Precision Medicine is driven by the idea that the rapidly increasing range of relatively cheap and efficient self-tracking devices make it feasible to collect multiple kinds of phenotypic data. Advocates of N = 1 research emphasize the countless opportunities personal data provide for optimizing individual health. At the same time, using biomarker data for lifestyle interventions has shown to entail complex challenges. In this paper, we argue that researchers in the field of precision medicine need to address the performative dimension (...) of collecting data. We propose the fun-house mirror as a metaphor for the use of personal health data; each health data source yields a particular type of image that can be regarded as a ‘data mirror’ that is by definition specific and skewed. This requires competence on the part of individuals to adequately interpret the images thus provided. (shrink)

Precision Medicine has become a common label for data-intensive and patient-driven biomedical research. Its intended future is reflected in endeavours such as the Precision Medicine Initiative in the USA. This article addresses the question whether it is possible to discern a new ‘medical cosmology’ in Precision Medicine, a concept that was developed by Nicholas Jewson to describe comprehensive transformations involving various dimensions of biomedical knowledge and practice, such as vocabularies, the roles of patients and physicians and the conceptualisation of disease. (...) Subsequently, I will elaborate my assessment of the features of Precision Medicine with the help of Michel Foucault, by exploring how precision medicine involves a transformation along three axes: the axis of biomedical knowledge, of biomedical power and of the patient as a self. Patients are encouraged to become the managers of their own health status, while the medical domain is reframed as a data-sharing community, characterised by changing power relationships between providers and patients, producers and consumers. While the emerging Precision Medicine cosmology may surpass existing knowledge frameworks; it obscures previous traditions and reduces research-subjects to mere data. This in turn, means that the individual is both subjected to the neoliberal demand to share personal information, and at the same time has acquired the positive ‘right’ to become a member of the data-sharing community. The subject has to constantly negotiate the meaning of his or her data, which can either enable self-expression, or function as a commanding Superego. (shrink)

Introduction Introducing Accessibility theory 0.1 On the role of context Utterances cannot be processed and interpreted on their own. ...

This document presents the Bonn PRINTEGER Consensus Statement: Working with Research Integrity—Guidance for research performing organisations. The aim of the statement is to complement existing instruments by focusing specifically on institutional responsibilities for strengthening integrity. It takes into account the daily challenges and organisational contexts of most researchers. The statement intends to make research integrity challenges recognisable from the work-floor perspective, providing concrete advice on organisational measures to strengthen integrity. The statement, which was concluded February 7th 2018, provides guidance on (...) the following key issues: § 1. Providing information about research integrity§ 2. Providing education, training and mentoring§ 3. Strengthening a research integrity culture§ 4. Facilitating open dialogue§ 5. Wise incentive management§ 6. Implementing quality assurance procedures§ 7. Improving the work environment and work satisfaction§ 8. Increasing transparency of misconduct cases§ 9. Opening up research§ 10. Implementing safe and effective whistle-blowing channels§ 11. Protecting the alleged perpetrators§ 12. Establishing a research integrity committee and appointing an ombudsperson§ 13. Making explicit the applicable standards for research integrity. (shrink)

“Postnatal depression” denotes the syndrome of dysphoria, debility, and anxiety that follows childbirth in about 10–20% of women (as variously estimated). Its etiology is seen to be lodged in a variety of psychosocial as well as biological factors, among which the isolating and pressured culture of contemporary society (especially for women/mothers) is commonly singled out as a powerful precipitator. This view is extended here through the evolutionary perspective which casts maternal distress as a set of adaptive responses with the function, (...) in ancestral environments, of soliciting support for a mother who feels that her maternal responsiveness may be threatened. As continuous caretaking of the infant is the active expression of evolved maternal responsiveness, departures from this pattern result in anxiety and distress that seek resolution. Manifestations of maternal distress in contemporary society are dysfunctional, however, since the present social structure does not provide spontaneous and immediate support that can spring forth within small, closely knit social units. Furthermore, for present-day mothers distress is self-perpetuating since the ingrained tendency toward continuing responsiveness rarely finds practical expression and is thus converted into anxious vigilance and depression. This view generates the hypothesis that the emotional and cognitive contents of maternal vigilance are associated with the needs of the infant and will therefore be focused on crying and feeding. A number of qualitative studies of women’s experiences during the postpartum bear out this prediction and support the feasibility of the evolutionary hypothesis of “postnatal depression” as a set of adaptive responses, now out of place in a novel environment. (shrink)

