Public reason in practice and theory -- False starts: unsuccessful justifications of public reason -- Respect for persons as a constraint on coercion -- Higher-order unanimity escape clause -- Civic friendship as a constraint on reasons for decision -- Public reason and (same-sex) marriage.

Andrew Cooper presents the first systematic study of Kant's account of natural history. Cooper contends that Kant made a decisive contribution to one of the most explosive and understudied revolutions in the history of science: the addition of time to the frame in which explanations are required, sought, and justified in natural science. Through addressing a wide range of Kant's works, Cooper challenges the claim that Kant's theory of science denies a developmental conception of nature and argues instead that (...) it establishes a method by which natural historians can genuinely dispute historical claims and potentially come to consensus. This method, Cooper argues, can be used to expose serious flaws in Kant's own historical reasoning, including the formation and defence of his racist views. The book will be valuable to philosophers seeking to discern both the power and limitations of Kant's theory of science, and to historians of science working on the fractured landscape of eighteenth-century Newtonianism. (shrink)

The greater good -- The intellectual and the existential -- The problem of evil and the problem of the slightest toothache -- The God of love -- Is God an agent? -- The real God.

ObjectiveTo present the ethical issues, moral arguments, and reasons found in the ethical literature on organoid models.DesignIn this systematic review of reasons in ethical literature, we selected sources based on predefined criteria: The publication mentions moral reasons or arguments directly relating to the creation and/or use of organoid models in biomedical research; These moral reasons and arguments are significantly addressed, not as mere passing mentions, or comprise a large portion of the body of work; The publication is peer-reviewed and published (...) in an academic article, book, national-level report, working paper, or Ph.D. thesis; The publications collected are in English.AnalysisEach article was read in-depth for identifiable moral reasons, arguments, and concerns. These were then inductively classified and synthesized to create broader categories of reasons, and eventually an overarching conceptual scheme was created.ResultsA total of twenty-three sources were included and analyzed out of an initial 266 collected sources. Five themes of ethical issues and arguments were found: Animal Experimentation; Clinical Applications and Experiments; Commercialization and Consent; Organoid Ontology and Moral Status; and Research Ethics and Research Integrity. These themes are then further broken down into sub-themes and topics. Given the extensive nature of the topics found, we will focus on describing the topics that comprised of more in-depth reasons and arguments rather than few, passing mentions or concerns.ConclusionsThe ethics of organoids requires further deliberation in multiple areas, as much of the discussions are not presented as in-depth arguments. Such sentiments are also echoed throughout the organoid ethics literature. (shrink)

Source [1] Andrew E. P. Mitchell, Federica Galli, Sondra Butterworth. (2023). Editorial: Equality, diversity and inclusive research for diverse rare disease communities. Front. Psychol., vol. 14. doi:10.3389/fpsyg.2023.1285774. "It is also important to recognize that certain mental health disorders are classified as rare conditions and have their own cultural concepts of distress, as defined in the DSM-5 (American Psychiatric Association, 2013)" and require “equal attention and support for individuals and their families, both physically and emotionally”. [1].

In this article, I focus on internal dimensions of moral responsibility. I argue that if such dimensions are real -- and it seems they are -- then moral responsibility is compatible with determinism.

