Despite a library full of literature on miRNA biology, core issues relating to miRNA target detection, biological effect, and mode of action remain controversial. This essay proposes that the predominant mechanism of direct miRNA action is translational inhibition, whereas the bulk of miRNA effects are mRNA based. It explores several issues confounding miRNA target detection, and discusses their impact on the dominance of “miRNA seed” dogma and the exploration of non‐canonical binding sites. Finally, it makes comparisons between miRNA target prediction (...) and transcription factor binding prediction, and questions the value of characterizing miRNA binding sites based on which miRNA nucleotides are paired with an mRNA. (shrink)

Nicole Shukin pursues a resolutely materialist engagement with the "question of the animal," challenging the philosophical idealism that has dogged the question by tracing how the politics of capital and of animal life impinge on one ...

In the context of recent populist rhetoric’s use of metaphors as a form of hate speech that inspires violence, Wolves at the Door: Migration, Dehumanization, Rewilding the World shows how the wolf...

This final comment provides, a theoretical framework on how to conceive the self as presented in the key-note paper ‘Meaningfulness, volunteering and being moved. The event of witnessing’. This is deemed requisite to achieve a full understanding of how depth in meaningfulness comes about.

Protection rackets are used by criminal organizations to secure power, wherein “protection” is offered to individuals for threats coming from the criminal organization itself. In this paper, I put forth the concept of a moral racket as a type of structural racket wherein social dominants exploit moral reputation to perpetuate systems of domination. A moral racket occurs when individuals forcefully position themselves as moral saints for moral issues that either don’t exist, or do, but were created by the wrongful actions (...) of these individuals themselves. Considering three real-world cases of moral rackets of white saviorism within nonprofits, elite philanthropy, and anti-LGBTQ legislation, I show how they are particularly pernicious instruments of oppression. Moral rackets do this by performing several key ideological functions, including creating a perception of legitimacy of systems of domination, undermining moral knowledge, thwarting attention from true sources of social problems, and blocking off avenues of resistance. (shrink)

We agree with Chapman et al. (2025) that the Common Rule needs revision, particularly regarding the application of artificial intelligence and machine learning (AI/ML) in health research with Indig...

Various authors debate the question of whether neuroscience is relevant to criminal responsibility. However, a plethora of different techniques and technologies, each with their own abilities and drawbacks, lurks beneath the label “neuroscience”; and in criminal law responsibility is not a single, unitary and generic concept, but it is rather a syndrome of at least six different concepts. Consequently, there are at least six different responsibility questions that the criminal law asks—at least one for each responsibility concept—and, I will suggest, (...) a multitude of ways in which the techniques and technologies that comprise neuroscience might help us to address those diverse questions. In a way, on my account neuroscience is relevant to criminal responsibility in many ways, but I hesitate to state my position like this because doing so obscures two points which I would rather highlight: one, neither neuroscience nor criminal responsibility are as unified as that; and two, the criminal law asks many different responsibility questions and not just one generic question. (shrink)

The pregnant female body and, more generally, the generative process tout court have been linked with metaphors since the dawn of Western philosophy, though this history has only recently been taken up and critically discussed (Rigotti 2010; Cavarero 1995). The research hypothesis I test in this paper is that pregnancy and childbirth ought to be considered as absolute metaphors, as per their “indissoluble alogicality” (Blumenberg 2010). Following the analyses presented in Paradigms for a Metaphorology, the goal of the article is (...) to enhance dialogue between Blumenberg’s conception of the metaphor and those philosophical reflections that focus on the pervasiveness of metaphors concerning pregnancy and childbirth. This paper is therefore an investigation on the link between female reproductive functions and philosophical knowledge. (shrink)

The face of the world is changing. The past century has seen the incredible growth of international institutions. How does the fact that the world is becoming more interconnected change institutions' duties to people beyond borders? Does globalization alone engender any ethical obligations? In Globalization and Global Justice, Nicole Hassoun addresses these questions and advances a new argument for the conclusion that there are significant obligations to the global poor. First, she argues that there are many coercive international institutions (...) and that these institutions must provide the means for their subjects to avoid severe poverty. Hassoun then considers the case for aid and trade, and concludes with a new proposal for fair trade in pharmaceuticals and biotechnology. Globalization and Global Justice will appeal to readers in philosophy, politics, economics and public policy. (shrink)

