Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

Placebo-controlled trials are controversial when individuals might be denied existing beneficial medical interventions. In the case of malaria, most patients die in rural villages without healthcare facilities. An artesunate suppository that can be given by minimally skilled persons might be of value when patients suddenly become too ill for oral treatment but are several hours from a facility that can give injectable treatment for severe disease. In such situations, by default, no treatment is (or can be) given until the patient (...) reaches a facility, making the placebo control design clinically relevant; alternative bioequivalence designs at the facility would misrepresent reality and risk incorrect conclusions. We describe the ethical issues underpinning a placebo-controlled trial in severe malaria. To protect patients and minimise risk, all patients were referred immediately to hospital so that each had a higher chance of prompt treatment through participation. There was no difference between artesunate and placebo in patients who reached clinic rapidly; among those who could not, a single artesunate suppository significantly reduced death or permanent disability, a finding of direct and indirect benefit to patients in participating villages and elsewhere. (shrink)

Mastery imagery (i.e., images of being in control and coping in difficult situations) is used to regulate anxiety. The ability to image this content is associated with trait confidence and anxiety, but research examining mastery imagery ability's association with confidence and anxiety in response to a stressful event is scant. The present study examined whether trait mastery imagery ability mediated the relationship between confidence and anxiety, and the subsequent associations on performance in response to an acute psychological stress. Participants (N= (...) 130; 55% male;Mage= 19.94 years;SD= 1.07 years) completed assessments of mastery imagery ability and engaged in a standardized acute psychological stress task. Immediately prior to the task, confidence, cognitive and somatic anxiety intensity, and interpretation of anxiety symptoms regarding the task were assessed. Path analyses supported a model whereby mastery imagery ability mediated the relationship between confidence and cognitive and somatic anxiety interpretation. Greater mastery imagery ability and confidence were both directly associated with better performance on the stress task. Mastery imagery ability may help individuals experience more facilitative anxiety and perform better during stressful tasks. Improving mastery imagery ability by enhancing self-confidence may help individuals successfully cope with anxiety elicited during stressful situations. (shrink)

The Euthyphro might well be given to undergraduates to read early in their philosophical training. The arguments are apparently simple, but some of them, as I shall show, lead naturally on to thorny problems of modern philosophy. Another benefit that could be gained from reading the Euthyphro is that the reader may learn to be forewarned against some common fallacies and debating tricks in moral disputes.

Objectives: To quantify the use of do-not-resuscitate orders in a tertiary-care children’s hospital and to characterise the circumstances in which such orders are written.Design: Retrospective study conducted in a 500-bed children’s hospital in Taiwan.Patients: The course of 101 patients who died between January 2002 and December 2005 was reviewed. The following data were collected: age at death, gender, disease and its status, place of death and survival. There were 59 males and 42 females with a median age of 103 months (...) . 50 children had leukaemias, and 51 had malignancies other than leukaemia. The t test and the χ2 test were applied as appropriate.Results: The study found that 44% of patient deaths occurred in the paediatric oncology ward; 29% of patient deaths occurred in the intensive care unit; and 28% of patients died in their home or at another hospital. Other findings included the following: 46 of 101 patients died after attempted cardiopulmonary resuscitation and 55 died with a DNR order in effect. The mean age at death was 9.8 years in both groups with or without DNR orders.Conclusions: From the study of patient deaths in this tertiary-care children’s hospital, it was concluded that an explicit DNR order is now the rule rather than the exception, with more DNR orders being written for patients who have been ill longer, who have solid tumours, who are not in remission and who are in the ward. (shrink)

Nucleation and motion of kink pairs on partial dislocations are examined by elasticity theory for materials with a high Peierls stress. Two approaches are used: one considers the change in average stacking-fault energy due to alloying elements and the other considers the change in local SFE due to a nearby solute atom. Both approaches highlight the role of SFE on kink nucleation, propagation and annihilation and both furnish strain rate as a function of stress, temperature and SFE. Model predictions are (...) compared with yield stress data for two systems: firstly, an intermetallic, MoSi 2 , which softens for alloying elements that decrease the SFE and hardens for Re additions that increase the SFE; secondly, a ceramic oxide, MgO-Al 2 O 3 spinel, which softens with increasing addition of excess alumina and at the same time exhibits a decrease in SFE. The average SFE approach agrees qualitatively with the data while quantitative agreement is obtained with the local SFE approach. The possibility is considered that the model applies to other materials, such as TiAl, HfV 2 and Fe 3 Al, which show softening with certain alloying additions. One requirement is that the dislocations are dissociated more than a few atomic distances; otherwise kink nucleation occurs on the perfect dislocation . Hence the model does not apply to materials such as bcc metals which only have a core dissociation. Normal hardening effects of solutes from size and modulus misfits are additive with any softening effects from a decrease in SFE and so may mask the latter, as occurs for W additions to MoSi 2. (shrink)

The author states: "in a recent article searle has shown the odd irrelevance of russell's criticisms of frege in the famous paper 'on denoting'. I here offer an explanation of the oddity: russell had excusably, But wrongly, Conflated frege's distinction between sinn and bedeutung with his own distinction between what an expression 'means' and what it 'denotes'.".

