There are few successful applications of automated reasoning over OWL-formalised bio-ontologies, and requirements are often unclearly formulated. Of what is available, usage and prospective scenarios of automated reasoning is often different from the straightforward classification and satisfiability. We list nine types of scenarios and specify the requirements in more detail. Several of these requirements are already possible in practice or at least in theory, others are in need of further research, in particular regarding the linking of the OWL ontology to (...) data, reasoning over roles, and dynamically linking modular ontologies. (shrink)

The four chapters of the book include the major educational controversies/debates that are being encountered presently in local school education.

Philosophy of technology is gaining recognition as an important field of philosophical scrutiny. This essay addresses the import of philosophy of technology in two ways. First, it seeks elucidate the place of technology within ontology, epistemology, and social/political philosophy. I argue technology inhabits an essential place in these fields. The philosophy of Henri Bergson plays a central role in this section. Second, I discuss how modern technology, its further development, and its inter-cultural transfer constitute a drive toward a global “hegemony (...) of technology”. The crux of the argument is that the technological impulse within humanity insinuates itself into nearly every aspect of human existence. The structures of the state, the economy, and culture, are each framed by this impulse. In the final analysis, it is argued that only a thorough examination of the intimate connection between humanity and technology can lay the foundation for a comprehensive philosophy of human existence. (shrink)

Bergson never dared to entitle his own work in such a fashion. However, his philosophical contribution on the workings of intelligence deserves such a high title. This article seeks to elucidate Bergson's contribution to philosophy in terms of his anticipation of several developments in human understanding. The work begins by investigating the relation between thought and the world (reality) by reviewing a series of constructivist concepts. In many ways, constructivism is related to both structuralism and post-structuralism, however this work does (...) not seek to detail these interrelations in any overt way. Instead, these concepts lay the groundwork for a review of Bergson's discussion of intellect in relation to life, psyche, and modern physics. Central concepts include limitation, circularity, and complementarity. Ultimately, the article seeks to display how Bergson's work is not only a precursor to constructivism but lays the foundation for a modified constructivism that can achieve a rigorous philosophical level. The proposed ground for the intellect is in the organic. Such an epistemological foundationalism would ultimately justify an evolutionary epistemology, in that, the structuring of the organic is evolving and thus the structuring of intellect would likewise evolve. Clarifying such an epistemology may aid in developing Delueze's an-organic bergsonism. (shrink)

Epilepsy surgery is the most effective therapeutic approach for children with drug resistant epilepsy. Recent advances in neurosurgery, such as the Laser Interstitial Thermal Therapy, improved the safety and non-invasiveness of this method. Electric and magnetic source imaging plays critical role in the delineation of the epileptogenic focus during the presurgical evaluation of children with DRE. Yet, they are currently underutilized even in tertiary epilepsy centers. Here, we present a case of an adolescent who suffered from DRE for 16 years (...) and underwent surgery at Cook Children's Medical Center. The patient was previously evaluated in a level 4 epilepsy center and treated with multiple antiseizure medications for several years. Presurgical evaluation at CCMC included long-term video electroencephalography, magnetoencephalography with simultaneous conventional EEG and high-density EEG in two consecutive sessions, MRI, and fluorodeoxyglucose - positron emission tomography. Video long-term EEG captured nine focal-onset clinical seizures with a maximal evolution over the right frontal/frontal midline areas. MRI was initially interpreted as non-lesional. FDG-PET revealed a small region of hypometabolism at the anterior right superior temporal gyrus. ESI and MSI performed with dipole clustering showed a tight cluster of dipoles in the right anterior insula. The patient underwent intracranial EEG which indicated the right anterior insular as seizure onset zone. Eventually LITT rendered the patient seizure free. Retrospective analysis of ESI and MSI clustered dipoles found a mean distance of dipoles from the ablated volume ranging from 10 to 25 mm. Our findings highlight the importance of recent technological advances in the presurgical evaluation and surgical treatment of children with DRE, and the underutilization of epilepsy surgery in children with DRE. (shrink)

Argumentation as the public exchange of reasons is widely thought to enhance deliberative interactions that generate and justify reasonable public policies. Adopting an argumentation-theoretic perspective, we survey the norms that should govern public argumentation and address some of the complexities that scholarly treatments have identified. Our focus is on norms associated with the ideals of correctness and participation as sources of a politically legitimate deliberative outcome. In principle, both ideals are mutually coherent. If the information needed for a correct deliberative (...) outcome is distributed among agents, then maximising participation increases information diversity. But both ideals can also be in tension. If participants lack competence or are prone to biases, a correct deliberative outcome requires limiting participation. The central question for public argumentation, therefore, is how to strike a balance between both ideals. Rather than advocating a preferred normative framework, our main purpose is to illustrate the complexity of this theme. (shrink)

This collection of 30 essays covers living a moral and ethical life as a lawyer and Christian, following the example of J. Reuben Clark, Jr. The mission and history of the BYU Law School is also adressed.

