting. This approach may represent a model for researchers conducting HIV prevention trials among other vulnerable populations in resource-poor settings. Trial registration Current Controlled Trials ISRCTN64716212. (shrink)

Adult humans show exceptional relational ability relative to other species. In this research, we trace the development of this ability in young children. We used a task widely used in comparative research—the relational match-to-sample task, which requires participants to notice and match the identity relation: for example, AA should match BB instead of CD. Despite the simplicity of this relation, children under 4 years of age failed to pass this test (Experiment 1), and their performance did not improve even with (...) initial feedback (Experiment 2). In Experiments 3 and 4, we found that two kinds of symbolic-linguistic experience can facilitate relational reasoning in young children. Our findings suggest that children learn to become adept analogical thinkers, and that language fosters this learning in at least two distinct ways. (shrink)

The argument of this paper hinges on Derrida's relation to Judaism as a religious heritage and/or as an essential experience. If he can be said to ‘appropriate his Jewish roots’ at all, as Colby Dickinson (2011) has recently proposed, this is not because Derrida concurs that all belief in an ultimate reality (‘as such’) must now be understood in merely conditional terms (‘as if’). Rather, it is because Derrida deconstructs the difference between the Jew and the non-Jew, along with the (...) differences between the ‘as if’ and the ‘as such’ and the performative and the constative, in his very demonstration of the impossibility of ‘being-jewish’. Dickinson thus misunderstands the way in which Derrida appropriates Kant's regulative ‘as if’, and thus misrepresents what is at stake in Derrida's ‘faith’ in ‘Jewishness’. What is at stake is what Derrida calls deconstructive responsibility, and it takes the form of a radical fidelity to the principle of reason (to an ‘unconditional theoreticism’). This responsibility, paradoxically, demands and impels the interrogation of critical thinking itself, with its principles, its essences and its identities. Accordingly, Derrida interrupts both the ‘as such’ and the ‘as if’ with the ‘if’ of a dangerous ‘perhaps’. (shrink)

In this paper we aim to show an intrinsic contradiction of contemporary Metaphysical Realism by focusing on the relation between the subject and the object. Metaphysical Realism considers facts and objects as being empirical, and therefore they are considered in relation to the subject, while at the same time facts are assumed to belong to an autonomous and independent reality. However, if a real object is considered to be independent from the subject, once it enters in a relation with the (...) latter, a real object must undergo an intrinsic transformation. However, since an object cannot avoid this transformation then recovering the real or “absolute” object from the perceived object is not possible. In this way, the inherent contradiction of the “absolute” as being determined, i.e., defined by virtue of a limit, is revealed. (shrink)

The excavation of a ceramic workshop in the region of the ancient town of Corfu brought to light many elements connected with ceramic production. The workshop was in operation from the 5th to the 3rd c. BC. Among the remains of vases and other objects was a large number of small objects, chiefly of bronze and bone. A group of thirty-seven objects was identified, which could hâve been used by the potters and painters of the workshop as tools. A comparison (...) of these tools with those employed by contemporary potters produced interesting facts about their utilisation. Lastly, the places where the tools were found made it possible to clarify precisely the way in which the ancient workshop operated. (shrink)

The current quality assurance culture demands the explicit articulation, by means of publication, of what have been hitherto tacit norms and conventions underlying disciplinary genres. The justification is that publication aids student performance and guarantees transparency and accountability. This requirement makes a number of questionable assumptions predicated upon what we will argue is an erroneous epistemology. It is not always possible to articulate in a publishable form a detailed description of disciplinary practices such as assessment. As a result publication cannot (...) achieve its stated goals. There are always elements of our knowledge that cannot be linguistically articulated. (shrink)

The emerging area of philosophy of birth is invaluable, first, to diagnose fallacious assumptions about the relation between the womb and reason, and, ultimately, to challenge potentially damaging narratives with major impact on birth care. With its analysis of eighteenth-century epistemic and medical discussions about the role of the uterus in women's reasoning, this article supports two arguments: first, that women's “flawed thinking” was a premise drawn by many modern intellectual men, one that was presented as based upon empirical evidence; (...) and second, that the pervasive construction of the uterus as an element that renders women wild, uncontrollable, and irrational continues to influence contemporary obstetrics, even as today's medicine and science consider themselves to be free of any such prejudices.This article shows the role that Giacomo Casanova played in debunking these prejudices and presents his short manuscript on the issue as an important contribution to the literature of the Enlightenment, with its argument against women's supposed “natural” inferiority and for the idea that differences in education were to blame for women's subordinate position in society.Detailed analysis of the “thinking uterus” debate illuminates the different ways in which various arguments from/by the “anti-uterine” lobby were used to justify the subordination of women: sometimes emphasizing the connection between the uterus and thought and sometimes negating it, but always concluding that women's inferiority is to be found in some known or yet-to-be-discovered anatomical, and mainly sexual, deficiency or problem. (shrink)

In The Metaphysics of Love, however, Stella Sandford argues that an over-emphasis on ethics in the reception of Levinas's thought has concealed the basis and ...

