ObjectiveFreezing of gait is detrimental to patients with idiopathic Parkinson’s disease. Its pathophysiology represents a multilevel failure of motor processing in the cortical, subcortical, and brainstem circuits, ultimately resulting in ineffective motor output of the spinal pattern generator. Electrophysiological studies pointed to abnormalities of oscillatory activity in freezers that covered a broad frequency range including the theta, alpha, and beta bands. We explored muscular frequency domain activity with respect to freezing, and used deep brain stimulation to modulate these rhythms thereby (...) evaluating the supraspinal contributions to spinal motor neuron activity.MethodsWe analyzed 9 PD freezers and 16 healthy controls. We studied the patients after overnight withdrawal of dopaminergic medication with stimulation off, stimulation of the subthalamic nucleus or the substantia nigra pars reticulate, respectively. Patients performed a walking paradigm passing a narrow obstacle. We analyzed the frequency-domain spectra of the tibialis anterior and gastrocnemius muscles in ‘regular gait’ and during the ‘freezing’ episodes.ResultsIn stimulation off, PD freezers showed increased muscle activity of the alpha and low-beta band compared to HC in both TA and GA. This activity increase was present during straight walking and during the freezes to similar extent. STN- but not SNr-DBS decreased this activity and paralleled the clinical improvement of freezing.ConclusionWe found increased muscle activation of the alpha and lower beta band in PD freezers compared to HC, and this was attenuated with STN-DBS. Future studies may use combined recordings of local field potentials, electroencephalography, and electromyography to interrogate the supraspinal circuit mechanisms of the pathological activation pattern of the spinal pattern generator. (shrink)

[1] Hagadah shel Pesaḥ -- [2] Pirḳe Avot -- [3] Mishle -- [4] Shir ha-shirim -- [5] Megilat Ḳohelet -- 6. Megilat Ekhah -- [7] Megilat Rut -- [8] Sefer Tehilim.

Critical study chiefly of the teachings of Ibn al-ʻArabī, 1165-1240 and various other noted Muslim personalities.

كتاب بحصي يتناول الصراع بين الصوفية والسلفية ويتناول قصة حياة الحلاج وابن الفارض والسهروردي ودواوينهم ويتناول الحب الإلهي عند الصوفية.

Study on Islamic religious life and Islamic ethics in view of various astonishing Islamic stories.

Study on the Qurʼānic teaching for ideal society.

Comparative analysis of Koranic ethics and those of the Prophet Muḥammad recorded in Hadith literature.

Nationalism; Arab countries; Islamic philosophy.

Islamic ethics; Islam and state; religious aspects; Algeria.

Islamic ethics -- Early works to 1800. ; Kāshifī, Ḥusayn Vāʻiẓ, -1504 or 150; Akhlāq-i Muḥsinī.

Islamic ethics in the light of Qurʼanic teaching and Hadith; Customs and practices.

Ibn al-ʻArabī, 1165-1240. Fuṣūṣ al-ḥikam. ; Qayṣarī, Dāwūd ibn Maḥmūd, -1350 or 135Sharḥ Fuṣūṣ al-ḥikam. ; Sufism ; Islamic philosophy.

دراسة صوفية تتناول مفهوم الطبيعة عند ابن العربي وقد جاء في قسمين الأول يتناول الجانب الوجودي من مرتبة الطبيعة بأسلوب واحد معظمهم بخلاصات من نصوص الشيخ الأكبر واشتمل على عدة موضوعات والثاني يتناول عيون مسائل الطبيعة في الفتوحات حيث يهدف إلى عرف الرؤية الأكبرية حول موضوع الطبيعة.