BackgroundThe preferable position of Deep Brain Stimulation electrodes is proposed to be located in the dorsolateral subthalamic nucleus to improve general motor performance. The optimal DBS electrode localization for the post-operative improvement of balance and gait is unknown.MethodsIn this single-center, retrospective analyses, 66 Parkinson’s disease patients were assessed pre- and post-operatively by using MDS-UPDRS, freezing of gait score, Giladi’s gait and falls questionnaire and Berg balance scale. The clinical outcome was related to the DBS electrode coordinates in x, y, z (...) plane as revealed by image-based reconstruction. Binomial generalized linear mixed models with fixed-effect variables electrode asymmetry, parkinsonian subtype, medication, age class and clinical DBS induced changes were analyzed.ResultsSubthalamic nucleus-deep brain stimulation improved all motor, balance and FoG scores in MED OFF condition, however there were heterogeneous results in MED ON condition. DBS electrode reconstructed coordinates impacted the responsiveness of axial symptoms. FoG and balance responders showed slightly more medially located STN electrode coordinates and less medio-lateral asymmetry of the electrode reconstructed coordinates across hemispheres compared to non-responders.ConclusionDeep brain stimulation electrode reconstructed coordinates, particularly electrode asymmetry on the medio-lateral axis affected the post-operative responsiveness of balance and FoG symptoms in PD patients. (shrink)

This article investigates the potential of fMRI to test assumptions about different components in models of complex cognitive tasks. If the components of a model can be associated with specific brain regions, one can make predictions for the temporal course of the BOLD response in these regions. An event‐locked procedure is described for dealing with temporal variability and bringing model runs and individual data trials into alignment. Statistical methods for testing the model are described that deal with the scan‐to‐scan correlations (...) in the errors of measurement of the BOLD signal. This approach is illustrated using a “sacrificial” ACT‐R model that involves mapping 6 modules onto 6 brain regions in an experiment from concerned with equation solving. The model's visual encoding predicted the BOLD response in the fusiform gyrus, its controlled retrieval predicted the BOLD response in the lateral inferior prefrontal cortex, and its subgoal setting predicted the BOLD response in the anterior cingulate cortex. On the other hand, its motor programming failed to predict anticipatory activation in the motor cortex, its representational changes failed to predicted the pattern of activity in the posterior parietal cortex, and its procedural component failed to predict an initial spike in caudate. The results illustrate the power of such data to direct the development of a theory of complex problem solving, both at the level of a specific task model as well as at the level of the cognitive architecture. (shrink)

The new Coronavirus (COVID-19) has been declared a global pandemic by the World Health Organization (WHO). The sudden outbreak of this new virus and the measure of lockdown adopted to contain the epidemic have profoundly changed the lifestyles of the Italian population, with an impact on people’s quality of life and on their social relationships. In particular, due to forced and prolonged cohabitation, couples may be subject to specific stressors during the epidemic. In addition, living with a chronic health condition (...) may add specific challenges to the ones posed by the epidemic itself. The present cross-sectional study aimed to provide a picture of the challenges as well as the resources for both individual and relational well-being of Italian individuals in a couple relationship (N= 1921), with a specific attention to the comparison between individuals living with and without a chronic disease. Results showed that people with a chronic disease had lower psychological well-being and more fears and worries about the COVID-19. People with a chronic disease perceived fewer resources than healthy people. Moreover, the challenges are shown to be associated with less psychological well-being and high pessimism about the future. Instead individual, relational, and social resources play a protective role during the pandemic for both healthy and chronically ill people. (shrink)

Background Record linkage is a useful tool for health research. Potential benefits aside, its use raises discussions on privacy issues, such as whether a written informed consent for access to health records and linkage should be obtained. The authors aim to systematically review studies that assess consent proportions to record linkage. Methods 8 databases were searched up to June 2011 to find articles which presented consent proportions to record linkage. The screening, eligibility and inclusion of articles were conducted by two (...) independent reviewers. The authors carried out meta-regression, subgroup and sensitivity analyses to assess heterogeneity. Results Of the 141 studies identified, only 11 presented empirical consent proportions and were included in the systematic review. The consent proportion varied widely from 39% to 97%. Seven studies presented consent proportions of 88% or higher, one of 72%, and only three presented consented proportion equal to or lower than 53%. None of the studies' characteristics evaluated explained heterogeneity. Conclusion The results of this review show that, in general, individuals tend to consent to the use of their data for record linkage, with exceptions in specific populations or minorities. The authors believe that this, as well as the cited literature, lends support to policies that, while keeping relevant ethical controls in place, do not require individual informed consent for each and every study that relies on secondary data. (shrink)

