This paper draws from critical data studies and related fields to investigate police officer-involved homicide data for Los Angeles County. We frame police officer-involved homicide data as a rhetorical tool that can reify certain assumptions about the world and extend regimes of power. We highlight the possibility that this type of sensitive civic data can be investigated and employed within local communities through creative practice. Community involvement with data can create a countervailing force to powerful dominant narratives and supplement activist (...) projects that hold local officials accountable for their actions. Our analysis examines four Los Angeles County police officer-involved homicide data sets. First, we provide accounts of the semantics, granularity, scale and transparency of this local data. Then, we describe a “counter data action,” an event that invited members of the community to identify the limits and challenges present in police officer-involved homicide data and to propose new methods for deriving meaning from these indicators and statistics. (shrink)

A boat is a floating piece of space, a place without place, which lives by itself, which is closed in on itself and that is at the same time exposed to the infinity of the sea. Nowadays one cannot conceive a utopia that does not address itself to nomads, peoples and individuals, to the homeless, to the excluded. After World War I a concrete barge made its way up and down the Seine between Rouen and Paris.1 It was called (...) the Liège, and its mission was to supply the French capital with English coal. When it was decommissioned in 1929, the Armée du salut (the French Salvation Army) bought it with the aid of a donation from Madeleine Zillhardt, the recently bereaved long-term companion of the painter .. (shrink)

Enjeu de pouvoir et reflet de controverses sur le rôle et la finalité de l’entreprise, l’intérêt social a fait son entrée dans le code civil, de manière éclatante, à la faveur de la « loi PACTE ». Contrairement à l’idée répandue selon laquelle cette consécration législative ne serait qu’une formalisation – à droit constant – de la jurisprudence, il est soutenu ici que le législateur a affirmé pour la première fois, bien qu’implicitement, une conception inédite, élargie, de l’intérêt social. En (...) imposant une obligation de gérer la société conformément à son intérêt social en prenant en considération les enjeux sociaux et environnementaux liés à son activité, l’article 1833 alinéa 2 du code civil recèle cependant une ambiguïté fondamentale : le législateur a entendu faire des enjeux sociaux et environnementaux une composante de l’intérêt social, tout en exigeant qu’ils soient simplement « pris en considération ». Cet apparent paradoxe traduit en réalité un nouveau modèle normatif. Contournant l’obstacle qui aurait consisté – aux prix d’une insécurité juridique majeure – à imposer directement aux sociétés de se conformer à des enjeux sociaux et environnementaux indéterminés, le législateur a érigé une obligation de réflexion et de délibération sur ces enjeux au cours du processus de décision sociale, faisant le pari que cet impératif procédural modifiera l’agir pratique des acteurs concernés. Ce nouveau modèle normatif traduit une conception renouvelée du rôle et de la finalité de l’entreprise sociétaire, expressément dépositaire d’une certaine conception de l’intérêt général. (shrink)

Le Tchouang-tseu est un des plus grands ouvrages du taoïsme et comme tous les grands livres, il appelle à lui des herméneutes. Sa qualité est d’abord d’offrir au lecteur une infinité d’angles par lesquels se révèle la vérité, décourageant du même coup les interprètes tentés d’en offrir une compréhension finale et systématique. Son sens, pourrait-on dire, se dérobe à nous comme un train file dans la nuit et Jean Levi, en bon sinologue, demeure attentif à cet aspect du taoïsme dit (...) « philosophiq.. (shrink)

In 1880 Spyridon Lambros discovered in the library of the Dionysiou monastery on Mount Athos a manuscript containing, among other things, the missing second book of a compilation of zoological lore made for the emperor Constantine VII Porphyrogennetos , generally referred to as the Sylloge Constantini. The first book, already known from a manuscript in Paris, proclaims in its heading that the compilation was based on the epitome of Aristotle's περ ζων by Aristophanes of Byzantium, with supplements from the (...) writings of Aelian, Timotheos and others. These supplements are found exclusively in the second book, which Lambros edited, along with the first, for the Supplementum Aristotelicum. They add greatly to our knowledge of the περ ζων by the fifth-century grammarian Timotheos of Gaza, a work hitherto known only from the so-called Epitome Augustana, a selection of 53 unconnected chapters made in the reign of Constantine IX Monomachos. (shrink)