Fred Adams and collaborators advocate a view on which empty-name sentences semantically encode incomplete propositions, but which can be used to conversationally implicate descriptive propositions. This account has come under criticism recently from Marga Reimer and Anthony Everett. Reimer correctly observes that their account does not pass a natural test for conversational implicatures, namely, that an explanation of our intuitions in terms of implicature should be such that we upon hearing it recognize it to be roughly correct. Everett argues that (...) the implicature view provides an explanation of only some of our intuitions, and is in fact incompatible with others, especially those concerning the modal profile of sentences containing empty names. I offer a pragmatist treatment of empty names based upon the recognition that the Gricean distinction between what is said and what is implicated is not exhaustive, and argue that such a solution avoids both Everett's and Reimer's criticisms. (shrink)

Nicole Hassoun here makes a philosophical argument for health, and access to essential medicines, as essential human rights, and she proposes the Global Health Impact system as a way to ensure those rights. She reports how life-saving medicines are inaccessible and costly for the global poor, and that rather than focusing on treatments for critical, deadly global health problems, pharmaceutical companies instead invest in more profitable drugs. To address this problem, Hassoun's proposal will rate pharmaceutical companies based on their (...) medicines' impact on the improvement of global health, and will reward highly-rated medicines with a Global Health Impact label. (shrink)

Hermeneutical injustice, as a species of epistemic injustice, is when members of marginalized groups are unable to make their experiences communicatively intelligible due to a deficiency in collective hermeneutical resources, where this deficiency is traditionally interpreted as a lack of concepts. Against this understanding, this paper argues that even if adequate concepts that describe marginalized groups’ experiences are available within the collective hermeneutical resources, hermeneutical injustice can persist. This paper offers an analysis of how this can happen by introducing the (...) notion of hermeneutical excess: the introduction of additional concepts into collective hermeneutical resources that function to obscure agents’ understanding of the lived experiences of marginalized groups. The injustice of hermeneutical excesses happens not due to hermeneutical marginalization (the exclusion of members of marginalized groups from the construction of hermeneutical resources), but rather hermeneutical domination: when members of dominant groups have been inappropriately included in the construction of hermeneutical resources. By taking as exemplary cases the concepts of “reverse racism” and “non-consensual sex” this paper shows how such excesses are introduced as a kind of defensive strategy used by dominant ideologies precisely when progress with social justice is made. (shrink)

Amsterdam University Press is a leading publisher of academic books, journals and textbooks in the Humanities and Social Sciences. Our aim is to make current research available to scholars, students, innovators, and the general public. AUP stands for scholarly excellence, global presence, and engagement with the international academic community.

This article is based on a conversation between the President of the Society for the Anthropology of Consciousness and the Editor‐in‐Chief of its journal. The aim of this conversation is threefold: (1) to engage a broader audience within the field of the anthropology of consciousness, (2) to discuss the recent history of the organization and its current direction, and (3) to recognize why concrete efforts toward a practice of decolonization is essential to maintaining the relevance of an anthropology of consciousness.

Passages from the writings of Immanuel Kant concerning how a person should treat her body are often cited in the present‐day debate about a market for human body parts. In this paper, I demonstrate that this has been a misuse of Kant because unlike those who cite him, Kant was not primarily concerned with prohibiting the sale of body parts. In the first section, I argue that once these particular passages are understood against the background of Kant’s moral philosophy, they (...) indicate he had much broader concerns relating to the correct moral relationship a rational person should have with her body. In the second section, I examine Stephen Munzer’s unusually detailed analysis of these passages, but conclude that like those who have provided less detailed analyses, he also fails fully to understand the rationale for Kant’s various prescriptions and prohibitions concerning the treatment of human body parts, and in doing so misrepresents Kant’s position. (shrink)