Social scientists regularly make use of multivariate models to describe complex social phenomena. It is argued that this approach is useful for modelling the variety of cognitive and social factors contributing to scientific change, and superior to the integrated models of scientific change currently available. It is also argued that care needs to be taken in drawing normative conclusions: cognitive factors are not instrinsically more "rational" than social factors, nor is it likely that social factors, by some "invisible hand of (...) reason," generally work to produce scientific success. A multivariate model of the biasing factors within a scientific community at particular times is developed. This model, which is an example of work in social epistemology, yields normative conclusions. (shrink)

This volume offers a collection of nine case studies from clinical social workers in K-12 schools, each from a phenomenological perspective, with the objective of educating Master of Social Work students and early career social work clinicians. Each chapter is framed with pre-reading prompts, reading comprehension questions, and writing assignments. This casebook provides a resource for understanding the range of practice in school social work as well as some of the challenges that school social workers face in today's complex world. (...) Using a phenomenological perspective the contributors stay close to the lived experience of students, teachers, parents, and social workers, revealing a deeper and more nuanced understanding of the genesis and treatment of students' problems in school. (shrink)

Ruim tweehonderd jaar geleden riep de Duitse filosoof Immanuel Kant de mens op zich te bevrijden van dogma's en slaafse volgzaamheid, van de macht van de kerk en van de macht der gewoonte. De ware Verlichting is volgens hem "het uittreden van de mens uit de onmondigheid waaraan hij zelf schuldig is". Filosoof Miriam Rasch vraagt zich af hoe dit moet, autonoom zijn in een tijd waarin Facebook beweert je beter te kennen dan je eigen moeder. Ze zoekt een (...) antwoord op de vraag of wij onszelf nog wel autonoom kunnen maken, en of we dit zouden moeten willen. Want wat is er eigenlijk zo erg aan algoritmes die beter weten dan wijzelf wat goed voor ons is? En is autonomie niet een verkapte vorm van egoïsme? Rasch zoekt scherp, open en geestig naar antwoorden op vragen die je niet durft te stellen omdat een ander dat vast beter kan. En zo gidst zij zichzelf en jou naar de overtuiging dat je in control bent."---Publisher information. (shrink)

The question of whether it is ever permissible to believe on insufficient evidence has once again become a live question. Greater attention is now being paid to practical dimensions of belief, namely issues related to epistemic virtue, doxastic responsibility, and voluntarism. In this book, McCormick argues that the standards used to evaluate beliefs are not isolated from other evaluative domains. The ultimate criteria for assessing beliefs are the same as those for assessing action because beliefs and actions are both products (...) of agency. Two important implications of this thesis, both of which deviate from the dominant view in contemporary philosophy, are 1) it can be permissible to believe for non-evidential reasons, and 2) we have a robust control over many of our beliefs, a control sufficient to ground attributions of responsibility for belief. (shrink)

How is medical knowledge made? There have been radical changes in recent decades, through new methods such as consensus conferences, evidence-based medicine, translational medicine, and narrative medicine. Miriam Solomon explores their origins, aims, and epistemic strengths and weaknesses; and she offers a pluralistic approach for the future.

PurposeThe paper's aim is to point out trends in scholarly communication – both some of the main advantages and the yet unsolved problems that technology – swift communication lines, digitalization and the web – brought into one of the most important activities of academic life: the reading – writing – publishing cycle.Design/methodology/approachThe different stages, which eventually give birth to a scientific paper, are described here as thinking – – reading – writing – publishing, and analyzed from handwritten to print to (...) digital texts, with an emphasis on the revolutionary changes that scholarly publishing is experiencing.FindingsThanks to computerization, hypertext and the web, academic life enjoys swift and effortless communication, ease of writing, rapid publishing, almost unlimited access, but there are several uncalled for developments as well.Originality/valueThe new technologies lack a convenient way of writing‐while‐reading, enhance plagiarism, eliminate traditional archiving methods without offering a satisfactory new substitute and give rise to a call for a revised way of citation, together with new ways of archiving and storing. (shrink)

