Different immunotherapeutic approaches are in the pipeline for the treatment of drug dependence. “Drug vaccines” aim to induce the immune system to produce antibodies that bind to drugs and prevent them from inducing rewarding effects in the brain. Drugs of abuse currently being tested using these new approaches are opioids, nicotine, cocaine, and methamphetamine. In human clinical trials, “cocaine and nicotine vaccines” have been shown to induce sufficient antibody levels while producing few side effects. Studies in humans, determining how these (...) vaccines interact in combination with their target drug, are underway. However, although vaccines can become a reasonable treatment option for drugs of abuse, there are several disadvantages that must be considered. These include i) great individual variability in the formation of antibodies, ii) the lack of protection against a structurally dissimilar drug that produces the same effects as the drug of choice, and iii) the lack of an effect on the drug desire that may predispose an addict to relapse. In addition, a comprehensive overview of several crucial ethical issues has not yet been widely discussed in order to have not only a biological approach to immunotherapy of addiction. Overall, immunotherapy offers a range of possible treatment options: the pharmacological treatment of addiction, the treatment of overdoses, the prevention of toxicity to the brain or the heart, and the protection of the fetus during pregnancy. So far, the results obtained from a small-scale experiment using vaccines against cocaine and nicotine suggest that a number of important technical challenges still need to be overcome before such vaccines can be approved for clinical use. (shrink)

We invited five Cavell scholars to write on this topic. What follows is a vibrant exchange among Paola Marrati, Andrew Norris, Jörg Volbers, Cary Wolfe and Thomas Dumm addressing the question whether, in the contemporary political context, Cavell’s skepticism and his Emersonian perfectionism amount to a politics at all.

How much do animals matter--morally? Can we keep considering them as second class beings, to be used merely for our benefit? Or, should we offer them some form of moral egalitarianism? Inserting itself into the passionate debate over animal rights, this fascinating, provocative work by renowned scholar Paola Cavalieri advances a radical proposal: that we extend basic human rights to the nonhuman animals we currently treat as "things." Cavalieri first goes back in time, tracing the roots of the debate (...) from the 1970s, then explores not only the ethical but also the scientific viewpoints, examining the debate's precedents in mainstream Western philosophy. She considers the main proposals of reform that recently have been advanced within the framework of today's prevailing ethical perspectives. Are these proposals satisfying? Cavalieri says no, claiming that it is necessary to go beyond the traditional opposition between utilitarianism and Kantianism and focus on the question of fundamental moral protection. In the case of human beings, such protection is granted within the widely shared moral doctrine of universal human rights' theory. Cavalieri argues that if we examine closely this theory, we will discover that its very logic extends to nonhuman animals as beings who are owed basic moral and legal rights and that, as a result, human rights are not human after all. (shrink)

Although remote working can involve positive outcomes both for employees and organizations, in the case of the sudden and forced remote working situation that came into place during the COVID-19 crisis there have also been reports of negative aspects, one of which is technostress. In this context of crisis, leadership is crucial in sustainably managing and supporting employees, especially employees with workaholic tendencies who are more prone to developing negative work and health outcomes. However, while research on the role of (...) the positive aspects of leadership during crises does exist, the negative aspects of leadership during the COVID-19 crisis have not yet been studied. The present study aimed to explore the role of authoritarian leadership in a sample of 339 administrative university employees who worked either completely from home or from home and the workplace. The study examined the moderating effect of a manager on this relationship and the connections between workaholism and technostress through conditional process analysis. Results pointed out that high authoritarian leadership had an enhancing effect, whereas low authoritarian leadership had a protective effect on the relationship between workaholism and technostress, only in the group of complete remote workers. Thus, authoritarian leadership should be avoided and training leaders to be aware of its effect appears to be essential. Limitations, future directions for the study, and practical implications are also discussed. (shrink)