Publiés dans le dernier quart du XVIIe siècle, les Essais de morale de Pierre Nicole (1625-1695), l'un des auteurs les plus importants de Port-Royal, constituèrent pendant plus d'un siècle une référence incontournable de la pensée morale. Fort de leur succès immédiat, les Essais furent très vite republiés et enrichis par les éditeurs de textes posthumes et de lettres jusqu'à former un ensemble de vingt-cinq tomes en 1771. Pour introduire à la lecture d'un tel massif, le présent volume offre un (...) choix de traités et lettres extraits de la série des Essais de morale, établis et annotés à partir des éditions originales. Ces textes proposent un parcours dont le fil directeur est la critique des attraits engendrés par le monde visible. Le monde des hommes est en effet envisagé par Nicole comme un spectacle chatoyant et trompeur dans lequel l'esprit, charmé par tant d'éclat, s'enfonce jusqu'à se perdre. Mais, outre le déploiement d'une anthropologie de la concupiscence fondée sur l'analyse précise des mécanismes psychiques et affectifs, la puissance théorique de ces Essais tient au fait qu'ils proposent des remèdes ordinaires et humains, et donc, praticables dès cette vie, pour neutraliser les effets de cette séduction qui s'exerce par l'entremise du regard. Pour ce faire, Nicole ne se contente pas de produire des exposés généraux et abstraits, il décrit au contraire avec une grande minutie les dangers souvent inapparaissants de ces instruments de fascination de l'âme. La plupart des essais proposés n'avaient pas été réédités depuis plus d'un siècle. Ce volume souhaite donc rendre à nouveau disponible ces textes majeurs et pourtant encore peu connus de la littérature morale du Grand siècle. (shrink)

Garrath Williams claims that truly responsible people must possess a “capacity … to respond [appropriately] to normative demands” (2008:462). However, there are people whom we would normally praise for their responsibility despite the fact that they do not yet possess such a capacity (e.g. consistently well-behaved young children), and others who have such capacity but who are still patently irresponsible (e.g. some badly-behaved adults). Thus, I argue that to qualify for the accolade “a responsible person” one need not possess such (...) a capacity, but only to be earnestly willing to do the right thing and to have a history that testifies to this willingness. Although we may have good reasons to prefer to have such a capacity ourselves, and to associate ourselves with others who have it, at a conceptual level I do not think that such considerations support the claim that having this capacity is a necessary condition of being a responsible person in the virtue sense. (shrink)

This paper considers the question ‘How should institutions enable people to meet their needs in situations where there is no guarantee that all needs can be met?’ After considering and rejecting several simple principles for meeting needs, it suggests a new effectiveness principle that 1) gives greater weight to the needs of the less well off and 2) gives weight to enabling a greater number of people to meet their needs. The effectiveness principle has some advantage over the main competitors (...) including a principle suggested by David Miller in Principles of Social Justice. Miller argues that his principle accounts for the existing data on individuals’ intuitions about meeting needs. The effectiveness principle better accounts for this data. Furthermore, this paper presents a new experiment on intuitions about meeting need that is consistent with the effectiveness principle but not Miller’s principle. (shrink)

Que la situation de certaines femmes se soit améliorée, cela ne signifie pas que la condition des femmes en général a changé en profondeur, et que le féminisme peut prendre congé. Au contraire, à la fois comme pensée, comme discours, comme pratique et comme éthique, le féminisme reste indispensable à l'avènement d'un monde meilleur.Although some women fare better in our society, this does not mean that the situation of women in general is no longer problematic, and that feminism is no (...) longer needed. On the contrary, as a way of thinking, as a discourse, as a praxis and as an ethics, feminism remains essential to the coming of a better society. (shrink)

L’accompagnement de fin de vie est devenu une pratique usuelle, conseillée, en France, dans les établissements d’hébergement pour personnes âgées dépendantes. Il fait l’objet de formation continue et est inscrit dans les recommandations des sociétés de soins palliatifs. Mais l’accompagnement de fin de vie est-il un concept ? Une pratique ? Une fonction ? Qui sont les acteurs de cet accompagnement ? Est-ce une attribution des professionnels de santé ou de tout un chacun dans la société ? Nous tenterons, d’abord, (...) de cerner le concept d’accompagnement dans le champ des pratiques sociales. Nous verrons qu’il s’agit bien d’une pratique qui s’appuie sur des fondements théoriques du souci de l’autre, de la bienveillance, de l’être-avec. Puis la description sociohistorique de l’accompagnement et du soin palliatif nous montrera l’idéal humain qu’il recouvre. Cependant les valeurs communes à l’un et l’autre tendent à la confusion entre accompagnement de fin de vie et soin palliatif. C’est pourquoi certains auteurs nous invitent à une réflexion éthique sur l’accompagnement. Ils nous proposent de préciser la fonction et la posture professionnelle qu’il requiert. Enfin, nous verrons l’importance de délimiter le contexte dans lequel s’insère cette pratique. (shrink)