The variety and complexity of the eight papers in this Symposium issue are evidence that immigration is a tough nut to crack both as a matter of policy and application. There is no way that any short summary can do justice to these papers, which take a variety of moral, economic, historical, and empirical approaches to some of the recurrent issues in the field, so it is best in this short issue to try to situate the problem in a general (...) classical liberal context, to show where the pressure points are most likely to appear.The initial way to approach this problem is to start with the simple proposition that the world today is divided into national territories where the practical norm is well-nigh universal: That each sovereign state has exclusive control over its own territory, which, among other things, allows it to decide which individuals are members of that state. These citizens have privileges that may be exercised, no questions asked, on such key matters as entering labor markets, owning property, voting, and otherwise participating in political affairs. All these activities may be denied or granted, at will, to any and all outsiders by the territorial sovereign.No one doubts the need for having some form of territorial control. The need to have some monopoly of force could not be achieved if the entire world, with its infinite diversity of locations and populations, were under a single sovereign. Indeed, in many cases, the divisions within a given country may be so pronounced that separation rather than aggregation is the norm. Thus, at the end of the British Raj, India split into India and Pakistan, and later Pakistan split into Pakistan and Bangladesh. Less dramatically, Czechoslovakia split into two countries, the Czech Republic and Slovakia, while the former Yugoslavia split into five nations, starting from the northwest: Slovenia, Croatia, Bosnia and Herzegovina, Serbia, and Macedonia. Clearly, these ethic differences, be they large or small, are a major obstacle to the expansion of the size of the state. And today, the territorial instinct reasserts itself as the member states of the European Union impose more restrictions on immigration.Yet at the same time, the normative foundations of this system seem elusive. There is the following deep skepticism about the importance of these borders, expressed in these essays by Jeremy Waldron and Ilya Somin, that these national boundary lines should have such a pronounced role in political economy. Michael Blake pursues this theme further by asking the extent to which classical liberals can justify exclusion through the use of violence—or is it force? The inquiry into the dominant role of territoriality can then be expanded, as by Peter Margulies, to examine all sorts of negative externalities that could be created both by easy and strict rules of admission.Taken as a whole, there is no doubt that these national barriers are a serious obstacle to the free trade in goods and services between two individuals, one inside the boundary and one outside. The general view is that these barriers block the gains from trade, which is what drives economic progress, so that ideally all tariffs and quantitative restrictions should give way to a system of free trade in which petty objections by domestic competitors of foreign firms should not dictate local policies.It should, of course, be evident that powerful conflicting forces on free trade and protectionism ebb and flow over time. It should therefore come as no surprise that the stakes are even higher where what is at stake is the movement of people across national boundaries. The loss to any given country from keeping out potential citizens can be enormous, and we see powerful political forces clamp down on open immigration, so many of these gains from trade are lost. The situation can be even more heartbreaking when the ability to leave a country exposes innocent people to imprisonment or death.So what is the explanation for so many nations closing their borders? Much of the explanation comes from old-fashioned protectionism. Your computer programmers will take the jobs of our specialists. There is all sorts of occupational licensing and other barriers to entry within a domestic economy, so there is no reason to expect that these forces will not exert even greater influence against outsiders who do not, after all, have a voice in the local economy and who, therefore, as Alex Nowrasteh, Michael Howard, and Andrew Forrester observe, have little ability to influence domestic policy even after they enter a country. In addition, as Gabriel Chin discusses, strong racial prejudices also lead to exclusions from the domestic economy. Not only are there objections in, say, the United States and much of Western Europe, of exclusion on straight racial grounds, as exemplified by Chinese exclusion acts. The force of these exclusions are also subject to political change. Thus, the Immigration Act of 1924 (the Johnson-Reed Act) was part of a white supremacist program, which gave way two decades later to a very different legal regime with the Immigration Act of 1965, which put an end to the venerable system of national-origin quotas.Yet two other reasons for exclusion are constantly at issue. Immigrants not only bring in their labor but also their families, cultures, and traditions that, in public spaces, may clash with local norms and cultures on such elementary and critical matters as to whether women should dress modestly and wear head coverings. Will freewheeling Danes and Swedes feel comfortable if large numbers of Muslims continue their traditional practices with strong barriers between men and women? There are no obvious market mechanisms that will mitigate these issues, and the situation becomes even more fraught if there are large welfare or educational costs that fall, at least in the short run, on local citizens. These are compounded by the fact that immigrants will typically gain political rights that could easily skew the balance of political power between established and newly arrived ethnic groups by altering the outcome of national and local elections. And letting people in is not just done on a simple open-borders policy. Thus, in many countries, as Lance Pritchett discusses, there is the controversial option of letting foreigners in on short-term labor visas that require them to leave after a certain period. And there are further questions about whether people should be deported if they lied on their entry applications or committed some crime while in the new country, as has occurred in the United States. The numbers of cases can be high and their complexity great, so it is fair to ask, along with Jill Family, whether some self-conscious exceptions to the Administrative Procedure Act of 1946, analogous statutes elsewhere, should be regarded as part of the new normal.It is therefore necessary to deal with the thrust and counterthrust on all these issues. It is also fair to ask whether classical liberalism has a distinctive view on these issues, or whether the combination of private gains and multidirectional externalities gives rise to empirical questions that, as always, require further reflection, even when certain situations—the major influx of illegal immigrants on the US southern border—will generate such powerful emotions that detached intellectual inquiry is ever more difficult. We cannot answer these questions, and thus offer to you a set of essays that take a stab at these difficult topics. (shrink)