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Life of Roman Republicanism by Joy ConnollyT. P. WisemanJoy Connolly. The Life of Roman Republicanism. Princeton: Princeton University Press, 2014. xix + 228 pp. Cloth. $39.95.This book was written for the best of reasons. Joy Connolly explains in her preface that she began to study the republican tradition in 2001, when “the Bush administration’s imprudence, paranoia, and disregard of democratic values stoked in me an anger equalled (...) only by the disgust I felt at my own and my fellow citizens’ inability or unwillingness to stand up to it” (xiv). The failure of the Left caused her “to ask questions that might help us to respond more intelligently and humanly to the situation in which we find ourselves” (xv). In particular, in this book her aim has been to exploit texts from the late Roman republic, to which students of political science have not paid enough attention, and thus recover “the suppressed history of republican political thought” (204). As she says in [End Page 372] conclusion, “I have sought to offer practical tools for civic education by articulating learnable practices of knowing the world that characterize late republican texts” (208, author’s emphasis). How well has this admirable ambition been achieved?According to the introduction, “[t]his book seeks to place Cicero’s Verrines, Caesarian orations, Republic, and Laws; Sallust’s Catiline and Jugurtha; and Horace’s Satires at the center of the republican tradition” (1); however, the Verrines and De legibus get only a couple of paragraphs each, and only one of the “Caesarian” orations is discussed at all. The actual contents are: chapter 1 on De republica (“Where Politics Begins”), which “presents Cicero as a thinker concerned with a collective of antagonists and competing interests, against conventional portrayals of his ideal republic as a homogeneous, unified, harmonious community” (20); chapter 2 on Sallust (“Justice in the World”), which argues that “Sallust’s withholding of judgment at the end of Jugurtha signifies the ways in which agents in the decaying republic withhold justice on a larger scale” (20); chapter 3 on Horace Satires I (“Non-Sovereign Freedom”), in which the obvious question (asked only at the end), “what might political and social progressives find worthy of consideration in Horace today?”, is answered with “Horatian satire undoes the claim to sovereignty that usually partners claims to moral judgment” (154); chapter 4 on Cicero’s view of oratory (“Dividual Advocacy”), which “reflects on the Roman preoccupation with faces, situations, the mutability of selfhood, and the degree to which the divided self mirrors the division of the polity” (21); and chapter 5 on Pro Marcello (“Imagination, Finitude, Responsibility, Irony”), which argues that “[b]y adopting hyperbole as the governing figure of this new style of senatorial speech, Cicero holds out the promise not of a morally legible universe, but of a recognition that every Roman now lives in conditions virtually ‘impossible to believe’, the emergence of one ruler, under whom the chains of traditional obligations do not consistently hold” (183). The short conclusion (“The Republic Remastered”) attacks “the tendency, dominant since the nineteenth-century emergence of sociology and economics, to treat human beings primarily as rational calculators or creatures of practical wisdom” (203) and expresses the hope that “close attention to these texts has the capacity to reshape the way we think about civic wisdom—the way schools teach history, literature, civics, and philosophy—about public discourse, especially public commentary on political oratory, and about the conversations we citizens hold among ourselves” (207).I have deliberately used the author’s own words to indicate what the book attempts to do, because I would find it impossible to summarise its argument any other way. Even with these formulae to help, Connolly’s selective and apparently random approach imposes a heavy burden on the reader to construct a coherent framework for her ideas. I think there are two main reasons for this. The first is a direct result of Connolly’s impressive mastery of the political-sciences literature. It is an excellent thing to be so thoroughly familiar with the works of Hannah Arendt, Simon Critchley, John Dewey, Michel Foucault, Dean Hammer, Bonnie Honig, Andreas Kalyvas, George Kareb... (shrink)

The title I have chosen naturally suggests the question: What are you saying omnipotence is irrelevant to? I reply: This doctrine is irrelevant to worthwhile discussion of the problem of evil. By this phrase I understand: the problem how the existence of a God with the attributes traditionally ascribed to him in Christian belief can be reconciled with the occurrence of the sorts of evil that we find in the world.

In an article published in the C.Q. of October 1937 I collected instances of the use of colloquial words and expressions in the dialogue passages of Euripides. It was there noted that a few of these expressions also appear in Aeschylus and Sophocles, and the purpose of the present study is to collect these, together with other instances of colloquialism which are found in the two earlier tragedians and not in Euripides. The colloquial element in the language of Aeschylus and (...) Sophocles is, of course, much smaller than in Euripides, but is perhaps greater than is sometimes supposed, and the topic has apparently not been treated elsewhere. (shrink)

I welcome the invitation of Eugene Freeman to contribute a paper on the subject of self, giving my own views. I have been devoted to comparative philosophy all my life, and I am naturally greatly influenced by Indian and Western thought. But I should warn both the Indian and Western readers against equating my views in their entirety with any of the past philosophies. It is also not possible to given an exhaustive theory of the self in a paper of (...) the present size. What is not given here may place my view in a wrong light and the reader may draw wrong conclusions. (shrink)