A pesar de los innumerables beneficios, hay varias críticas y preocupaciones en relación con el uso de la Inteligencia Artificial (IA), especialmente en Brasil, donde no hay ninguna legislación federal en vigor hasta el momento. Las legislaciones estatales existentes y los proyectos de ley que se están votando en el Congreso, como el PL 21/20, son defectuosos e incompletos, especialmente en lo que respecta a algunas aplicaciones de la IA que implican altos riesgos para los derechos y libertades fundamentales, además (...) de traer a menudo un sesgo potencial, duplicando o potenciando el racismo institucionalizado existente en la sociedad u otras formas de discriminación. Existe una inequidad codificada que propicia infraestructuras injustas, sinembargo, donde hay poder hay resistencia, y en este sentido es necesario señalar la importancia de las contra codificaciones basadas en la solidaridad y que repiensan la justicia, es decir, un enfoque emancipador de la tecnología. Este es el cambio paradigmático necesario, y siendo necesario, tiene que ser posible y debe buscarse con el máximo esfuerzo. Se trata de verdaderas formas de resistencia, como instrumentos abolicionistas para el “Nuevo Código Jim”, nuevas formas de discriminación de raza, género y clase existentes a través del uso de las nuevas tecnologías, en el sentido de prácticas de diseño orientadas a la justicia. (shrink)

This text was first published in Theory, Culture & Society, May 13, 2015. For a special issue of Body & Society on ‘Rhythm, Movement, Embodiment', Paola Crespi presents two previously untranslated texts, Rudolf Bode's ‘Rhythm and its Importance for Education' and Rudolf Laban's ‘Eurhythmy and Kakorhythmy'. In the following interview she uncovers further unpublished and untranslated sources and she discusses some of the main themes of these texts in relation to the more widely known text - Danse, théâtre et (...) spectacle vivant – GALERIE – Nouvel article. (shrink)

This book takes the reader on a philosophical quest to understand the dark side of emotions. The chapters are devoted to the analysis of negative emotions and are organized in a historical manner, spanning the period from ancient Greece to the present time. Each chapter addresses analytical questions about specific emotions generally considered to be unfavorable and classified as negative. The general aim of the volume is to describe the polymorphous and context-sensitive nature of negative emotions as well as changes (...) in the ways people have interpreted these emotions across different epochs. The editors speak of ‘the dark side of the emotions’ because their goal is to capture the ambivalent – unstable and shadowy – aspects of emotions. A number of studies have taken the categorial distinction between positive and negative emotions for granted, suggesting that negative emotions are especially significant for our psychological experience because they signal difficult situations. For this reason, the editors stress the importance of raising analytical questions about the valence of particular emotions and focussing on the features that make these emotions ambivalent: how – despite their negativity – such emotions may turn out to be positive. This opens up a perspective in which each emotion can be understood as a complex interlacing of negative and positive properties. The collection presents a thoughtful dialogue between philosophy and contemporary scientific research. It offers the reader insight by illuminating the dark side of the emotions. (shrink)

In this study, Paola Marrati approaches—in an extremely insightful, rigorous, and well-argued way—the question of the philosophical sources of Derrida's thought through a consideration of his reading of both Husserl and Heidegger. A central focus of the book is the analysis of the concepts of genesis and trace as they define Derrida's thinking of historicity, time, and subjectivity. Notions such as the contamination of the empirical and the transcendental, dissemination and writing, are explained as key categories establishing a guiding (...) thread that runs through Derrida's early and later works. Whereas in his discussion of Husserl Derrida problematizes the relationship between the ideality of meaning and the singularity of its historical production, in his interpretation of Heidegger he challenges the very idea of the originary finitude of temporality. This book is essential reading not only for those interested in the philosophical roots of deconstruction, but for all those interested in the central questions of history and temporality, subjectivity and language, that pervade contemporary debates in cultural, literary, and visual theory alike. (shrink)