The ethics literature has identified moral motivation as a factor in ethical decision-making. Furthermore, moral identity has been identified as a source of moral motivation. In the current study, we examine religiosity as an antecedent to moral identity and examine the mediating role of self-control in this relationship. We find that intrinsic and extrinsic dimensions of religiosity have different direct and indirect effects on the internalization and symbolization dimensions of moral identity. Specifically, intrinsic religiosity plays a role in counterbalancing the (...) negative impact of extrinsic religiosity on the internalization of moral identity. Further, intrinsic religiosity also counterbalances the negative and indirect impact of extrinsic religiosity on symbolization of moral identity via self-control. Lastly, self-control does not play a mediating role in the impact of religiosity on the internalization dimension of moral identity. We conclude that this study presents important findings that advance our understanding of the antecedents of moral identity, and that these results may have implications for the understanding of ethical decision-making. (shrink)

Principally under the influence of Saul Kripke (1972), philosophical semantics since the closing decades of 20th century has been dominated by thephenomenon Nathan Salmon (1986) aptly dubbed Direct Reference “mania.” Accordingly, it is now practically orthodox to hold that the meanings of proper names are entirely exhausted by their referents and devoid of any descriptive content. The return to a purely referential semantics of names has, nevertheless, coincided with a resurgence of some of the very puzzles that motivated description theories (...) of names in the first place, to wit: the informativeness of true identity statements of the form ‘a=b’ and the failure of substitutivity salve veritate for co-referential names in propositional attitude ascriptions. I argue that a Metalinguistic Description Theory of proper names, which treats the meaning of an arbitrary proper name as roughly equivalent to the definite description ‘the bearer of NN,’ offers a novel, semantically innocent solution to these puzzles when synthesized with Keith Donnellan’s (1966) insight that descriptions are semantically ambiguous between attributive and referential meanings. The ensuing account is then defended against two well-known Kripkean objections to metalinguisticsemantics: the Circularity Objection and the Paderewski Puzzle. (shrink)

In “Unity of Action in a Latin Social Model of the Trinity,” I objected to William Hasker’s Social Model of the Trinity on the grounds that it does not secure the necessary agreement between the divine persons. Further, I developed a Latin Social model of the Trinity. Hasker has responded by defending his Social Model and by raising seven objections against my Latin Social Model. Here I raise a new objection against Hasker on the grounds that it is inconsistent with (...) Conciliar Trinitarianism, and I respond to the seven objections and in so doing further develop the Latin Social Model. (shrink)

Journey Back to God explores Origen of Alexandria's creative, complex, and controversial treatment of the problem of evil. It argues that his layered cosmology functions as a theodicy that deciphers deeper meaning beneath cosmic disparity. Origen asks: why does God create a world where some suffer more than others? On the surface, the unfair arrangement of the world defies theological coherence. In order to defend divine justice against the charge of cosmic mismanagement, Origen develops a theological cosmology that explains the (...) ontological status and origin of evil as well as its cosmic implications. Origen's theodicy hinges on the journey of the soul back to God. Its themes correlate with the soul's creation, fall and descent into materiality, gradual purification, and eventual divinization. The world, for Origen, functions as a school and hospital for the soul where it undergoes the necessary education and purgation. Origen carefully calibrates his cosmology and theology. He portrays God as a compassionate and judicious teacher, physician, and father who employs suffering for our amelioration. Journey Back to God frames the systematic study of Origen's theodicy within a broader theory of theodicy as navigation, which signifies the dynamic process whereby we impute meaning to suffering. It unites the logical and spiritual facets of his theodicy, and situates it in its third-century historical, theological, and philosophical context, correcting the distortions that continue to plague Origen scholarship. Furthermore, the study clarifies his ambiguous position on universalism within the context of his eschatology. Finally, it assesses the cogency and contemporary relevance of Origen's theodicy, highlighting the problems and prospects of his bold, constructive, and optimistic vision. (shrink)