Gareth Evans's two articles on the syntax and semantics of pronouns unfortunately seem to have been written far more with the desire of showing Peter Geach to have been wrong all along the line than in an endeavour to formulate, clearly and coherently, a comprehensive theory of his own. Some scattered passages of constructive theorizing there are, and in the latter part of this note I shall have something to say about them; but the controversial motive prevails.It would be wearisome (...) for me, and unrewarding for readers, if I were to work through Evans's arguments against me in detail: his misrepresentations of me are frequent and gross, and exposure of them in detail, together with restatement of the arguments misrepresented, would take up many more pages than the articles themselves. I here document just two of the more flagrant examples; with this warning before their eyes, readers may be disposed not to believe Evans's account of my works without checking for themselves. (shrink)

On the very first page of Spinoza's Ethics we find the perplexing definition of ‘attribute’: ‘By an attribute I mean what the understanding perceives in regard to a substance as constituting its essence’. Each attribute of a substance by itself thus constitutes the essence of a substance; if there are many attributes of the same substance, it does not take all of them together to constitute its essence. Spinoza, as we all know, in fact held that there is only one (...) substance, God, but there are infinitely many attributes, of which only two, Thought and Extension, are accessible to the human mind. Each attribute, we further learn, has to be conceived on its own account ; being conceived on its own account is, however, a distinguishing mark of the one substance, so how is it that the many attributes, which Spinoza says are really distinct, are not so many distinct substances, so many gods? That is the ontological side of the puzzle. Now for the logical or grammatical side — about which writers on Spinoza have, I think, said a great deal less, though it has been much discussed as regards less deviant theology than Spinoza's. Each attribute is clearly meant to be a concrete, active, individual entity; yet the attributes are designated by abstract nouns — ‘Thought’ and ‘Extension’. Now can we make sense of such a sentence as ‘God is Thought’ or ‘God is Extension’, as opposed to ‘God thinks’ or ‘God is extended’? What does it mean to predicate an abstract noun of a concrete individual? And if this ‘is’ here is not a bare copula of predication but an identity sign, then how can we avoid passing from ‘God is Thought’ and ‘God is Extension’ to ‘Thought is Extension’? Spinoza would deny the conclusion, and it is quite essential to his system to do so. For if Thought just is Extension, identically so, then any mode of the attribute Thought is a mode of the attribute Extension and vice versa. But for Spinoza, the last is diametrically opposite to the truth: no mode is a mode of more than one attribute, and indeed no causal relations link modes of different attributes — a causal linkage is always confined to one attribute. (shrink)

Open peer commentary on the article “Communication Emerging? On Simulating Structural Coupling in Multiple Contingency” by Manfred Füllsack. Upshot: Our criticism aims at the premises of Füllsack’s simulation model, i.e., we claim that his interpretation of the Luhmannian concept of double contingency contradicts the systems theoretical approach in fundamental ways. Neither the view of communication as an emergent system, nor the theory of double contingency is addressed in an adequate manner. Thus Füllsack in fact does not simulate a systems theoretical (...) approach to double contingency but simulates a mere reduction of the social to the individual psyches. (shrink)

It is suggested that anoversight occurred in classical mechanics when time-derivatives of observables were treated on the same footing as the undifferentiated observables. Removal of this oversight points in the direction of quantum mechanics. Additional light is thrown on uncertainty relations and on quantum mechanics, as a possible form of a subtle statistical mechanics, by the formulation of aclassical uncertainty relation for a very simple model. The existence of universal motion,i.e., of zero-point energy, is lastly made plausible in terms of (...) a gravitational constant which is time-dependent. By these three considerations an attempt is made to link classical and quantum mechanics together more firmly, thus giving a better understanding of the latter. (shrink)

Can the Âtman in its infinity and transcendence be made the basis for civil rights? Can we deduce the idea of civil rights and their number from the conception of the Âtman? Can historicity be preserved in the bosom of the Âtman? It has been said that only ideas like that of the dictatorship are possible on the basis of the Âtman as conceived by Indian thinkers. Individual freedom and initiative necessary for new scientific discoveries and inventions are taught by (...) Christ and other Israel-born religions, and the discovery of the atom bomb is due to such ideas. Long ago the late Prof. C.A. Moore of Hawaii urged me several times to handle such criticisms of Indian philosophy and religion. I tried to answer them in some early papers. The most important considerations are: As Kant said, from the highest metaphysical reality it is not logically possible to deduce anything particular or even lower; for instance, we cannot even deduce from “All men are mortal” whether Socrates is or is not mortal, unless we add “Socrates is a man,” which is an empirical statement. And If the Âtman is one and all-comprehensive, no democracy is said to be possible because individual men cannot be real then; but it is overlooked that then nothing is possible, not even trees and stones. Again, if there is only one personal God and if his will is supreme, will he not be a tyrant or a Louis XIV of the heavens, thundering his unquestionable commands? Where do democracy and freedom of the individual go then? On the other hand, if every one is the Supreme Âtman in essence, then everyone is free with all the initiative one can have by birth. Civil rights will then have a metaphysical foundation because every finite individual is inherently one with the Supreme Person and has the same rights and freedom as any king or emperor. But these arguments and counter-arguments cannot impress every one because to deduce anything from the highest Being leads only to antinomies and will be counter-productive in our search for truth. In metaphysics or ontology we can go only from the lower to the higher in logic or discursive thinking, but not vice versa. (shrink)