While moral perfectionists rank conscious beings according to their cognitive abilities, Paola Cavalieri launches a more inclusive defense of all forms of subjectivity. In concert with Peter Singer, J. M. Coetzee, Harlan B. Miller, and other leading animal studies scholars, she expands our understanding of the nonhuman in such a way that the derogatory category of "the animal" becomes meaningless. In so doing, she presents a nonhierachical approach to ethics that better respects the value of the conscious self. Cavalieri (...) opens with a dialogue between two imagined philosophers, laying out her challenge to moral perfectionism and tracing its influence on our attitudes toward the "unworthy." She then follows with a roundtable "multilogue" which takes on the role of reason in ethics and the boundaries of moral status. Coetzee, Nobel Prize winner for Literature and author of _The Lives of Animals_, emphasizes the animality of human beings; Miller, a prominent analytic philosopher at Virginia Polytechnic Institute, dismantles the rationalizations of human bias; Cary Wolfe, professor of English at Rice University, advocates an active exposure to other worlds and beings; and Matthew Calarco, author of _Zoographies: The Question of the Animal from Heidegger to Derrida_, extends ethical consideration to entities that traditionally have little or no moral status, such as plants and ecosystems. As Peter Singer writes in his foreword, the implications of this conversation extend far beyond the issue of the moral status of animals. They "get to the heart of some important differences about how we should do philosophy, and how philosophy can relate to our everyday life." From the divergences between analytical and continental approaches to the relevance of posthumanist thinking in contemporary ethics, the psychology of speciesism, and the practical consequences of an antiperfectionist stance, _The Death of the Animal_ confronts issues that will concern anyone interested in a serious study of morality. (shrink)

La obra poética de Olga Orozco (1920-1999) es profundamente religiosa. El cuerpo es uno de los temas centrales en su preocupación por alcanzar lo divino. En este sentido, el cuerpo tiene doble valencia: opera como impedimento y también como condición de posibilidad. El abordaje interdisciplinario entre literatura y filosofía que asume este trabajo permite una relectura original del cuerpo en Orozco, que revela las implicancias filosóficas de su intuición poética. La primera parte recorre pasajes en los que el cuerpo es (...) considerado un obstáculo que aísla a los seres y dificulta el retorno a la divinidad. Se analizan sus figuras oscuras y despectivas, como “muro”, “lastre”, “sombra”. La segunda parte examina el poema titulado “El narrador”, del libro _En el revés del cielo_ (1987), como punto de inflexión. El cuerpo reviste allí una significación nueva. La poeta le atribuye el poder de narrar su propia historia. Se puede vislumbrar la profunda analogía entre cuerpo y lenguaje: su función mediadora. El recurso a herramientas conceptuales de la fenomenología hermenéutica ayuda a pensar, desde el poema, la experiencia ambivalente del cuerpo. La noción de carne como alteridad primera explica el extrañamiento que describe la poeta y es condición indispensable para la mediación del sí mismo con el mundo, con los otros y con la ipseidad. La hermenéutica de “El narrador” arroja la luz del registro poético a la interpretación del cuerpo como signo y como condición de posibilidad del encuentro con la alteridad. Seguramente, otras lecturas de Orozco iluminen diversos temas antropológicos y metafísicos, ya que poesía y pensamiento se orientan hacia el mismo misterio. (shrink)

La pandemia ha provocado una crisis global de salud, un estancamiento en el comercio internacional y un quiebre en la cooperación internacional. Se convirtió en el escenario en donde se hicieron evidentes la desigualdad y la vulnerabilidad de muchos estados, como India. Se plantea que eventos como el Covid-19 se constituyen en catalizadores de cambios y transformaciones; es la ocasión para capitalizar los beneficios de la cooperación bilateral y multilateral, y así promover un mayor desarrollo. La pregunta que surge es (...) cuál puede ser el rol de América Latina en la política de desarrollo de India en la pospandemia. Ambos necesitan una estrategia multidimensional para potenciar el comercio bilateral y activar convenios de cooperación en diferentes áreas que no han sido puestos en marcha o han tenido una aplicación limitada. El objetivo es explorar la profundización de la asociación de India con América Latina para colaborar en el desarrollo mutuo en la era de la pospandemia, tomando como eje su política exterior en las dimensiones comercial, diplomática y de la cooperación. La investigación se basó en un estudio de carácter exploratorio y descriptivo, con la utilización de una metodología cualitativa y con énfasis en las fuentes secundarias. La presencia del otro gigante asiático en la región latinoamericana ha generado muchas especulaciones y pocas acciones concretas, más allá del incremento en el comercio y las inversiones. Entonces, explorar las oportunidades y desafíos que el mundo pospandemia presenta a las vinculaciones entre ambos se vuelve prioritario. (shrink)

