This study explored calibrating a large item bank for use in multidimensional health measurement with computerized adaptive testing, using both item responses and response time (RT) information. The Activity Measure for Post-Acute Care is a patient-reported outcomes measure comprised of three correlated scales (Applied Cognition, Daily Activities, and Mobility). All items from each scale are Likert type, so that a respondent chooses a response from an ordered set of four response options. The most appropriate item response theory model for analyzing (...) and scoring these items is the multidimensional graded response model (MGRM). During the field testing of the items, an interviewer read each item to a patient and recorded, on a tablet computer, the patient’s responses and the software recorded RTs. Due to the large item bank with over 300 items, data collection was conducted in four batches with a common set of anchor items to link the scale. Van der Linden’s (2007) hierarchical modeling framework was adopted. Several models, with or without interviewer as a covariate and with or without interaction between interviewer and items, were compared for each batch of data. It was found that the model with the interaction between interviewer and item, when the interaction effect was constrained to be proportional, fit the data best. Therefore, the final hierarchical model with lognormal model for RT and the MGRM for response data was fitted to all batches of data via a concurrent calibration. Evaluation of parameter estimates revealed that (1) adding response time information did not affect the item parameter estimates and their standard errors significantly; (2) adding response time information helped reduce the standard error of patients’ multidimensional latent trait estimates, but adding interviewer as a covariate did not result in further improvement. Implications of the findings for follow up adaptive test delivery design are discussed. (shrink)

As novas modalidades de operações financeiras realizadas por bancos tradicionais versus suas contrapartes no ambiente virtual, as quais utilizam dados bancários e informações pessoais e sensíveis dos usuários naquilo que se chama de open banking é o tema central do trabalho. Assim, partiu-se de uma definição geral desse termo, declinando sua tentativa de regulação para analisar seu acoplamento com LGPD, concluindo-se da necessidade de uma intervenção do órgão regulador (BACEN) balanceando proteção de dados e aumento da concorrência gerado pelo instituto (...) estudado. A pesquisa bibliográfica foi utilizada e o método dialético foram utilizados pelo prisma da Análise Econômica do Direito. (shrink)

Plasmids are a major type of mobile genetic elements (MGEs) that mediate horizontal gene transfer. The stable maintenance of plasmids plays a critical role in the functions and survival for microbial populations. However, predicting and controlling plasmid persistence and abundance in complex microbial communities remain challenging. Computationally, this challenge arises from the combinatorial explosion associated with the conventional modeling framework. Recently, a plasmid‐centric framework (PCF) has been developed to overcome this computational bottleneck. This framework enables the derivation of a simple (...) metric, the persistence potential, to predict plasmid persistence and abundance. Here, we discuss how PCF can be extended to account for plasmid interactions. We also discuss how such model‐guided predictions of plasmid fates can benefit from the development of new experimental tools and data‐driven computational methods. (shrink)

Vascular calcifications are the consequence of several pathological conditions such as atherosclerosis, diabetes, hypercholesterolemia and chronic renal insufficiency. They are associated with risks of amputation, ischemic heart disease, stroke and increased mortality. A growing body of evidence indicates that vascular smooth muscle cells (VSMCs) undergo chondrogenic commitment eventually leading to vascular calcification, by mechanisms similar to those governing ossification in the cartilage growth plate. Our knowledge of the formation of cartilage growth plate can therefore help us to understand why and (...) how arteries calcify and, consequently, develop new therapeutic strategies. Reciprocally, thorough consideration of the events leading to ectopic chondrocyte differentiation appears crucial to further increase our understanding of growth plate formation. In this context, we will review the effects of known or suspected factors that promote chondrogenic differentiation in growth plate and arteries. BioEssays 27:708–716, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

This commentary examines the interpretation of Parmenides developed by Rose Cherubin in her paper, “Parmenides, Liars, and Mortal Incompleteness.” First, I discuss the tensions Cherubin identifies between the definitions and presuppositions of justice, necessity, fate, and the other requisites of inquiry. Second, I critically assess Cherubin’s attribution of a sort of liar paradox to Parmenides. Finally, I argue that Cherubin’s handling of the Doxa, the section of Parmenides’ poem that deals with mortal opinion and cosmology, is unsatisfactory. I suggest that (...) her reading may contradict the text in denying that the Doxa contains truths. (shrink)

