The genetically manipulated organism crisis demonstrated that technological development based solely on the law of the marketplace and State protection against serious risks to health and safety is no longer a warrant of ethical acceptability. In the first part of our paper, we critique the implicitly individualist social-acceptance model for State regulation of technology and recommend an interdisciplinary approach for comprehensive analysis of the impacts and ethical acceptability of technologies. In the second part, we present a framework for the analysis (...) of impacts and acceptability, devised—with the goal of supporting the development of specific nanotechnological applications—by a team of researchers from various disciplines. At the conceptual level, this analytic framework is intended to make explicit those various operations required in preparing a judgement about the acceptability of technologies that have been implicit in the classical analysis of toxicological risk. On a practical level, we present a reflective tool that makes it possible to take into account all the dimensions involved and understand the reasons invoked in determining impacts, assessing them, and arriving at a judgement about acceptability. (shrink)

The in vitro spontaneous contractions of human myometrium samples can be described using a phenomenological model involving different cell states and adjustable parameters. In patients not receiving hormone treatment, the dynamic behavior could be described using a three-state model similar to the one we have already used to explain the oscillations of intra-uterine pressure during parturition. However, the shape of the spontaneous contractions of myometrium from patients on progestin treatment was different, due to a two-step relaxation regime including a latched (...) phase which cannot be simulated using the previous model without introducing an ad hoc mechanism to account for the extra energy involved in this sustained contraction. One way to do this is to introduce an anomalous rate of ATP consumption, the biochemical reasons for which have not yet been elucidated and which cannot be mathematically simulated using our experimental data. An alternative explanation is the reduced cycling rate of actin-myosin cross-bridges known to occur during the latch-phase. Our experimental findings suggest a third possibility, namely a sol-gel transition with a specific relaxation time constant, which would maintain a significant part of the cell population in the contracted-state until the intracellular-medium returns to its normal fluid behavior. (shrink)

Este artículo presenta los resultados de una investigación sobre el proceso de reparación de víctimas adelantado en varios municipios del Tolima, departamento que ha sido golpeado drásticamente por el conflicto armado. Siguiendo el modelo de trabajo realizado en Antioquia, en los municipios de Medellín y San Carlos, se tomaron en este caso los municipios de Ibagué, Prado, Coyaima, Totarco y Dinde, identificados como algunas de las principales zonas del país afectadas por la guerra. Se trabajó con doscientas cuarenta víctimas, mediante (...) grupos de discusión y entrevistas distribuidas en los municipios, con el fin de establecer la forma en que ellas perciben, interpretan y construyen los significados del proceso de reparación, respecto a cada componente que se establece en la ley 1448 de 2011. Los significados que han construido las víctimas frente a la reparación propuesta por el Estado señalan las implicaciones psicosociales y emocionales que el conflicto armado ha dejado en estas zonas del departamento. De esta manera, las acciones adelantas por el Gobierno Nacional, para la reparación integral, dejan en las víctimas una sensación de ineficacia y descuido. (shrink)

L’objectif de ce numéro spécial est d’ouvrir la réflexion sur la notion de vague à partir du prisme de la philosophie des sciences, afin d’interroger le sens de cette notion dans différents domaines de la recherche scientifique.

Le philosophe Charles Peirce a accordé un rôle prépondérant à la communauté des enquêteurs, à la fois comme groupe de chercheurs et comme idéal conduisant vers la vérité. Si Peirce parlait pour sa part de « théorie sociale de la réalité », les trois textes qui suivent – inédits en français, et en anglais pour le dernier – justifient d’y voir une véritable épistémologie sociale. Ils montrent dans quelle mesure la connaissance scientifique, et même commune, trouve son fondement dans (...) une composante nécessairement sociale. La rationalité probable n’a pas de sens à l’échelle individuelle (premier texte) ; la science est une entreprise collective (deuxième texte) ; et la vérité se définit en fonction de la communauté (troisième texte). (shrink)

A listing is given of the published writings of the logician and philosopher Hao Wang (1921—1995), which includes all items known to the authors, including writings in Chinese and translations into other languages.