De re aedificatoria by Leon Battista Alberti, Trattato di Architettura by Filarete, Trattati di architettura, ingegneria e arte militare by Francesco di Giorgio Martini, and Leonardo da Vinci’s works of engineering and inventions exemplify the ways in which fifteenth-century Italian thinkers could blend speculative and rational approaches. Libellus vere aureus was published in Leuven in 1516. Mambrino Roseo praised the simple, earnest people of Garamanti in Institutione del prencipe christiano, dating to 1543. The first version of More’s Latin text in (...) vernacular Italian was published in Venice in 1548, and the first translation into English by Ralph Robinson was printed in London in... (shrink)

A key role in inference is played by randomization, which has been extensively used in clinical trials designs. Randomization is primarily intended to prevent the source of bias in treatment allocation by producing comparable groups. In the frequentist framework of inference, randomization allows also for the use of probability theory to express the likelihood of chance as a source for the difference of end outcome. In the Bayesian framework, its role is more nuanced. The Bayesian analysis of clinical trials can (...) afford a valid rationale for selective controls, pointing out a more limited role for randomization than it is generally accorded. This paper is aimed to offer a view of randomization from the perspective of both frequentist and Bayesian statistics and discussing the role of randomization also in theoretical decision models. (shrink)

This paper tackles the question of whether the order of concepts was still a relevant aspect of scientific rigour in the 19th and 20th centuries, especially in the case of authors who were deeply influenced by the Leibnizian project of a universal characteristic. Three case studies will be taken into account: Hermann Graßmann, Giuseppe Peano and Kurt Gödel. The main claim will be that the choice of primitive concepts was not only a question of convenience in modern hypothetico-deductive investigations, but (...) sometimes also the result of philosophical investigations onto the foundation of scienti­fic disciplines. The question of the "right" order of concepts is an ideal to be followed rather than a task that can be fulfilled, but remains nonetheless an essential part of the axiomatic enterprise. This paper aims to question whether there is in fact such a stark contrast, as there is often claimed to be in the literature, between the debates relating to the right order of concepts and the foundational questions concerning modern axiomatics. The scientific rupture determined by the appearance of hypothetico-deductive systems in mathema­tics and logic should thus not be dissociated from some relevant continuities concerning the ideal of knowledge as the search for a general theory of concepts deriving from some fundamental elements. (shrink)

The present study aims at exploring whether the level of well-being vary as a function of fertility status in different phases of the ovulatory cycle. We investigated the multidimensional well-being, including the cognitive component of subjective well-being related to judgments about one’s life satisfaction, the psychological well-being concerning the full growth and self-realization of the individual, and self-esteem, that is the personal judgment of overall self-worth and is recognized as one indicator of well-being. On the basis of the cycle phase (...) estimation at the moment of the experiment, one hundred and sixteen normally cycling women were divided into “fertile” and “non-fertile” groups and were administered the Psychological Well-Being Scale, the Basic Self-Esteem Scale and the Satisfaction with Life Scale. A Multivariate Analysis of Variance has been performed to examine whether there were differences between groups according to their ovulatory phase. All dimensions of psychological well-being, self-esteem and satisfaction with life were found to be stable in the different phases of the menstrual cycle. The implications of these results are discussed. (shrink)

