An emerging concept is that quiescent mature skeletal cells provide an important cellular source for bone regeneration. It has long been considered that a small number of resident skeletal stem cells are solely responsible for the remarkable regenerative capacity of adult bones. However, recent in vivo lineage‐tracing studies suggest that all stages of skeletal lineage cells, including dormant pre‐adipocyte‐like stromal cells in the marrow, osteoblast precursor cells on the bone surface and other stem and progenitor cells, are concomitantly recruited to (...) the injury site and collectively participate in regeneration of the damaged skeletal structure. Lineage plasticity appears to play an important role in this process, by which mature skeletal cells can transform their identities into skeletal stem cell‐like cells in response to injury. These highly malleable, long‐living mature skeletal cells, readily available throughout postnatal life, might represent an ideal cellular resource that can be exploited for regenerative medicine. (shrink)

Endosteal stem cells are a subclass of bone marrow skeletal stem cell populations that are particularly important for rapid bone formation occurring in growth and regeneration. These stem cells are strategically located near the bone surface in a specialized microenvironment of the endosteal niche. These stem cells are abundant in young stages but eventually depleted and replaced by other stem cell types residing in a non‐endosteal perisinusoidal niche. Single‐cell molecular profiling and in vivo cell lineage analyses play key roles in (...) discovering endosteal stem cells. Importantly, endosteal stem cells can transform into bone tumor‐making cells when deleterious mutations occur in tumor suppressor genes. The emerging hypothesis is that osteoblast‐chondrocyte transitional identities confer a special subset of endosteal stromal cells with stem cell‐like properties, which may make them susceptible for tumorigenic transformation. Endosteal stem cells are likely to represent an important therapeutic target of bone diseases caused by aberrant bone formation. (shrink)

Immanuel Kant's moral thesis is that reason alone must identify moral laws. Examining various interpretations of his ethics, this essay shows that the thesis fails. G. W. F. Hegel criticizes Kant's Formula of Universal Law as an empty formalism. Although Christine Korsgaard's Logical and Practical Contradiction Interpretations, Barbara Herman's contradiction in conception and contradiction in will tests, and Kenneth Westphal's paired use of Kant's universalization test all refute what Allen Wood calls a stronger form of the formalism charge, they are (...) not free from a weaker form of it. Some philosophers try to avoid both forms of the formalism charge in the following ways: First, some underline the roles of Kant's other formulas. Second, some interpret the Formula of Universal Law teleologically. Third, some claim that a maxim must be something all those potentially affected by it can rationally accept. Fourth, Robert Louden introduces the empirical to evaluate a maxim. All those attempts introduce heteronomy into Kant's ethics. Besides, on the third response, from the fact that all those potentially affected accept a maxim, it does not follow that it is morally right. It is impossible to avoid the formalism charge without making his ethics heteronomous. Thus, Kant's ethics is either empty or heteronomous. Either way it fails to identify moral laws by reason alone. (shrink)

Although the philosophical literature on social institutions has been insightful for social scientific studies, the application of its core concepts, such as collective intentionality, to real inst...

This study analyzed the effects of aging on post-error behavioral adjustments from the perspective of cognitive control. A modified error awareness task was administered to young and older adults. In this task, two buttons were placed on the left and right sides in front of the participants, who were instructed to use the right button to perform a go/no-go task, and were notified if they made an error. There were three experimental conditions : participants had to push the right button (...) once in Condition A and twice in Condition B and C when a go-stimulus was presented. Conversely, participants were asked to withhold their response when a no-go stimulus was presented. Response inhibition differed depending on the experimental condition. The participants were asked to push the left button as quickly as possible when an error occurred. The results showed relatively longer reaction times to sudden errors among older adults compared with young adults. Furthermore, the difference in the error responses strongly influenced older adults’ response time after an error. These results suggest that the shift from proactive to reactive control may significantly influence post-error behavioral adjustments in older adults. (shrink)

Glivenko-type theorems for substructural logics are comprehensively studied in the paper [N. Galatos, H. Ono, Glivenko theorems for substructural logics over FL, Journal of Symbolic Logic 71 1353–1384]. Arguments used there are fully algebraic, and based on the fact that all substructural logics are algebraizable 279–308] and also [N. Galatos, P. Jipsen, T. Kowalski, H. Ono, Residuated Lattices: An Algebraic Glimpse at Substructural Logics, in: Studies in Logic and the Foundations of Mathematics, vol. 151, Elsevier, 2007] for the details). As (...) a complementary work to the algebraic approach developed in [N. Galatos, H. Ono, Glivenko theorems for substructural logics over FL, Journal of Symbolic Logic 71 1353–1384], we present here a concise, proof-theoretic approach to Glivenko theorems for substructural logics. This will show different features of these two approaches. (shrink)

