Working memory has been one of the most intensively studied systems in cognitive psychology. The Cognitive Neuroscience of Working Memory brings together world class researchers from around the world to summarise our current knowledge of this field, and directions for future research.

Measuring gene expression on a global scale has been one of the vexing problems of cell biology. Velculescu et al.(1) recently proposed a system for identifying gene expression levels based on very short sequence tags – about nine base pairs – located at a specific site within a gene transcript. By coupling the strategy to current automated sequencing machines and the large expressed sequence tag databases, it should be possible to follow changes in gene expression for large numbers of genes (...) economically and accurately. (shrink)

In "Behavioral Law and Economics: The Assault on Consent, Will, and Dignity," Mark D. White uses the moral philosophy of Immanuel Kant to examine the intersection of economics, psychology, and law known as "behavioral law and economics." Scholars in this relatively new field claim that, because of various cognitive biases and failures, people often make choices that are not in their own interests. The policy implications of this are that public and private organizations, such as the state and employers, (...) can and should design the presentation of options and default choices in order to "steer" people to the decision they would make, were they able to make choices in the absence of their cognitive biases and failures. Such policies are promoted under the name "libertarian paternalism," because choice is not blocked or co-opted, but simply "nudged." White argues that such manipulation of choice is impossible to conduct in people's true interests, and any other goal pursed by policymakers substitutes their own ends, however benevolent they may be, for people's true ends. Normatively, such manipulation should not be conducted because it fails to respect the dignity and autonomy of persons, what some hold to be the central idea in Kant's ethical system, and which serves to protect the individual from coercion, however subtle, from other persons or the state. (shrink)

Clinical bioethics is big business. There are now hundreds of people who bioethics in community and university hospitals, nursing homes, rehabilitation and home care settings, and some who play the role of clinical ethics consultant to transplant teams, managed care companies, and genetic testing firms. Still, there is as much speculation about what clinically active bioethicists actually do as there was ten years ago. Various commentators have pondered the need for training standards, credentials, exams, and malpractice insurance for ethicists engaged (...) in clinical consultation. Much of the discussion seems to accept an implicit presumption that all clinical ethics consultation practices look pretty much alike. But is this accurate? What do clinical ethicists do, how and where do they do it, and what kind of clinical ethics is useful in the hospital and in other settings? (shrink)

American orthodox medicine consolidated its professional authority in the early 20th Century on the basis of its unbiased scientific method. The centerpiece of such a method is a strategy for identifying truly effective new therapies, i.e., the randomized clinical trial (RCT). A crucial component of the RCT in illnesses without established treatment is the placebo control. Placebo effects must be identified and distinguished from pharmacological effects because placebos produce actual but unexplained therapeutic successes. The blinding necessary for a proper placebo-controlled (...) RCT therefore introduces an epistemic bias into orthodox medicine: therapeutic successes that rely upon a direct link between knowing and healing, such as placebo effects, are discarded in favor of therapeutic successes that rely upon an indirect link between knowing and healing, such as pharmacological interventions. Where the capacity to produce therapeutic results once validated the method of clinical medical science, now method validates results. The clinical consequences of this method of testing therapies include a diminished vision of the therapeutic potential of the doctor-patient relationship and of the potential human resources available for healing. Keywords: doctor-patient relationship, epistemology, placebo effect, professionalization, randomized clinical trials CiteULike Connotea Del.icio.us What's this? (shrink)

This chapter looks at another executive virtue that Captain America exemplifies: the judgment he needs to arrive at the best action in a difficult situation. Despite his humility, Captain America exemplifies both sound judgment and unshakeable determination, which are often misunderstood as representing “black‐and‐white” ethics or stubbornness. Just like judges as Dworkin describes them, we can use our own judgment to find the “right answer” to each moral dilemma, the decision that is consistent with our own principles and maintains the (...) integrity of our own moral character. There is a special category of situations that superheroes all too often find themselves in. Such choices are what philosophers call tragic dilemmas. Applying basic moral virtues and principles to specific circumstances, including all of their context, nuance, and subtlety, is the key to sound judgment, and that is important to everyone in the real world and to Cap in the comics. (shrink)

We extend Shelah's first many model result to show that an unstable theory has 2 κ many non-permutation group isomorphic models of size κ, where κ is an uncountable regular cardinal.