The development of research ethics in the college environment raises specific concerns given the particularities of this environment. This study focuses on three priority issues for the college research ethics community: 1) the question of resources for ethics review by college network research ethics boards; 2) the review of multi-jurisdictional research projects; and 3) the review of student course-based research activities. In order to sound out this community on its concrete realities with regard to these issues, we carried out a (...) mixed real time Delphi study using the Surveylet platform, during which we engaged 31 panelists in dialogue over a total period of five weeks. This article presents the results of our statistical and thematic analysis of the responses obtained, the main consensuses and dissensus identified on the three issues, as well as possible solutions to overcome these issues inspired by the panelists’ proposals. (shrink)

"Aujourd'hui, la rationalité africaine, véritable socle pour le développement de l'Afrique, peut être systématisée et retransmise à l'humanité à travers l'école du savoir africain. Cette école est fondé sur les sources d'inspiration et de savoir chez l'Africain, puis sur l'initiation. Partant des cultures africaines et de la culture bassa en particulier, l'auteur a identifié et recensé des savoirs et des valeurs, qui peuvent être convertibles en base d'un développement économique authentique et multipolaire pour l'Afrique."--.

Building on their important findings in The Source of the River, the authors now probe even more deeply into minority underachievement at the college level. Taming the River examines the academic and social dynamics of different ethnic groups during the first two years of college. Focusing on racial differences in academic performance, the book identifies the causes of students' divergent grades and levels of personal satisfaction with their institutions. Using survey data collected from twenty-eight selective colleges and universities, Taming the (...) River considers all facets of student life, including who students date, what fields they major in, which sports they play, and how they perceive their own social and economic backgrounds. The book explores how black and Latino students experience pressures stemming from campus racial climate and "stereotype threat"--when students underperform because of anxieties tied to existing negative stereotypes. Describing the relationship between grade performance and stereotype threat, the book shows how this link is reinforced by institutional practices of affirmative action. The authors also indicate that when certain variables are controlled, minority students earn the same grades, express the same college satisfaction, and remain in school at the same rates as white students. A powerful look at how educational policies unfold in America's universities, Taming the River sheds light on the social and racial factors influencing student success. (shrink)

Speech act theory describes units of language as acts which function to change the behavior or beliefs of the partner. Therefore, with every utterance an individual seeks a communicative goal that is the underlying motive for the utterance’s production; this is the utterance’s function. Studies of deaf and hearing human children classify utterances into categories of communicative function. This study classified signing chimpanzees’ utterances into the categories used in human studies. The chimpanzees utilized all seven categories of communicative functions and (...) used them in ways that resembled human children. The chimpanzees’ utterances functioned to answer questions, request objects and actions, describe objects and events, make statements about internal states, accomplish tasks such as initiating games, protest interlocutor behavior, and as conversational devices to maintain and initiate conversation. (shrink)

Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to (...) genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED. (shrink)

Despite increased efforts to ensure diversity in genomic research, the exclusion of minority groups from data analyses and publications remains a critical issue. This paper addresses the ethical implications of these exclusions and proposes accountability for reasonableness (A4R) as a framework to promote fairness and equity in research. Originally conceived by Norman Daniels and James Sabin to guide resource allocation in the context of health policy, A4R emphasizes publicity, relevance of reasons, enforcement, and revision as essential for legitimacy and trust (...) in the decision‐making process. The authors argue that A4R is also relevant to resource allocation in research and that, if adequately informed and incentivized by funding agencies, institutional review boards, and scientific journals, researchers are well‐positioned to assess data‐selection justifications. The A4R framework provides a promising foundation for fostering accountability in genomics and other fields, including artificial intelligence, where lack of diversity and pervasive biases threaten equitable benefit sharing. (shrink)