New research demonstrates that mechanics can serve as a means of information propagation in developing embryos. Historically, the study of embryonic development has had a dichotomy between morphogens and pattern formation on the one hand and morphogenesis and mechanics on the other. Secreted signals are the preeminent means of information propagation between cells and used to control cell fate, while physical forces act downstream or in parallel to shape tissue morphogenesis. However, recent work has blurred this division of function by (...) demonstrating that mechanics can serve as a means of information propagation. Adhesive or repulsive interactions can propagate through a tissue as a wave. These waves are rapid and directional and can be used to control the flux of cells through a developmental trajectory. Here, two examples are reviewed in which mechanics both guides and mediates morphogenesis and two examples in which mechanics intertwines with morphogens to regulate cell fate. (shrink)

Many studies show a developmental advantage for transitive sentences with familiar verbs over those with novel verbs. It might be that once familiar verbs become entrenched in particular constructions, they would be more difficult to understand (than would novel verbs) in non-prototypical constructions. We provide support for this hypothesis investigating German children using a forced-choice pointing paradigm with reversed agent-patient roles. We tested active transitive verbs in study 1. The 2-year olds were better with familiar than novel verbs, while the (...) 2½-year olds pointed correctly for both. In study 2, we tested passives: 2½-year olds were significantly below chance for familiar verbs and at chance for novel verbs, supporting the hypothesis that the entrenchment of the familiar verbs in the active transitive voice was interfering with interpreting them in the passive voice construction. The 3½-year olds were also at chance for novel verbs but above chance with familiar verbs. We interpret this as reflecting a lessening of the verb-in-construction entrenchment as the child develops knowledge that particular verbs can occur in a range of constructions. The 4½-year olds were above chance for both familiar and novel verbs. We discuss our findings in terms of the relative entrenchment of lexical and syntactic information and to interference between them. (shrink)

For the last forty years, two claims have been at the core of disputes about scientific change: that scientists reason rationally and that science is progressive. For most of this time discussions were polarized between philosophers, who defended traditional Enlightenment ideas about rationality and progress, and sociologists, who espoused relativism and constructivism. Recently, creative new ideas going beyond the polarized positions have come from the history of science, feminist criticism of science, psychology of science, and anthropology of science. Addressing the (...) traditional arguments as well as building on these new ideas, Miriam Solomon constructs a new epistemology of science. After discussions of the nature of empirical success and its relation to truth, Solomon offers a new, social account of scientific rationality. She shows that the pursuit of empirical success and truth can be consistent with both dissent and consensus, and that the distinction between dissent and consensus is of little epistemic significance. In building this social epistemology of science, she shows that scientific communities are not merely the locus of distributed expert knowledge and a resource for criticism but also the site of distributed decision making. Throughout, she illustrates her ideas with case studies from late-nineteenth- and twentieth-century physical and life sciences. Replacing the traditional focus on methods and heuristics to be applied by individual scientists, Solomon emphasizes science funding, administration, and policy. One of her goals is to have a positive influence on scientific decision making through practical social recommendations. (shrink)

In this paper, I begin by defending permissivism: the claim that, sometimes, there is more than one way to rationally respond to a given body of evidence. Then I argue that, if we accept permissivism, certain worries that arise as a result of learning that our beliefs were caused by the communities we grew up in, the schools we went to, or other irrelevant influences dissipate. The basic strategy is as follows: First, I try to pinpoint what makes irrelevant influences (...) worrying and I come up with two candidate principles. I then argue that one principle should be rejected because it is inconsistent with permissivism. The principle we should accept implies that it is sometimes rational to maintain our beliefs, even upon learning that they were caused by irrelevant influences. (shrink)