We show that the fundamental legal structure of a well-written financial contract follows a state-transition logic that can be formalized mathematically as a finite-state machine (specifically, a deterministic finite automaton or DFA). The automaton defines the states that a financial relationship can be in, such as “default,” “delinquency,” “performing,” etc., and it defines an “alphabet” of events that can trigger state transitions, such as “payment arrives,” “due date passes,” etc. The core of a contract describes the rules by which different (...) sequences of events trigger particular sequences of state transitions in the relationship between the counterparties. By conceptualizing and representing the legal structure of a contract in this way, we expose it to a range of powerful tools and results from the theory of computation. These allow, for example, automated reasoning to determine whether a contract is internally coherent and whether it is complete relative to a particular event alphabet. We illustrate the process by representing a simple loan agreement as an automaton. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Spheres of Philosophical Inquiry and the Historiography of Medieval Philosophy by John InglisMark D. JordanJohn Inglis. Spheres of Philosophical Inquiry and the Historiography of Medieval Philosophy. Brill’s Studies in Intellectual History, volume 81. Leiden, Boston, Köln: Brill, 1998. Pp. x + 324. Cloth, $99.50.Modern philosophers have shown themselves quite unphilosophical about the academic history of their own discipline. Content with grand stories that move from Plato to themselves, (...) they have treated institutional histories, recent histories, and bibliographical histories as unworthy of attention. John Inglis sets out to change all that for the study of medieval philosophy. He demonstrates by the book’s end that we have failed to recognize our historiographical procedures as conventions—with very particular histories of their own.The first part of the book traces the genealogy of the dominant (one might say, hegemonic) model in recent studies of medieval philosophy. The genealogy is prefaced with two chapters that show how various were the motives for reconstructions of medieval thought before 1850 in authors such as Billuart, Goudin, and Brucker or Hegel, Ritter, and Hauréau. These chapters might be dismissed by contemporary scholars as so much antiquarianism. There can be no dismissing the relevance to contemporary work of Inglis’s main genealogy, which runs with surprising directness from Joseph Kleutgen (1811–1883) and Albert Stöckl (1823–1895) to Norman Kretzmann and Anthony Kenny.It adds to the piquancy of Inglis’s argument that most specialists in medieval philosophy will not even recognize the names of Kleutgen and Stöckl, much less feel kinship with them. But Inglis shows convincingly what Kleutgen and Stöckl did to make the study of medieval philosophy possible in modern universities. Kleutgen mapped the medieval texts onto a system of “spheres,” of fields or topics, recognizable to professors of philosophy. This means that he necessarily privileged epistemology, as he necessarily connected a medieval thinker’s views across the “spheres” into a system—or a failed attempt at one. Kleutgen then emphasized the reason/revelation dichotomy and an allegiance to what he understood as the system of Thomas Aquinas. Put these elements together and you have a surprisingly familiar story. It remained for Stöckl to write it up as an erudite and monumental narration.Inglis follows this „Kleutgen-Stöckl model” through a number of more familiar authors, including De Wulf, Gilson, Boehner, Weinberg, and the editors of the Cambridge [End Page 530] History of Later Medieval Philosophy. Of course, in reducing the genealogy to a list of famous names I ignore two of its great virtues. The first is the detail with which it retells the institutional circumstances and the forgotten intermediaries of the scholarly tradition. Behind the genealogy, around its borders, there stands Inglis’s enormous effort of original research, much of it archival. The genealogy’s second virtue is the dialectical subtlety with which it locates continuities under contradictions. Gilson is usually touted as the antithesis of De Wulf, and Kretzmann of Gilson. Inglis makes such antitheses seem superficial by comparing them with an abiding if tacit agreement about how medieval texts can be appropriated within modern philosophy. To seal the comparison, Inglis suggests in the book’s second part what a real antithesis to the Kleutgen-Stöckl model might be. He reconstructs, in his last two chapters, Thomas’s accounts of human knowledge and of theology’s relations to philosophy in opposition to that model’s prescriptions.No review can represent—or even adequately praise—the enormous learnedness of this book. Moreover, since the book already discusses so much, it must seem ungrateful to suggest that it ought to discuss anything else. Let me end then rather by posing two questions beyond the book’s end. First, does Inglis’s genealogy mean to suggest that the Kleutgen-Stöckl model is now chiefly received in English-speaking philosophy departments? I wonder, for example, how far Inglis might judge Alain de Libera’s Penser au Moyen Age (Paris: Éds. de Seuil, 1991) an alternative to that model. Certainly de Libera shows more self-consciousness about the culturally determined history behind our historiography. His emphasis on the thirteenth-century recovery... (shrink)