It is largely acknowledged that natural languages emerge not just from human brains but also from rich communities of interacting human brains (Senghas, ). Yet the precise role of such communities and such interaction in the emergence of core properties of language has largely gone uninvestigated in naturally emerging systems, leaving the few existing computational investigations of this issue at an artificial setting. Here, we take a step toward investigating the precise role of community structure in the emergence of linguistic (...) conventions with both naturalistic empirical data and computational modeling. We first show conventionalization of lexicons in two different classes of naturally emerging signed systems: (a) protolinguistic “homesigns” invented by linguistically isolated Deaf individuals, and (b) a natural sign language emerging in a recently formed rich Deaf community. We find that the latter conventionalized faster than the former. Second, we model conventionalization as a population of interacting individuals who adjust their probability of sign use in response to other individuals' actual sign use, following an independently motivated model of language learning (Yang, , ). Simulations suggest that a richer social network, like that of natural (signed) languages, conventionalizes faster than a sparser social network, like that of homesign systems. We discuss our behavioral and computational results in light of other work on language emergence, and other work of behavior on complex networks. (shrink)

Whether or not conscious recollection in autobiographical memory is affected in schizophrenia is unknown. The aim of this study was to address this issue using an experiential approach. An autobiographical memory enquiry was used in combination with the Remember/Know procedure. Twenty-two patients with schizophrenia and 22 normal subjects were asked to recall specific autobiographical memories from four lifetime periods and to indicate the subjective states of awareness associated with the recall of what happened, when and where. They gave Remember, Know (...) or Guess responses according to whether they recalled these aspects of the event on the basis of conscious recollection, simply knowing, or guessing. Results showed that the frequency and consistency of Remember responses was significantly lower in patients than in comparison subjects. In contrast, the frequency of Know responses was not significantly different, whereas the frequency of patients’ Guess responses was significantly enhanced. It is concluded that the frequency and consistency of conscious recollection in autobiographical memory is reduced in patients with schizophrenia. (shrink)

A listing is given of the published writings of the logician and philosopher Hao Wang , which includes all items known to the authors, including writings in Chinese and translations into other languages.

This book has been considered by academicians and scholars of great significance and value to literature. This forms a part of the knowledge base for future generations. So that the book is never forgotten we have represented this book in a print format as the same form as it was originally first published. Hence any marks or annotations seen are left intentionally to preserve its true nature.

This volume presents fourteen essays by leading figures in the fields of ancient philosophy and contemporary metaphysics, discussing Aristotle's theory of the unity and identity of substances, a topic that remains at the center of metaphysical enquiry. The contributors examine the nature of essences, how they differ from other components of substance, and how they are related to these other components. The central questions discussed are: What does Aristotle mean by "potentiality" and "actuality?" How do these concepts explicate matter and (...) form, and how are they related to the actuality of a substance? What is the role of actuality in accounting for the unity and identity of substance? These questions are crucial to an understanding of the unity of composite substances and their identity over time. The aim of the volume is both exegetical and philosophical: to give answers to central problems in Aristotle's metaphysics, and also to stimulate further investigation of the problems defined and the controversies embodied. (shrink)

Police officers are vital to maintaining security and the continuity of national functions. Thus, Police officers are more exposed to different kinds of psychological concerns. However, a female in this kind of profession, based on various studies, experienced higher levels of stress because of other factors. Further, the primary goal of this study is to investigate the psychological well-being, lived experiences, challenges, and coping mechanisms of female police officers. Employing the Interpretative Phenomenological Analysis, the findings of this study were: (1) (...) Female police officers had conceptualized themselves as brave, flexible, and adaptive. And they cope with stress with positive thinking that results in healthy psychological well-being. (2) Female police officers showed dedication and engagement to serve the people. They even used their resources for the public and sacrificed most of their time in the office. (3) Female police officers' primary motivation to continue their careers is their families, and serving the public brings joy to them. (4) However, female police officers experience disrespect while working in the field, and they always have fear in their life as police officers. Moreover, they need more time to spend with their families. Furthermore, it is highly suggested to provide opportunities for enhancing quality time with their family, specifically with their children. (shrink)