This new reading of Jean-Jacques Rousseau challenges traditional views of the eighteenth-century political philosopher's attitudes toward women and his perceived pessimism about human experience. Mira Morgenstern finds in Rousseau an appreciation of the complexities and multidimensionality of life that allowed him to criticize various easy dualisms promoted by his fellow liberal thinkers and point to the crucial mediating role that women fulfill between the private and public spheres. Morgenstern sees Rousseau as an important contributor to the feminist thoughts and (...) concerns that animate so much of our public and private discourse today. While Rousseau is commonly seen as a patriarchal misogynist, Morgenstern finds evidence in his writing that belies much of this claim. Rousseau was very much a man of his time, but he also believed that women were the key to transmitting his ideals of personal and political authenticity, thereby transforming his theory from ephemeral ideas into practical reality. A careful evaluation of Rousseau's writings on women reveals his highly complex sense of reality, especially his awareness that the solutions to life's complex problems are often temporary and must be renegotiated over time. Rousseau is more persistent than most in highlighting the weaknesses and pitfalls of liberal political thought, whose fundamental characteristic is its categorization of life on the basis of dualistic categories: public and private, outside and inside, male and female. Ultimately, what makes Rousseau worth reading today, argues Morgenstern, is his ability to illuminate critical weaknesses in the dualisms of liberal political theory and his pointing out, if only by implication, alternative ways of reaching the full measure of our individual and communal humanity. In honoring the traditional liberal emphasis on individual liberty and self-development, Rousseau’s meditations on the proper aim of political life are especially helpful to those today who seek ways to expand liberalism's promise of freedom and authenticity, while not losing sight of the common threads of meaning and community that continue to bind us together. (shrink)

La fraternidad nace en la experiencia sensible y se eleva luego a concepto racional. Radica ahí la dificultad de la aprehensión de su doble naturaleza, así como su eficacia política. Próxima a conceptos como amistad cívica, solidaridad o humanismo, se diferencia de todos ellos. Al analizar la fraternidad tal y como emerge a lo largo de la Revolución francesa a través de distintos autores en un contexto histórico político bien particular de crisis económica que se transmuta en revolución y cambio, (...) llegamos a la conclusión de que la fraternidad es una fuerza de acción colectiva que emerge en ese impás entre lo individual y lo colectivo que hace necesaria una restructuración del orden económico y político establecido. Por consiguiente, si aceptamos que el ser humano es un ser político, la fraternidad nos revela algo de la real naturaleza política, entendida más allá del simple pacto social, a saber: cuando el ser humano se apodera de la palabra, dirigida siempre al otro, conjugándola con la acción. (shrink)

Alfonso Monsalve Solórzano: Colombia: democracia y paz. Medellín, Fondo Editorial Universidad Pontificia Bolivariana, 1999, pp. 378.

Despite ever‐increasing accumulation of genomic data, the fundamental question of how individual genes are switched on during development, lineage‐specification and differentiation is not fully answered. It is widely accepted that this involves the interaction between at least three fundamental regulatory elements: enhancers, promoters and insulators. Enhancers contain transcription factor binding sites which are bound by transcription factors (TFs) and co‐factors expressed during cell fate decisions and maintain imposed patterns of activation, at least in part, via their epigenetic modification. This information (...) is transferred from enhancers to their cognate promoters often by coming into close physical proximity to form a ‘transcriptional hub’ containing a high concentration of TFs and co‐factors. The mechanisms underlying these stages of transcriptional activation are not fully explained. This review focuses on how enhancers and promoters are activated during differentiation and how multiple enhancers work together to regulate gene expression. We illustrate the currently understood principles of how mammalian enhancers work and how they may be perturbed in enhanceropathies using expression of the α‐globin gene cluster during erythropoiesis, as a model. (shrink)