The experience of the use of applied containerized biomedical software tools in cloud environment is summarized. The reproducibility of scientific computing in relation with modern technologies of scientific calculations is discussed. The main approaches to biomedical data preprocessing and integration in the framework of the intelligent analytical system are described. At the conditions of pandemic, the success of health care system depends significantly on the regular implementation of effective research tools and population monitoring. The earlier the risks of disease can (...) be identified, the more effective process of preventive measures or treatments can be. This publication is about the creation of a prototype for such a tool within the project «Development of methods, algorithms and intelligent analytical system for processing and analysis of heterogeneous clinical and biomedical data to improve the diagnosis of complex diseases», implementted by the V.M. Glushkov Institute of Cybernetics, National Academy of Sciences of Ukraine, together with the United Institute of Informatics Problems, National Academy of Sciences of Belarus. The insurers, entering the market, can insure mostly low risks by facilitating more frequent changes of insurers by consumers and mixing the overall health insurance market. Socio-demographic variables can be risk adjusters. Since age and gender have a relatively small explanatory power, other socio-demographic variables were studied – marital status, retirement status, disability status, educational level, income level. Because insurers have an interest in beneficial diagnoses for their policyholders, they are also interested in the ability to interpret relevant information – upcoding: insurers can encourage their policyholders to consult with doctors more often to select as many diagnoses as possible. Many countries and health care systems use diagnostic information to determine the reimbursement to a service provider, revealing the necessary data. For processing and analysis of these data, software implementations of construction for classifiers, allocation of informative features, processing of heterogeneous medical and biological variables for carrying out scientific research in the field of clinical medicine are developed. The experience of the use of applied containerized biomedical software tools in cloud environment is summarized. The reproducibility of scientific computing in relation with modern technologies of scientific calculations is discussed. Particularly, attention is paid to containerization of biomedical applications, this permits to get reproducibility of the conditions in which the calculations took place, technologies of software pipelining of calculations, that allows to organize flow calculations, and technologies for parameterization of software environment, that allows to reproduce, if necessary, an identical computing environment. The main approaches to biomedical data preprocessing and integration in the framework of the intelligent analytical system are described. The experience of using the developed linear classifier, gained during its testing on artificial and real data, allows us to conclude about several advantages provided by the containerized form of the created application: it permits to provide access to real data located in cloud environment; it is possible to perform calculations to solve research problems on cloud resources both with the help of developed tools and with the help of cloud services; such a form of research organization makes numerical experiments reproducible, i.e. any other researcher can compare the results of their developments on specific data that have already been studied by others, in order to verify the conclusions and technical feasibility of new results; there exists a universal opportunity to use the developed tools on technical devices of various classes from a personal computer to powerful cluster. (shrink)

The ethics of hastened death are complex. Studies on physicians’ opinions about assisted dying exist, but changes in physicians’ attitudes towards hastened death in clinical decision-making and the background factors explaining this remain unclear. The aim of this study was to explore the changes in these attitudes among Finnish physicians. A questionnaire including hypothetical patient scenarios was sent to 1182 and 1258 Finnish physicians in 1999 and 2015, respectively. Two scenarios of patients with advanced cancer were presented: one requesting an (...) increase in his morphine dose to a potentially lethal level and another suffering a cardiac arrest. Physicians’ attitudes towards assisted death, life values and other background factors were queried as well. The response rate was 56%. The morphine dose was increased by 25% and 34% of the physicians in 1999 and 2015, respectively. Oncologists approved the increase most infrequently without a significant change between the study years. Oncological specialty, faith in God, female gender and younger age were independent factors associated with the reluctance to increase the morphine dose. Euthanasia, but not assisted suicide, was considered less reprehensible in 2015. In both years, most physicians withheld cardiopulmonary resuscitation. Finnish physicians accepted the risk of hastening death more often in 2015 than in 1999. The physicians’ specialty and many other background factors influenced this acceptance. They also regarded euthanasia as less reprehensible now than they did 16 years ago. (shrink)

This is a collection of twenty-four articles evenly divided among five topical areas: skepticism, sensory perception, memory, self-knowledge, and the foundations of empirical knowledge. With the exception of an article by Meinong, all the selections belong to the twentieth century and, except for four other articles, to the past thirty years. The selections in each of the five parts compliment one another in content and are arranged chronologically. For example, the section entitled "Contemporary Skepticism" begins with Leonard Nelson’s "The Impossibility (...) of the ‘Theory of Knowledge'," moves into Moore’s early criticism and Lehrer’s recent defense of skepticism, examines Quine’s attempt to convert epistemology into psychology, and concludes with Rozeboom’s "Why I Know So Much More Than You Do." A similar format is followed in each of the other four sections. Many of the selections have never before appeared in an anthology. For example, the valuable Reichenbach-Goodman-Lewis 1952 debate on phenomenalism and the foundations of knowledge appears in its entirety. (shrink)

