This paper argues that a range of current AI systems have learned how to deceive humans. We define deception as the systematic inducement of false beliefs in the pursuit of some outcome other than the truth. We first survey empirical examples of AI deception, discussing both special-use AI systems (including Meta's CICERO) built for specific competitive situations, and general-purpose AI systems (such as large language models). Next, we detail several risks from AI deception, such as fraud, election tampering, and losing (...) control of AI systems. Finally, we outline several potential solutions to the problems posed by AI deception: first, regulatory frameworks should subject AI systems that are capable of deception to robust risk-assessment requirements; second, policymakers should implement bot-or-not laws; and finally, policymakers should prioritize the funding of relevant research, including tools to detect AI deception and to make AI systems less deceptive. Policymakers, researchers, and the broader public should work proactively to prevent AI deception from destabilizing the shared foundations of our society. (shrink)

Inflammatory responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled chronic inflammation can occur. Chronic inflammation is now recognized as a contributing factor to many age‐associated diseases including metabolic disorders, arthritis, neurodegeneration, and cardiovascular disease. Due to the connection between chronic inflammation and these diseases, it is essential to understand underlying mechanisms behind this process. In this review, factors that contribute to chronic inflammation are discussed. Further, we (...) emphasize the emerging roles of microRNAs (miRNAs) and other noncoding RNAs (ncRNA) in regulating chronic inflammatory states, making them important future diagnostic markers and therapeutic targets. Copyright Line: © 2015 The Authors BioEssays Published by Wiley‐VCH Verlag GmbH & Co. KGaA. (shrink)

Book reviewed in this article: Having Children: Philosophical and Legal Reflections on Parenthood. Edited by Onora O'Neill and William Ruddick.

U.S. researchers and scholars often point to two legal factors as significant obstacles to the inclusion of pregnant women in clinical research: the Department of Health and Human Services’ regulatory limitations specific to pregnant women's research participation and the fear of liability for potential harm to children born following a pregnant woman's research participation. This article offers a more nuanced view of the potential legal complexities that can impede research with pregnant women than has previously been reflected in the literature. (...) It reveals new insights into the role of legal professionals throughout the research pathway, from product conception to market, and it highlights a variety of legal factors influencing decision-making that may slow or halt research involving pregnant women. Our conclusion is that closing the evidence gap created by the underrepresentation and exclusion of pregnant women in research will require targeted attention to the role of legal professionals and the legal factors that influence their decisions. (shrink)

This paper is a personal reflection on involvement in the development of the first voluntary assisted dying legislation in Australia. Points of contention are discussed, where plural values were evident, as the legislation progressed towards implementation. Finally, ongoing areas of difficulty with the legislation are listed, where further thought is required to ensure ease of access for those in need.

This article discusses the place of sedation in the care of the terminally ill, as used in the practice of palliative care using case studies, clinical pragmatism forms the theoretical framework from which to elucidate the varying part that sedation plays in the overall management of a person facing the end of life. We contend that when used appropriately, sedation is an ethical and legitimate intervention that enhances comfort at the end of life and ought not sedate the person onto (...) “oblivion”. (shrink)

Contemporary political disputes have a long history of expression and contestation through the genre of history‐writing in Ireland. The role of history writing and political science writing during the nearly 40 years of the so‐called ‘Troubles’ has been no exception to this. Battles between competing versions of what the conflict ‘is about’, mediated through academic and popular texts have themselves in turn become constitutive of it. This builds upon centuries of the representation of the complicated politics of this island as (...) ‘an issue’ in British domestic politics – first ‘the Catholic question’, then ‘the Irish question’. The location of political power outside the island for centuries has created successive battles for the representation of sectional interests in a metropolitan centre. The skills of propaganda, history writing, newspaper writing have consequently been deployed at a remarkable level of skill and intensity. In the recent period one of the consequences of this has been the removal from the debate of the actuality of partition; this builds upon a particular historical representation of partition as an historical inevitability. To seek to restore partition to the debate is not to call for its undoing but to recognise that seeking to circumvent debates about its origins in the key period of democratisation in Irish politics (1880–1920) has been counter‐productive. This essay examines the genealogies of partition in Irish and international contexts in the light of these battles for representation, and aims to return a lost dimension to the debate about the so‐called ‘Troubles’in Ireland. The genealogy of partition is the issue that has been marginalised in academic study and this has affected both policy and politics. (shrink)

This is the first modern, annotated and scholarly edition of Jean-Baptiste Du Bos’ _Critical Reflections on Poetry and Painting_, one of the seminal works of modern aesthetics in any language.