_In _Diverse Families, Desirable Schools_, Mira Debs offers a richly detailed study of public Montessori schools, which make up the largest group of progressive schools in the public sector._ As public Montessori schools expand rapidly as alternatives to traditional public schools, the story of these schools, Debs points out, is a microcosm of the broader conflicts around public school choice. Drawing on historical research, interviews with public Montessori educators, and ethnographic case studies, Debs explores the forces that pull intentionally (...) diverse, progressive schools toward elitism. At the heart of Debs’s book is a thoughtful analysis of the notion of “fit” between parents and schools—an idea that is central to school choice, which is often marketed as an opportunity for parents to find the perfect fit for their kids. By exploring parents’ varied motivations in choosing these schools and observing how families experience—or fail to experience—a “good fit” _after_ having chosen a particular school, Debs makes an original contribution to the literature on school choice and sheds light on the dilemmas entailed in maintaining diversity in progressive charter and magnet schools. (shrink)

Inspired by the Enlightenment readings of Hebrew biblical texts generated in the seventeenth through the nineteenth centuries, Mira Morgenstern's _Reframing Politics in the Hebrew Bible_ goes beyond the pioneering interpretations of various biblical texts penned by such noted Bible students as Spinoza, Rousseau, and Angelina Grimké to present an introduction to the Hebrew Bible as a whole from the perspective of a modern-day political theorist. In doing so, it offers a brilliant thematic guide to the Hebrew Bible's most politically (...) salient passages, complete with text and commentary. Morgenstern's account of the significance of these ancient yet strangely modern texts will fascinate students of both ancient and modern political theory—as well as all readers of the Hebrew Bible itself. (shrink)

Authenticity has become one of the key ethics in contemporary society and culture. This research analyses the present ideals of authenticity in work-life, building on theories on post-secularization and new spiritualities, neoliberalism, and the concept of ideal worker deriving from organizational studies. Corporate mindfulness is looked at as a topical example of authenticity practices in current work-life. The research utilizes interview data was produced in a knowledge work organization that had launched its own mindfulness program and become part of the (...) wider workplace spirituality movement. The research question focused on what kind of discourses on authenticity are born when the organization simultaneously discourages full expressions of one’s personality as not being professional or adequate in work-life context, and roots for mindfulness, which hails for recognizing reality as it is, accepting oneself and finding authentic self. Using discourse analysis, four themes were found in data, each revealing a different discourse on authenticity. (shrink)

Comparative study of discipline in Theravada and Sarvastivada Buddhism.

What role should the political ideal of non-domination play in theorizing global justice? The importance of this ideal is defended most prominently in neo-republican political thought where non-domination embodies a conception of political freedom and serves as the foundational ideal of state citizenship [Pettit, Philip. 1997. Republicanism: A Theory of Freedom and Government. Oxford: Clarendon Press; Laborde, Cecile. 2008. Critical Republicanism. Oxford, New York: Oxford University Press]. It has been argued, however, that these theories can be extended to the global (...) political community and yield a separate framework for global justice. This paper agrees with proponents of non-domination that there is a significant critical and normative potential in the ideal's capacity to speak to the structural inequalities of power in the global order and to make them central, in a way that not only encompasses but also moves beyond questions of redistribution. Yet it argues that this should be conceived as a complement to existing approaches to global justice, rather than a full-fledged alternative. Non-domination's central contribution lies in reframing our perspective on the political authority of states and global institutions. As such it should be viewed as a freestanding principle to assess the political legitimacy of institutionalized global power relations. (shrink)