Brian Loar [1976] observed that communicative success with singular terms requires more than correct referent assignment. For communicative success to be achieved, the audience must assign the right referent in the right way. Loar, and others since, took this to motivate Fregean accounts of the semantics of singular terms. Ray Buchanan [2014] has recently responded, maintaining that, although Loar is correct to claim that communicative success with singular terms requires more than correct referent assignment, this is compatible with direct reference (...) approaches, as long as one also endorses an independently motivated Gricean view of communicative intentions. This paper argues that Buchanan's Gricean view cannot account for the full range of Loar cases. In doing so, it aims to explicate the structure of Loar's cases and thus to clarify the conditions that a theory must meet in order to adequately meet his challenge. (shrink)

Much recent work on moral responsibility has focused on responsibility as accountability—a type of responsibility associated with the blame-oriented reactive attitudes of resentment, indignation, and guilt. The preoccupation with this admittedly important form of responsibility fosters a truncated portrait of our moral lives by largely ignoring responsibility for actions that merit praise and emulation. Through an examination of what is presupposed in the attitudes of gratitude and esteem, this essay argues that praiseworthiness is not best understood as the mirror image (...) of blameworthiness in the accountability sense. To make sense of praiseworthiness one must raise the profile of another type of responsibility —what Gary Watson has identified as its attributability, or aretaic face. Doing so also helps reveal some important features of virtuous agency, including a sense in which such agency may exhibit oft-overlooked and distinctive enhancements of an agent’s freedom. (shrink)

This paper focuses on the most common state policy responses to the opioid crisis, dividing them into six broad categories. Within each category we highlight the rationale behind the group of policies within it, discuss the details and support for individual policies, and explore the research base behind them. The objective is to better understand the most prevalent state responses to the opioid crisis.

In a first major study, the UK’s Royal Society found that 76% of people in the UK are in favour of therapeutic germline genomic editing to correct genetic diseases in human embryos, but found there was little appetite for germline genomic editing for non‐therapeutic purposes. Assuming the UK and other governments acted on these findings, can lawmakers and policymakers coherently regulate the use of biomedical innovations by permitting their use for therapeutic purposes but prohibiting their use for enhancement purposes? This (...) paper examines the very common claim in the enhancement literature that the therapy v enhancement distinction does little meaningful work in helping us think through the ethical issues, a claim that has significant implications for these lawmakers and policymakers who may wish to regulate genomic editing techniques to reflect the findings of this important study. The focus of this paper is on germline genomic editing as one of the main themes in this special issue. (shrink)

In Thailand the pre-reform Therav?da meditation system, bor?n kamma??h?na, is now practised only by small and isolated groups. To promote detailed comparative study of bor?n kamma??h?na, the tradition of it taught at Wat Ratchasittharam, Thonburi, is explored through a translation of a text on?n?p?nasati attributed to Suk Kaitheun, the head of its lineage. This is followed by a detailed discussion and comparison with the description of the same technique in the Visuddhimagga. Some close connections between these two sources are identified (...) and it is speculated that, despite features concerning nimitta, bodily location, terminology etc. that are diagnostically distinctive for bor?n kamma??h?na, its method for?n?p?nasati can be seen as a rational development of earlier techniques advocated by Buddhaghosa. (shrink)