Over the last decade, businesses, policymakers, and researchers alike have advocated the need for value creation through inter-organizational collaboration. Researchers have widely argued that organizations that are engaged in collaborative processes create value. Because researchers have tended to focus on the identification of organizational motivations and on key success factors for collaboration, however, both the nature and processes of value creation in inter-organizational collaboration have yet to be examined. A recent theory by Austin and Seitanidi :726–758, 2012a; Nonprofit Volunt Sect (...) Q 41:929–968, 2012b) has proposed an analytical framework for analyzing value creation in inter-organizational collaboration, based on four types of value. The purpose of this current study is to empirically test this framework, and to provide key pointers for analyzing the nature of value, particularly in relation to learning. Our detailed empirical research is based on a 6-year retrospective case study of an inter-organizational partnership within an international development project for local economic development in Guatemala. The study’s contributions are twofold. First, it provides evidence of the critical path of the creation of diverse types of values in a collaborative process; second, it links the different types of value creation with the types of learning that occur in an inter-organizational process. (shrink)

Over the last decade, businesses, policymakers, and researchers alike have advocated the need for value creation through inter-organizational collaboration. Researchers have widely argued that organizations that are engaged in collaborative processes create value. Because researchers have tended to focus on the identification of organizational motivations and on key success factors for collaboration, however, both the nature and processes of value creation in inter-organizational collaboration have yet to be examined. A recent theory by Austin and Seitanidi :726–758, 2012a; Nonprofit Volunt Sect (...) Q 41:929–968, 2012b) has proposed an analytical framework for analyzing value creation in inter-organizational collaboration, based on four types of value. The purpose of this current study is to empirically test this framework, and to provide key pointers for analyzing the nature of value, particularly in relation to learning. Our detailed empirical research is based on a 6-year retrospective case study of an inter-organizational partnership within an international development project for local economic development in Guatemala. The study’s contributions are twofold. First, it provides evidence of the critical path of the creation of diverse types of values in a collaborative process; second, it links the different types of value creation with the types of learning that occur in an inter-organizational process. (shrink)

While Dicer plays an important antiviral role through the RNAi pathway in plants and invertebrates, its contribution to antiviral immunity in vertebrates and more specifically mammals is more controversial. The apparent limited RNAi activity in mammalian cells has been attributed to the reduced long dsRNA processive activity of mammalian Dicer, as well as a functional incompatibility between the RNAi and IFN pathways. Why Dicer has lost this antiviral activity in the profit of the IFN pathway is still unclear. We propose (...) that the primary direct antiviral activity of Dicer has been functionally replaced by other sensors in the IFN pathway, leading to its specialization toward microRNA maturation. As a result, Dicer can regulate the innate immune response and prevent basal activation of the IFN pathway in mammals. Here, we discuss this hypothesis, highlighting how the adaptation of the helicase domain of mammalian Dicer may be key to this process. (shrink)

Soon after modern spiritualism announced itself with the “Rochester knockings” of 1848, tables took on a new and controversial life. No longer were they content to live out their days impassively upholding dishes and glasses and silverware, vases, papers and books, bibelots, elbows, or weary heads. They were changed: they began to move. Tables all over the United States and then in England, France, and other countries commenced rapping, knocking, tilting, turning, tapping, dancing, levitating, and even “thrilling”—though this last was (...) uncommon. So Mrs. Sophia Elizabeth De Morgan said in her discussion of Daniel Dunglas Home, probably the most famous nineteenth-century medium:It is only in Mr. Home’s presence that I have witnessed that very curious appearance, or process, the thrilling of the table. This takes place for some seconds, perhaps more, before it rises from the floor. The last time I witnessed this phenomenon, an acute surgeon present said that this thrilling, the genuineness of which was unmistakable, was exactly like what takes place in that affection of the muscles called subsultus tendinum.2And the tables did still more. Their actions were a language; and so they came to symbolize “the ‘movement,’ as it has been called,”3 of modern spiritualism. Spirits had chosen the table as an organ of speech.Tables were customarily viewed as objects of economics, aesthetics, utility, diversion, tradition, even theology . Now, though, as Professor De Morgan jokes, “London and Paris were running after tables in a new sense.”4 Tables had become a different kind of thing. Whatever one might think about reports of spiritual communications, the conception of tables had changed. They had become moral objects. 2. C. D. [Mrs. Sophia Elizabeth De Morgan], From Matter to Spirit. The Result of Ten Years’ Experience in Spirit Manifestations, with a preface by A. B. [Augustus De Morgan] , p. 27. Daniel Cottom is an associate professor of English at the University of Florida. His most recent books are Social Figures: George Eliot, Social History, and Literary Representation and Text and Culture: The Politics of Interpretation . This essay is adapted from a work in progress on spiritualism and surrealism. (shrink)