I investigate what we mean when we hold people responsible for beliefs. I begin by outlining a puzzle concerning our ordinary judgments about beliefs and briefly survey and critique some common responses to the puzzle. I then present my response where I argue a sense needs to be articulated in which we do have a kind of control over our beliefs if our practice of attributing responsibility for beliefs is appropriate. In developing this notion of doxastic control, I draw from (...) John Fischer's discussions of “guidance control”. A central feature of this kind of control is the idea of “ownership”. I argue that we can own our beliefs and that we expect each other to do so. We take responsibility for our beliefs and taking responsibility includes taking control of them. I end by considering objections to my view as well as some implications of it. (shrink)

The Queen's College, Oxford, UK In his article `Facts and Principles', G.A. Cohen attempts to refute constructivist approaches to justification by showing that, contrary to what their proponents claim, fundamental normative principles are fact- in sensitive. We argue that Cohen's `fact-insensitivity thesis' does not provide a successful refutation of constructivism because it pertains to an area of meta-ethics which differs from the one tackled by constructivists. While Cohen's thesis concerns the logical structure of normative principles, constructivists ask how normative principles (...) should be justified . In particular, their claim that justified fundamental normative principles are fact-sensitive follows from a commitment to agnosticism about the existence of objective moral facts. We therefore conclude that, in order to refute constructivism, Cohen would have to address questions of justification, and take a stand on those long-standing meta-ethical debates about the ontological status of moral notions (for example, realism versus anti-realism) with respect to which he himself wants to remain agnostic. Key Words: John Rawls • normative justification • realism versus anti-realism • methodological versus substantive principles. (shrink)

The American Journal of Bioethics, Volume 11, Issue 8, Page 50-52, August 2011.

Dictionaries have long been seen as an essential contribution by linguists to work on endangered languages. We report on preliminary investigations of actual dictionary usage and usability by 76 speakers, semi-speakers and learners of Australian Aboriginal languages. The dictionaries include: electronic and printed bilingual Warlpiri-English dictionaries, a printed trilingual Alawa-Kriol- English dictionary, and a printed bilingual Warumungu-English dictionary. We examine competing demands for completeness of coverage and ease of access, and focus on the prospects of electronic dictionaries for solving many (...) traditional problems, based in particular on observations on the usability of a prototype interface developed in our project. The flexibility of computer interfaces can help accommodate different needs including those of speakers with emerging literacy skills, but they are not useful in communities where computer access is generally unavailable. (shrink)

These studies of Catholic higher education reflect the current passion for self-examination and self-criticism through social surveys in the United States. The main terms of reference are the American norms which claim to be religiously neutral; the treatment of the problems confronting Catholic education solely in the context of American society, is reflected in the absence of references in the footnotes or bibliographies to the relevant European literature. The main focus is on the shape and quality of undergraduate education, though (...) the research findings and the issues discussed have implications for the whole range of Catholic education from parochial primary schools to research-centred schools of graduate studies. Most of the research projects on which the conclusions are based were designed in the late ‘fifties and reflect that era’s preoccupation with the nature of the Authoritarian Personality and the relationship between closed minds and firmly held belief-systems, a preoccupation to which the ‘brain washing’ techniques used in Korea and the power of MacCarthyism doubtless contributed. In Catholic circles Monsignor Tracy Ellis’s criticism of the poor standard of scholarship within the colleges and the poverty of the Catholic contribution to American intellectual life made a remarkable impact. (shrink)

This book summarizes the intense research that the author performed for his Ph.D. thesis , revised and with the addition of an intuitionistic critique of Husserl's concept of number. His starting point consisted of a double conviction: 1) Brouwerian intuitionism is a valid way of doing mathematics but is grounded on a weak philosophy; 2) Husserlian phenomenology can provide a suitable philosophical ground for intuitionism. In order to let intuitionism and phenomenology match, he had to solve in general two problems: (...) 1) the question of the reciprocal indifference that the authors had toward each other's theorizing which indeed they knew; 2) Husserl's general attitude of accepting classical mathematics, which contrasts with the critical attitude of the intuitionists.Moreover, in the specific case focused on by this book—concerning choice sequences, that is, sequences that can be completely lawless and that were admitted as mathematical entities by Brouwer—van Atten had to handle a further problem: such sequences do not fit the characteristic of omnitemporality that the late Husserl seemed to consider a necessary attribute of entities if they were to be considered mathematical. In as far as they are lawless we cannot predict at any moment how they will develop in the future, hence they are not determined at any particular time—they will be determined only in the future.Let us begin with van Atten's first conviction, i.e., that Brouwerian intuitionism is grounded on a weak philosophy. We have to recall that Brouwer provided a mystical attitude for proposing his intuitionism: man can obtain happiness only by keeping himself closed inside the inner Self. Any attempted movement towards the exterior world is a source of pain: in particular language and the sciences. Mathematics, in order to be morally acceptable …. (shrink)