The intent of ethics is to establish a set of standards that will provide a framework to modify, regulate, and possibly enhance moral behaviour. Eleven focus groups were conducted with physicians from six culturally distinct countries to explore their perception of formalized, written ethical guidelines (i.e., codes of ethics, credos, value and mission statements) that attempt to direct their ethical practice. Six themes emerged from the data: lack of awareness, no impact, marginal impact, other codes or value statements supersede, personal (...) codes or values dictate, and ethical guidelines are useful. Overall, codes were valued only when they were congruent with existing personal morality. The findings suggest the need to re-evaluate the purpose, content, and delivery of codes for them to improve their function in promoting ethical conduct. (shrink)

A continuoxis t- norm is a continuous map * from [0, 1]² into [0,1] such that is a commutative totally ordered monoid. Since the natural ordering on [0,1] is a complete lattice ordering, each continuous t-norm induces naturally a residuation → and becomes a commutative naturally ordered residuated monoid, also called a hoop. The variety of basic hoops is precisely the variety generated by all algebras, where * is a continuous t-norm. In this paper we investigate the structure of the (...) variety of basic hoops and some of its subvarieties. In particular we provide a complete description of the finite subdirectly irreducible basic hoops, and we show that the variety of basic hoops is generated as a quasivariety by its finite algebras. We extend these results to Hájek's BL-algebras, and we give an alternative proof of the fact that the variety of BL-algebras is generated by all algebras arising from continuous t-norms on [ 0,1] and their residua. The last part of the paper is devoted to the investigation of the subreducts of BL- algebras, of Gödel algebras and of product algebras. (shrink)

Background The European Union aims to optimize patient protection and efficiency of health-care research by harmonizing procedures across Member States. Nonetheless, further improvements are required to increase multicenter research efficiency. We investigated IRB procedures in a large prospective European multicenter study on traumatic brain injury, aiming to inform and stimulate initiatives to improve efficiency. Methods We reviewed relevant documents regarding IRB submission and IRB approval from European neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury. (...) Documents included detailed information on IRB procedures and the duration from IRB submission until approval. They were translated and analyzed to determine the level of harmonization of IRB procedures within Europe. Results From 18 countries, 66 centers provided the requested documents. The primary IRB review was conducted centrally or locally and primary IRB approval was obtained after one, two or three review rounds with a median duration of respectively 50 and 98 days until primary IRB approval. Additional IRB approval was required in 55% of countries and could increase duration to 535 days. Total duration from submission until required IRB approval was obtained was 114 days and appeared to be shorter after submission to local IRBs compared to central IRBs. Conclusion We found variation in IRB procedures between and within European countries. There were differences in submission and approval requirements, number of review rounds and total duration. Research collaborations could benefit from the implementation of more uniform legislation and regulation while acknowledging local cultural habits and moral values between countries. (shrink)

As a generation of ‘digital natives,’ secondary students who were born from 2002 to 2010 have various approaches to acquiring digital knowledge. Digital literacy and resilience are crucial for them to navigate the digital world as much as the real world; however, these remain under-researched subjects, especially in developing countries. In Vietnam, the education system has put considerable effort into teaching students these skills to promote quality education as part of the United Nations-defined Sustainable Development Goal 4 (SDG4). This issue (...) has proven especially salient amid the COVID−19 pandemic lockdowns, which had obliged most schools to switch to online forms of teaching. This study, which utilizes a dataset of 1061 Vietnamese students taken from the United Nations Educational, Scientific, and Cultural Organization (UNESCO)’s “Digital Kids Asia Pacific (DKAP)” project, employs Bayesian statistics to explore the relationship between the students’ background and their digital abilities. Results show that economic status and parents’ level of education are positively correlated with digital literacy. Students from urban schools have only a slightly higher level of digital literacy than their rural counterparts, suggesting that school location may not be a defining explanatory element in the variation of digital literacy and resilience among Vietnamese students. Students’ digital literacy and, especially resilience, also have associations with their gender. Moreover, as students are digitally literate, they are more likely to be digitally resilient. Following SDG4, i.e., Quality Education, it is advisable for schools, and especially parents, to seriously invest in creating a safe, educational environment to enhance digital literacy among students. (shrink)

Drawing on the general ethics and social psychology literature, this study presents a model to delineate the major factors likely to affect consumers’ intentions to bring their own shopping bags when visiting a supermarket (called “bring your own bags” or “BYOB” intention). The model is empirically validated using a survey of 250 Chinese consumers. Overall, the findings support the hypothesized direct influence of teleological evaluation and habit on BYOB intention, as well as that of deontological evaluation and teleological evaluation on (...) ethical judgment about the BYOB practice. Teleological evaluation exerts a much stronger influence on ethical judgment than does deontological evaluation. In addition, the findings reveal that consumers who perceive the BYOB practice to be more important are more inclined to rely on their ethical judgment to derive their BYOB intention. Academically, these findings provide some encouraging evidence for the application of general ethics theories to explain green consumption-related practices. Practically, the findings also suggest that a utilitarian approach (i.e., emphasizing the consequences of BYOB) may represent an effective means for the Chinese government to promote BYOB practice among consumers. (shrink)