This article critically extends Kant's 1786 discussion of “orientation in thinking” to ask what it means to “orient oneself in thinking” around the concepts of race and sex, addressed in the context of 1) the central place and historical importance of Kant in Western philosophy; and 2) Kant's theory of race and its relation to his critical philosophy. As presumptions about race and sex are already built into the history of philosophy, taking these concepts as an explicit orientation is not (...) the expression of subjective interests, but a reflection and criticism of some of the objective forces that shape the world and have shaped the history of philosophy. An intellectual orientation around the concepts of race or sex can thus be understood as a critical position in relation to the problematic “historical universality” of these concepts, with the aim of transforming the false universality of biological race thinking, in particular, into the historical universality of critical social analysis. (shrink)

With online communication being of growing importance in the organizational context, the aim of this research is to measure its relevance and acceptance among Nigerian businesses and employees. Therefore, a case study focusing on Nigeria Breweries Plc. has been designed and conducted, permitting conclusions on the implementation, efficiency, overall perception, and challenges related to the use of online communication tools in the context of Nigerian businesses of today and tomorrow.

Jacques Derrida regularly appeals to an affirmative gesture that is ‘prior’ to or more ‘originary’ than the form of the question, and this suggests one way to understand deconstruction's critical force. The ‘Yes, yes’, he says, situates a ‘vigil or beyond of the question’ with respect to an ‘irreducible responsibility’. Some Derrida scholars therefore construe the double affirmation as a source or ground of critique. In this paper, I refute this suggestion. While an originary ‘Yes, yes’ or ‘come’ (viens) does (...) open the fields of (for example) ‘inheritance’, language, or ‘holistic webs’, I argue, it only marks (will have marked) the processes of différance or of trace that make signification possible in general. No thing, as such, is thereby affirmed. This is why the originary affirmation cannot be said to constitute, in itself, the imperative (il la faut) of the logic (la logique) of ethical-political critique. To explain why a certain ethical imperative can be associated with deconstruction, one must determine why one is always already subject to a vigil that opens critique to its own possibility. One must also determine how the affirmative gesture relates to deconstruction's critical force. (shrink)

Critical phenomenology is gaining currency as a progressive philosophy of emancipation, but there is no consensus on what its “criticality” entails. From a Derridean perspective, critique can be said to involve radical self-interrogation; a philosophy that questions its own conditions of possibility or grounds is one that opens itself to its auto-deconstruction. Deconstruction produces undecidability, however, which means that the philosophy in question can no longer account for its political claims or its normative force. This is the predicament in which (...) critical phenomenology, like any other critical theory, will find itself when it takes its critical injunction to heart. (shrink)

High throughput time-resolved observations of accreting collapsed objects at X-ray energies provide key information on the motions of matter orbiting a few gravitational radii away from black holes. Predictions of general relativity in the strong field regime, such as relativistic epicyclic motions, precession, light bending and the presence and radius of an innermost stable circular orbit in the close vicinity of a black hole can be verified by making use of two powerful diagnostics, namely relativistically broadened \ lines and variability (...) on dynamical timescales, quasi periodic oscillations in particular. Moreover tomography and reverberation techniques relying upon combined spectral timing and polarimetric timing provide an entirely new perspective in the field. Both the low and high spacetime curvature regimes of gravity can be probed by studying black holes of vastly different masses in X-ray binaries and Active Galactic Nuclei, opening up the possibility of testing also some alternative theories of gravity. To achieve these goals, very large area X-ray instrumentation with good spectral resolution and polarimetric capability is required. Prospects and projects in this area of research are briefly surveyed. (shrink)

Um das Ansehen von medizinischen Forschern ist es in der westlichen Welt nicht überall gut bestellt. In den 1990er-Jahren gelangte das Thema »Medizinischer Forschungsbetrug« erstmals in den USA in das öffentliche Bewusstsein. Eine Debatte um begünstigende Strukturen und denkbare Kontrollinstrumente zur Eindämmung von Missbrauch entbrannte – in Deutschland blieb ein solcher Diskurs bis zur Jahrhundertwende zunächst aus. Der Band nimmt wissenschaftlich arbeitende Ärzte, die ethischen Anforderungen, denen sie sich ausgesetzt sehen, und das System, in dem sie arbeiten, in den Fokus. (...) Stella Elaine Urbans Analyse von Betrugsfällen deckt wissenschaftsimmanente und individuelle Fallstricke auf, die unredliche Forschung begünstigen. Es zeigt sich, dass die wissenschaftliche Integrität unterstützt und geschützt werden muss, um das Vertrauen in die Medizin wiederherzustellen. (shrink)

Descartes’s doctrine of clarity and distinctness states that whatever is clearly and distinctly perceived is true. This paper looks at his early doctrine from Rules for the Direction of the Mind, and its application to the demarcation problem of curves in Descartes’s Geometry. This paper offers and defends a novel account of the demarcation criterion of curves: a curve is geometrical just in case it is clearly and distinctly perceivable. This account connects Descartes’s rationalist epistemological programme with his ontological views (...) about mathematics. (shrink)

The article introduces some aspects of Levinas's writings which are important to review his reception within feminist circles. It then analyses his text `And God Created Woman', and shows to what extent his view of women can be criticized as being traditional and patriarchal. Finally, it deals with the relation between Levinas and feminism of difference, and rejects the idea that his theory can be effectively applied to move beyond the debate equality vs difference.

