In a companion review1 we discussed the data supporting the conclusion that at least two subtypes of spectrin exist in mammalian brain. One form is found in the cell bodies, dendrites, and post‐synaptic terminals of neurons (brain spectrin(240/235E)) and the other subtype is located in the axons and presynaptic terminals (brain spectrin(240/235)). Our recent understanding of brain spectrin subtype localization suggests a possible explanation for a conundrum concerning brain 4.1 localization. Amelin, an immunoreactive analogue of red blood cell (rbc) cytoskeletal (...) protein 4.1, is localized in neuronal cell bodies and dendrites when brain sections are stained with antibody against rbc protein 4.1. However, it has recently been suggested that synapsin I, a neuron‐specific phosphoprotein associated with the cytoplasmic surface of small synaptic vesicles, is related to erythrocyte 4.1. In this review we hypothesize that there are at least two forms of brain 4.1: a cell body/dendritic form (amelin) which is detected with rbc protein 4.1 antibody, and a unique form found exclusively in the presynaptic terminal (synapsin I). The binding of synapsin I to brain spectrin(240/235), and its ability to stimulate the spectrin/F‐actin interaction in a phosphorylation‐dependent manner suggests a model for the regulation of synaptic transmission mediated by the neuronal cytoskeleton. (shrink)

Contributed articles on Advaita, Hindu philosophy, Vedic and Sanskrit literature.

Sometimes, there are reasons for which we believe, intend, resent, decide, and so on: these reasons are the “bases” of the latter, and the explanatory relation between these bases and the latter is what I will call “the basing relation.” What kind of explanatory relation is this? Dispositionalists claim that the basing relation consists in the agent’s manifesting a disposition to respond to those bases by having the belief, intention, resentment, and so on, in question. Representationalists claim that the basing (...) relation consists in the agent’s representing the bases as justifying the belief, intention, resentment, and so on, in question. This article shows that an adequate account of the basing relation requires a particular refinement and combination of these two views. On the hybrid account defended here, the basing relation involves a disposition exercise that is individuated by the agent’s object-involving de se representation of that very exercise as justifying. (shrink)

In his recent Knowledge and its Limits, Timothy Williamson argues that no non-trivial mental state is such that being in that state suffices for one to be in a position to know that one is in it. In short, there are no “luminous” mental states. His argument depends on a “safety” requirement on knowledge, that one’s confident belief could not easily have been wrong if it is to count as knowledge. We argue that the safety requirement is ambiguous; on one (...) interpretation it is obviously true but useless to his argument, and on the other interpretation it is false. (shrink)

This volume features the complete text of all regular papers, posters, and summaries of symposia presented at the 16th annual meeting of the Cognitive Science ...

I have argued that orthographic processing cannot be understood and modeled without considering the manner in which orthographic structure represents phonological, semantic, and morphological information in a given writing system. A reading theory, therefore, must be a theory of the interaction of the reader with his/her linguistic environment. This outlines a novel approach to studying and modeling visual word recognition, an approach that focuses on the common cognitive principles involved in processing printed words across different writing systems. These claims were (...) challenged by several commentaries that contested the merits of my general theoretical agenda, the relevance of the evolution of writing systems, and the plausibility of finding commonalities in reading across orthographies. Other commentaries extended the scope of the debate by bringing into the discussion additional perspectives. My response addresses all these issues. By considering the constraints of neurobiology on modeling reading, developmental data, and a large scope of cross-linguistic evidence, I argue that front-end implementations of orthographic processing that do not stem from a comprehensive theory of the complex information conveyed by writing systems do not present a viable approach for understanding reading. The common principles by which writing systems have evolved to represent orthographic, phonological, and semantic information in a language reveal the critical distributional characteristics of orthographic structure that govern reading behavior. Models of reading should thus be learning models, primarily constrained by cross-linguistic developmental evidence that describes how the statistical properties of writing systems shape the characteristics of orthographic processing. When this approach is adopted, a universal model of reading is possible. (shrink)