We asked a series of questions to Luca Cobbe and Paola Rudan, authors of two books foregrounding the turning point of the 18th century by which, moving from the experience of the revolution, the structure of the constitution and configuration of government were deeply rethought. The two works, respectively about David Hume and Jeremy Bentham, contribute significantly to illuminate the way by which obedience has been reconsidered when society and opinion became the sources of political legitimation. This dialogue at (...) distance clearly shows the presence of a plurality of constitutional registers which were necessary for the affirmation of the centrality of government in the era of the rising popular sovereignty. (shrink)

To contribute to our understanding of the relationship between philosophical ideas and medical and healthcare models. A diachronic analysis is put in place in order to evaluate, from an innovative perspective, the influence over the centuries on medical and healthcare models of two philosophical concepts, particularly relevant for health: how Man perceives his identity and how he relates to Nature. Five epochs are identified—the Archaic Age, Classical Antiquity, the Middle Ages, the Modern Age, the ‘Postmodern’ Era—which can be seen, à (...) la Foucault, as ‘fragments between philosophical fractures’. From a historical background perspective, up to the early 1900s progress in medical and healthcare models has moved on a par with the evolution of philosophical debate. Following the Second World War, the Health Service started a series of reforms, provoked by anti-positivistic philosophical transformations. The three main reforms carried out however failed and the medical establishment remained anchored to a mechanical, reductionist approach, perfectly in line with the bureaucratic stance of the administrators. In this context, future scenarios are delineated and an anthropo-ecological model is proposed to re-align philosophy, medicine and health care. (shrink)

The article evaluates the Domain Postulate of the Classical Model of Science and the related Aristotelian prohibition rule on kind-crossing as interpretative tools in the history of the development of mathematics into a general science of quantities. Special reference is made to Proclus’ commentary to Euclid’s first book of Elements , to the sixteenth century translations of Euclid’s work into Latin and to the works of Stevin, Wallis, Viète and Descartes. The prohibition rule on kind-crossing formulated by Aristotle in Posterior (...) analytics is used to distinguish between conceptions that share the same name but are substantively different: for example the search for a broader genus including all mathematical objects; the search for a common character of different species of mathematical objects; and the effort to treat magnitudes as numbers. (shrink)

Nos séculos XIII e XIV há um grande aprofundamento da lógica, salientando-se, entre outros autores, Guilherme de Ockam e Walter Burleigh. Entre estes dois autores há um debate a respeito da composição das proposições, perguntando-se qual a relação entre as proposições verbais e escritas e seus contrapontos mentais.

ABSTRACTThe paper focuses on the gradual separation between materialism and mechanism in early modern German philosophy. In Germany the distinction between the two concepts, originally introduced by Leibniz, was definitively stated by Wolff who was the first to provide a definition of the new philosophical term Materialismus, and of the related philosophical sect. In the first part I describe the initial identification of mechanism and materialism in German philosophy between the last decades of the seventeenth century and 1720. Mechanism is (...) here mostly conceived within a monistic metaphysics of body, which refers mainly to Hobbes and to some interpretations of Spinoza’s pantheism. This tight connection between a mechanical explanation of nature and the Deus sive natura issue leads to a negative judgement on mechanism and its materialistic implications, both charged with a form of more or less explicit atheism. In the second part I describe the gradual emancipation in Germany of mechanism fro... (shrink)

​This book proposes and defends the practice of urban gardening as an ecologically and socially beneficial, culturally innovative, morally appropriate, ethically uplifting, and politically incisive way for individuals and variously networked collectives to contribute to a successful management of some defining challenges of the Anthropocene – this new epoch in which no earthly place, form, entity, process, or system escapes the reach of human activity – including urban resilience and climate change.