Subjects enrolled in studies testing high risk interventions for incurable or progressive brain diseases may be vulnerable to deficiencies in informed consent, such as the therapeutic misconception. However, the definition and measurement of the therapeutic misconception is a subject of continuing debate. Our qualitative pilot study of persons enrolled in a phase I trial of gene transfer for Parkinson disease suggests potential avenues for both measuring and preventing the therapeutic misconception. Building on earlier literature on the topic, we developed and (...) tested an interview guide that focuses on how the subjects decided to participate, emphasizing the integration of subjects’ various statements that are relevant to assessing the therapeutic misconception, rather than evaluating them as isolated statements. The results indicate that a subject’s understanding of the purpose of research is best explored in juxtaposition to the subject’s motivation for participating. (shrink)

Introduction: -/- It is likely that Boethius (480-524ce) inaugurates, in Latin Christian theology, the consideration of personhood as such. In the Treatise Against Eutyches and Nestorius Boethius gives a well-known definition of personhood according to genus and difference(s): a person is an individual substance of a rational nature. Personhood is predicated only of individual rational substances. This chapter situates Boethius in relation to significant Christian theologians before and after him, and the way in which his definition of personhood is a (...) particular answer to the question, “Jesus has two natures, a divine nature and a human nature, but is one what?” Among Greek (and Syriac) speaking theologians, the typical answer is that Jesus is one ‘hypostasis’. Among Latin speaking theologians, the typical answer is that Jesus is one ‘persona’. It is Boethius’s definition of ‘persona’ that inaugurates personhood as such in Latin speaking theology. Although the Greek and Syriac theologians that I survey come close to a concept of personhood as a distinct category, they do not have such a concept and did not need it for their theological purposes. I show that Rusticus the Deacon is an early witness to this Latin theological invention, and also show that for later Latin theologians, the rationality condition for personhood does very little metaphysical work for their Trinitarian theology or Christology. -/- Further, this chapter surveys Patristic and Medieval Christian theologians’ answers to the question, “God the Father, God the Son, and God the Holy Spirit are one God, but each is one what?” The same replies as above are typically given by Christian theologians. These two theological questions frame the discussion about personhood (and ‘hypostasis’) and put a boundary around what a satisfying account of personhood (and ‘hypostasis’) would be. -/- In contemporary philosophy, there is a lot of attention paid to the rationality condition for personhood. But if we look at the text in which Boethius defines a person, we do not find any precise criteria for it. In other texts, he says that a rational being is one compatible with (capable of) thought and free choice of the will. What we find is that detailed discussion of personhood shows up in theological questions about the Trinity and Incarnation, but not in e.g., applied ethics. The intrusion of personhood into contemporary applied ethics with a focus on detailed and disputed criteria for rationality as a condition for personhood seems to be a modern development. From a Patristic and Medieval Christian theology point of view, trying to find just the right detailed criteria for rationality in order to define personhood is a wild goose chase. This chapter makes clear another contribution that Christian theology had for personhood. Given the theological issues at play in developing a notion of personhood, Christian theologians came to posit that e.g., an individual human is a person contingently (i.e. not essentially), but God the Father, God the Son, and God the Holy Spirit are each a person essentially. The contingency for created persons is not based on whether e.g., an individual human has conscious acts (as might be the case for John Locke) but on the possibility of a divine person’s assuming e.g., an individual human nature. -/- This sampling of Christian intellectual history spans over one thousand years. I make no claim of being exhaustive. The chapter consists of six sections, where each section covers significant historical conversation partners who together represent the sorts of things that Patristic and Medieval Christian theologians where concerned with in theorizing about ‘persona’ or ‘hypostasis’. -/- 1. Origen of Alexandria and the Cappadocians: Basil of Caesarea and Gregory of Nyssa 2. Miaphysites: Severus of Antioch, John Philoponus, and Peter of Callinicum 3. Boethius and Rusticus the Deacon: Rationality, Subsistence, and the Invention of Personhood 4. Neo-Chalcedonians (II): Leontius of Byzantium 5. Scholastic Neo-Chalcedonians (I): Gilbert of Poitiers, Richard of St. Victor, William of Auxerre, Alexander of Hales, Bonaventure, Thomas Aquinas, and William of Ware 6. Scholastic Neo-Chalcedonians (II): Henry of Ghent, John Duns Scotus, and William of Ockham . (shrink)

Recent progress in the study of short‐distance (cell‐to‐cell) movement of plant virus, facilitated by ‘movement proteins’, has led to a resurgence of interest in long‐distance virus transport in the phloem. Relatively little is known about phloem‐specific barriers to virus movement or about the form in which virus enters, travels within and exits this tissue. Progress in understanding virus and photoassimilate transport is limited by a paucity of information on the substructure and properties of plasmodesmata at specific interfaces. The direction of (...) virus movement, once it has entered the phloem, can be understood by following photoassimilate translocation, a complex and dynamic process influenced by plant growth, development and vascular topology. (shrink)