Rieber 1998 proposes an account of "S knows that p" that generates a contextualist solution to Closure. In this paper, I’ll argue that Rieber’s account of "S knows that p" is subject to fatal objections, but we can modify it to achieve an adequate account of "S knows that p" that generates a unified contextualist solution to all four puzzles. This is a feat that should matter to those philosophers who have proposed contextualist solutions to Closure: all of them have (...) motivated their contextualism by appeal to the fact that they can explain the plausibility of each of the statements in Closure taken individually, and they can do this without having to deny that each of those statements is true, at least in the context in which it is plausible. But notice that this consideration would equally well motivate a contextualist approach to the other puzzles. Nonetheless, no contextualist has yet suggested how a contextualist solution to the other puzzles might go. (shrink)

(NEG) is widely accepted both by internalist and by externalists. In fact, there have been very few opponents of (NEG). Timothy Williamson (e.g., 2000) rejects (NEG), for reasons that have by now received a great deal of scrutiny.2 John McDowell also rejects (NEG), but his reasons have not received the scrutiny they deserve. This is in large part because those reasons have not been well understood. We believe that McDowell’s challenge to (NEG) is important, worthy of fair assessment, and maybe (...) even correct. In this paper, we explain McDowell’s challenge to (NEG), and also explain how McDowell can address a seemingly fatal objection to his view. (shrink)

Wittgenstein’s On Certainty is sometimes read as providing a response to the skeptical puzzle from closure, according to which our commitment to the trustworthiness of our evidence is not itself evidentially grounded. In this paper, I argue both that this standard reading of Wittgenstein is incorrect, and that a more accurate reading of Wittgenstein provides us with a more plausible solution to the Closure Puzzle.

In the last decade, reading research has seen a paradigmatic shift. A new wave of computational models of orthographic processing that offer various forms of noisy position or context-sensitive coding have revolutionized the field of visual word recognition. The influx of such models stems mainly from consistent findings, coming mostly from European languages, regarding an apparent insensitivity of skilled readers to letter order. Underlying the current revolution is the theoretical assumption that the insensitivity of readers to letter order reflects the (...) special way in which the human brain encodes the position of letters in printed words. The present article discusses the theoretical shortcomings and misconceptions of this approach to visual word recognition. A systematic review of data obtained from a variety of languages demonstrates that letter-order insensitivity is neither a general property of the cognitive system nor a property of the brain in encoding letters. Rather, it is a variant and idiosyncratic characteristic of some languages, mostly European, reflecting a strategy of optimizing encoding resources, given the specific structure of words. Since the main goal of reading research is to develop theories that describe the fundamental and invariant phenomena of reading across orthographies, an alternative approach to model visual word recognition is offered. The dimensions of a possible universal model of reading, which outlines the common cognitive operations involved in orthographic processing in all writing systems, are discussed. (shrink)

Subliminal perception (SP) is today considered a well-supported theory stating that perception can occur without conscious awareness and have a significant impact on later behaviour and thought. In this article, we first present and discuss different approaches to the study of SP. In doing this, we claim that most approaches are based on a dichotomic measure of awareness. Drawing upon recent advances and discussions in the study of introspection and phenomenological psychology, we argue for both the possibility and necessity of (...) using an elaborated measure of subjective states. In the second part of the article, we present findings where these considerations are implemented in an empirical study. The results and implications are discussed in detail, both with reference to SP, and in relation to the more general problem of using elaborate introspective reports as data in relation to studies of cognition. (shrink)

According to a doctrine that I call “Cartesianism”, knowledge – at least the sort of knowledge that inquirers possess – requires having a reason for belief that is reflectively accessible as such. I show that Cartesianism, in conjunction with some plausible and widely accepted principles, entails the negation of a popular version of Fallibilism. I then defend the resulting Cartesian Infallibilist position against popular objections. My conclusion is that if Cartesianism is true, then Descartes was right about this much: for (...) S to know that p, S must have reasons for believing that p which are such that S can know, by reflection alone, that she has those reasons, and that she could not possibly have those reasons if p is not true. Where Descartes went wrong was in thinking that our ordinary, fallible, non-theologically grounded sources of belief (e.g., perception, memory, testimony), cannot provide us with such reasons. (shrink)

Basic philosophical concepts and major works of the Sautrantrika school in Buddhist philosophy; a study.