My aim in this note is to shed light on ways of interpreting Kant’s Formula of Universal Law (FUL), by looking at relevant similarities and differences between Pauline Kleingeld and Mark Timmons. I identify both their readings as a formal interpretation of Kant’s FUL, in contrast to the substantive interpretations that favor a robust conception of rational agency as a necessary requirement for moral deliberation. I highlight the benefits that arise from Kleingled’s interpretation in showing the immediacy involved in the (...) volitional self-contradiction when universalizing a maxim. Alongside Timmons, I address a question as to whether Kleingeld’s interpretation is completely free from at least a minimal set of assumptions about practical deliberation more broadly, that seem to play a role in generating the volitational self-contradiction she is defending. I close by raising some skeptical worries about the capacity of this kind of contradiction to translate into a moral judgment triggering action. (shrink)

This article discusses the encounter between virtue ethics and environmental ethics and the ways in which environmental virtue ethics confronts nonhuman axiology and the controversial theme of moral anthropocentrism. It provides a reasoned review of the relevant literature and a historical–conceptual rendition of how environmental and virtue ethics came to converge as well as the ways in which they diverge. It explains that contrary to important worries voiced by some non-anthropocentric environmental ethicists, environmental virtue ethics enables and requires a rich (...) and nuanced engagement with nonhuman values of all sorts—intrinsic as well as extrinsic, moral as well as nonmoral, anthropocentric as well as non-anthropocentric—and neither presupposes nor implies moral anthropocentrism in its normativity. Finally, the article considers the fortunes of, and some challenges for, environmental virtue ethics in its application to the ethics of climate change, an increasingly central topic in environmental ethics. This article proceeds as follows: the first section introduces virtue ethics; the second section looks at axiological and normative themes in environmental ethics; the third section discusses environmental virtue ethics; and the fourth section considers its application to climate change. The fifth section draws some conclusions. (shrink)

We animals have evolved a variety of mechanisms to avoid conspecifics who might be infected. It is currently unclear whether and why this “behavioral immune system” targets unfamiliar individuals more than familiar ones. Here I answer this question in humans, using publicly available data of a recent study on 1969 participants from India and 1615 from the USA. The apparent health of a male stranger, as estimated from his face, and the comfort with contact with him were a direct function (...) of his similarity to the men in the local community. This held true regardless of whether the face carried overt signs of infection. I conclude that our behavioral immune system is finely tuned to degrees of outgroupness — and that cues of outgroupness are partly processed as cues of infectiousness. These findings, which were consistent across the two cultures, support the notion that the pathogens of strangers are perceived as more dangerous. (shrink)

Μελέτη συλλογῆς δακτυλιολίθων, πού συγκροτήθηκε στήν Αἴγυπτο καί στεγάζεται στό Μουσεῖο 'Αλεξανδρείας. Περιέχει μερικά ἑλληνιστικά δείγματα, πολλά ρωμαϊκά αὐτοκρατορικῶν χρόνων, ὕστερών χρόνων ἀκόμη καί σύγχρονα. 'Ορισμένα εἶναι ἐξαιρετικῆς τέχνης : μιά προτομή πτολεμαϊκῶν χρόνων τῆς Ἴσιδας, ἤ ἕνα πορτραῖτο τοῦ Σεπτιμίου Σεβήρου καί τῆς οἰκογενείας του. Πολλά συνδέονται ἀπό τό θέμα τους (ἰσιακή τριάδα, κανωπικά ἀγγεῖα, σύνθετα ἑλληνοαιγυπτιακά σχήματα, μαγικές σφραγίδες) ἤ τήν τεχνοτροπία μέ τήν ἑλληνορωμαϊκή Αἴγυπτο.

The paper discusses some difficulties that life in Anthropocene poses to our ethical thinking. It describes the sort of ethical task that individuals find themselves confronting when dealing with the planetary environmental quandaries that characterise the new epoch. It then asks what, given the situation, would count as environmentally virtuous ways of looking at and going about our lives, and how relevant virtues can be developed. It is argued that the practice of gardening is distinctively conducive to that objective. Finally, (...) some garden virtues that will be of special importance in the Anthropocene, but have so far been largely neglected by environmental ethicists, are listed and described. (shrink)

Interest in German Romanticism has been revitalized in recent years by new post-structural, interdisciplinary, and intertextual perspectives. However until now this renewed interest has not led to a re-examination of Jakob Böhme's formative influence on.