The publishing industry has a variety of gatekeepers that play a role in deciding which works become books. This article acknowledges the main gatekeepers as the agent and publishers, but also draws attention to the author, who is the first gatekeeper, and the reader, who is the last. The connections between gatekeepers highlight the role of power in these positions. Using Foucault’s theories of archaeology and genealogy, this article argues that positions within the industry provide space for the gatekeepers to (...) say what works deserve to be published. In doing so it highlights the dynamic flow of power, which rises from the bottom and provides a hierarchical structure within the industry. (shrink)

Die Studie "Leonardos Bart" liefert erstmals aus kunsthistorisch-interdisziplinärer Perspektive umfassend und systematisch Einblick in die Sozialfigur des Künstler-Philosophen, die sie in den Selbstformungen frühneuzeitlicher Künstler findet. Dabei sind es antike Größen wie Sokrates und Aristoteles, die von Künstlern wie Leonardo da Vinci und Michelangelo Buonarroti als Vorbilder einer Annäherung gewählt werden. Der Band dient gleichermaßen als Nachschlagewerk für (Selbst-)Darstellungen Leonardos und Michelangelos in Bild und Text. Für diese Übersicht bewegt sich die Analyse zwischen Kunstgeschichte, Philosophie, Literaturwissenschaft und Klassischer Archäologie.

The thought of the ancient atomists about the activity of the soul in the body is an important chapter in the history of reflection on the soul in ancient philosophy. A review of testimonies and fragments attributed to Democritus of Abdera shows its singular conception of the soul as a complex network of transactions through which it exercises, inside compound bodies, its role in driving principle of beings animated. These texts show the tension and dynamism that characterize the activity of (...) the soul and especially the close relationship between the activities of perceiving and thinking, essential activities to the economy of living beings, now for what is the management of biological life, now in terms of knowledge and human action. What we propose here is to examine how Democritus conceived the activity of the soul in its complexity and the various operations through which it accomplishes its function in the animation and the maintenance of life of animate beings, and particularly of human life. To do this, we will take as a basis the testimonies referred to the nature of the soul – especially the testimony of Aristotle and his disciples and commentators – and then examine the activities through which proceeds its role of motor principle, namely the sensations and the intellection. And, finally, we intend to demonstrate that these operations should not be considered, in the context of atomist thought, as two independent and opposed faculties or activities, but as two different levels or degree, contiguous and complementary, of one and the same activity. (shrink)

The author argues that both Maine & Holmes were overly influenced by others, which prevented both of their works from being as significant as they could have been.

Evidence-Based Medicine (EBM) developed from the work of clinical epidemiologists at McMaster University and Oxford University in the 1970s and 1980s and self-consciously presented itself as a "new paradigm" called "evidence-based medicine" in the early 1990s. The techniques of the randomized controlled trial, systematic review and meta-analysis have produced an extensive and powerful body of research. They have also generated a critical literature that raises general concerns about its methods. This paper is a systematic review of the critical literature. It (...) finds the description of EBM as a Kuhnian paradigm helpful and worth taking further. Three kinds of criticism are evaluated in detail: criticisms of procedural aspects of EBM (especially from Cartwright, Worrall and Howick), data showing the greater than expected fallibility of EBM (Ioaanidis and others), and concerns that EBM is incomplete as a philosophy of science (Ashcroft and others). The paper recommends a more instrumental or pragmatic approach to EBM, in which any ranking of evidence is done by reference to the actual, rather than the theoretically expected, reliability of results. Emphasis on EBM has eclipsed other necessary research methods in medicine. With the recent emphasis on translational medicine, we are seeing a restoration of the recognition that clinical research requires an engagement with basic theory (e.g. physiological, genetic, biochemical) and a range of empirical techniques such as bedside observation, laboratory and animal studies. EBM works best when used in this context. (shrink)