This paper details an algorithm for a binary, primitive recursive function that apparently computes, for any $i$ and $n$, $f_i\left(i,n\right)$. The algorithm works by exploiting the fact that, in the formal system described, the index assigned to a p.r. function codes the definitional composition of the function. The algorithm exploits such a code to generate a "canonical proof" of $f_i\left(i,n\right)=m$. Since this kind of algorithm is shown impossible by diagonal arguments, the algorithm must be in error. But the error is (...) worth investigating, for it is unclear upon sustained, earnest reflection where it lies. I thus offer this material to readers with a humble request for assistance. (shrink)

Presents a plethora of approaches to developing human potential in areas not conventionally addressed. Organized in two parts, this international collection of essays provides viable educational alternatives to those currently holding sway in an era of high-stakes accountability.

[1]. Nonmun p'yŏn -- [2-3]. Charyo p'yŏn, 1-2.

This paper argues for a completely universal scepticism, according to which no beliefs at all are justified to the least degree. The argument starts with a version of the Agrippan trilemma, according to which, if we accept that a belief is justified, we must choose between foundationalism, coherentism of a particular sort, and an infinite regress of justified beliefs. Each of these theories is given a careful specification in terms of the relationship of “justifiedness in p depending on justifiedness in (...) q”. It is then argued that no beliefs – not even beliefs about phenomenal experiences – are foundational in the required way. Both coherentism and infinitism are untenable, since, since they face various objections, most significantly the objection that acceptance of either would commit one to allowing that all beliefs were justified. Because the three possible accounts of justificational structure all fail radically, it is concluded that no beliefs are justified. (shrink)

In the recent past, several papers have pointed to the possibility that tumour removal generates a permissive environment in which tumour growth is potentiated. This phenomenon has been coined “perioperative tumour growth” and whilst it represents a departure in terms of our attitude to the surgical process, this concept was first hinted at by Paget1Sir James Paget (1814–1899) was a surgeon and physiologist who is widely held (along with Rudolph Virchow) to be the father of the science of pathology. Paget (...) described Paget's disease of the nipple as well as Paget's disease of bone. himself. Despite this, the time interval immediately before and after cancer surgery (i.e. the perioperative period) remains an underutilised interval during which chemotherapeutic regimens are rarely implemented. Herein, we present a summarised review of the literature that supports the concept that tumour removal may potentiate the growth of residual neoplastic disease. We also outline current knowledge regarding underlying mechanisms and in this manner highlight potential therapeutic entry points. Finally, we emphasise the urgent need for trials of agents that could protect patients against the harmful host–tumour interactions that may occur during the perioperative period. BioEssays 28: 433–437, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Background: Not all patients are considered equal. For patients who are considered to be “very important persons,” care can be different from that of other patients with advantages of greater access to resources, special attention from staff, and options for luxurious hospital amenities. While very important person care is common and widely accepted by healthcare administration, it has negative implications for both very important person and non-very important person patients, supports care disparities and inequities, and can create serious ethical dilemmas (...) for healthcare professionals. Very important person care can also result in negative care outcomes for its recipients. Objective: This article sought to explore the implications and ethical considerations of very important person care within the context of United States healthcare system, and integrate bioethical principles and American Nurses Association Code of Ethics for Nurses to influence recommendations for managing ethical dilemmas associated with very important person care. Method: A synthesis of the literature on very important person care was undertaken for this article. Ethical considerations: Ethical conduct was considered and respected when performing the literature review, referencing sources, and establishing authorship. Findings: According to the published literature, very important person care bares both positive and negative implications for patients, and negative implications for nurses. Nurses are the most affected by the demands from their administrators to provide special care and attention to patients in the “very important person” category and their families. Very important person care can be disruptive, disorienting, challenging, and stressful to nurses. Conclusion: While physicians and other healthcare professionals have commented on very important person care, limited work has been done in nursing. There have not been any empirical studies on very important person care. Therefore, in order to minimize the negative implications of very important person care, studies of this phenomenon are warranted. Exposing very important person care is important in the development of an ethical healthcare system. Moreover, understanding the ethical principles surrounding the concept of very important person care will empower nurses to effectively manage conflicts and ethical dilemmas that arise with very important person care. (shrink)

Orthodoxy says that the thesis that composition is identity (CAI) entails universalism: the claim that any collection of entities has a sum. If this is true it counts in favour of CAI, since a thesis about the nature of composition that settles the otherwise intractable special composition question (SCQ) is desirable. But I argue that it is false: CAI is compatible with the many forms of restricted composition, and SCQ is no easier to answer given CAI than otherwise. Furthermore, in (...) seeing why this is the case we reveal an objection to CAI: that it allows for the facts concerning what there is to be settled whilst leaving open the question about what is identical to what. (shrink)