Although there is wide agreement that ethics consults are at risk for conflicts of interest, ethics consultants have limited guidance with regard to how to identify and approach COIs. We aim to address these concerns and provide practical guidance. We will define and consider four categories of COIs: consult type, team composition, dual clinical roles and other concerns. We will define and consider six actions available for ECs to take in response to COIs: no action, disclosure only, obtaining a second (...) opinion, referring to another EC, referring to an institutional ethics committee or seeking an outside consult. We will then propose a points-based algorithm for ECs to use to determine the appropriate response to COI. Finally, we will discuss the strengths and limitations of our proposed algorithm. (shrink)

Despite claims of pure pragmatism, Hertwig and Ortmann's negative perspective on deception suggests a selfish psychologist willing to sacrifice the reputation of the discipline in order to expedite the research. Although questions that appear to have correct answers may be investigated with complete openness, research that delves into personal secrets often requires deception as a tool to counter self-presentation bias.

This essay explores classical rabbinic literature's understanding of the prohibition of bloodshed alongside its understanding that "the image of God" corresponds to the physically embodied individual. This conception generates radical implications so that, apart from the narrow instance of a direct aggressor with intent to kill or rape, it is never legitimate to cause the death of any person, even in pursuit of a supposed "greater good." While notions of war and execution are retained in principle, the requirement of direct (...) divine sanction for such actions neutralizes them in practice, removing them from the domain of human judgment and justification. (shrink)

I argue that a practice can only be taken to be one of apparent rule following if it contains a practice of policing moves within the practice. So the existence of an apparently rule-governed practice entails the existence of, what I call, a policing practice. I then argue that this entailment cannot be reconciled with a non-factualist construal of the policing practice. Thus non-factualism about the policing practice is false. Factualism about the policing practice entails realism about rules. So I (...) conclude that we ought to be realists about rules. Finally I distinguish a position which I call ultra-realism about rules and note that this too is a casualty of the view developed here. (shrink)

This article is a slightly modified version of a paper presented to the International Conference on ‘Malthus Yesterday and Today’, Société de démographie historique Paris, 27–29 May 1980.

Frequently, theological particularity can hinder attempts at inter-religious conversations in theological ethics, as each tradition’s reasoning is inextricably bound up with core doctrinal elements not shared by other traditions. I argue, however, that elements of particularity can facilitate conversation when emphasis is placed on movements of ethical reasoning between particular statements within each tradition. By examining the classical rabbinic practice of verbal forewarning in capital cases, I show that although the starting point and ending point of an instance of theological (...) reasoning may be ‘exclusivistic’, the relationship between those points can serve as the basis for comparison and dialogue. (shrink)

In his response to my article, “Historicism and Science: Thoughts on Quine” , Paul Bernays distinguishes between two aspects of the article: my criticism of Quine's theory of knowledge and my contention that the epistemological foundations of modern science lead to historicism. Bernays substantially accepts my criticism of Quine, particularly insofar as I reject Quine's behaviorism and “physicalism”. He opposes, however, my claim that historicism is implicit in the presuppositions of modern science. I argued that the historicism inherent in modern (...) science is due to the essentially changeable character of modern science. Quine's theory of knowledge tacitly takes account of this changeable character a) through his view of sense experience as being constituted by posits, b) through his recognition that individual scientific statements are dependent upon a broad linguistic‐conceptual framework that is itself subject to change, and c) through his pragmatic conception of reason and the concomitant emphasis upon the criterion of simplicity. (shrink)

Courses in the philosophy of law provide philosophy departments an opportunity to focus on timely and relevant questions affecting the lives of undergraduates as well as attract students interested in the legal profession to the study of philosophy. This review article examines four recent texts in philosophy of law, three anthologies and a single-authored introductory text, and discusses their suitability to the classroom. After an overview identifying key features of each text, several comparative points are made relevant to teaching philosophy (...) of law. The diversity of issues, cases, and approaches to philosophy of law evinced by these textbooks suggests that the faculty member selecting texts should choose carefully. (shrink)