According to Agrippa's trilemma, an attempt to justify something leads to either infinite regress, circularity, or dogmatism. This essay examines whether and to what extent the trilemma applies to ethics. There are various responses to the trilemma, such as foundationalism, coherentism, contextualism, infinitism, and German idealism. Examining those responses, the essay shows that the trilemma applies at least to rational justification of contentful moral beliefs. This means that rationalist ethics based on any contentful moral belief are rationally unjustifiable.

David Hume pense que les affections de l’homme sont naturellement partielles, tandis que Francis Hutcheson considère que l’homme est originellement d’une bienveillance désintéressée. Michael Gill soutient que la théorie morale de Hume l’emporte sur celle de Hutcheson car cette dernière rompt le lien entre l’explication et la justification de la moralité. D’après Gill, Hutcheson a tort d’assumer que notre nature originelle devrait être le fondement de la moralité. La compréhension par Gill de la théorie de Hutcheson ne reflète pas celle-ci (...) complètement puisque l’amour de soi-même et l’intérêt personnel de Hutcheson sont, sous certaines conditions, admissibles, voire souhaitables ou nécessaires pour le bien de la société. Il y a peu de différence entre les théories de Hutcheson et de Hume dans le sens où elles déduisent la moralité impartiale du caractère humain tel qu’il est. La théorie de Hume ne l’emporte pas sur celle de Hutcheson car Hume ne propose pas une meilleure façon de déduire la moralité ni d’expliquer tous les phénomènes moraux. (shrink)

John Henry Newman has rightly been hailed as a giant in the Catholic intellectual tradition. His contributions to theology, literature, and education have been studied at length; however, his contribution to philosophy has not received appropriate attention. This essay 1) explores Newman’s unique philosophical insights in terms of the phenomenological tradition of Edmund Husserl; 2) analyzes the transcendental approach of certain British scientists—notably Ronald Knox and Charles Darwin; and 3) discusses how Newman might be considered a phenomenologist.

This essay shows that a moral sense or moral sentiments alone cannot identify appropriate morals. To this end, the essay analyzes three defenses of Francis Hutcheson's, David Hume's, and Adam Smith's moral sense theories against the relativism charge that a moral sense or moral sentiments vary across people, societies, cultures, or times. The first defense is the claim that there is a universal moral sense or universal moral sentiments. However, even if they exist, a moral sense or moral sentiments alone (...) cannot identify appropriate morals. The second defense is to adopt a general viewpoint theory, which identifies moral principles by taking a general viewpoint. But it needs to employ reason, and even if not, it does not guarantee that we identify appropriate morals. The third defense is to adopt an ideal observer theory, which draws moral principles from sentimental reactions of an ideal observer. Yet it still does not show that a moral sense or moral sentiments alone can identify appropriate morals. (shrink)

Although finance is ubiquitous in modern life, its ontological foundation is rarely discussed. This essay considers some key characteristics of finance from a social ontological perspective. It initially argues that money requires some sort of representation, and that financial institutions rely on various forms of cognition as well as documents anchoring representations. From that standpoint, one of the crucial aspects of finance is that it provides reference points through the process of quantification. These reference points are numerical representations that allow (...) people to make comparisons. Comparing numbers inevitably creates different hierarchies. However, a specific hierarchy can become outdated or less significant. In such situations, a heterarchy can be created outside the hierarchy. This essay illustrates the appearance of heterarchy in the recent shift toward impact finance, in which financial hierarchies encompass heterarchical systems that are finally replaced by quantifiable hierarchical metrics. With this example, the present research demonstrates that finance tends to convert heterarchical systems into hierarchical ones by quantification through monetary units. (shrink)

Although social ontology (SO) has attracted the attention of scholars in various disciplines, how it is applied to social scientific studies is still under-researched. To tackle this issue, this paper initially considers major streams of research on SO. It then argues that one of the aims of SO in the social sciences is to identify the rhetorical expression of social dynamism. To support this argument, the present study introduces a perspective of performativity and proposes that generic performativity should be identified (...) by social scientists. Finally, such an attempt is demonstrated with reference to the global pursuit of financialization. (shrink)