How should we respond to the humanity of others? Should we care for others’ well-being? Respect them as autonomous agents? Largely neglected is an answer we can find in the religious traditions of Judaism, Christianity and Buddhism: we should love all. This paper argues that an ideal of love for all can be understood apart from its more typical religious contexts and moreover provides a unified and illuminating account of the the nature and grounds of morality. I defend a novel (...) account of love for all that avoids serious worries about the incoherence or impossibility of loving everyone. Doing so requires countenancing a neglected form of love. Love admits as its object not just individual entities like people and groups; we can also bear a love for the Fs in general---for all the Joneses, all the philosophers, or even all the human beings. I go on to argue that while it is possible for ordinary agents like us to love all, we shouldn't. Instead, we should approximate love for all. The minimal approximation of love for all is, surprisingly, respect; I derive the basic, structural features of deontological ethics (including anti-paternalism and anti-aggregation) from the ideal of loving all. (NB: This paper used to be titled "Ethics in the Shadow of Love" and has been cited as an unpublished manuscript under that title.). (shrink)

Many of our concepts are introduced to us via, and seem only to be constrained by, roughand-ready explanations and some sample paradigm positive and negative applications. This happens even in informal logic and mathematics. Yet in some cases, the concepts in question – although only informally and vaguely characterized – in fact have, or appear to have, entirely determinate extensions. Here’s one familiar example. When we start learning computability theory, we are introduced to the idea of an algorithmically computable function (...) (from numbers to numbers) – i.e. one whose value for any given input can be determined by a step-by-step calculating procedure, where each step is fully determined by some antecedently given finite set of calculating rules. We are told that we are to abstract from practical considerations of how many steps will be needed and how much ink will be spilt in the process, so long as everything remains finite. We are also told that each step is to be ‘small’ and the rules governing it must be ‘simple’, available to a cognitively limited calculating agent: for we want an algorithmic procedure, step-by-minimal-step, to be idiot-proof. For a classic elucidation of this kind, see e.g. Rogers (1967, pp. 1–5). Church’s Thesis, in one form, then claims this informally explicated concept in fact has a perfectly precise extension, the set of recursive functions. Church’s Thesis can be supported in a quasi-empirical way, by the failure of our searches for counterexamples. It can be supported too in a more principled way, by the observation that different appealing ways of sharpening up the informal chararacterization of algorithmic computability end up specifying the same set of recursive functions. But such considerations fall short of a demonstration of the Thesis. So is there a different argumentative strategy we could use, one that could lead to a proof? Sometimes it is claimed that there just can’t be, because you can never really prove results involving an informal concept like algorithmic computability.. (shrink)

In this article, I consider the cases of religious Moorean propositions of the form ‘d, but I don't believe that d’ and ‘d, but I believe that ~d’, where d is a religious dogma, proposition, or part of a creed. I argue that such propositions can be genuinely and rationally asserted and that this fact poses a problem for traditional analysis of religious assertion as an expression of faith and of religious faith as entailing belief. In the article, I explore (...) the possibility of undermining these commonly held assumptions and argue that the assertability of religious Moorean propositions can be justified by an account of faith as an intention to form religious beliefs. In the end, I also consider the consequences of such a stance, especially concerning the debate on the ethics of religious belief and doxastic voluntarism. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Burma’s Healthcare Under Fire: My Experience as an Exiled Medical ProfessionalP. P. KyawI used to work as a medical doctor in a less developed state than many big cities in Burma1 that experienced prolonged civil wars and current similar atrocities decades before the urban areas of the country experienced them. Before everything started, I was responsible for the medical management of the most vulnerable communities and had been struggling (...) with pandemic-related medical activities. Those were the happiest years of my life. I was with one of the best international organizations, where every effort I made was directly delivered to the patients with no unnecessary paperwork. The system was efficient, my colleagues were supportive, and I had a good work-life balance. I supported my family and whoever needed temporary financial support, played music weekly, met good friends who I hung out with every weekend, and [End Page 164] found hobbies like gardening and crocheting. I was content and happy. I even postponed my plans to get registered as a doctor in the Western world.Before moving to this beautiful ethnic state in 2019, I previously worked as a government medical doctor in Yangon, the capital. As much as I loved working in those civilian hospitals, I could not support myself with a monthly pay of $100-$150 USD. It was a hard decision to leave the service because it meant I could not pursue the medical specialty that I had always longed for and had to leave like-minded supportive colleagues. In Myanmar, unless you are a civil servant, you cannot pursue further clinical specialties. However, after leaving the government’s service to work in humanitarian medical assistance in hard-to-reach areas of Burma, I learned that life is still beautiful outside my comfort zone, until February 2021 when the coup began. Democratically elected members of the country’s ruling party were overthrown by the military, which then bestowed power in a military junta.I expected the election prior to the coup in November 2020 to be an uphill battle for Burma, but nothing more. I was still in denial when I first heard the news from one of the town’s NGO staff. The person had to travel on a motorbike to inform everyone that the junta had staged the coup. No telephone or internet was working at that time. My colleagues and I cried in our office, saying, “We are so young, and the future is still ahead. I don’t think this is going to last long. Maybe it will be over in a few days or, at most, a few weeks.” Once the peaceful protests started nationwide, my friends and I provided medical cover for the protesters, initially for minor medical problems such as low sugar, low blood pressure, injuries from accidental minor slips and falls, etc. Never in my life had I imagined that I would be taking care of bullet wounds and people injured by live rounds. While learning about gunshot wounds in forensic medicine, I thought, “Oh, this is not going to be very useful because Burma is not America, and I am not going there.” Then suddenly, it became too real and more useful than I would’ve liked it to be.I always think back to one especially bloody day when many people in the town were shot with live rounds. We assisted many patients. Usually, we would go around with the protest groups until they were over in the late afternoon. The protesters were always peaceful. There were no riots, no harmful acts, or vandalism. Only when the protesters were cruelly dispersed with tear gas, high-pressure pumps, rubber bullets, and live rounds (to the head) did they decide to defend themselves while still making their voices heard. The only defenses people had to counteract the live rounds were things like metal covers, firecrackers, and slingshots.One afternoon in March 2021, my team and I took an early break for lunch—unaware that some people would lose their lives that afternoon. We followed the local protests through Facebook Live while having lunch and started to hear firecracker sounds. A few seconds later, we knew... (shrink)