This paper focuses on ethics in community-based participatory research (CBPR) from inception to post-publication. Central to CBPR is a collaborative, partnership approach that recognises the strengths of partners and engages their distinctive voice and knowledge in the research process. While the ethical complexities that arise in the course of research practice in CBPR can transcend individual projects, they are also grounded in the particularity of the project, community, and research partners. This paper reflects on the experiences of two participatory social (...) policy research projects on housing in Ireland, conducted over the past three years. These projects involved collaborating with older people living in rural areas nationwide and with residents of small communities on offshore islands. The paper explores the ethics of engagement (regarding methods of involvement and access), and the ethics of representation (incorporating the depiction and sharing of research findings) and argues that researchers must pay attention to the specificity of each project and be alive to generating an organic research ethics in how research is set up, conducted, represented, and disseminated. In so doing, we can better foster agency and authenticity in the relationships developed throughout research processes and reflect on and meet shared values and responsibilities. (shrink)

It has long been known that Jean-Baptiste Du Bos exercised a considerable influence on Hume’s essays and, in particular, on the ‘Of the Standard of Taste’ and ‘Of Tragedy’. It has also been noted that some passages in the Treatise bear marks of Du Bos’ influence. In this essay, we identify many more passages in the Treatise that bear unmistakable signs of Du Bos’ influence. We demonstrate that Du Bos certainly had a significant impact on Hume as he wrote the (...) Treatise. We go on to argue that Hume’s views on morality are an extension to the moral realm of Du Bos’ views on beauty and criticism. Du Bos may also have influenced Hume’s distinction between ideas and impressions. (shrink)

The impact of gender on assessments of leadership performance and leadership potential was examined through two clusters of leadership behaviors, one set related to traditional constructions of leadership labeled directing others and another associated with contemporary constructions of leadership labeled engaging others. Based on data collected from a sample of 91 senior leaders in one US financial services organization over a 3-year period prior to Covid-19, the results showed a negative relationship between directing others behaviors and leadership potential ratings for (...) females and a positive relationship between these variables for males. A negative relationship between engaging others behaviors and performance assessments was also found for females. This study highlights the continuing bias in leadership assessments of women and explores the contradictions between the perception and the reality of women's leadership. (shrink)

In this article we assess the extant literature on women’s careers appearing in selected career, management and psychology journals from 1990 to the present to determine what is currently known about the state of women’s careers at the dawn of the 21st century. Based on this review, we identify four patterns that cumulatively contribute to the current state of the literature on women’s careers: women’s careers are embedded in women’s larger-life contexts, families and careers are central to women’s lives, women’s (...) career paths reflect a wide range and variety of patterns, and human and social capital are critical factors for women’s careers. We also identify paradoxes that highlight the disconnection between organizational practice and scholarly research associated with each of the identified patterns. Our overall conclusion is that male-defined constructions of work and career success continue to dominate organizational research and practice. We provide direction for a research agenda on women’s careers that addresses the development of integrative career theories relevant for women’s contemporary lives in hopes of providing fresh avenues for conceptualizing career success for women. Propositions are identified for more strongly connecting career scholarship to organizational practice in support of women’s continued career advancement. (shrink)

Background: The right of children to have their voice heard has been accepted by researchers, and there are increasing numbers of qualitative health studies involving children. The ethical and methodological issues of including children in research have caused worldwide concerns, and many researchers have published articles sharing their own experiences. Objectives: To systematically review and synthesise experts’ opinions and experiences about ethical and methodological issues of including children in research, as well as related solution strategies. Research design: The research design (...) was a systematic review of opinion-based evidence, based on the guidelines by Joanna Briggs Institute. Methods: A search of five computerised databases has been conducted in April 2014 and 2271 articles were found. After screening the titles, abstracts, full texts and appraising the quality, 30 articles were finally included in the review. A meta-aggregative approach was applied in the data analysis and synthesis process. Ethical considerations: Ethical approval is not needed as it is a systematic review of published literature. Results: Six themes were identified, including evaluating potential risks and benefits, gaining access, obtaining informed consent/assent, protecting confidentiality and privacy, building rapport and collecting rich data. The similarities and differences between research involving children and that involving adults were indicated. Conclusion: All potential incentives should be justified when designing the study. Further studies need to research how to evaluate individual capacity of children and how to balance protecting children’s right to participate and their interests in the research. Cultural differences related to researching children in different regions should also be studied. (shrink)