This essay develops standards for grading religions including various forms of spiritualism. First, I examine the standards proposed by William James, John Hick, Paul Knitter, Dan Cohn-Sherbok, and Harold Netland. Most of them are useful in grading religions with or without conditions. However, those standards are not enough for refined and piercing evaluation. Thus, I introduce standards used in spiritualism. Although those standards are for grading spirits and their teachings, they are useful in refined and piercing evaluation of religious phenomena. (...) The spiritual standards complement James's, Hick's, Knitter's, and Netland's standards. Although most of the spiritual standards are rationally unjustifiable, they have practical value. (shrink)

Examining the moral sense theories of Francis Hutcheson, David Hume, and Adam Smith from the perspective of the is-ought problem, this essay shows that the moral sense or moral sentiments in those theories alone cannot identify appropriate morals. According to one interpretation, Hume's or Smith's theory is just a description of human nature. In this case, it does not answer the question of how we ought to live. According to another interpretation, it has some normative implications. In this case, it (...) draws normative claims from human nature. Anyway, the sentiments of anger, resentment, vengeance, superiority, sympathy, and benevolence show that drawing norms from human nature is sometimes morally problematic. The changeability of the moral sense and moral sentiments in Hume's and Smith's theories supports this idea. Hutcheson's theory is morally more appropriate because it bases morality on disinterested benevolence. Yet disinterested benevolence is not enough for morality. There are no sentiments the presence of which alone makes any action moral. (shrink)

Both Ambrose St. John (1815–1875) and John Henry Newman (1801–1890), who were received into the Roman Catholic Church in 1845, became members of the Birmingham Oratory. Newman’s closest companion for over three decades, St. John’s death was extremely painful for Newman, not only because it was unexpected, but because of his devotion to Newman as well as his dedication to his spiritual duties. Along with presenting Newman’s narrative of the last few weeks of St. John’s life, this essay raises the (...) question: why did Newman write this “account.”. (shrink)

We will give here a purely algebraic proof of the cut elimination theorem for various sequent systems. Our basic idea is to introduce mathematical structures, called Gentzen structures, for a given sequent system without cut, and then to show the completeness of the sequent system without cut with respect to the class of algebras for the sequent system with cut, by using the quasi-completion of these Gentzen structures. It is shown that the quasi-completion is a generalization of the MacNeille completion. (...) Moreover, the finite model property is obtained for many cases, by modifying our completeness proof. This is an algebraic presentation of the proof of the finite model property discussed by Lafont [12] and Okada-Terui [17]. (shrink)

U ovome ogledu najprije uvodim u teorije moralnog osjećaja Francisa Hutchesona, Davida Humea i Adama Smitha te razjašnjavam važne razlike među njima. Potom ispitujem da li moralni sud koji se zasniva na moralnom osjećaju varira ovisno o metafizičkim vjerovanjima. U tu svrhu te teorije uglavnom primjenjujem na pitanja kao što su istraživanje matičnih stanica, pobačaj i aktivna eutanazija. U svim trima teorijama neistinita religijska vjerovanja mogu iskriviti moralni sud. U Hutchesonovoj teoriji odgovori na problem istraživanja matičnih stanica, pobačaja i aktivne (...) eutanazije ne mijenjaju se ovisno o metafizičkim vjerovanjima promatrača. No odgovori na ta pitanja mogu se promijeniti ovisno o djelatnikovim metafizičkim vjerovanjima. Humeova teorija ne može pružiti odgovore na problem istraživanja matičnih stanica i pobačaja kada primatelj (onaj na koga utječe djelatnikova radnja) jest embrij ili fetus, dok odgovor na problem aktivne eutanazije ne može pružiti kada je pacijent nesvjestan. Može pružiti odgovore na problem pobačaja kada je primatelj trudnica, a na problem aktivne eutanazije kada je pacijent svjestan. No odgovori mogu varirati ovisno o ženinim ili pacijentovim metafizičkim vjerovanjima. Smithova teorija može pružiti odgovore na problem istraživanja matičnih stanica, pobačaja i eutanazije. No odgovori mogu varirati ovisno o djelatnikovim metafizičkim vjerovanjima. To pokazuje da sam moralni osjećaj u tim teorijama ne može identificirati primjereno moralno stajalište. (shrink)

