Biochemical networks, including those containing signaling pathways, display a wide range of regulatory properties. These include the ability to propagate information across different time scales and to function as switches and oscillators. The mechanisms underlying these complex behaviors involve many interacting components and cannot be understood by experiments alone. The development of computational models and the integration of these models with experiments provide valuable insight into these complex systems‐level behaviors. Here we review current approaches to the development of computational models (...) of biochemical networks and describe the insights gained from models that integrate experimental data, using three examples that deal with ultrasensitivity, flexible bistability and oscillatory behavior. These types of complex behavior from relatively simple networks highlight the necessity of using theoretical approaches in understanding higher order biological functions. BioEssays 24:1110–1117, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)

The attitude that ordinary language description of experience is in fact a description of the world is called “naïve realism.” There is an entire branch of modern Western philosophy that is devoted to critically examining the assumptions behind the everyday language we use to describe the macroscopic world in which we live and the validity of naïve realism as an adequate description of the world. This branch of philosophy is called “ordinary language philosophy.” Surprisingly, it has something in common with (...) quantum physics: insight into the inadequacy of ordinary language to describe observable reality. It is this connection between ordinary language philosophy and quantum physics that we shall explore in this article. In the process, we shall also offer a basic introduction to both basic philosophy and basic quantum theory. (shrink)

The spread of digital technology to all parts of our lives has led to meaningful benefits, ranging from the conveniences offered by ride-sharing apps to prediction of mental health crises and track...

We have considered a simple word game called the word-morph. After making our participants play a stipulated number of word-morph games, we have analyzed the experimental data. We have given a detailed analysis of the learning involved in solving this word game. We propose that people are inclined to learn landmarks when they are asked to navigate from a source to a destination. We note that these landmarks are nodes that have high closeness-centrality ranking.

Libertarians are an increasingly prominent ideological group in U.S. politics, yet they have been largely unstudied. Across 16 measures in a large web-based sample that included 11,994 self-identified libertarians, we sought to understand the moral and psychological characteristics of self-described libertarians. Based on an intuitionist view of moral judgment, we focused on the underlying affective and cognitive dispositions that accompany this unique worldview. Compared to self-identified liberals and conservatives, libertarians showed 1) stronger endorsement of individual liberty as their foremost guiding (...) principle, and weaker endorsement of all other moral principles; 2) a relatively cerebral as opposed to emotional cognitive style; and 3) lower interdependence and social relatedness. As predicted by intuitionist theories concerning the origins of moral reasoning, libertarian values showed convergent relationships with libertarian emotional dispositions and social preferences. Our findings add to a growing recognition of the role of personality differences in the organization of political attitudes. (shrink)

Although quantum theory is presented as a radically non classical theory in physics, it is an open secret that our present understanding of it is based on a conceptual base borrowed from classical physics, leading to the situation that all of the radical implications of quantum theory are expressed using terminology that, in other circumstances would be considered blatantly self contradictory. To give but a few examples: wave particle duality (one and the same ontological entity can be ascribed two mutually (...) differing space time pictures), superposition (a microscopic object is required to be simultaneously in two distinct and mutually exclusive classical states), and non locality (two objects presumed to.. (shrink)

I argue that moral principles involve the same sort of generalization as ordinary yet elusive generic generalizations in natural language such as ‘Tigers are striped’ or ‘Peppers are spicy’. A notable advantage of the generic view is that it simultaneously allows for pessimism and optimism about the role and status of moral principles in our lives. It provides a new perspective on the nature of moral principles on which principles are not apt for determining the moral status of particular actions (...) while they may be apt, and even fundamental, to our acquisition of moral knowledge. A natural consequence of the view is variation among moral principles, with some regularly warranting exceptions and some appearing arguably exceptionless. I will also argue that this generic conception of moral principles has significant advantages, as a normative model of moral reasoning, over the view of moral principles as defaults advanced in recent years. (shrink)

In part-1, I shall outline the principle details of Bohr’s interpretation. Bohr’s basic interpretive insight is ‘ quantum inseparability’ . Complementarity of phenomena and a “revision to our attitude towards physical explanation” then follow. Together , these can be said to constitute Bohr’s general viewpoint of ‘complementarity’. Bohr does not quite clearly spell out the content of these three ideas; I do.