Small family businesses have generally been shown to exhibit significant concern for social responsibility, especially at the community level. Despite the reported heterogeneity of family firms in their preferences for and participation in social responsibility, the drivers of such differences are not agreed upon in the literature. We draw from enlightened self-interest and social capital theories by exploring their complementary and competing implications for the effect of duration and community satisfaction on participation in community-oriented social responsibility. Additionally, drawing on the (...) association between gender and self-construal and evidence that gender shapes helping and giving behaviors, we assess the moderating role of the gender of the firm manager in these relationships. We test our hypotheses on a sample of 279 family businesses and find support that gender moderates the relationship between community duration and satisfaction and measures of CSR. (shrink)

This study examined whether holding a status-consistent or status-inconsistent position affected the work satisfaction of college-educated, white-collar employees. The status-consistent group contained 128 women and 118 men. The status-inconsistent group was composed of 89 women and 102 men. Our results indicated that workers in occupations in which the majority of workers are the same gender had significantly higher levels of work satisfaction than those in status-inconsistent occupations. However, subsequent analyses revealed that men and women employed in occupations in which the (...) majority of workers are men had higher levels of work satisfaction than those employed in women-dominated occupations. These findings held when controlling for other work-satisfaction factors, such as individual earnings, hours worked per week, and length of time employed. We suggest that the effect of status consistency on work satisfaction is mediated by the cultural value attached to the occupations men dominate. (shrink)

Data from 590 college graduates are used to assess the relationship between family employment status and gender role attitudes for a predominately European American sample. The women in this study are employed full time, part time, or are full-time homemakers, and all report being married to men employed full time. The men in the study are all employed full time and report having wives who are employed full time, part time, or are full-time homemakers. Controlling for the effects of selected (...) background factors, full-time employed women are the most supportive of nontraditional family gender roles, followed by part-time employed women. The attitudes of homemakers are more similar to those of the men. Few significant differences exist when comparing the men with full-time employed wives, those with part-time employed wives, and men married to homemakers. The findings suggest an important link between work experiences, lifestyle choices, and gender role attitudes, particularly for women. (shrink)

Research has shown that paternal involvement positively impacts on child health and development. We aimed to develop a conceptual model of dimensions of fatherhood, identify and categorise methods used for linking fathers with their children in administrative data, and map these methods onto the dimensions of fatherhood. We carried out a systematic scoping review to create a conceptual framework of paternal involvement and identify studies exploring the impact of paternal exposures on child health and development outcomes using administrative data. We (...) identified four methods that have been used globally to link fathers and children in administrative data based on family or household identifiers using address data, identifiable information about the father on the child's birth registration, health claims data, and Personal Identification Numbers. We did not identify direct measures of paternal involvement but mapping linkage methods to the framework highlighted possible proxies. The addition of paternal National Health Service numbers to birth notifications presents a way forward in the advancement of fatherhood research using administrative data sources. (shrink)

Este artigo visa demonstrar como se vem instaurando a formação do cidadão através do Orçamento Participativo, na cidade de Porto Alegre, após 1990.

We prove, by explicit construction, that not all sets definable in polynomially bounded o-minimal structures have mild parameterization. Our methods do not depend on the bounds particular to the definition of mildness and therefore our construction is also valid for a generalized form of parameterization, which we call G-mild. Moreover, we present a cell decomposition result for certain o-minimal structures which may be of independent interest. This allows us to show how our construction can produce polynomially bounded, model complete expansions (...) of the real ordered field which, in addition to lacking G-mild parameterization, nonetheless still have analytic cell decomposition. (shrink)