For some contemporary liberal philosophers, a huge concern is liberal neutrality, which is the idea that the state should be neutral among competing conceptions of the moral good pursued by the people. In The Morality of Freedom, Joseph Raz argues that we can neither achieve nor even approximate such neutrality. He shows that neutrality and fairness are different ideas. His notion of neutrality is stricter than John Rawls's and Ronald Dworkin's. Raz shows that both helping and not helping can be (...) neutral or non-neutral, thus neutrality is chimerical. Wojciech Sadurski's appeal to rational expectations does not necessarily tell us which action is neutral. Distinguishing between comprehensive and narrow neutrality, Raz also claims that only the former is a proper response to conflicts. Sadurski criticizes it, claiming that conflicts are comprehensive in a sense which does not deny the adequacy of the narrow neutrality. In reality, however, it is almost impossible to achieve even the narrow neutrality. A theory is presented to explain why political neutrality is almost impossible to achieve. Philosophically, there is no neutral ground for neutral politics. (shrink)

An intermediate predicate logicS + n (n>0) is introduced and investigated. First, a sequent calculusGS n is introduced, which is shown to be equivalent toS + n and for which the cut elimination theorem holds. In § 2, it will be shown thatS + n is characterized by the class of all linear Kripke frames of the heightn.

Epistemological investigation belonged to the core topics in Indian philosophical traditions, too. Right cognition had generally been regarded as one of the important means to emancipation (niḥśreyasa) since ancient times. To reach this religious goal, they keenly discussed the problems of what kinds of cognition we should accept as right or what kinds of objects a right cognition refers to. Specifically it is about the number and the nature of the means of right cognition that opinions differ from school to (...) school. The number ranges from one (perception) to six or even ten (perception, inference, comparison, testimony, implication, non-perception, equivalence, tradition, gesture, and intuition). The concept of each means of right cognition, too, varies greatly among schools. In this paper I take up the Nyāya System, a rationalistic school of Brahmanic philosophy. In Nyāya the inference is regarded as particularly important, but it never means that logical thinking dominates testimony or the authority of religious scriptures in the Nyāya System. On the contrary we find such cases as the religious authority seems to delimit the validity of inference. Some inferences are obstructed by an axiom established in the school, whereas others by a ristriction of Brahmanic tradition. In this manner they seemed to protect their whole system from followers of other Schools. By examining this topic I would like to throw a tiny light on the characteristic affinity between philosophy and religion in Indian thought. (shrink)

This paper discusses Crawley completions of residuated lattices. While MacNeille completions have been studied recently in relation to logic, Crawley completions (i.e. complete ideal completions), which are another kind of regular completions, have not been discussed much in this relation while many important algebraic works on Crawley completions had been done until the end of the 70’s. In this paper, basic algebraic properties of ideal completions and Crawley completions of residuated lattices are studied first in their conncetion with the join (...) infinite distributivity and Heyting implication. Then some results on algebraic completeness and conservativity of Heyting implication in substructural predicate logics are obtained as their consequences. (shrink)

In this paper, we will develop an algebraic study of substructural propositional logics over FLew, i.e. the logic which is obtained from intuitionistic logics by eliminating the contraction rule. Our main technical tool is to use residuated lattices as the algebraic semantics for them. This enables us to study different kinds of nonclassical logics, including intermediate logics, BCK-logics, Lukasiewicz’s many-valued logics and fuzzy logics, within a uniform framework.

In this paper, a theorem on the existence of complete embedding of partially ordered monoids into complete residuated lattices is shown. From this, many interesting results on residuated lattices and substructural logics follow, including various types of completeness theorems of substructural logics.

Kajiyama has argued that the basis for the concept of _jāti_ (false rejoinder) as described in the _Nyāyasūtra_ is the concept _xiang ying_ (相応) as found in the _Fangbian xin lun_ (方便心論). Kajiyama has also shown that the sophistic arguments called _xiang ying_ are very similar to the _prasaṅga_ arguments of Nāgārjuna, the founder of the Madhyamaka school. It thus seems worthwhile to investigate how later Mādhyamika philosophers treated the concept of _jāti_ that originally appeared as the result of the (...) _Nyāyasūtra’s_ criticism of the concept _xiang ying_ and was later accepted by Buddhist logicians such as Dignāga. This paper shows that there were two entirely opposite Mādhyamika positions regarding the concept of _jāti_. In order to demonstrate this difference, this paper examines in detail statements about _jāti_s that appear in various treatises, especially two works by Bhāviveka and three works by Candrakīrti. As the result, it becomes clear that the differences in the two positions correspond essentially to the differences in how Dignāgaʼs logic was evaluated by the so-called Svātantrika and Prāsaṅgika within the Madhyamaka school. (shrink)