This paper offers a defense of veritic epistemic consequentialism, addressing its principal critiques. I argue that the core of epistemological value lies in its conduciveness to truth, rendering true beliefs intrinsically valuable. In response to the criticism that this approach may sacrifice individual truths for a greater aggregate and undervalues autonomous inquiry, I emphasize the well-connectedness of beliefs. Each belief's content is a proposition. Propositions are classified as first-order, second-order, third-order, etc., depending on what they are about. Higher-order propositions are (...) about lower-order ones. I assume that if an epistemic agent believes in p, then she tends to believe in higher-order propositions that are about p. These higher-order propositions are more structural beliefs of the agent. If p is false, then falsity may spread over the whole network through higher-order propositions about p. Thus, sacrificing a single belief may bring more damage to the network, which is not acceptable for veritic epistemic consequentialism. Regarding the issue of autonomy, epistemic acts like reflection, inference, etc. can be represented as higher-order propositions. Therefore, veritic epistemic consequentialism values them. (shrink)

North .—What is the trouble about moral facts? When someone denies that there is an objective moral order, or asserts that ethical propositions are pseudo-propositions, cannot I refute him by saying: “You know very well that Brown did wrong in beating his wife. You know very well that you ought to keep promises. You know very well that human affection is good and cruelty bad, that many actions are wrong and some are right”? West .—Isn't the trouble about moral facts (...) another case of trouble about knowing, about learning? We find out facts about the external world by looking and listening; about ourselves, by feeling; about other people, by looking and listening and feeling. When this is noticed, there arises a wish to say that the facts are what is seen, what is heard, what is felt; and, consequently, that moral facts fall into one of these classes. So those who have denied that there are “objective moral characteristics” have not wanted to deny that Brown's action was wrong or that keeping promises is right. (shrink)

P. T. Geach, notoriously, holds the Relative Identity Thesis, according to which a meaningful judgment of identity is always, implicitly or explicitly, relative to some general term. ‘The same’ is a fragmentary expression, and has no significance unless we say or mean ‘the same X’, where ‘X’ represents a general term (what Frege calls a Begriffswort or Begriffsausdruck). (P. T. Geach, Mental Acts (London: Routledge and Kegan Paul, 1957), p. 69. I maintain that it makes no sense to judge whether (...) things are ‘the same’, or remain ‘the same’, unless we add or understand some general term - ‘the same F’. (P. T. Geach, Reference and Generality, third Edition (Ithaca, N.Y.: Cornell University Press, 1980), pp. 63f. I am arguing for the thesis that identity is relative. When one says ‘x is identical with y’, this, I hold, is an incomplete expression; it is short for ‘x is the same A as y’, where ‘A’ represents some count noun understood from the context of utterance - or else, it is just a vague expression of a half-formed thought. (P. T. Geach, ‘Identity,’ Review of Metaphysics 21 (1967-8), p. 3.) One of the ways Geach seeks to support this is by tying it to the well nigh universally admired Fregean thesis about cardinality. (shrink)

For people to live together in pluralistic communities, they must find someway to cope with the practices of others that they abhor. For that reason, tolerance has always seemed an appealing medium of accommodation. But tolerance also has its critics. One wing charges that the tolerant are too easygoing. They are insensitive to evil in their midst. At the same time, another wing attacks the tolerant for being too weak in their sentimentsof respect. “The Christian does not wish to be (...) tolerated,” as T. S. Eliot said; and by this he meant to claim, presumably, that the Christian desires respect and acceptance, and not merely the forbearance suggested by “tolerance.” To make the case for tolerance, we must engage in a three-front campaign: first, against intolerance; second, against the moral failing of indifference; and third, against the desirability of respecting and accepting everyone. The central claim in making this case will be that unlike these three competing sentiments, tolerance is a complex attitude toward the behavior and beliefs of others. Its complexity consists in both moral disapproval and the avoidance of interference. If there is a case to be made for tolerance, it must derive from this peculiar complexity. After surveying its alternatives, I will argue that the complex sentimentof tolerance is more readily praised than its alternatives. (shrink)