The article investigates the feasibility of district heating in a small town adjacent to a Kraft pulp mill in eastern Canada. A detailed heat demand analysis is performed for all buildings using a geographical information system and archived data provided by the municipality. The study shows that the entire space heating requirement of the town can be supplied by steam from the mill, even during exceptional peak demands. A screening test based on load density indicators, however, reveals that a district (...) heating serving the entire town would probably not be economically viable. An economic analysis of partial districts show that a district covering about half of the town can be economically viable with a proper balance between the price of the steam sold by the mill to the district operator and the cost of the energy sold to customers. (shrink)

Objective: The aim of the study was to identify clinical variables associated with changes in specific domains of self-reported depression during treatment by antidepressant and/or repetitive Transcranial Magnetic Stimulation in patients with Major Depressive Disorder.Methods: Data from a trial involving 170 patients with MDD receiving either venlafaxine, rTMS or both were re-analyzed. Depressive symptoms were assessed each week during the 2 to 6 weeks of treatment with the 13-item Beck Depression Inventory. Associations between depression changes on BDI13 domains, treatment arm, (...) time, and clinical variables were tested in a mixed linear model.Results: A significant decrease of self-reported depressive symptoms was observed over time. The main characteristics associated with persistent higher depressive symptomatology on Negative Self-Reference domain of the BDI13 were personality disorders, a past history of suicide attempt, age under 65 years old, and female sex.Conclusions: Early cognitive intervention targeting specifically negative self-referencing process could be considered during pharmacological or rTMS treatment for patients with personality disorders and past history of suicide attempt. (shrink)

Introduction A Brief Conceptual Framework for Biology PART ONE: UNDERSTANDING NATURE 1. The Antecedents of Scientific Thought Animism, Totemism, and Shamanism The Paleolithic View Mesopotamia Egypt 2. Aristotle and the Greek View of Nature The Science of Animal Biology The Parts of Animals The Classification of Animals The Aristotelian System Basic Questions 3. Those Rational Greeks? Theophrastus and the Science of Botany The Roman Pliny Hippocrates, the Father of Medicine Erasistratus Galen of Pergamum The Greek Miracle 4. The Judeo-Christian Worldview (...) The Bishop of Hippo Scholastic Thought Islamic Science Books on Beasts Antecedents of a Revolution 5. The Revival of Science Andreas Vesalius and the Study of Structure William Harvey and the Study of Function Sir Francis Bacon’s Great Instauration Induction, Hypothesis, Deduction The Very Small--Animalcules Robert Hooke and the Discovery of Cells 6. Figur’d Stones and Plastick Virtue Marine Life on Mountain Tops? Figured Stones of Unknown Creatures Baron Cuvier Quarries of the Paris Basin Catastrophism and Uniformitarianism William Smith and the Geological Column Understanding Nature in 1850 PART TWO: THE GROWTH OF EVOLUTIONARY THOUGHT 7. The Paradigm of Evolution First Questions The Paradigm of Natural Theology First Answers 8. Testing Darwins Hypotheses Have Life Forms Changed over Time? Do Species Evolve into Different Species over Time? Has There Been Time Enough for Evolution? Is Natural Selection the Mechanism of Change? The Genetic Basis of Natural Selection Accounting for the Diversity of Life 9. In the Light of Evolution Comparative Anatomy Embryonic Development Classification Microstructure Molecular Processes 10. Life over Time The Origin of Life The Rise of Multicelled Organisms What Is a Phylum? Burgess Shale Metazoans Early Evolution of the Vertebrates The Age of Dinosaurs Birds, Mammals, and Flowering Plants The Rancho La Brea Tar Pits Human Evolution The Role of Extinction in Evolution PART THREE: CLASSICAL GENETICS 11. Pangenesis What Is the Question? Hippocrates and Aristotle The Darwinian Answer Assembling the Data Formulating the Hypothesis by Induction Galton’s Rabbits 12. The Cell Theory The Discovery of Cells: Robert Hooke Schwann and Cells in Animals Gametes as Cells Omnis cellula e cellula? The Technology of Cell Research 13. The Hypothesis of Chromosomal Continuity The Ephemeral Nucleus Schneider, Flemming, and Cell Division The Chromosomes and inheritance Gamete Formation Fertilization 14. Mendel and the Birth of Genetics Model for Monohybrid Crosses Model for Dihybrid Crosses Mendel’s Laws Initial Opposition to Mendelism 15. Genetics + Cytology: 1900-1910 Sutton’s Model The Cytological Basis of Mendel’s Laws Boveri and Abnormal Chromosome Sets Variations in Mendelian Ratios The Discovery of Sex Chromosomes 16. The Genetics of the Fruit Fly Morgan’s First Hypothesis Morgan’s Second Hypothesis The Fly Room Linkage and Crossing-Over The Cytological Proof of Crossing-Over Mapping the Chromosomes The Final Proof The Determinants of Sex The Conceptual Foundations of Classical Genetics 17. The Structure and Function of Genes One Gene, One Enzyme The Substance of Inheritance The Watson-Crick Model of DNA Genes and the Synthesis of Proteins The Genetic Code PART FOUR: THE ENIGMA OF DEVELOPMENT 18. First Principles The Peripatetic Stagirite The Death and Rebirth of Scientific Thought Harvey and Malpighi A Two-Millennial Summing Up Preformation versus Epigenesis 19. The Century of Discovery Von Baer’s Discovery of the Mammalian Ovum Darwin’s Contribution to Embryology Haeckel and Recapitulation 20. Descriptive Embryology Germ Layers The External Development of the Amphibian Embryo The Internal Development of the Amphibian Embryo 21. The Dawn of Analytical Embryology His, Roux, and Mosaic Development Driesch and Regulative Development Novelty in Development Cell Lineage Nucleus or Cytoplasm? Fin de Siècle 22. Interactions during Development Amphibian Organizers Secondary Organizers The Reacting Tissue The Chemical Nature of the Organizer Putting It All Together Conclusion Further Reading References Illustration Credits Index. (shrink)