Le rôle des femmes dans le commerce maritime reste largement méconnu à l'époque moderne à Nantes. Pourtant, différents documents, en particulier les archives notariales, permettent d'appréhender la diversité de la participation des femmes : elles peuvent être propriétaires de navires, marchandes de divers produits ou intervenir dans les aspects financiers liés au commerce maritime. Les sources révèlent la diversité des profils de ces femmes : elles ne sont pas toutes veuves, certaines femmes mariées commercent seules ou avec leur époux. En (...) outre, des femmes que nous qualifions aujourd'hui de célibataires ont également été recensées. (shrink)

A heterogeneous survey sample of for-profit, non-profit and government employees revealed that organizational factors but not personal characteristics were significant antecedents of misconduct and job satisfaction. Formal organizational compliance practices and ethical climate were independent predictors of misconduct, and compliance practices also moderated the relationship between ethical climate and misconduct, as well as between pressure to compromise ethical standards and misconduct. Misconduct was not predicted by level of moral reasoning, age, sex, ethnicity, job status, or size and type of organization. (...) Demographic variables predicted job satisfaction and organizational variables added significant incremental variance. Results suggest the importance of promoting a moral organization through the words and actions of senior managers and supervisors, independent of formal mechanisms such as codes of conduct. (shrink)

« Rites » sont d'abord de séquences d'actions corporelles définies socialement plus ou moins strictement. Très souvent, mais pas toujours les sociétés attendent qu'aux actes extérieurs correspondent des motivations, des croyances et des émotions intérieures ou « psychiques ». Il ya des sociétés où l'efficacité supposée des rites dépend de la correspondance entre mouvements corporels et «réalité » intérieure. Mais il y en a d'autres où ce qui compte c'est uniquement l'exécution minutieuse des gestes corporels en tant que tels. De (...) toute façon, des actions rituelles ne sauraient être interprétées comme suivant exclusivement un calcul rationnel, bien qu'un observateur sociologique pourrait constater une fonction objectivement positive d'un rite sur le plan social ou psychique sans qu'il y ait une relation causale sur le plan physique. C'est surtout dans le cas des rites de deuil où on observe que des actions objectivement ineffectives, donc symboliques, « répondent » à une situation qui ne peut être altérée sur le plan « réel », mais qui aident à supporter l'insupportable. On constate quand même la possibilité que ce qui n'était d'abord qu'un mouvement extérieur s'imprègne de valeurs symboliques, comme si par exemple une douleur rituellement infligée devient le symbôle de l'appartenance à un groupe social. Les rites sont donc l'incarnation du social dans les corps des sujets. Ils s'y inscrivent. Surtout dans les grandes civilisations les rites deviennent un système administré par des spécialistes, qui développent un « code élaboré » qui n'est déchiffrable que par les experts. L'article montre qu'il ya une certaine opposition entre contrôle rituel et moral de comportements humains."Rites" are first sequences bodily actions socially defined more or less strictly. Very often, but not always expect companies as external acts are the motivations, beliefs and inner emotions or "psychic". There are societies where the supposed efficacy of rites depends on the correspondence between body movements and "reality" inside. But there are others where what counts is only the meticulous execution of bodily gestures as such. Anyway, ritual actions can not be interpreted exclusively as following a rational calculation, although a sociological observer could see a positive function objectively a rite of social or psychic without a causal relationship to the physical plane. It is especially in the case of mourning rites which we observe that actions objectively ineffective, so symbolic, "respond" to a situation that can not be altered on the "real", but help to bear the unbearable. There is still the possibility that what was at first a movement outside soaks symbolic values, such as if ritually inflicted pain becomes the symbol of belonging to a social group. The rites are the incarnation of social issues in the body. They enroll. Especially in the great civilizations rituals are a system administered by specialists who develop "elaborated code" that is decipherable only by experts. The article shows that there is a tension between moral and ritual control of human behavior. (shrink)