This monograph is divided into four parts: 1. AMERICAN PHILOSOPHY: Unlike the philosophies of other countries today, it does not pivot about a particular authoritative university or school. Most positions, though, agree in acknowledging a plurality of irreducible ultimate principles and realities. 2. PROCESS PHILOSOPHY: This has been of primary interest to theologians, and is occupied mainly with pointing up differences with Thomism. The strength and weaknesses of both these positions is outlined, and alternative views indicated. 3. THE MODAL PHILOSOPHY: (...) A summary account is given, justifying and describing five irreducible, conditioning realities which govern individual substances, severally and together. 4. QUESTIONS AND ANSWERS: These have mainly to do with the problem of the One and the Many, raised by the audience. Each finality, it is held, is a One for the Many actualities; each actuality is a One for the Many finalities. (shrink)

This text examines the philosophy of Paul Weiss. Much of Dr Weiss's impact has come through his example, discussions, and such activities as founding and editing the Review of Metaphysics and founding and leading the Metaphysical Society of America.

An interview with Gail Weiss concerning her interests and influences, especially the body and embodiment.

Author note: Penny A. Weiss, Associate Professor of Political Science at Purdue University, is the author of Gendered Community: Rousseau, Sex, and Politics. Marilyn Friedman, Associate Professor of Philosophy at Washington University, is the author of What Are Friends For? Feminist Perspectives on Personal Relationships and Moral Theory.

In this article, I provide Urquhart-style semilattice semantics for three connexive logics in an implication-negation language (I call these “pure theories of connexive implication”). The systems semantically characterized include the implication-negation fragment of a connexive logic of Wansing, a relevant connexive logic recently developed proof-theoretically by Francez, and an intermediate system that is novel to this article. Simple proofs of soundness and completeness are given and the semantics is used to establish various facts about the systems (e.g., that two of (...) the systems have the variable sharing property). I emphasize the intuitive content of the semantics and discuss how natural informational considerations underly each of the examined systems. (shrink)

An important question that is often raised, whether directly or indirectly, in philosophical discussions of shame‐inducing behavior concerns whether the experience of shame has unique moral value. Despite the fact that shame is strongly associated with negative affective responses, many people have argued that the experience of being ashamed plays an important motivating role, rather than being an obstacle, in living a moral life. These discussions, however, tend to take for granted two interrelated assumptions that I will be problematizing: 1) (...) that the subject's shame is warranted; 2) that the shame is directly attributable to the subject's own actions. I challenge these assumptions by turning to a phenomenon I call secondhand shame, namely, shame that is induced by another person's shameless behavior. This essay examines the gender and racial dynamics that so frequently intensify secondhand shame, and suggests that this troubling phenomenon, when shared as a group experience, can be morally transformative, particularly when it leads to unified public resistance to shameless conduct. (shrink)

In her recent book, Russell (2023) examines various so-called “barriers to entailment,” including Hume’s law, roughly the thesis that an ‘ought’ cannot be derived from an ‘is.’ Hume’s law bears an obvious resemblance to the proscription on fallacies of modality in relevance logic, which has traditionally formally been captured by the so-called Ackermann property. In the context of relevant modal logic, this property might be articulated thus: no conditional whose antecedent is box-free and whose consequent is box-prefixed is valid (for (...) the connection, interpret box deontically). While the deontic significance of Ackermann-like properties has been observed before, Russell’s new book suggests a more broad-scoped formal investigation of the relationship between barrier theses of various kinds and corresponding Ackermann-like properties. In this paper, I undertake such an investigation by elaborating a general relevant bimodal logical framework in which several of the barriers Russell examines can be given formal expression. I then consider various Ackermann-like properties corresponding to these barriers and prove that certain systems satisfy them. Finally, I respond to some objections Russell makes against the use of relevance logic to formulate Hume’s law and related barriers. (shrink)

Putting laypeople in an active role as direct expert contributors in the design of service robots becomes more and more prominent in the research fields of human–robot interaction and social robotics. Currently, though, HRI is caught in a dilemma of how to create meaningful service robots for human social environments, combining expectations shaped by popular media with technology readiness. We recapitulate traditional stakeholder involvement, including two cases in which new intelligent robots were conceptualized and realized for close interaction with humans. (...) Thereby, we show how the robot narrative together with aspects of power balancing stakeholders, such as hardware constraints and missing perspectives beyond primary users, and the adaptivity of robots through machine learning that creates unpredictability, pose specific challenges for participatory design processes in HRI. We conclude with thoughts on a way forward for the HRI community in developing a culture of participation that considers humans when conceptualizing, building, and using robots. (shrink)