ABSTRACT: BACKGROUND: The governments and citizens of the developed nations are increasingly called upon to contribute financially to health initiatives outside their borders. Although international development assistance for health has grown rapidly over the last two decades, austerity measures related to the 2008 and 2011 global financial crises may impact negatively on aid expenditures. The competition between national priorities and foreign aid commitments raises important ethical questions for donor nations. This paper aims to foster individual reflection and public debate on (...) donor responsibilities for global health. METHODS: We undertook a critical review of contemporary accounts of justice. We selected theories that: (i) articulate important and widely held moral intuitions; (ii) have had extensive impact on debates about global justice; (iii) represent diverse approaches to moral reasoning; and (iv) present distinct stances on the normative importance of national borders. Due to space limitations we limit the discussion to four frameworks. RESULTS: Consequentialist, relational, human rights, and social contract approaches were considered. Responsibilities to provide international assistance were seen as significant by all four theories and place limits on the scope of acceptable national autonomy. Among the range of potential aid foci, interventions for health enjoyed consistent prominence. The four theories concur that there are important ethical responsibilities to support initiatives to improve the health of the worst off worldwide, but offer different rationales for intervention and suggest different implicit limits on responsibilities. CONCLUSIONS: Despite significant theoretical disagreements, four influential accounts of justice offer important reasons to support many current initiatives to promote global health. Ethical argumentation can complement pragmatic reasons to support global health interventions and provide an important foundation to strengthen collective action. (shrink)

Replacements for corporate farm managers are increasingly hard to find. At the same time, there is a large pool of potential managers that has been hardly tapped into: young female professionals. Focusing on the supply side of the labor market for farm managers, we investigate how gender-specific life aspirations impact occupational intention. To explain gender-specific occupational intention, we operationalize two conceptual frameworks: a behavioral economic conceptualization that focuses on the material and non-material cost and benefits associated with occupational choice, and (...) a psychological conceptualization based on the theory of planned behavior. Our analysis of survey data among agricultural students shows that participating women are less inclined to pursue a farm manager position than participating men for two main reasons: first, they expect less internal benefits from such a position. Second, they believe to be less suited to meet the professional requirements. (shrink)

De un tiempo a la actualidad el denominado modelo chileno se encuentra en jaque. Las exigencias de la sociedad civil chilena se vuelven palpables por las calles de nuestro país. La molestia y, por consiguiente, protesta social, ha tomado cada vez más fuerza y adhesión entre quienes no se sienten representados en lo más mínimo ni por el Estado ni por la clase política, generando como resultado diferentes frentes de conflictividad, tales como activistas ecológicos, trabajadores del cobre, estudiantes secundarios y (...) universitarios, profesores y el pueblo mapuche entre otros, que han desembocado en la amplia impopularidad y rechazo del ahora Presidente de Chile, Sebastián Piñera. No obstante, la dicotomía generada es interesante. Mientras en el foro interno del país se sucede una histórica protesta social de proporciones por la amplia brecha de desigualdad, éste refleja una pujante economía, cuyos indicadores macroeconómicos lo muestran como los mejores de América Latina. (shrink)

El objetivo de este trabajo es analizar las diversas manifestaciones de transgresión que tienen su origen en los últimos años de la década de los 70 y en los 80 en España, y su reflejo en los estereotipos de género. Desde las actitudes libertarias, pasando por la superwoman como modelo de mujer emancipada, hasta los nuevos modelos de maternidad intensiva que comienzan a introducirse a finales de los ochenta, la transgresión se ha manifestado de diversas formas durante este periodo en (...) el que las españolas a duras penas lograron superar el modelo tradicional impuesto por el franquismo. En este contexto, la transgresión se manifestó como un fenómeno superficial, inherente al momento sociopolítico y vaciada de un contenido reivindicativo. (shrink)

In his works for a few decades since the 1960s, Theodore Roszak, professor of California State University, has made an emphatic call to rethink all the fundamental objectives and values of the techno-scientific civilization and consumer society. His name became famous when he published his book “The Making of a Counterculture. Reflections on the Technotronic Society and Its Youthful Opposition” (New York, 1968), supporting the oppositional movement of the young Americans which he named counterculture. Theodore Roszak came to the conclusion (...) that the consumer society did not bring happiness to all people, that it could rapidly bring mankind to an environmental disaster, and that it is a blind alley in terms of social development. (shrink)