With its Vedāntic metaphysics and devotionally rich narratives, the Bhāgavata Purāṇa can provide valuable models for ecological care and preservation. Throughout the Purāṇa, we find narratives that can be harnessed in service of the environment, whether it be Kṛṣṇa battling the serpent Kāliya or Varāha lifting the Earth from the depths of the cosmic ocean. This article, however, will focus on a little-known narrative found in Book Four, namely, the Pracetās’ destruction, and eventual protection, of the Earth’s trees. The Pracetās’ (...) narrative is significant for several reasons: instead of simply venerating nature, the story demonstrates the challenge of balancing human needs and the needs of other life forms; it accords agency to the Earth by giving the forest a voice within the narrative; and it bridges the boundary between human beings and the natural world by building kinship relationships between them. This article will explore the ways in which Vaiṣṇava commentators have interpreted this episode as they attempt to negotiate the question: who has priority—humans or nature? (shrink)

In the model theory of modules the Ziegler spectrum, the space of indecomposable pure-injective modules, has played a key role. We investigate the possibility of defining a similar space in the context of G-sets where G is a group.

The dissertation analyzes the ontological and epistemological arguments that motivate Plato's theory of Forms.

A prevailing thought is that generics have a covert modal operator at logical form. I claim that if this is right, the covert generic modality is a weak necessity modal. In this paper, I pr...

"The definitive work by B.K.S. Iyengar, the world's most respected yoga teacher. B.K.S. Iyengar has devoted his life to the practice and study of yoga. It was B.K.S. Iyengar's unique teaching style, bringing precision and clarity to the practice, as well as a mindset of 'yoga for all', which has made it into the worldwide phenomenon it is today. 'Light on Yoga' is widely called 'the bible of yoga' and has served as the source book for generations (...) of yoga students around the world. It is the classic text for all serious students of yoga." --Publisher description. (shrink)

Iyengar Yoga Wisdom & Practice" is a practical and an inspiring anthology of Iyengar's insights into yoga, life and the path to peace and happiness. Yoga practice lies at the heart of the book, and it is illustrated with over 60 new step-by-step sequences of yoga postures specially shot in India and accompanied by Iyengar's illuminating observations on technique, their significance, and their benefits. This book not only presents Iyengar's practical advice on how to perform key (...) yoga postures, but also draws on a wide range of other material taken from interviews and world lecture tours, to the many texts Iyengar has written about yoga and about his own life's journey. (shrink)

Critical analysis of the commercialization and malpractice current in the profession of medicine.

The call of the wild -- A stranger in strange lands -- Song of myself -- Senses and sensibilities -- I, robot -- Lord of the things -- And then there were none.

We developed an on-line intelligent argumentation system which facilitates stakeholders in exchanging dialogues. It provides decision support by capturing stakeholders’ rationale through arguments. As part of the argumentation process, stakeholders tend to both polarise their opinions and form polarisation groups. The challenging issue of assessing argumentation polarisation had not been addressed in argumentation systems until recently. Arvapally, Liu, and Jiang [, ‘Identification of Faction Groups and Leaders in Web-Based Intelligent Argumentation System for Collaborative Decision Support’, in Proceedings of International Conference (...) on Collaborative Technologies and Systems] earlier developed a method to identify polarisation groups. These groups, however, tend to overlap to a certain degree; each stakeholder may be a member of multiple polarisation groups to varied degrees. Quantifying stakeholders’ membership in multiple polarisation groups is an important issue in the argumentation for collaborative decision-making, which is not addressed earlier. We present a novel approach using fuzzy clustering algorithm to address this issue in this article. The method is evaluated using data sets produced from the discussions of 24 stakeholders. Experimental results indicate that our method is effective for both identifying polarisation groups and quantifying stakeholders’ degree of membership in each polarisation group. (shrink)

How people think about poverty is shown to be dependent on how the issue is framed..