Seven decades ago, a new global order emerged. However, as the COVID-19 pandemic rages across the planet, those older ways of being are under unprecedented stress. Already, a new world order is taking shape--one that will put long-standing agenda items like trade, commerce and defence on the backburner. In a post-pandemic world, they will be edged out by issues like climate change, holistic healthcare, education for innovation and creativity, as well as the management of frontier technologies like artificial intelligence, robotics, (...) blockchain and big data. Human dignity and human rights will be critical issues in this modern reality. To represent the changed actuality of the twenty-first century, global governance needs fresh ideas and novel institutions. More than five decades ago, Deen Dayal Upadhyay articulated a coherent economic philosophy, at the core of which was human-centric development. In the Hindutva Paradigm, author and thinker Ram Madhav provides clarifying insights into the reasoning of a philosopher who has remained an enigma through the decades. At the crossroads where we stand, this refreshing and stimulating philosophy could be the answer to managing the new world order."--Amazon.com. (shrink)

Your evidence constrains your rational degrees of confidence both locally and globally. On the one hand, particular bits of evidence can boost or diminish your rational degree of confidence in various hypotheses, relative to your background information. On the other hand, epistemic rationality requires that, for any hypothesis h, your confidence in h is proportional to the support that h receives from your total evidence. Why is it that your evidence has these two epistemic powers? I argue that various proposed (...) accounts of what it is for something to be an element of your evidence set cannot answer this question. I then propose an alternative account of what it is for something to be an element of your evidence set. 1 Introduction 2 The elements of one's evidence set are propositions 3 Which kinds of propositions are in one's evidence set? 3.1 Doxastic accounts of evidence 3.2 Non-doxastic accounts of evidence 4 Elaborating and defending the LIE CiteULike Connotea Del.icio.us What's this? (shrink)

A number of philosophers have recently defended “contrastivist” theories of knowledge, according to which knowledge is a relation between at least the following three relata: a knower, a proposition, and a contrast set. I examine six arguments that Jonathan Schaffer has given for this thesis, and show that those arguments do not favour contrastivism over a rival view that I call “evidentiary relativism”. I then argue that evidentiary relativism accounts for more data than does contrastivism.

Contemporary consciousness studies, where it is not explicitly religious, is mostly physicalist. Theories of self and consciousness in classical Hindu thought can easily be seen to contribute to religious issues in consciousness studies. But it is also the case that there is much in that that can be useful within broadly physicalist parameters of study as well. The Mīmāṃsā and Nyāya schools, while having (nonphysicalist) soteriological goals for the metaphysical self, nonetheless provide theories of its relationship with consciousness that allow (...) for interpretative strategies that can make their theories relevant to a broadly physicalist study of consciousness. Advaita Vedānta cannot be so interpreted, but its inquiry into the nature of consciousness can provide material for a fundamental critique of the project of objectifying consciousness. (shrink)

Stephen Schiffer has argued that contextualist solutions to skepticism rest on an implausible "error theory" concerning our own semantic intentions. Similar arguments have recently been offered also by Thomas Hofweber and Patrick Rysiew. I attempt to show how contextualists can rebut these arguments. The kind of self-knowledge that contextualists are committed to denying us is not a kind of self-knowledge that we need, nor is it a kind of self-knowledge that we can plausibly be thought to possess.

A skeptic claims that I do not have knowledge of the external world. It has been thought that the skeptic reaches this conclusion because she employs unusually stringent standards for knowledge. But the skeptic does not employ unusually high standards for knowledge. Rather, she employs unusually restrictive standards of evidence. Thus, her claim that we lack knowledge of the external world is supported by considerations that would equally support the claim that we lack evidence for our beliefs about the external (...) world. These considerations do not threaten the truth of our ordinary attributions of evidence, however, for such attributions are context-sensitive in their semantics. It is argued that this solution to the problem of the external world enjoys all of the benefits, and suffers none of the problems, of other solutions to the problem of the external world. (shrink)

Although there are various studies comparing Greek and Indian philosophy and religion, and Chinese and Western philosophy and religion, Brahman and Dao: Comparatives Studies in Indian and Chinese Philosophy and Religion is a first of its kind that brings together Indian and Chinese philosophies and religions. Brahman and Dao helps close the gap on a much needed examination on the rich history of Buddhist transmission to China, and the many generations of Indian Buddhist missionaries to China and Chinese Buddhist pilgrims (...) to India, including the legendary Bodhidharma, and Faxian and Xuanzang. (shrink)

Aphoristic work on Nyaya and Vaiśeṣika school of Hindu philosophy; Sanskrit auto commentary with Hindi interpretation and translation.