The concept of πρoπαειαι or "pre-emotions" is known not only to the Roman Stoics and Christian exegetes but also to Philo of Alexandria. Philo also supplies the term πρoπαεια at QGen 1.79. As Philo cannot have derived what he knows from Seneca, nor from Cicero, who also mentions the point, he must have found it in older Stoic writings. The πρoπαεια concept, rich in implications for the voluntariness and phenomenology of the passions proper, is thus confirmed for the Hellenistic period. (...) It is not to be expected that Philo's handling of this or any concept will necessarily conform to the usage of his Stoic sources. His evidence is nonetheless of great value where it coincides with that of other witnesses. In QGen 4.73 the emphasis falls upon involuntariness and the mechanisms of impression and assent as in Epictetus fr. 9. The πρoπαεια saves the virtuous person's insusceptibility to emotion exactly as it does for the Stoic spokesman in Gellius NA 19.1; this point is of some interest in view of the Christological use of this concept in Origen and Didymus. QGen 1.55 and 3.56 indicate that the occurrence of the πρoπαειαι is dependent upon uncertainty, and further, that for Philo, as for Seneca in Ira 2.3.4, a thought not acted upon can count as a πρoπαεια. In QGen 4.15-17 and 1.79, Philo indicates that hope and perhaps laughter may be related to joy as πρoπαεια to παoς; these assertions are not paralleled in extant Stoic texts. Further, in QGen 2.57, he names "biting and contraction" as the ευπαεια corresponding to grief, supplying a helpful parallel for Cic. Tusc. 3.83 and Plut. Virt. Mor. 449a. The topic may well have been discussed by Posidonius, as suggested by Cooper and others, but Posidonius' attested innovations are rather different in character from the points which have caught the attention of Philo. Taking together the indirect evidence of Philo, Seneca, and Cicero, we may reasonably infer that the πρoπαεια concept belonged already to an earlier period of Stoicism. (shrink)

This book is a rich blend of analyses by leading experts from various cultures and disciplines. A compact introduction to a complex field, it illustrates biotechnology's profound impact upon the environment and society. Moreover, it underscores the vital relevance of cultural values. This book empowers readers to more critically assess biotechnology's value and effectiveness within both specific cultural and global contexts.

This book, a collection of articles on women's contributions to the history of philosophy, can accurately be described as long-awaited. Originally conceived in, I gather, roughly its present form in 2006, it is now finally in 2019 reaching the light of day. Although unavoidable delays are always a pity, in this case the result is certainly worth the wait, and the significantly high quality of the volume has not been undercut by its belated appearance. In 2006, the editors secured contributions (...) from most of the leading contributors to the field of women in the history of philosophy, and since twelve years is not all that long a time, they remain leading contributors. Anyone interested in teaching, writing about, or... (shrink)

Margaret Cavendish was an English natural philosopher. Influenced by Hobbes and by ancient Stoicism, she held that the created, natural world is purely material; there are no incorporeal substances that causally affect the world in the course of nature. However, she parts company with Hobbes and sides with the Stoics in rejecting a participate theory of matter. Instead, she holds that matter is a continuum. She rejects the mechanical philosophy's account of the essence of matter as simply extension. For (...) Cavendish, matter is also essentially living, sensing, and rational. She also rejects the mechanical philosophy's explanation of change solely in terms of transference of motion. Her own explanation of change relies upon a notion of "occasional cause." This paper argues that Cavendish's occasional causes are not to be confused with those of Malebranche; hers have some efficient causal powers. It traces the concept of an occasional cause from the ancient Stoics, through Galen, to Renaissance natural philosophers such as J. B. van Helmont, and ultimately to Cavendish and to Descartes. Thus, the aim of the paper is to explicate Cavendish's non-mechanical model of natural change and to show how the key concept in this model, that of "occasional cause," has a long philosophical pedigree. L'anglaise Margaret Cavendish pratique la philosophic naturelle. Sous l'influence de Hobbes et du stoïcisme ancien, elle a soutenu que le monde naturel créé est purement matériel ; dans le cours de la nature, il n'y a pas de substances incorporelles qui affectent causalement le monde. Elle se sépare néanmoins de Hobbes et rejoint les Stoïciens dans son rejet d'une théorie de la matière particulaire. Elle considère au contraire que la matière est un continuum. Elle rejette l'explication de l'essence de la matière comme simple extension, fournie par la philosophic mécaniste. Pour Cavendish, la matière est de plus essentiellement vivante, sentante et rationnelle. Elle rejette aussi l'explication mécaniste du changement en simples termes de transmission de mouvement. Sa propre explication du changement s'appuie sur la notion de cause occasionnelle. Cet article defend l'idée que les causes occasionnelles de Cavendish ne doivent pas être confondues avec celles de Malebranche ; les siennes ont des pouvoirs causaux efficients. Il permet done de suivre l'histoire du concept de cause occasionnelle des anciens Stoïciens, en passant ensuite par Galien jusqu'aux Philosophes de la nature de la Renaissance, comme J. B. van Helmont, et finalement jusqu'à Cavendish et Descartes. Le but de cet article est ainsi de rendre explicite le modèle que Cavendish donne du changement naturel et de montrer comment le concept clé de ce modèle, celui de cause occasionnelle, est le produit d'une longue filiation philosophique. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)