The “class play” is an annual tradition in residency training programs and medical schools that celebrates the end of the academic year. It is also a locally generated narrative that reveals important components of an institution’s values, culture, and group dynamics. Exploring the class play is a reflexive exercise that allows one to reflect on his or her professional development and place in the department in a structural, historical, and experience-near driven way. In this way, the creation of and examining (...) of the class play may be seen as an opportunity to understand and expand upon medicine’s Hidden Curriculum. (shrink)

The practice of paying prisoners to for their participation in research has long been debated, and the controversy is reflected in the differing policies in the U.S. prison systems. Empirical study of financial payments to inmates who enroll in research has focused on whether this practice is coercive. In this study, we examined whether monetary incentives have the potential to be unduly influential among fifty HIV‐positive prisoners. The majority of prisoners surveyed believed that inmates should receive some compensation for their (...) involvement in research and disagreed with statements suggesting that the offer of payment constitutes undue influence. However, a sense of potentially being susceptible to undue influence was significantly higher among participants who had spent a longer time in prison and had less education. Overall, our findings suggest that most prisoners feel that they would be able to make a decision about research enrollment that is not solely based on an offer of monetary payment. (shrink)

Study on the works of Prabhākaramiśra, ancient Sanskrit philosopher and thinker of Mimamsa philosophy.

This article discusses preliminary results from two experiments and puts forth the notion that the development of sensory systems might be more geared toward discerning differences rather than for...

Since the end of the Second World War, the Australasian economies have fared poorly relative both to the high-income states of western Europe and North America and to the `miracle' economies strung along the Pacific coasts of Asia. This article attempts to analyze the post-war trajectories of antipodean economies in the context of the reconstruction of the world market under US hegemony after the end of the Second World War. The first section traces the rise of Japan and the emergence (...) of Pacific Asia as a consolidated nexus of densely interwoven patterns of relational networks. The second section examines how ongoing processes of capitalist restructuring undermined the Asian miracle economies. Finally, the last section seeks to analyze the causes for the disproportionately adverse impact that processes of worldwide transformation have had for the two antipodean settler states. (shrink)

In discussing Gail Fine’s contribution, Sharma challenges the idea that the pseudo-Platonic Sisyphus can productively be interpreted using the philosophical devices of Plato’s Meno. Sharma then explores another approach to the Sisyphus, which involves reading the dialogue as an attack on the tendency to assimilate deliberation to theoretical inquiry and, relatedly, as an attempt to call attention to the practical skills that are uniquely involved in deliberation. Sharma ends by speculating that the dialogue was composed by a member of the (...) school of Isocrates and was intended as a criticism of the intellectual orientation of Plato’s Academy. (shrink)

Rather than a hatha how-to guide with asanas and step-by-step instructions, The Spiritual Roots of Yoga explains yoga’s origin and underlying philosophy. The book dives straight to the heart of the yogic tradition embodied in the figure of Krishna in the Bhagavad Gita, an understanding broadened through an examination of Patanjali’s Yoga Sutra. It then provides the framework for an accessible comparison between yoga and Christian, Buddhist, and other systems of thought. The author of several acclaimed interfaith studies, Ravi (...) Ravindra writes from a deep understanding of not only the philosophy but the context from which yoga evolved, as well as its standing within the community of religious thought and practice, offering practitioners and other spiritual pilgrims a deeper appreciation of the tradition. (shrink)

Individualized customer information is at the heart of on-line commerce. Using increasing amounts of customer-specific data enhances the success and value of one-to-one on-line marketing; but the extensive gathering and use of data specific to individuals also causes alarm over the loss of digital privacy, setting up a confrontation between e-commerce and society. Governments and nations, particularly in Europe, have reacted with a reliance on sweeping laws governing digital privacy protection while other nations such as the U.S. have generally preferred (...) to allow companies and industry associations to regulate themselves. This tenuous balance is under attack from both sides. In this paper, we set up a framework which incorporates the environmental context, ethical perspectives and firm-specific considerations to help firms develop a strategy for handling digital privacy concerns. (shrink)

A contemporary of Krishnamurti, Ravi Ravindra explores Krishnamurti's assertion that the miracle of personal transformation can be linked directly to the art of seeing rightly.