There is no question that the work of John Dewey has been invaluable with regard to theories of education. What has too often been neglected, however, is Dewey's work on the philosophy of science as it pertains specifically to science education.1 Although educators might well concede that children should be encouraged to be "philosophical" within the arts or humanities, most neglect or fail to heed Dewey's insights concerning the child as philosopher-scientist within the science classroom. Dewey recognized that children were (...) too often taught "science" while not learning "the scientific way of treating the familiar material of ordinary experience" (MW 9: 228). The view of science as a nonphilosophical, highly .. (shrink)

Within common mental health treatments there exists a paradox, in which personal agency over a problem appears to increase by disownership of the problem. I endeavor to explain this paradox and by doing so, shed light on the relationships among identity, psychopathology, and therapeutic agency. The work of the philosopher Harry Frankfurt, with emphasis on his concept of externality, is used as the model for unraveling the paradox of agency.

If libertarianism is true, then there is a sense in which agents have it within their power to bring it about that some world is actual. Against recent arguments for the incompatibility of divine foreknowledge and human freedom, I offer an account of power over the past which takes this implication of libertarianism into consideration. I argue that the resulting account is available to Ockhamists and that it is immune to recent criticisms of the notion of counterfactual power over the (...) past. But I contend that it is not an option for Molinists and that this fact leaves that position vulnerable to incompatibilist arguments. (shrink)

The newly proposed framework for non-addictive psychoactive substances postulated by Müller & Schumann (M&S) provides an interesting and plausible explanation for non-addictive drug use. However, with specific reference to the relevant behavioral addiction literature, this commentary argues that the model may unexpectedly hold utility not only for non-addictive use of drugs, but also for non-addictive use of other potentially addictive behaviors.

T'Challa, the Black Panther, wears many hats, both at home and abroad. He is the chieftain of the Panther Tribe, which makes him the spiritual leader of his people as well as the king of Wakanda and its head of state. One key aspect that separates virtue ethics from its rival moral theories, consequentialism and deontology, is its focus on character. Judgment, or what Aristotle called "practical wisdom", is the ability to decide how best to act on one's virtues in (...) a particular situation. When T'Challa believed that agents within the US government were helping to overthrow his own, he and the Dora Milaje drove a truck into a building and abducted a businessman involved in the operation. T'Challa's duties as an Avenger come into conflict with his role as king of Wakanda, but other conflicts result from his role as a spiritual leader, which he regards as more important. (shrink)

This book is an interpretation of the moral teaching of Thomas Aquinas's Summa of Theology. It argues that teaching on the virtues can only be understood by turning to the patterns of divine teaching in the incarnation and the sacraments. It presents this not only as Thomas's great originality in the Summa but also as his contribution to Christian thought in the present.

The issue of the dimensionality of materialism and postmaterialism, and their impact on key social and personal indicators, has been a hotly debated topic for decades. This study sought to achieve two goals to further our understanding of these constructs. First, it assessed whether an interactive materialism–postmaterialism conceptualization could be expanded to predict outcomes related to well-being. Second, the study extended the interactive model by using Richins’ three dimensions of materialism instead of the unidimensional construct utilized in previous studies. Results (...) indicated that the interactive model successfully predicted three different measures of well-being, specifically physical symptoms, stress, and subjective vitality. Results are discussed in terms of extending materialism–postmaterialism theory, both with respect to refining the materialism construct as well as its associations with new criterion variables. (shrink)