Este trabajo es una reconstrucción hipotética de la desaparecida iglesia románica medieval de Samper de Calanda, que se basa en las fuentes documentales conservadas y en los materiales procedentes de su fábrica, reutilizados en la iglesia barroca actual. Destacan sendos dinteles de puerta insertos en las paredes norte y sur, cuyo diseño se debe al arquitecto Giacomo de Vignola, que fechamos en el siglo xvii. Palabras clave: iglesias románicas, iglesias barrocas, Giacomo Vignola, arquitectura renacentista, siglo XVII This work is a (...) hypothetical rebuilding of the missing medieval Romanesque church of Samper de Calanda, wich is based on preserved sources of information and material from its masonry, which have been reused in the existent church, which was built during the Baroque period. We must speak about two separate lintels in north and south walls, designed by architect Giacomo de Vignola, dated in the 17thcentury. Key words: Romanesque churches, Baroque churches, Giacomo Vignola, Renaissance architecture. (shrink)

Philosophical aesthetics has recently been expanding its purview—with exciting work on everyday aesthetics, somaesthetics, gustatory aesthetics, and the aesthetics of imperceptibilia like mathematics and human character—reclaiming territory that was lost during the nineteenth and twentieth centuries, when the discipline begun concentrating almost exclusively on the philosophy of art and restricted the aesthetic realm to the distally perceptible. Yet there remains considerable reluctance towards acknowledging the aesthetic character of many of these objects. This raises an important question—partly made salient again by (...) the ongoing expansion of the aesthetic domain, and partly by the fact that many still seem resistant to this aesthetic diversification—which aestheticians seem to avoid: what, if anything, constrains the scope of beauty or the aesthetic? I argue that form, construed as comprising a degree, however minimal, of experienceable complexity, is necessary and sufficient for an object's candidature for the possession of aesthetic properties. Such a condition serves to discriminate between attempts to expand the scope of the aesthetic that are legitimate and those that are not. If correct, my view suggests that the aesthetic realm, though not limitless, is very broad indeed—but this, I think, is as it should be. (shrink)

Reasoning under uncertainty, that is, making judgements with only partial knowledge, is a major theme in artificial intelligence. Professor Paris provides here an introduction to the mathematical foundations of the subject. It is suited for readers with some knowledge of undergraduate mathematics but is otherwise self-contained, collecting together the key results on the subject, and formalising within a unified framework the main contemporary approaches and assumptions. The author has concentrated on giving clear mathematical formulations, analyses, justifications and consequences of (...) the main theories about uncertain reasoning, so the book can serve as a textbook for beginners or as a starting point for further basic research into the subject. It will be welcomed by graduate students and research workers in logic, philosophy, and computer science as a textbook for beginners, a starting point for further basic research into the subject, and not least, an account of how mathematics and artificial intelligence can complement and enrich each other. (shrink)