This article is devoted to the study of the nature of the influence of elections on the risks of revolutionary destabilization. The authors study different approaches to estimating the probability of revolutionary events in an election year. Different types of revolutionary events are distinguished within the framework of the level of political violence. The primary reasons for the activation of the politically active part of the population, both in autocracies and in transitional political regimes, are identified, including the factionalization of (...) elites, the activation of "sleeping" institutions, the growth of political competence among individuals, the consolidation of the prodemocratic opposition and its institutionalization, electoral fraud and other manifestations of unfair political competition, greater emotional involvement of the population in political processes, and so on. The findings support the conclusion that elections promote peaceful revolutionary episodes and reduce the likelihood of armed uprisings. The novelty of the study lies in the fact that the influence of elections on the risks of revolutionary destabilization is considered in the regime context. The authors explore how elections affect violent or non-violent revolutionary actions in certain political regimes, according to Jack A. Goldstone's typology (full autocracies, partial autocracies, factional democracies, partial democracies and full democracies). The authors conclude that holding elections reduces the risks of armed revolutionary destabilization in all types of regimes, except for factional democracies. On the other hand, unarmed revolutionary action is more likely in an election year - in all regime types except full democracies. At the same time, holding elections primarily increases the risks of unarmed revolutionary uprisings in intermediate regimes / anocracies. However, even among anocracies, factional democracies stand out, where in the election year the risks of unarmed (as well as armed) revolutionary episodes increase significantly more than in partial autocracies and in partial non-factional democracies. At the same time, for consolidated democracies, holding elections is a factor that inhibits rather than provokes revolutionary destabilization. In full autocracies, the risk of unarmed revolutionary action increases in an election year, but not as much as in intermediate regimes. (shrink)

This is the second of two articles that are connected in a reading of The plague by Albert Camus. The other article is a determined narration of the events of a tragedy that befalls a city on the coast of Algeria. That article resists analysis beyond the decisions that are made regarding text to use, and of course interpretations to make. This article is juxtaposed to the first, with the intention of taking key themes of education and narration and considering (...) them within the context of another tragedy and another kind of narration. In this article the narratives of government education policy are considered in relation to the event of a tragic earthquake in Christchurch, New Zealand. The government narratives are then replaced by the narratives of Oran to consider alternative ways of thinking about tragedy and education and in particular to think about the ways in which the narrative relates to the tragedy and to any learning that might happen as a result of, and during, a tragedy. (shrink)

The plague narrates the stories of a group of men whose lives interconnect around the experience of exile during the event of a plague. This article selects and summarizes themes from each of their stories. The purpose of these selections is to present an interpretation of Camus’ narratives that can be juxtaposed to an analysis, overleaf, of the educational nature of narratives, and in particular of the event of the tragedy. This article then maps out the narrative of the town (...) and of seven men. It may be read alone as a reading of Camus’ novel with rich, yet unmapped, contributions to thinking about education, or it may be read concurrently with its analytical partner through which the meaning of Camus’ work is traced onto a contemporary tragedy and a city’s educational responses. (shrink)

This article is intended as a response rather than counterpoint to Bennett's careful argument that amnesty cannot amount to an act of collective forgiveness. I agree that a state cannot forgive perpetrators of grave human rights violations. However, I am concerned that conceiving the question of amnesty strictly in terms of a choice between the Art of Compromise or the Hard Line of retribution may unduly limit our understanding of the potential relation between amnesty and forgiveness in politics. To show (...) this, I consider the question of amnesty in relation to the possibility of forgiving those ordinary citizens implicated in the perpetration of wrongs as bystanders and beneficiaries of an unjust regime. Following Arendt, I argue that political grounds for forgiveness in such circumstances are the frailty of the world and the natality of the other . On this account, forgiveness is not necessarily the final term in a process of reconciliation that restores a wrongdoer to the moral community. Rather, the disposition to forgive makes possible a politics in which members of a divided polity contest each other's understandings of the violence of the past and its significance for their political association. (shrink)