IntroductionConcussion is a growing public health concern. No uniformly established therapy exists; neurofeedback studies report treatment value. We use infralow frequency neuromodulation to remediate disabling neurological symptoms caused by traumatic brain injury and noted improved outcomes with a novel concussion protocol. Postconcussion symptoms and persistent postconcussion symptoms are designated timelines for protracted neurological complaints following TBI. We performed a retrospective study to explore effectiveness of ILF in PCS/PPCS and investigated the value of using this concussion protocol.MethodPatients with PCS/PPCS seen for (...) their first neurology office visit or received their first neurofeedback session between 1 August 2018 and 31 January 2021 were entered. Outcomes were compared following treatment as usual vs. TAU with ILF neurotherapy. The study cohort was limited to PPCS patients; the TAU+ILF group was restricted further to PPCS patients receiving at least 10 neurotherapy sessions. Within the TAU+ILF group, comparisons were made between those who trained at least 10 sessions using concussion protocol and those who trained for at least 10 sessions of ILF regardless of protocol.ResultsAmong our resultant PPCS cohort leading persistent neurological complaints were headache, memory impairment, and brain fog. PPCS patients in TAU+ILF+CP demonstrated greater net and percent improvement of symptoms compared to PPCS subjects in TAU. PPCS patients in TAU+ILF-CP trended toward significant symptom improvements compared to TAU, and TAU+ILF+CP trended toward greater efficacy than TAU+ILF-CP.ConclusionPPCS patients who received TAU+ILF+CP demonstrated significantly greater improvement as a group when compared to TAU. When used as an integrative modality to treatment as usual in managing patients with PPCS, ILF neuromodulation with use of concussion protocol provided significant symptom improvements. (shrink)

Analogical reasoning is a foundational tool for human learning, allowing learners to recognize relational structures in new events and domains. Here I sketch some grounds for understanding and applying analogical reasoning in social learning. The social world is fundamentally characterized by relations between people, with common relational structures—such as kinships and social hierarchies—forming social units that dictate social behaviors. Just as young learners use analogical reasoning for learning relational structures in other domains—spatial relations, verbs, relational categories—analogical reasoning ought to be (...) a useful cognitive tool for acquiring social relations and structures. (shrink)

M. Lipman and P. Freire are two thinkers who support the practice of liberty. Liberty is liberty to learn to think, and to exist in communities of dialogue, questioning, and search. This is the project that leads human beings to understand themselves and recognize others. Without liberty there..

In this article, I argue that Habermas’s genealogical approach to modern reason and methodological agnosticism can lead us to a better understanding of the role of religion in our societies. I underline the relevance of Habermas’s awareness that ‘something is missing’ when we take faith out of modernity and consider the truths of philosophical reason to be infallible. Habermas succeeds in highlighting the complexity of the modern relationship between the religious and the secular domains, a relationship that is not merely (...) epistemic, but also embodied in various practical relationships between religious and secular citizens. On this basis, and in the light of Habermas’s idea of modernity as an unfinished project, I argue that religion can be interpreted as a dimension allied to political modernity and democracy as well. (shrink)

Le poste routier du lieu-dit Παράγκα, à Χοιρόμανδρες, est l'un des postes de garde les plus importants de la route reliant l'habitat minoen d'Aμπέλoς (Ξηρόκαμπος) à la région fortement peuplée de Πάνω Ζάκρος et à la ville palatiale du même nom. La dernière campagne de fouille de la construction, dans le courant de l'année 1989, et les études topographiques complémentaires effectuées dans la vallée de Χοιρόμανδρες, ont confirmé qu'il s'agit d'une puissante construction à caractère défensif, s'insérant dans un programme plus (...) vaste, destiné à contrôler les communications. Il fut fondé au MM II et resta en usage jusqu'au MR IB, époque à laquelle il s'écroula, mais il est impossible de préciser si son utilisation a changé lors des occupations successives. L'aménagement architectural et les trouvailles ont des parallèles, aussi bien dans d'autres postes de garde routiers que dans des édifices datant du Minoen Moyen, l'époque où devrait avoir été dessiné le réseau routier minoen. (shrink)

Partiendo de las preguntas planteadas por Patočka a propósito de su filosofía fenomenológica de la historia, el objetivo de este artículo es arrojar luz sobre la manera cómo, en la reflexión del autor checo, la política y la historia han venido vinculándose alrededor del problema del cuidado de sí y de los otros, allí donde éste último coincide con la filosofía en tanto instauración de una inédita perspectiva de comprensión –acontecimiento por el que, según Patočka, se desencadena el curso de (...) la historia. (shrink)