We’ve all heard people say ‘Beauty is only skin-deep’, or ‘Beauty is in the eye of the beholder’: our culture promulgates a conception of beauty as subjective, superficial, and independent of other values like moral goodness or knowledge and understanding. Yet our taste in beauty affects many aspects of our lives, sometimes playing a decisive––and often detrimental––role in areas as wide-ranging as our identity and self-esteem, our morally salient decisions, and our relationship to the environment. This presents us with a (...) choice: we can either ignore the facts––leaving our conception of beauty unchanged and allowing our taste to influence much in our lives while either not acknowledging such influence, or perhaps seeking to reprimand it; or we can take the power of beauty seriously and seek to harmonise our taste with our values. I argue for the latter option, and propose a way of bringing beauty and taste in line with what matters to us using the notion of functional beauty. Adopting this strategy, I suggest, can have a powerful––and positive––impact on our self-esteem and wellbeing, our relationship to others, as well as our attitudes towards the environment. (shrink)

ABSTRACTAlthough formative of modern value theory, the moral beauty view—which states that moral virtue is beautiful and moral vice is ugly—is now mostly neglected by philosophers. The two contemporary defences of the view mostly capitalize on its intuitive attractiveness, but to little avail: such considerations hardly convince sceptics of what is nowadays a rather unpopular view. Historically, the view was supported by thought experiments; and although these greatly increase its plausibility, they also raise empirical questions, which they leave unanswered. Here, (...) I offer a novel defence of the moral beauty view, capitalizing on empirical evidence and arguing via an inference to the best explanation. (shrink)

We examine the closure conditions of the probabilistic consequence relation of Hawthorne and Makinson, specifically the outstanding question of completeness in terms of Horn rules, of their proposed (finite) set of rules O. We show that on the contrary no such finite set of Horn rules exists, though we are able to specify an infinite set which is complete.

This paper concerns the question of how to draw inferences common sensically from uncertain knowledge. Since the early work of Shore and Johnson (1980), Paris and Vencovská (1990), and Csiszár (1989), it has been known that the Maximum Entropy Inference Process is the only inference process which obeys certain common sense principles of uncertain reasoning. In this paper we consider the present status of this result and argue that within the rather narrow context in which we work this complete (...) and consistent mode of uncertain reasoning is actually characterised by the observance of just a single common sense principle (or slogan). (shrink)

We give an account of some relationships between the principles of Constant and Atom Exchangeability and various generalizations of the Principle of Instantial Relevance within the framework of Inductive Logic. In particular we demonstrate some surprising and somewhat counterintuitive dependencies of these relationships on ostensibly unimportant parameters, such as the number of predicates in the overlying language.

George Turnbull is one of the figures of the Scottish Enlightenment who has been largely overlooked. In this thesis I give the first detailed analysis of his major writings by focusing on a set of principles that guided and unified his work. I show that he constructed a unified system of philosophy and a proper Science of Man, which in turn draws attention to his relevance as an important figure of the early stages of the Scottish Enlightenment. I present an (...) interpretation of Turnbull’s work that takes into account the deep interconnectedness of his texts and considers his anatomy of the human mind as the foundation on which he develops his theories of education, painting, religion, law, and politics. The unity of his work and the set of principles that guide it allow us to gain a deeper understanding of Turnbull’s thought and its place within its eighteenth-century context, highlighting his unique contribution to the development of the Science of Man. (shrink)

Considerable hope surrounds the use of disease‐specific pluripotent stem cells to generate models of human disease allowing exploration of pathological mechanisms and search for new treatments. Disease‐specific human embryonic stem cells were the first to provide a useful source for studying certain disease states. The recent demonstration that human somatic cells, derived from readily accessible tissue such as skin or blood, can be converted to embryonic‐like induced pluripotent stem cells (hiPSCs) has opened new perspectives for modelling and understanding a larger (...) number of human pathologies. In this review, we examine the opportunities and challenges for the use of disease‐specific pluripotent stem cells in disease modelling and drug screening. Progress in these areas will substantially accelerate effective application of disease‐specific human pluripotent stem cells for drug screening. (shrink)

Volume 19, Issue 12, December 2019, Page 49-51.

For many students of global governance who explore the myriad institutions, rules, norms, and coordinating arrangements that transcend individual states and societies, what really marks the contemporary era is not the absence of such governance but its “astonishing diversity.” In addition to “long-standing universal-membership bodies,” such as the United Nations, writes Stewart Patrick, “there are various regional institutions, multilateral alliances and security groups, standing consultative mechanisms, self-selecting clubs, ad hoc coalitions, issue-specific arrangements, transnational professional networks, technical standard-setting bodies, global action (...) networks, and more.” The proliferation and diversification of governance mechanisms—yielding a jumble of formal and informal arrangements—has supplanted the simpler image of state representatives gathering at official assemblies. Many scholars believe this pluralism opens important new avenues for tackling a growing array of complex transnational problems, particularly at a time when the responsiveness of traditional multilateral institutions is being called into question. (shrink)