This paper investigates how ethics is incorporated in the qualification process for prospective professional accountants across Australia and New Zealand. It does so by examining the structure of these qualification processes and by analysing the learning objectives and summarised content for ethics courses that prospective accountants take either at university or through the post-degree programs provided by CPA Australia and Chartered Accountants Australia and New Zealand. We do this to understand how the ‘sandwich’ approach to teaching ethics :77–92, 1993) is (...) implemented. This approach advocates a standalone ethics course, followed by ethical cases that are integrated across accounting courses, and subsequently a capstone course that combines ethics and professionalism. We test the extent to which this approach is adopted and examine how its application relates to the components of moral behaviour. The results provide three significant contributions. The first is that the ‘sandwich’ approach is not in place for most prospective accountants as only a minority of programs include a mandatory course with a substantial ethics component, and this is more likely in undergraduate rather than postgraduate programs. The second contribution is that although moral sensitivity and moral judgement are widely considered, little attention is given to issues of moral motivation and moral character. We suggest that change is unlikely without explicit ethical education requirements from the professional accounting bodies. The paper also makes a final contribution by proposing a more nuanced typology characterising the degree to which ethics is incorporated in particular courses. (shrink)

What happens when an entire group of human beings is excluded from the definition of humanity? How is the power of language used to distort reality? What happens when a comprehensive economic plan is based on theft, brainwashing, slave labor, and murder? These and other philosophical questions about the Holocaust are contemplated in Contemporary Portraits of Auschwitz. In 1988, a group of philosophers who had survived the Holocaust, or had known people at the Auschwitz death camp, decided to found an (...) organization that would examine the philosophical implications of Shoah: the Society for the Philosophic Study of Genocide and the Holocaust. Noting that the history and the personal horror stories had been told and retold, SPSGH's founders Sander Lee, Berel Lang, and Alan Rosenberg argued that too little study had been so far devoted to the philosophy of Hitler's final solution and other genocides. Auschwitz problematized the Enlightenment concept of humanity, and other concepts. The perfection of state-sponsored and -administered mass death issued in new forms of language, moral indifference, and forgetting. Philosophy often even fails to mention the Holocaust in discussions of National Socialism. And the disaster of Auschwitz has been largely neutralized by the normalization of a "ruined" language. This volume includes essays in several areas: Witnesses and Testimonies; Morality and Ethics; Art and Poetry; History and Memory; and The Crisis of Representation. Contributors are Karyn Ball, Eve Bannet, Debra Bergoffen, James Bernauer, Klaus Dorner, Jennifer N. Fink, Roger Fjellstrom, Ruth Liberman, Burkhard Liebsch, Alan Milchman, Raj Sampath, Paul Sars, Hans Seigfried, Thomas W. Simon, Dan Stone, Peter Strasser, Frans van Peperstratten, Erik M. Vogt, Andrew Weinstein, and others. (shrink)

This article provides an overview of the analysis of technological zones. A technological zone can be understood as a space within which differences between technical practices, procedures and forms have been reduced, or common standards have been established. Such technological zones take broadly one of three forms: (1) metrological zones associated with the development of common forms of measurement; (2) infrastructural zones associated with the creation of common connection standards; and (3) zones of qualification which come into being when objects (...) and practices are assessed according to common standards and criteria. The article argues that technological zones can have more or less clear borders, but such borders increasingly do not correspond to the borders of nation-states. Through a discussion of the global oil industry, some of the ways in which the formation of technological zones has become critical to contemporary economic and political life are examined. (shrink)