Superman has incredible powers and, luckily for us, he chooses to use them for good. But good intentions are not enough to actually do good with his powers—he must know what to do with them as well. The need for judgment is what brings all superheroes down to Earth, and what ultimately makes them relatable to their fans despite their fantastic abilities. Moral philosophy (or ethics) is the area of philosophy dealing with what we should do, what kind of people (...) we should be, and what kind of lives we should live. Despite his superpowers, Superman still confronts ethical dilemmas and still needs to use judgment to solve them. For him, however, the stakes are usually much higher than those the average person deals with. The weight of Superman’s choices is often like that of world leaders’ choices, potentially affecting millions of lives and the future of nations. (shrink)

Thomas Aquinas’s explanation of the (then new) doctrine of sacramental character can seem a crudely mechanical view of the causality of rites of church membership. It explains in fact the capacity and horizon for moral action in salvation history. Participation in the priesthood of Christ enables the believer to inhabit the pedagogy through which history is brought back to Trinitarian life. This sort of account, which is for Thomas the indispensable ground of moral theology, sounds archaic to many contemporary Christian (...) readers who nonetheless want to excerpt from Thomas particular ethical conclusions. They fail to appreciate the challenge posed by change in the deep categories of moral performance—a change nowhere more consequential or invisible than in contemporary debates over sexuality. (shrink)

Understanding arithmetic word problems involves a complex interaction of text comprehension and mathematical processes. This article presents a computer simulation designed to capture the working memory demands required in “bottomup” comprehension of arithmetic word problems. The simulation's sentence‐level parser and text integration component reflect the importance of processing the problem from its original natural language presentation. Children's probability of solution was analyzed in exploratory regression analyses as a function of the simulation's sentence‐level and text integration processes. Working memory variables measuring (...) the combined effects of concepts to remember and text integration inferences account for a significant proportion of variance in children's solution probabilities across the first four grade levels (K‐3). Consistent with previous results from others, which highlighted the significance of small changes in problem wording, the simulation offers a process‐oriented perspective as to why natural language presentation constrains the comprehension of mathematical relationships. (shrink)

An Argument From Evolutionary Naturalism An Argument from Personal Dignity References.

I argue in this article that there is a mistake in Searle's Chinese room argument that has not received sufficient attention. The mistake stems from Searle's use of the Church-Turing thesis. Searle assumes that the Church-Turing thesis licences the assumption that the Chinese room can run any program. I argue that it does not, and that this assumption is false. A number of possible objections are considered and rejected. My conclusion is that it is consistent with Searle's argument to hold (...) onto the claim that understanding consists in the running of a program. (shrink)

For more than 20 years, both here and abroad, significant efforts have been undertaken to provide equal access to nutritional food for all citizens. Yet, the numbers of under-nourished continue to rise, as do those afflicted with non-communicable diseases (NCDs) such as obesity, diabetes, hypertension, and heart disease. Clearly, current efforts are not working. Relying on the psychological phenomena of learned helplessness and fundamental attribution error, it is argued that certain individuals may not be willing, or able, to take actions (...) that are currently prescribed regarding access to nutritious food. The water is muddied regarding potential solutions as the various actors involved (e.g., corporations, governments, individuals) cannot agree on a starting point and continue to point fingers regarding responsibility. It is posited that emphasis needs to shift from the current “one-size-fits-all” approach to one that is more tailored to the various actors, specifically the individuals. Within the group of individuals (consumers), based on Wenar’s Least Cost Theory, even further distinction must be made between those who see themselves as capable actors and those who do not. In this conceptual piece intended to refocus the discussion surrounding food access, we propose that future research should approach these issues from a unit of analysis perspective in an attempt to identify the solutions most likely to succeed at various participating levels. (shrink)

This chapter provides a quick primer on the volumes of the comic titles Captain America and Avengers. It talks about the beginnings and endings of which usually coincide with major events in the Marvel Universe. The story starts with the first volume of Avengers, since it was in the classic issue #4 of that title that Captain America was found in a block of ice and revived. These long‐running volumes of Captain America and Avengers lasted until 1996. Both series ended (...) when the Avengers were apparently killed in a battle with the villainous Onslaught. After the Avengers vs. X‐Men event, Marvel Comics relaunched many of its books and introduced new ones. The Watcher only knows what volume Captain America and the various Avengers titles are on, but Cap will live in on comics, movies, and TV long after this book has changed the course of American history. (shrink)