Recent years have seen mounting challenge to the model of the criminal trial on the grounds it is not cost-effective, not preventive, not necessary, not appropriate, or not effective. These challenges have led to changes in the scope of the criminal law, in criminal procedure, and in the nature and use of criminal trials. These changes include greater use of diversion, of fixed penalties, of summary trials, of hybrid civil–criminal processes, of strict liability, of incentives to plead guilty, and of (...) preventive orders. The paper will assess the implications of these changes for the function of the criminal law, assessing the reasons behind them, and examining whether or not they are to be welcomed. Identifying the larger import of these changes draws attention to the changing relationship between state and citizen as well as changes in the nature of the state itself. These can in turn be attributed to a jostling among the different manifestations of the authoritarian state, the preventive state, and the regulatory state. These changes have profound normative implications for a liberal theory of the criminal law that require its re-articulation and its defence. A modest start may be to insist that where the conduct is criminal and the consequences are punitive the protections of criminal procedure and trial must be upheld. (shrink)

In recent years, and especially in the wake of Barack Obama's reelection, projections that whites will soon become a minority have proliferated. In this essay, I will argue that such predictions are misleading at best, as they rest on questionable philosophical presuppositions, including the presupposition that racial concepts like ‘whiteness’ are static and unchanging rather than fluid and continually being reconstructed. If I am right about these fundamental inaccuracies, one must wonder why the myth of the white minority persists. I (...) will argue that by reenvisioning whites as a minority culture struggling against a hostile dominant group, and by promoting white solidarity as a response to a crisis, such predictions actually serve to defend and legitimize white supremacy. (shrink)

"I have been using the book in a freshman seminar in which we are exploring college. Most of the texts we are using are academic satire novels, but we are using Delbanco's book to help us talk about the place of college in American culture.

On 5th June 2022 Wales played Ukraine for a place in the FIFA World Cup finals, which are due to be held in Qatar in November and December 2022.I suspect that all right-mined people wanted Ukraine...

Written by experts in the field, this volume presents a comprehensive investigation into the relationship between argumentation theory and the philosophy of mathematical practice. Argumentation theory studies reasoning and argument, and especially those aspects not addressed, or not addressed well, by formal deduction. The philosophy of mathematical practice diverges from mainstream philosophy of mathematics in the emphasis it places on what the majority of working mathematicians actually do, rather than on mathematical foundations. -/- The book begins by first challenging the (...) assumption that there is no role for informal logic in mathematics. Next, it details the usefulness of argumentation theory in the understanding of mathematical practice, offering an impressively diverse set of examples, covering the history of mathematics, mathematics education and, perhaps surprisingly, formal proof verification. From there, the book demonstrates that mathematics also offers a valuable testbed for argumentation theory. Coverage concludes by defending attention to mathematical argumentation as the basis for new perspectives on the philosophy of mathematics. ​. (shrink)

Centuries of scientific progress have been devoted to reducing uncertainty. Newtonian physics, introduced over 300 years ago, allowed for precise prediction of planetary and tidal motion, falling bodies and infinitely more, in addition to allowing the construction of the material world. The 20th century witnessed a revolution in our understanding of organ and cellular function and dysfunction, elucidation of pathways, mediators, receptors, and molecular interactions, and breakthroughs in the characterization of replication, transcription, and translation, all of which has been integral (...) to our understanding of human physiology and pathophysiology. Clinical epidemiology has had a revolutionary impact on our .. (shrink)

Boarding school is a major educational option for many students (e.g., students living in remote areas, or whose parents are working interstate or overseas, etc.). This study explored the motivation, engagement, and achievement of boarding and day students who are educated in the same classrooms and receive the same syllabus and instruction from the same teachers (thus a powerful research design to enable unique comparisons). Among 2,803 students (boardingn= 481; dayn= 2,322) from 6 Australian high schools and controlling for background (...) attributes and personality, we found predominant parity between boarding and day students in their motivation, engagement, and achievement. We also found that classroom-average motivation, engagement, and achievement was not significantly affected by the number of boarders (relative to day students) in the classroom. In addition, the effects of boarding were generally not moderated by students’ background or personality attributes. We conclude that boarders have academic opportunities and outcomes that are comparable to their day student counterparts. Implications for students, teachers, and parents are discussed. (shrink)

Ancient thought, particularly that of Plato and Aristotle, has played an important role in the development of the field of aesthetics, and the ideas of ancient thinkers are still influential and controversial today. "Ancient Aesthetics "introduces and discusses the central contributions of key ancient philosophers to this field, carefully considering their theories regarding the arts, especially poetry, but also music and visual art, as well as the theory of beauty more generally. With a focus on Plato and Aristotle, the philosophers (...) who have given us their thought about the arts at the greatest length, this volume also discusses Hellenistic aesthetics and Plotinus theory of beauty, which was to prove very influential in later thought. "Ancient Aesthetics "is a valuable contribution to its field, and will be of interest to students of philosophy and classics. ". (shrink)

I argue that sometimes a group can author a work of art without the work being either co-authored or multiply-authored. Sometimes the group, itself, is an author, rather than any of its members alone or together. I argue that when a group is an author like this, it has mental properties that no individual member of the group possesses. For example, we can consider the groups that authored digital remixes based on a film titled #INTRODUCTIONS created by the artists LaBeouf, (...) Rönkkö & Turner. YouTubers posted their digital remixes online, and the question is: Who authored those remixes? I contend that many digital remixes are authored by groups that are capable of cognition. (shrink)

Recent years have seen an explosion of interest in the field of ‘art-science’ collaborations for their perceived capacity to develop new cultural understandings of technology and science. In this article, and through an engagement with the philosophy of Gilbert Simondon, I argue that if art-science represents an important site for the formation of an alternate technical culture today, then it is because of the new technical mentalities that such practices might cultivate. Here, creating a new technical mentality is more than (...) just a representational concern with enhancing ‘public awareness’ of technology, instead referring to more material transformations in our embodied capacities for perceiving and affectively engaging with technologies. I flesh this potential out through an encounter with work of Art Orienté objet, whose art-science collaborations challenge the anthropocentric and utilitarian mentalities of contemporary bioscience through explorations of the transindividual conditions of human embodiment and its material immersion within nonhuman ecologies. (shrink)

Journal of Social Philosophy, EarlyView.

Sexual reproduction is the dominant reproductive mode in eukaryotes but, in many taxa, it has never been observed. Molecular methods that detect evidence of sex are largely based on the genetic consequences of sexual reproduction. Here we describe a powerful new approach to directly search genomes for genes that function in meiosis. We describe a “meiosis detection toolkit”, a set of meiotic genes that represent the best markers for the presence of meiosis. These genes are widely present in eukaryotes, function (...) only in meiosis and can be isolated by degenerate PCR. The presence of most, or all, of these genes in a genome would suggest they have been maintained for meiosis and, implicitly, sexual reproduction. In contrast, their absence would be consistent with the loss of meiosis and asexuality. This approach will help to understand both meiotic gene evolution and the capacity for meiosis and sex in putative obligate asexuals. BioEssays 30:579–589, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Progress in emergency and critical care requires that clinical research be performed on patients who are incapable of granting consent for research participation. Analyses of the ethics of such research have left some questions incompletely answered. Why should we be permitted to expose vulnerable patients to research risks without their consent? In particular, how do we justify research interventions that have no potential benefit for participants (nontherapeutic interventions)? This article presents a moral justification for nontherapeutic interventions in emergency research. By (...) relying on a framework for assessing research risks, and by drawing on the example of pediatric research, this justification is founded in how institutional review boards, and society in general, analyze risk. Our justification for emergency research also suggests additional protections for emergency research participants, including a stringent threshold for research risk, that still permit important research to proceed. (shrink)

Recent research suggests that, regardless of the truth of libertarianism about free will, there appears to be a widespread belief among nonphilosopher laypersons that the choices of free agents are not causally necessitated by prior states of affairs. In this paper, I propose a new class of debunking explanation for this belief which I call ‘reasons-based accounts’. I start the paper by briefly recounting the failures of extant approaches to debunking explanations, and then use this as a jumping off point (...) to articulate several alternatives, highlighting the strengths and weaknesses of each. (shrink)